{"id":"https://openalex.org/W2563986723","doi":null,"title":"The Role of the Glucagon-like Peptide-1 Receptor in Atherosclerosis","display_name":"The Role of the Glucagon-like Peptide-1 Receptor in Atherosclerosis","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2563986723","mag":"2563986723"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/42405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/42405","pdf_url":"https://utoronto.scholaris.ca/bitstreams/755fc35c-0dae-49a6-8694-c268fdeed950/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/755fc35c-0dae-49a6-8694-c268fdeed950/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086144149","display_name":"Naim Panjwani","orcid":"https://orcid.org/0000-0001-7551-0759","observed_orcids":["https://orcid.org/0000-0001-7551-0759"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Naim Panjwani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7551-0759","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086144149"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9480000138282776},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.7379999756813049},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6579999923706055},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.753000020980835},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.8600000143051147},{"id":"https://openalex.org/keywords/aortic-plaque","display_name":"aortic plaque","score":0.7820000052452087},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9819999933242798},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5979999899864197},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6639999747276306},{"id":"https://openalex.org/keywords/intrahepatic-triglyceride","display_name":"intrahepatic triglyceride","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8450958728790283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7809842824935913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7043105363845825},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5217714905738831},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5109654664993286},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.5089349746704102},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48220622539520264},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.42365899682044983},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3663984537124634}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/42405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/42405","pdf_url":"https://utoronto.scholaris.ca/bitstreams/755fc35c-0dae-49a6-8694-c268fdeed950/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/42405","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/42405","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2563986723","doi":null,"is_oa":false,"landing_page_url":"https://oatd.org/oatd/record?record=handle\\:1807\\%2F42405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/42405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/42405","pdf_url":"https://utoronto.scholaris.ca/bitstreams/755fc35c-0dae-49a6-8694-c268fdeed950/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2563986723.pdf","grobid_xml":"https://content.openalex.org/works/W2563986723.grobid-xml"},"referenced_works_count":166,"referenced_works":["https://openalex.org/W95884546","https://openalex.org/W172609984","https://openalex.org/W752895202","https://openalex.org/W1492983784","https://openalex.org/W1519601357","https://openalex.org/W1545460826","https://openalex.org/W1592844971","https://openalex.org/W1752045965","https://openalex.org/W1770661046","https://openalex.org/W1886864374","https://openalex.org/W1943482912","https://openalex.org/W1964439024","https://openalex.org/W1965772617","https://openalex.org/W1966309593","https://openalex.org/W1968939832","https://openalex.org/W1969932276","https://openalex.org/W1972960247","https://openalex.org/W1977179808","https://openalex.org/W1978279496","https://openalex.org/W1978953702","https://openalex.org/W1979037052","https://openalex.org/W1979259269","https://openalex.org/W1979916078","https://openalex.org/W1982294133","https://openalex.org/W1983269691","https://openalex.org/W1987150557","https://openalex.org/W1987621836","https://openalex.org/W1990210584","https://openalex.org/W1991900197","https://openalex.org/W1992980650","https://openalex.org/W1993718080","https://openalex.org/W1994016991","https://openalex.org/W1995209325","https://openalex.org/W1997332398","https://openalex.org/W1999381401","https://openalex.org/W2000976083","https://openalex.org/W2001271520","https://openalex.org/W2005230361","https://openalex.org/W2005657338","https://openalex.org/W2008411184","https://openalex.org/W2008960002","https://openalex.org/W2009371336","https://openalex.org/W2013082477","https://openalex.org/W2013438463","https://openalex.org/W2013623208","https://openalex.org/W2016291847","https://openalex.org/W2016632734","https://openalex.org/W2021307215","https://openalex.org/W2022101780","https://openalex.org/W2022788684","https://openalex.org/W2023644010","https://openalex.org/W2026544876","https://openalex.org/W2029071587","https://openalex.org/W2030562170","https://openalex.org/W2030825062","https://openalex.org/W2031468509","https://openalex.org/W2031891480","https://openalex.org/W2034171544","https://openalex.org/W2035730649","https://openalex.org/W2040403084","https://openalex.org/W2041232193","https://openalex.org/W2041620296","https://openalex.org/W2041844170","https://openalex.org/W2042740225","https://openalex.org/W2044238158","https://openalex.org/W2044437167","https://openalex.org/W2046535650