{"id":"https://openalex.org/W2565621925","doi":null,"title":"Activating PIK3CA and AKT mutations in triple-receptor-negative breast cancer","display_name":"Activating PIK3CA and AKT mutations in triple-receptor-negative breast cancer","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2565621925","mag":"2565621925"},"language":"en","primary_location":{"id":"mag:2565621925","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/C42","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073488441","display_name":"Ana Maria Gonzalez-Angulo","orcid":"https://orcid.org/0000-0002-9816-2707","observed_orcids":["https://orcid.org/0000-0002-9816-2707"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana M. Gonz\u00e1lez-Angulo","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-9816-2707","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004102701","display_name":"Bryan T. Hennessy","orcid":"https://orcid.org/0000-0002-7871-6477","observed_orcids":["https://orcid.org/0000-0002-7871-6477"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan T. Hennessy","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-7871-6477","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004954310","display_name":"Katherine Stemke\u2010Hale","orcid":"https://orcid.org/0000-0002-1231-4192","observed_orcids":["https://orcid.org/0000-0002-1231-4192"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Stemke\u2010Hale","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-1231-4192","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068491553","display_name":"Kristine R. Broglio","orcid":"https://orcid.org/0000-0002-8405-3702","observed_orcids":["https://orcid.org/0000-0002-8405-3702"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine Broglio","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-8405-3702","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018264282","display_name":"Mark Stafford Carey","orcid":"https://orcid.org/0000-0002-0473-6993","observed_orcids":["https://orcid.org/0000-0002-0473-6993"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Carey","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-0473-6993","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Davies","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-0977-0912","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076426660","display_name":"Funda Meric\u2010Bernstam","orcid":"https://orcid.org/0000-0001-6816-6072","observed_orcids":["https://orcid.org/0000-0001-6816-6072"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Funda Meric\u2010Bernstam","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0001-6816-6072","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018617106","display_name":"Gabriel N. Hortob\u00e1gyi","orcid":"https://orcid.org/0000-0002-4873-4412","observed_orcids":["https://orcid.org/0000-0002-4873-4412","https://orcid.org/0000-0001-9030-4136"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Hortobagyi","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["UT MD ANDERSON CANCER CENTER, houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-0144-9614","affiliations":[{"raw_affiliation_string":"UT MD ANDERSON CANCER CENTER, houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30236318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akt-mutations","display_name":"AKT mutations","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/distant-metastasis-free-survival","display_name":"distant metastasis-free survival","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4569999873638153},{"id":"https://openalex.org/keywords/metastasis-risk-stratification","display_name":"metastasis risk stratification","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6453233361244202},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6267648935317993},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.6150004863739014},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.5453951954841614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5453523993492126},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5077239274978638},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.49094346165657043},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.47795629501342773},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.44699302315711975},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41694384813308716},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4118482768535614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4106699824333191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