{"id":"https://openalex.org/W2565352147","doi":"https://doi.org/10.1080/13543776.2017.1273350","title":"Tyrosyl-tRNA synthetase inhibitors: a patent review","display_name":"Tyrosyl-tRNA synthetase inhibitors: a patent review","publication_year":2016,"publication_date":"2016-12-19","ids":{"openalex":"https://openalex.org/W2565352147","doi":"https://doi.org/10.1080/13543776.2017.1273350","mag":"2565352147","pmid":"https://pubmed.ncbi.nlm.nih.gov/27977303"},"language":"en","primary_location":{"id":"doi:10.1080/13543776.2017.1273350","doi":"https://doi.org/10.1080/13543776.2017.1273350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2017.1273350","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017505910","display_name":"Juan Sun","orcid":"https://orcid.org/0000-0001-6099-2193","observed_orcids":["https://orcid.org/0000-0001-6099-2193"]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Sun","raw_affiliation_strings":["School of Life Sciences, Shandong University of Technology, Zibo, PR China","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Shandong University of Technology, Zibo, PR China","institution_ids":["https://openalex.org/I119203015"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061890892","display_name":"Peng\u2010Cheng Lv","orcid":"https://orcid.org/0000-0001-5552-9364","observed_orcids":["https://orcid.org/0000-0001-5552-9364"]},"institutions":[{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng-Cheng Lv","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376356","display_name":"Hai\u2010Liang Zhu","orcid":"https://orcid.org/0000-0003-4738-7655","observed_orcids":["https://orcid.org/0000-0003-4738-7655"]},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-Liang Zhu","raw_affiliation_strings":["School of Life Sciences, Shandong University of Technology, Zibo, PR China","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Shandong University of Technology, Zibo, PR China","institution_ids":["https://openalex.org/I119203015"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China","institution_ids":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061890892","https://openalex.org/A5100376356"],"corresponding_institution_ids":["https://openalex.org/I119203015","https://openalex.org/I4391768045","https://openalex.org/I881766915"],"apc_list":null,"apc_paid":null,"fwci":0.0577,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.02620545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"5","first_page":"557","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.8619999885559082},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bacterial-translation","display_name":"bacterial translation","score":0.4959999918937683},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7509999871253967},{"id":"https://openalex.org/keywords/selective-inhibitors","display_name":"selective inhibitors","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7527705430984497},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.7288442254066467},{"id":"https://openalex.org/C2910418148","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Amino Acyl-tRNA Synthetases","level":5,"score":0.5598193407058716},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5094130635261536},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.47610554099082947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47364866733551025},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4587692320346832},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45238471031188965},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4405442476272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4059072434902191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3613359332084656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2098887860774994},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17895251512527466},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.07372400164604187}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014448","descriptor_name":"Tyrosine-tRNA Ligase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13543776.2017.1273350","doi":"https://doi.org/10.1080/13543776.2017.1273350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543776.2017.1273350","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},{"id":"pmid:27977303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27977303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic patents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335961","display_name":"National Science and Technology Planning