{"id":"https://openalex.org/W2565097288","doi":"https://doi.org/10.1182/blood.v120.21.3452.3452","title":"Randomized Double Blind Placebo Controlled PK/PD Study On the Effects of a Single Intravenous Dose of the Anti-Hepcidin Spiegelmer Nox-H94 On Serum Iron During Experimental Human Endotoxemia","display_name":"Randomized Double Blind Placebo Controlled PK/PD Study On the Effects of a Single Intravenous Dose of the Anti-Hepcidin Spiegelmer Nox-H94 On Serum Iron During Experimental Human Endotoxemia","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2565097288","doi":"https://doi.org/10.1182/blood.v120.21.3452.3452","mag":"2565097288"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.3452.3452","doi":"https://doi.org/10.1182/blood.v120.21.3452.3452","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.3452.3452","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027651871","display_name":"Lucas Theodorus van Eijk","orcid":"https://orcid.org/0000-0003-4141-3701","observed_orcids":["https://orcid.org/0000-0003-4141-3701"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lucas van Eijk","raw_affiliation_strings":["Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086860007","display_name":"Dorine W. Swinkels","orcid":"https://orcid.org/0000-0002-1040-9446","observed_orcids":["https://orcid.org/0000-0002-1040-9446"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dorine W. Swinkels","raw_affiliation_strings":["Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands,","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103557338","display_name":"John Aaron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"John Aaron","raw_affiliation_strings":["Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038663155","display_name":"Frank Schwoebel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148657","display_name":"Noxxon Pharma (Germany)","ror":"https://ror.org/04g007714","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210148657"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Schwoebel","raw_affiliation_strings":["NOXXON Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOXXON Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210148657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036316214","display_name":"Frank Fliegert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148657","display_name":"Noxxon Pharma (Germany)","ror":"https://ror.org/04g007714","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210148657"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Fliegert","raw_affiliation_strings":["NOXXON Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOXXON Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210148657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073832437","display_name":"Luciana Summo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148657","display_name":"Noxxon Pharma (Germany)","ror":"https://ror.org/04g007714","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210148657"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Luciana Summo","raw_affiliation_strings":["NOXXON Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOXXON Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210148657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vauleon Ste\u0301phanie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148657","display_name":"Noxxon Pharma (Germany)","ror":"https://ror.org/04g007714","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210148657"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Vauleon Ste\u0301phanie","raw_affiliation_strings":["NOXXON Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOXXON Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210148657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109009289","display_name":"Coby M. Laarakkers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Coby Laarakkers","raw_affiliation_strings":["Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chem. 441, Radboud Univ. Nijmegen Medical centre, Nijmegen, Netherlands,","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082069884","display_name":"Kai Riecke","orcid":"https://orcid.org/0000-0002-1580-498X","observed_orcids":["https://orcid.org/0000-0002-1580-498X"]},"institutions":[{"id":"https://openalex.org/I4210148657","display_name":"Noxxon Pharma (Germany)","ror":"https://ror.org/04g007714","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210148657"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kai Riecke","raw_affiliation_strings":["NOXXON Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOXXON Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I4210148657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047186731","display_name":"Peter Pikkers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Peter Pikkers","raw_affiliation_strings":["Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands,","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027651871","https://openalex.org/A5036316214","https://openalex.org/A5038663155","https://openalex.org/A5047186731","https://openalex.org/A5073832437","https://openalex.org/A5082069884","https://openalex.org/A5103557338","https://openalex.org/A5109009289"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210148657"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.6133,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73796558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"120","issue":"21","first_page":"3452","last_page":"3452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-iron","display_name":"serum iron","score":0.7020000219345093},{"id":"https://openalex.org/keywords/anemia-of-chronic-disease","display_name":"anemia of chronic disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9070000052452087},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hepcidin-25","display_name":"hepcidin-25","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.7427075505256653},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6528580784797668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6157897710800171},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5250149369239807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4697471261024475},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4427035450935364},{"id":"https://openalex.org/C2775989426","wikidata":"https://www.wikidata.org/wiki/Q2549029","display_name":"Anemia of chronic disease","level":4,"score":0.42405954003334045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.402020663022995},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3924066424369812},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3544487953186035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11598825454711914},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.3452.3452","doi":"https://doi.org/10.1182/blood.v120.21.3452.3452","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.3452.3452","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025328028","https://openalex.org/W2570012529","https://openalex.org/W2129185886","https://openalex.org/W1974845135","https://openalex.org/W2030348489","https://openalex.org/W3217282922","https://openalex.org/W2477135732","https://openalex.org/W2419119266","https://openalex.org/W1987460376","https://openalex.org/W1993107727"],"abstract_inverted_index":{"Abstract":[0,1],"3452":[2],"Objective":[3],"Anemia":[4],"of":[5,32,75,90,93,152,168,197,242,269,294,303,330,498],"chronic":[6],"disease":[7],"(ACD)":[8],"is":[9,26],"generally":[10],"attributed":[11],"to":[12,190,276,300,336,339,370,377,413,506],"increased":[13,367],"hepcidin":[14,18,464],"production.":[15],"The":[16,62,166,351],"first-in-class":[17],"antagonist":[19],"NOX-H94,":[20,337],"a":[21,277,286,291,301,371,459,467],"PEGylated":[22],"anti-hepcidin":[23,500],"L-RNA":[24],"oligonucleotide,":[25],"in":[27,85,106,207,217,231,252,309,358,422,430,446,451,470,488],"development":[28,505],"for":[29,138,150,503],"targeted":[30],"treatment":[31,199,254],"ACD.":[33,510],"We":[34],"investigated":[35],"whether":[36],"NOX-H94":[37,128,156,218,256,320,397,423,447,475,502],"prevents":[38],"the":[39,50,71,76,88,94,198,229,267,319,328,359,362,384,396,418,485,495,499],"inflammation-induced":[40,486],"serum":[41,169,353,365,399,419,442,471,489],"iron":[42,164,170,354,366,400,420,443,490],"decrease":[43,469],"during":[44],"experimental":[45],"human":[46,456],"endotoxemia.":[47],"Effects":[48],"on":[49,479],"innate":[51,480],"immune":[52],"response":[53,462],"were":[54,426],"studied":[55],"as":[56,178,184,227],"secondary":[57],"endpoints.":[58],"Materials":[59],"and":[60,82,140,145,161,163,219,246,250,312,333,345,381,405,439,466],"Methods":[61],"study":[63],"protocol":[64],"(ClinicalTrials.gov":[65],"identifier":[66],"NCT01522794)":[67],"was":[68,83,103,120,135,176