4090462923049927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3787451684474945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33912792801856995},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20706704258918762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20492088794708252},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12302985787391663}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2565621925","doi":null,"is_oa":false,"landing_page_url":"https://mct.aacrjournals.org/content/6/11_Supplement/C42","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2158967203","https://openalex.org/W2321545712","https://openalex.org/W2891587526","https://openalex.org/W4231482650","https://openalex.org/W7099662941","https://openalex.org/W2079120139","https://openalex.org/W2921329853","https://openalex.org/W1537747962","https://openalex.org/W2601999635","https://openalex.org/W3013587102"],"abstract_inverted_index":{"C42":[0],"Background:":[2],"The":[3,54,196],"PI3K":[4,18],"pathway":[5,19,32],"mediates":[6],"key":[7],"cellular":[8],"functions":[9],"including":[10],"metabolism,":[11],"angiogenesis,":[12],"survival,":[13],"growth":[14],"and":[15,63,72,90,95,123,148,270],"proliferation.":[16],"Multiple":[17],"members":[20],"are":[21,323],"mutated":[22],"in":[23,40,49,66,136,167,171,202,214,249,293,303,328],"human":[24],"cancers":[25,71,312],"creating":[26],"an":[27],"expectation":[28],"that":[29],"targeting":[30],"this":[31,57,294],"will":[33],"have":[34,45,318],"broad":[35],"antitumour":[36],"activity.":[37],"Functional":[38],"mutations":[39,65,79,211,269,290,301,315],"the":[41,75,163,168,187,205,245,262,278,306],"three":[42],"AKT":[43,64,94],"isoforms":[44],"been":[46],"reported":[47],"(E17K-AKT1)":[48],"8%":[50],"of":[51,56,77,162,186,204,231,296,305,331],"breast":[52,70,208,218,298,311],"cancers.":[53,209,219,299],"purpose":[55],"study":[58],"was":[59,108,151,183,199,222,259],"to":[60,73,153,317],"detect":[61],"PIK3CA":[62,96,210,268,300,314],"triple":[67],"receptor-negative":[68],"(TN)":[69],"correlate":[74],"presence":[76],"these":[78,329],"with":[80,251,253,267,309,313],"distant":[81,242],"metastasis-free":[82],"survival":[83],"(DMFS).\u2028":[84],"Methods:":[85],"Polymerase":[86],"chain":[87],"reaction":[88],"(PCR)":[89],"extension":[91],"primers":[92],"for":[93,261,277],"were":[97,134,174,212,291],"designed":[98],"using":[99,110,119,129],"Sequenom":[100,140,145],"(San":[101],"Diego,":[102],"CA)":[103],"Assay":[104],"Design.":[105],"PCR-amplified":[106],"DNA":[107],"cleaned":[109],"EXO-SAP":[111],"(Sequenom),":[112],"primer":[113],"extended":[114],"by":[115],"IPLEX":[116],"chemistry,":[117],"desalted":[118],"Clean":[120],"Resin":[121],"(Sequenom)":[122],"spotted":[124],"onto":[125],"Spectrochip":[126],"matrix":[127],"chips":[128],"a":[130,139,227,319],"nanodispenser":[131],"(Samsung).":[132],"Chips":[133],"run":[135],"duplicate":[137],"on":[138],"MassArray":[141,143],"MALDI-TOF":[142],"system.":[144],"Typer":[146],"Software":[147],"visual":[149],"inspection":[150],"used":[152],"interpret":[154],"mass":[155,165],"spectra.":[156],"Reactions":[157],"where":[158],"more":[159],"than":[160],"15%":[161],"resultant":[164],"ran":[166],"mutant":[169],"site":[170],"both":[172],"reactions":[173],"scored":[175],"as":[176],"positive.\u2028":[177],"Results:":[178],"Tissue":[179],"from":[180],"91":[181,206],"patients":[182,188,240,250,263,279],"available.":[184],"90%":[185],"received":[189],"anthracyclin":[190],"and/or":[191],"taxane":[192],"based":[193],"chemotherapy":[194],"regimen.":[195],"E17K-AKT1":[197,289],"mutation":[198],"not":[200],"detected":[201,213],"any":[203],"TN":[207,217,297,310],"8/91":[215],"(9%)":[216],"Median":[220],"age":[221],"51":[223],"years":[224,258],"(27-83).":[225],"At":[226],"median":[228],"follow":[229],"up":[230],"19.9":[232],"months":[233],"(range":[234],"5.9":[235],"-":[236],"233.3),":[237],"25":[238],"(27%)":[239],"developed":[241],"metastasis.":[243],"All":[244],"systemic":[246],"recurrences":[247],"occurred":[248,302],"tumors":[252,266],"wtPIK3CA.":[254],"DMFS":[255],"at":[256],"3":[257],"100%":[260],"who":[264,280],"had":[265,281],"61.9%":[271],"(95%":[272],"CI":[273],"=":[274,285],"49.5,":[275],"77.4)":[276],"wtPIK3CA":[282],"tumors,":[283],"p":[284],"0.11.\u2028":[286],"Conclusion:":[287],"No":[288],"seen":[292],"group":[295],"9%":[304],"tumors.":[307,332],"Patients":[308],"seem":[316],"better":[320],"prognosis.":[321],"We":[322],"currently":[324],"studying":[325],"PTEN":[326],"levels":[327],"set":[330]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-01-06T00:00:00"}