Project","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1131277739","https://openalex.org/W1170365972","https://openalex.org/W1410164491","https://openalex.org/W1509732336","https://openalex.org/W1543336689","https://openalex.org/W1552416876","https://openalex.org/W1870386153","https://openalex.org/W1963675451","https://openalex.org/W1964633735","https://openalex.org/W1968117772","https://openalex.org/W1968164135","https://openalex.org/W1971056111","https://openalex.org/W1972686135","https://openalex.org/W1973042550","https://openalex.org/W1976375282","https://openalex.org/W1977982769","https://openalex.org/W1982068796","https://openalex.org/W1984372933","https://openalex.org/W1990890588","https://openalex.org/W1997320387","https://openalex.org/W2002437040","https://openalex.org/W2015983150","https://openalex.org/W2019835759","https://openalex.org/W2023706654","https://openalex.org/W2029972030","https://openalex.org/W2033640874","https://openalex.org/W2034889652","https://openalex.org/W2036448942","https://openalex.org/W2039587496","https://openalex.org/W2040227470","https://openalex.org/W2050299992","https://openalex.org/W2054879453","https://openalex.org/W2058082432","https://openalex.org/W2062759972","https://openalex.org/W2067659890","https://openalex.org/W2070559089","https://openalex.org/W2072165486","https://openalex.org/W2089392384","https://openalex.org/W2097099115","https://openalex.org/W2115227691","https://openalex.org/W2115486016","https://openalex.org/W2147516929","https://openalex.org/W2148135968","https://openalex.org/W2149215043","https://openalex.org/W2158023121","https://openalex.org/W2167637849","https://openalex.org/W2168583864","https://openalex.org/W2273181488","https://openalex.org/W2318283290","https://openalex.org/W2322531281","https://openalex.org/W2323483995","https://openalex.org/W2337559814","https://openalex.org/W2345082447","https://openalex.org/W2406460615","https://openalex.org/W2464417828","https://openalex.org/W2493285474","https://openalex.org/W2905827304","https://openalex.org/W3021344764"],"related_works":["https://openalex.org/W2602886183","https://openalex.org/W1131277739","https://openalex.org/W2065329713","https://openalex.org/W2406460615","https://openalex.org/W3037785826","https://openalex.org/W2518221380","https://openalex.org/W2070559089","https://openalex.org/W2026359905","https://openalex.org/W1991069607","https://openalex.org/W2522976910"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Bacterial":[1],"infection":[2],"has":[3,25,142],"been":[4,26,143],"a":[5,40,85,146,150],"consistent":[6],"and":[7,55,77,157,182,197],"relentless":[8],"threat":[9],"to":[10,17,88,100,125,134,174],"human":[11],"health":[12],"because":[13],"of":[14,22,31,42,79,153,162,203],"emerging":[15],"resistance":[16],"existing":[18],"antibiotics.":[19],"Therefore,":[20,74],"much":[21],"the":[23,29,48,51,56,65,75,135,163,186,200],"research":[24],"focused":[27],"on":[28,112,185],"design":[30],"new":[32,104,151],"potent":[33],"antibacterial":[34,204],"agents.":[35,205],"Tyrosyl-tRNA":[36],"synthetase":[37,44,81,141,192],"(TyrRS),":[38],"as":[39,108,145,199],"member":[41],"aminoacyl-tRNA":[43],"family,":[45],"could":[46,194],"recognize":[47],"information":[49,67],"including":[50],"coincident":[52],"tRNA":[53],"molecules":[54],"amino":[57],"acids'":[58],"structures,":[59],"which":[60,128],"are":[61,129],"essential":[62],"in":[63,71,92,138],"translating":[64],"coded":[66],"into":[68],"protein":[69],"structures":[70],"nucleic":[72],"acids.":[73],"discovery":[76],"application":[78],"tyrosyl-tRNA":[80,140,191],"inhibitors":[82,110,127,165,178,193],"might":[83],"be":[84,195],"potential":[86],"strategy":[87],"control":[89],"these":[90],"diseases":[91],"humans.":[93],"Areas":[94],"covered:":[95],"This":[96],"review":[97],"covers":[98],"1999":[99],"2016":[101],"wherein":[102],"several":[103],"analogues":[105],"were":[106],"claimed":[107],"TyrRS":[109,126,164,177],"based":[111],"their":[113],"chemical":[114],"structures.":[115],"Xiao,":[116],"Z.P.":[117],"et":[118],"al":[119],"patented":[120],"two":[121],"Chinese":[122],"patents":[123],"related":[124],"included.":[130],"Expert":[131],"opinion:":[132],"Due":[133],"pivotal":[136],"role":[137],"translation,":[139],"recognized":[144],"promising":[147],"target":[148],"for":[149],"generation":[152,202],"antibiotics":[154],"with":[155,179],"selectivity":[156],"specificity.":[158],"However,":[159],"while":[160],"some":[161],"showed":[166],"encouraging":[167],"results,":[168,189],"there":[169],"is":[170],"an":[171],"urgent":[172],"need":[173],"develop":[175],"novel":[176],"higher":[180],"activity":[181],"selectivity.":[183],"Based":[184],"published":[187],"SAR":[188],"selective":[190],"designed":[196],"developed":[198],"next":[201]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-01-06T00:00:00"}