,214,228,257,444],"approved":[69],"by":[70,125,204,285],"local":[72],"ethics":[73],"committee":[74],"Radboud":[77],"University":[78],"Nijmegen":[79],"Medical":[80,96],"Centre":[81],"conducted":[84],"accordance":[86],"with":[87,280,290,463,474,509],"Declaration":[89],"Helsinki":[91],"(2000)":[92],"World":[95],"Association.":[97],"This":[98],"randomized,":[99],"double-blind,":[100],"placebo-controlled":[101],"trial":[102],"carried":[104],"out":[105],"24":[107],"healthy":[108],"young":[109],"men.":[110],"At":[111,436],"T=0":[112],"hours":[113],"(h),":[114],"2":[115],"ng/kg":[116],"E.":[117],"coli":[118],"endotoxin":[119,148],"administered":[121],"intravenously":[122],"(i.v.),":[123],"followed":[124,284],"1.2":[126],"mg/kg":[127],"or":[129],"placebo":[130,220,363,431,452],"i.v.":[131],"at":[132,141,174,194,212,233,263,306,314,342,373,379,387,393],"T=0.5h.":[133],"Blood":[134],"drawn":[136],"serially":[137],"24h":[139],"day":[142,349],"3,":[143],"8":[144],"15":[146],"after":[147,266,271],"administration":[149,188],"measurements":[151],"inflammatory":[153,461],"parameters,":[154],"cytokines,":[155],"pharmacokinetics,":[157],"total":[158,323],"hepcidin-25":[159,324,332,334],"(free":[160],"NOX-H94-bound),":[162],"parameters.":[165],"difference":[167],"change":[171],"from":[172,368],"baseline":[173,369,378,385],"T=9h":[175,388],"defined":[177],"primary":[179],"endpoint.":[180],"Data":[181],"are":[182,356],"expressed":[183],"mean\u00b1SD.":[185],"Results":[186],"Endotoxin":[187],"led":[189],"flu-like":[191],"symptoms":[192],"peaking":[193],"T=1.5h,":[195],"irrespective":[196],"group.":[200],"Body":[201],"temperature":[202],"rose":[203,299,338,402],"1.9\u00b10.5":[205],"\u00b0C":[206],"both":[208,253],"groups.":[209,255],"Peak":[210],"CRP":[211],"T=24h":[213],"also":[215],"similar":[216],"treated":[221,321,424,432,448],"groups":[222],"(34.3\u00b118.0":[223],"vs.":[224,237],"36.8\u00b18.7":[225],"mg/L)":[226],"rise":[230],"leucocytes":[232],"T=6":[234],"h":[235,265,308,344,415,438],"(12.1\u00b12.2":[236],"12.1\u00b12.3":[238],"\u00d7109/L).":[239],"Plasma":[240,260],"levels":[241],"TNF-\u03b1,":[243],"IL-6,":[244],"IL-10,":[245],"IL-1RA":[247],"peaked":[248,262],"markedly":[249],"similarly":[251],"well":[258],"tolerated.":[259],"concentrations":[261,355,401,421],"0.7\u00b10.4":[264],"start":[268],"administration,":[270],"which":[272,326],"they":[273],"declined":[274,408],"according":[275],"two-compartment":[278],"model,":[279],"rapid":[281],"initial":[282],"elimination":[283,288],"slower":[287],"phase":[289],"plasma":[292],"half-life":[293],"22.5":[295],"\u00b1":[296],"4.28h.":[297],"Hepcidin-25":[298],"peak":[302,372],"23.0\u00b15.2":[304],"nM":[305,341],"T=5.5\u00b10.05":[307],"control":[310],"subjects":[311,425,433,449],"normalized":[313,346],"about":[315],"T=24":[316,437],"h.":[317],"In":[318,361,395],"group,":[322,364,398],"concentrations,":[325],"represent":[327],"sum":[329],"free":[331],"bound":[335],"559\u00b1112":[340],"T=9.5\u00b11.5":[343],"slowly":[347,407],"until":[348,403,409],"15.":[350],"observed":[352],"shown":[357],"table.":[360],"T=3h,":[374],"returned":[375],"close":[376],"T=6h":[380,404],"decreased":[382],"under":[383],"concentration":[386],"reaching":[389],"its":[390],"lowest":[391],"point":[392],"T=12h.":[394],"then":[406],"T=24h.":[410],"From":[411],"6":[412],"12":[414],"post":[416],"LPS,":[417],"significantly":[427],"higher":[428],"than":[429,450],"(P<0.0001,":[434],"ANCOVA).":[435],"48":[440],"h,":[441],"lower":[445],"controls.":[453],"Conclusion":[454],"Experimental":[455],"endotoxemia":[457],"induced":[458],"robust":[460],"release":[465],"subsequent":[468],"iron.":[472],"Treatment":[473],"had":[476],"no":[477],"effect":[478],"immunity,":[481],"but":[482],"effectively":[483],"prevented":[484],"drop":[487],"concentrations.":[491],"These":[492],"findings":[493],"demonstrate":[494],"clinical":[496],"potential":[497],"drug":[501],"further":[504],"treat":[507],"patients":[508],"Disclosures:":[511],"van":[512],"Eijk:":[513],"NOXXON":[514],"Pharma":[515,520,525,529,533,537,541,545],"AG:":[516,521,526,530,534,538,542,546],"Research":[517,522,547],"Funding.":[518,523,548],"Swinkels:NOXXON":[519],"Schwoebel:NOXXON":[524],"Employment.":[527,531,535,539,543],"Fliegert:NOXXON":[528],"Summo:NOXXON":[532],"Ste\u0301phanie:NOXXON":[536],"Riecke:NOXXON":[540],"Pikkers:NOXXON":[544]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-01-06T00:00:00"}