{"id":"https://openalex.org/W2564131069","doi":"https://doi.org/10.1158/1538-7445.am2015-1247","title":"Abstract 1247: Reduction of oxidative stress promotes daunorubicin resistance in acute lymphoblastic leukemia cells","display_name":"Abstract 1247: Reduction of oxidative stress promotes daunorubicin resistance in acute lymphoblastic leukemia cells","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2564131069","doi":"https://doi.org/10.1158/1538-7445.am2015-1247","mag":"2564131069"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-1247","doi":"https://doi.org/10.1158/1538-7445.am2015-1247","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1247","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xia Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Sheng","raw_affiliation_strings":["USC/Children's Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC/Children's Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036167667","display_name":"Jonathan Tucci","orcid":"https://orcid.org/0000-0001-6365-0121","observed_orcids":["https://orcid.org/0000-0001-6365-0121"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Tucci","raw_affiliation_strings":["USC/Children's Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC/Children's Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018231342","display_name":"Steven D. Mittelman","orcid":"https://orcid.org/0000-0003-2867-1298","observed_orcids":["https://orcid.org/0000-0003-2867-1298"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Mittelman","raw_affiliation_strings":["USC/Children's Hospital Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USC/Children's Hospital Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"1247","last_page":"1247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daunorubicin-resistance","display_name":"daunorubicin resistance","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/caspase-3-cleavage","display_name":"caspase-3 cleavage","score":0.7609999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5600000023841858},{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.6359999775886536},{"id":"https://openalex.org/keywords/leukemia-cell-lines","display_name":"leukemia cell lines","score":0.47200000286102295},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.4410000145435333},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.47699999809265137},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.8798617124557495},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7212242484092712},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.6970551609992981},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5341870784759521},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5280595421791077},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5079558491706848},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4940052628517151},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47797390818595886},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4377225637435913},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42427337169647217},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40815073251724243},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40628674626350403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4001203775405884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38789117336273193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3380325436592102},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23641687631607056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1733269989490509},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16993790864944458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-1247","doi":"https://doi.org/10.1158/1538-7445.am2015-1247","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1247","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2523998273","https://openalex.org/W2740890406","https://openalex.org/W1820620501","https://openalex.org/W2742081678","https://openalex.org/W3162128792","https://openalex.org/W2134844954","https://openalex.org/W6964462798","https://openalex.org/W2979384704","https://openalex.org/W7134269889","https://openalex.org/W6958385662"],"abstract_inverted_index":{"Abstract":[0],"The":[1,150,382],"regulation":[2],"of":[3,18,20,182,235,267,298,308,320,373,384,436,450,455],"oxidative":[4,119,237,286,349,407,437],"stress":[5,14,120,238,287,350,408,438],"is":[6,15,56,112,414],"fundamental":[7],"to":[8,34,209,336,402,416],"cell":[9,29,63,138,187],"survival":[10],"and":[11,31,45,70,89,96,135,146,243,358,367,375],"function.":[12],"Oxidative":[13],"a":[16,52,57,130,159,203,314,371],"result":[17],"accumulation":[19],"reactive":[21],"oxygen":[22],"species":[23],"(ROS),