","https://openalex.org/W2048890665","https://openalex.org/W2048986424","https://openalex.org/W2053196978","https://openalex.org/W2054544120","https://openalex.org/W2055611619","https://openalex.org/W2059903872","https://openalex.org/W2060571859","https://openalex.org/W2063690632","https://openalex.org/W2064119981","https://openalex.org/W2064492226","https://openalex.org/W2067314875","https://openalex.org/W2068291692","https://openalex.org/W2069227990","https://openalex.org/W2071251286","https://openalex.org/W2071319752","https://openalex.org/W2072239150","https://openalex.org/W2072633424","https://openalex.org/W2075567076","https://openalex.org/W2078128383","https://openalex.org/W2079793296","https://openalex.org/W2080128749","https://openalex.org/W2081283952","https://openalex.org/W2082502030","https://openalex.org/W2082908243","https://openalex.org/W2082913643","https://openalex.org/W2083411559","https://openalex.org/W2083783526","https://openalex.org/W2084310603","https://openalex.org/W2084948079","https://openalex.org/W2086036309","https://openalex.org/W2086985270","https://openalex.org/W2090360729","https://openalex.org/W2090687004","https://openalex.org/W2094498915","https://openalex.org/W2094629035","https://openalex.org/W2096844695","https://openalex.org/W2097879299","https://openalex.org/W2098025594","https://openalex.org/W2100377339","https://openalex.org/W2103516789","https://openalex.org/W2107179502","https://openalex.org/W2108589716","https://openalex.org/W2109327370","https://openalex.org/W2113934014","https://openalex.org/W2114481251","https://openalex.org/W2114749112","https://openalex.org/W2115872041","https://openalex.org/W2118792139","https://openalex.org/W2121157069","https://openalex.org/W2123946565","https://openalex.org/W2124977666","https://openalex.org/W2126528640","https://openalex.org/W2128077095","https://openalex.org/W2129730863","https://openalex.org/W2130064617","https://openalex.org/W2131541226","https://openalex.org/W2132169136","https://openalex.org/W2132613598","https://openalex.org/W2132802847","https://openalex.org/W2135490930","https://openalex.org/W2140625608","https://openalex.org/W2141228342","https://openalex.org/W2141428319","https://openalex.org/W2142097676","https://openalex.org/W2142400535","https://openalex.org/W2142903571","https://openalex.org/W2143014102","https://openalex.org/W2145185779","https://openalex.org/W2146917818","https://openalex.org/W2146939182","https://openalex.org/W2149341824","https://openalex.org/W2149350026","https://openalex.org/W2150563156","https://openalex.org/W2150913805","https://openalex.org/W2152978153","https://openalex.org/W2153042980","https://openalex.org/W2153660163","https://openalex.org/W2154356580","https://openalex.org/W2154843786","https://openalex.org/W2157869836","https://openalex.org/W2158417144","https://openalex.org/W2158666727","https://openalex.org/W2159346623","https://openalex.org/W2160286139","https://openalex.org/W2161407981","https://openalex.org/W2162910243","https://openalex.org/W2165463540","https://openalex.org/W2166120350","https://openalex.org/W2167522349","https://openalex.org/W2168140349","https://openalex.org/W2169382415","https://openalex.org/W2169562373","https://openalex.org/W2170048668","https://openalex.org/W2172277730","https://openalex.org/W2885413639","https://openalex.org/W4210953420","https://openalex.org/W4233349015","https://openalex.org/W4234825176","https://openalex.org/W4256475235"],"related_works":["https://openalex.org/W1992116679","https://openalex.org/W7097922428","https://openalex.org/W2901979245","https://openalex.org/W4361213565","https://openalex.org/W2626992208","https://openalex.org/W2075567076","https://openalex.org/W7148313485","https://openalex.org/W3155655893","https://openalex.org/W2735594337","https://openalex.org/W2142097676"],"abstract_inverted_index":{"Objective:":[0],"Glucagon-like":[1],"peptide-1":[2],"receptor":[3],"(GLP-1R)":[4],"agonists":[5,21],"have":[6],"been":[7],"shown":[8],"to":[9],"reduce":[10,23,48,59],"atherosclerosis":[11,27,120],"in":[12,28,136],"non-diabetic":[13],"mice.":[14,31],"We":[15],"hypothesized":[16],"that":[17],"treatment":[18,34,70],"with":[19],"GLP-1R":[20,134],"would":[22],"the":[24,63,146],"development":[25,147],"of":[26,37,76,148],"diabetic":[29,77,140],"Apoe-/-":[30],"Results:":[32],"Exendin-4":[33],"(10":[35],"nmol/kg/day)":[36],"high-fat":[38],"diet-induced":[39],"glucose-intolerant":[40,138],"mice":[41,78,141],"for":[42,71],"22":[43],"weeks":[44,73],"did":[45,57],"not":[46,58,143],"significantly":[47,144],"oral":[49,86,106],"glucose":[50,87],"tolerance":[51,88,108],"(P=0.62)":[52],"or":[53,113,126,139],"HbA1c":[54],"(P=0.85),":[55],"and":[56,93,96,104],"plaque":[60],"size":[61],"at":[62],"aortic":[64,119],"sinus":[65],"(P":[66],"=":[67],"0.35).":[68],"Taspoglutide":[69],"12":[72],"(0.4-mg":[74],"tablet/month)":[75],"reduced":[79],"body":[80],"weight":[81],"(P<0.05),":[82,85,89],"food":[83],"intake":[84],"intrahepatic":[90],"triglycerides":[91,111],"(P<0.05)":[92],"cholesterol":[94,114],"(P<0.001),":[95],"plasma":[97,110],"IL-6":[98],"levels":[99],"(P<0.01);":[100],"increased":[101],"insulin:glucose":[102],"(P<0.05);":[103],"unaltered":[105,118],"lipid":[107],"(P=0.21),":[109],"(P=0.45)":[112],"(P=0.92).":[115],"Nonetheless,":[116],"taspoglutide":[117],"(P=0.18,":[121],"sinus;":[122,130],"P=0.19,":[123],"descending":[124],"aorta)":[125],"macrophage":[127],"infiltration":[128],"(P=0.45,":[129],"P=0.26,":[131],"arch).":[132],"Conclusions:":[133],"activation":[135],"either":[137],"does":[142],"modify":[145],"atherosclerosis.":[149]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
