{"id":"https://openalex.org/W2563893574","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","title":"Molecular profiling of melanoma tumor biopsies to identify a response signature to the multi-RTK inhibitor, E7080.","display_name":"Molecular profiling of melanoma tumor biopsies to identify a response signature to the multi-RTK inhibitor, E7080.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2563893574","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","mag":"2563893574"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.8595","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055054082","display_name":"John J. Nemunaitis","orcid":"https://orcid.org/0000-0002-2234-2381","observed_orcids":["https://orcid.org/0000-0002-2234-2381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. J. Nemunaitis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108475491","display_name":"D.S. Hong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. S. Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Kurzrock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111839131","display_name":"Neil N. Senzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. N. Senzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087463666","display_name":"Natalie C. Twine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. C. Twine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080333158","display_name":"Tadashi Kadowaki","orcid":"https://orcid.org/0000-0002-5932-5454","observed_orcids":["https://orcid.org/0000-0002-5932-5454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Kadowaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108617620","display_name":"Meijin Ren","orcid":"https://orcid.org/0009-0004-0637-8773","observed_orcids":["https://orcid.org/0009-0004-0637-8773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014636334","display_name":"Yoriko Funahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Funahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106081522","display_name":"James P. O\u2019Brien","orcid":"https://orcid.org/0000-0003-2784-6906","observed_orcids":["https://orcid.org/0000-0003-2784-6906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. P. O'Brien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053605782","display_name":"J Simon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. S. Simon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015502042","display_name":"Andrew Eisen","orcid":"https://orcid.org/0000-0002-1447-2725","observed_orcids":["https://orcid.org/0000-0002-1447-2725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Eisen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"8595","last_page":"8595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9330000281333923},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.5370000004768372},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.722000002861023},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.6759999990463257},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6930000185966492},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6179999709129333},{"id":"https://openalex.org/keywords/recist-response","display_name":"RECIST response","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7863914370536804},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6888185143470764},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5121092796325684},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43842801451683044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43078166246414185},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4245273172855377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3711232841014862},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3424970209598541},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25113797187805176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.239076167345047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13020041584968567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.8595","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.8595","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1973628760","https://openalex.org/W2589470651","https://openalex.org/W3028748814","https://openalex.org/W3045574564","https://openalex.org/W4401947363","https://openalex.org/W3104106514","https://openalex.org/W4376280059","https://openalex.org/W4285494503","https://openalex.org/W3161563078","https://openalex.org/W99600945"],"abstract_inverted_index":{"8595":[0],"Background:":[1],"E7080":[2,60],"is":[3],"an":[4,296],"oral":[5],"TKI":[6],"targeting":[7],"VEGFR1-3,":[8],"FGFR1-4,":[9],"PDGFR\u03b2,":[10],"RET":[11],"and":[12,19,28,73,93,103,107,113,136,162,197,278],"KIT,":[13],"which":[14],"affects":[15],"tumor":[16,20,114,195,276],"cell":[17],"proliferation":[18],"vascularization":[21],"in":[22,37,41,242,253,295],"laboratory":[23],"models.":[24],"Tumor":[25,100],"response":[26,252],"(RECIST)":[27],"prolonged":[29],"disease":[30],"stabilization":[31],"(>":[32],"6":[33,186],"months)":[34],"were":[35,105,119],"observed":[36,233],"melanoma":[38,58,157,243,254,269],"patients":[39,55,97,255],"treated":[40],"phase":[42],"I.":[43],"The":[44,77,170,205,258],"present":[45],"study":[46],"sought":[47],"to":[48,249,256],"identify":[49],"predictive":[50,293],"genomic/proteomic":[51],"signatures.":[52],"Methods:":[53],"25":[54,149],"with":[56,231],"metastatic":[57],"received":[59],"10mg":[61],"twice":[62],"daily":[63],"continuously.":[64],"Biopsy":[65],"of":[66,194,211,220,227,240,268],"accessible":[67],"lesions":[68],"was":[69,173,224],"performed":[70],"pre-treatment":[71],"D1":[72,153],"on":[74,132,179,203,264],"D22":[75],"post-treatment.":[76],"patient":[78,150],"responses":[79],"were:":[80],"2":[81,91],"PR,":[82],"14":[83],"SD":[84,89,184],">":[85,90],"3":[86],"months,":[87],"1":[88],"months":[92],"5":[94],"PD":[95],"(3":[96],"non":[98],"evaluable).":[99],"biopsies":[101],"(D1":[102],"D22)":[104],"frozen":[106],"preserved":[108],"for":[109,126,160,190,280,291],"sectioning.":[110],"Melanoma":[111],"cells":[112,131,139,244],"infiltrating":[115],"vasculature":[116,277],"(IHC":[117],"CD31+)":[118],"separately":[120],"collected":[121],"by":[122,198],"laser":[123],"capture":[124],"micro-dissection":[125],"profiling":[127],"from":[128,137,166,274,283],"~":[129],"5,000":[130],"Affymetrix":[133],"U133+2":[134],"microarrays":[135],"~30,000":[138],"via":[140],"a":[141,225],"gel":[142],"electrophoretic-tryptic":[143],"digest-LC/MS/":[144],"MS":[145],"method.":[146],"Results:":[147],"From":[148],"samples,":[151],"22":[152],"samples":[154,159],"yielded":[155],"quality":[156],"mRNA":[158],"hybridization":[161],"analyses":[163,223],"used":[164,248],"data":[165,172,273],"~24,000":[167],"RMA-normalized":[168],"probes.":[169],"genomic":[171],"analyzed":[174],"using":[175],"Student's":[176],"T-test":[177],"based":[178,202,263],"clinical":[180,234,251],"benefit":[181],"(=PR":[182],"or":[183],"\u2265":[185],"months);":[187],"regression":[188,201,222],"analysis":[189,206,267],"the":[191,212,218,221,232,275],"continuous":[192],"measure":[193],"shrinkage":[196],"Cox":[199],"proportional":[200],"PFS.":[204],"identified":[207],"genes":[208,229,241],"encoding":[209],"elements":[210],"target":[213],"RTK":[214],"signaling":[215],"pathways.":[216],"At":[217],"intersection":[219],"set":[226,239],"46":[228],"correlating":[230],"response.":[235],"Conclusions:":[236],"A":[237],"small":[238],"may":[245],"potentially":[246],"be":[247,261,289],"predict":[250],"E7080.":[257],"list":[259],"will":[260,288],"refined":[262],"on-going":[265],"proteomic":[266],"cells,":[270],"gene":[271],"expression":[272],"genotyping":[279],"melanoma-associated":[281],"mutations":[282],"these":[284],"same":[285],"tumors.":[286],"These":[287],"tested":[290],"their":[292],"value":[294],"ongoing":[297],"Ph2":[298],"trial.":[299]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-06T00:00:00"}