":[24],"which":[25,212],"are":[26],"produced":[27],"by":[28,93,116,175,192,215,289,405],"metabolism":[30],"in":[32,87,113,121,206,247,305,409,442],"response":[33,239],"certain":[35],"stressors.":[36],"Cancer":[37,460,470],"cells":[38,84,98,104,127,152,249,292,318,330,360,389],"have":[39,74],"higher":[40],"than":[41],"normal":[42],"ROS":[43,172],"levels":[44],"elevated":[46],"antioxidant":[47],"defense":[48],"mechanisms.":[49],"Daunorubicin":[50],"(DNR),":[51],"widely":[53],"used":[54],"chemotherapy,":[55],"topoisomerase":[58],"II":[59],"inhibitor":[60],"that":[61,77,90,109,200,399],"induces":[62],"death":[64],"through":[65],"DNA":[66],"double":[67],"strand":[68],"breaks":[69],"increased":[71],"ROS.":[72],"We":[73,107],"previously":[75],"shown":[76],"adipocytes":[78,95,117,157,193,268,334,400],"protect":[79,102],"acute":[80,443],"lymphoblastic":[81,444],"leukemia":[82,137,186,445],"(ALL)":[83],"against":[85,194],"DNR":[86,195,201,228,251,299,354,364,374,391],"vitro":[88],"media":[91],"cultured":[92],"both":[94],"ALL":[97,103,122,126,151,410],"together":[99],"(ALCM)":[100],"can":[101],"from":[105,129,390],"DNR.":[106],"hypothesize":[108],"this":[110,270],"protection":[111],"part":[114],"mediated":[115],"alleviating":[118,348,406],"cells.":[123,411,446],"Murine":[124],"pre-B":[125],"isolated":[128],"BCR/ABL":[131],"transgenic":[132],"mouse":[133],"(8093)":[134],"human":[136,185],"lines":[139,188],"(BV173,":[140],"Nalm6,":[141],"REH,":[142],"SEM,":[143],"RS4;11,":[144],"HL60,":[145],"Molt4)":[147],"were":[148,153,163,190,293,327,361],"used.":[149],"co-cultured":[154,332],"with":[155,178,295,333,363],"3T3-L1":[156],"using":[158,169],"transwell":[160],"system.":[161],"Cells":[162],"collected":[164],"for":[165,227,300,422,459],"gene":[166],"expression":[167],"analysis":[168],"qPCR.":[170],"Intracellular":[171],"was":[173,213,245,313],"measured":[174],"flow":[176],"cytometry":[177],"2\u2032-7\u2032-dichlorodihydrofluorescein":[179],"(DCFH-DA).":[180],"Four":[181],"the":[183,207,236,265,285,306,376,388,418,451,456],"six":[184],"tested":[189],"protected":[191,387],"treatment.":[196],"Western":[197],"blots":[198],"showed":[199],"induced":[202,288],"significant":[204],"increase":[205,316],"cleaved":[208],"procaspase-3":[210],"ratio,":[211],"reversed":[214],"ALCM":[216],"(No":[217],"drug:":[218],"0.24\u00b10.2,":[219],"DNR:":[220],"0.83\u00b10.14,":[221],"ALCM+DNR:":[222],"0.24\u00b10.19;":[223],"p":[224],"=":[225,232,262,281,343,394],"0.004":[226],"vs.":[229],"ALCM+DNR,":[230],"n":[231,261,280,342,393],"4).":[233],"Expression":[234],"genes":[240],"gclc,":[241],"gclm":[242],"p21":[244],"upregulated":[246],"8093":[248],"upon":[250],"treatment":[252],"(fold":[253,272],"change":[254,273],"over":[255,274],"baseline:":[256,275],"1.82\u00b10.37,":[257],"2.35\u00b10.73,":[258],"5.55\u00b11.50;":[259],"p<0.05,":[260,279],"3),":[263],"while":[264],"presence":[266,307],"prevented":[269],"upregulation":[271],"0.83\u00b10.11,":[276],"0.88\u00b10.02,":[277],"1.75\u00b10.57;":[278],"3).":[282,344,395],"To":[283,345],"investigate":[284],"DNR,":[290,325],"Nalm6":[291,357],"treated":[294,362],"five":[296],"doses":[297],"6":[301],"hours":[302],"alone":[303,351],"or":[304,310,339,370],"pre-adipocytes":[309,340],"adipocytes.":[311],"There":[312],"dose-dependent":[315],"in%ROShigh":[317],"regardless":[319],"feeder":[321,338],"type.":[322],"At":[323],"200nM":[324],"there":[326],"significantly":[328,386],"fewer%ROShigh":[329],"when":[331],"compared":[335],"no":[337],"(p<0.05,":[341,392],"test":[346],"whether":[347],"would":[352],"cause":[353],"resistance,":[355],"BV173,":[356],"REH":[359],"(100,":[365],"200":[366],"300nM,":[368],"respectively)":[369],"combination":[372],"anti-oxidant,":[377],"N-acetyl":[378],"cysteine":[379],"(NAC;":[380],"20mM).":[381],"addition":[383],"NAC":[385],"These":[396],"findings":[397],"demonstrate":[398],"contribute":[401],"drug":[403],"resistance":[404,441],"Further":[412],"research":[413],"required":[415],"identify":[417],"soluble":[419],"factors":[420],"responsible":[421],"these":[423],"protective":[424],"effects.":[425],"Citation":[426],"Format:":[427],"Xia":[428],"Sheng,":[429],"Jonathan":[430],"Tucci,":[431],"Steven":[432],"D.":[433],"Mittelman.":[434],"Reduction":[435],"promotes":[439],"daunorubicin":[440],"[abstract].":[447],"In:":[448],"Proceedings":[449],"106th":[452],"Annual":[453],"Meeting":[454],"American":[457],"Association":[458],"Research;":[461],"2015":[462],"Apr":[463],"18-22;":[464],"Philadelphia,":[465],"PA.":[466],"Philadelphia":[467],"(PA):":[468],"AACR;":[469],"Res":[471],"2015;75(15":[472],"Suppl):Abstract":[473],"nr":[474],"1247.":[475],"doi:10.1158/1538-7445.AM2015-1247":[476]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2017-01-06T00:00:00"}
