{"id":"https://openalex.org/W2563620482","doi":"https://doi.org/10.1182/blood.v116.21.4497.4497","title":"Imatinib Mesylate (IM) Versus IM + Low Dose of Pegylated Interferon Alfa 2a (Peg-IFN 2a) In Newly-Diagnosed Chronic-Phase (CP) Chronic Myeloid Leukemia (CML).","display_name":"Imatinib Mesylate (IM) Versus IM + Low Dose of Pegylated Interferon Alfa 2a (Peg-IFN 2a) In Newly-Diagnosed Chronic-Phase (CP) Chronic Myeloid Leukemia (CML).","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2563620482","doi":"https://doi.org/10.1182/blood.v116.21.4497.4497","mag":"2563620482"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.4497.4497","doi":"https://doi.org/10.1182/blood.v116.21.4497.4497","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.4497.4497","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008888432","display_name":"Luis Antonio Meillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Luis Antonio Meillon","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019831373","display_name":"Salvador Campos-Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Salvador Campos-Cabrera","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031900238","display_name":"Nancy Delgado-L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Nancy Delgado-Lopez","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008716206","display_name":"Angel A. Fernandez-Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Angel A. Fernandez-Martinez","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090459363","display_name":"Jes\u00fas Medrano-Contreras","orcid":"https://orcid.org/0000-0002-9782-9135","observed_orcids":["https://orcid.org/0000-0002-9782-9135"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Jesus Medrano-Contreras","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010241546","display_name":"Gabriel Manjarrez\u2010Guti\u00e9rrez","orcid":"https://orcid.org/0000-0003-0101-6875","observed_orcids":["https://orcid.org/0000-0003-0101-6875"]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guillermo Gutierrez","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico D.F., Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico D.F., Mexico","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075025795","display_name":"Juan Fernando P\u00e9rez-Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Juan F. Perez-Rocha","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056466852","display_name":"Eduardo Terreros-Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Eduardo Terreros-Mun\u0303oz","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090304326","display_name":"Sue C. G\u00f3mez Cort\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Sue C. Gomez-Cortes","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054928009","display_name":"Susana Guerrero-Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Susana Guerrero-Rivera","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico,","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086960678","display_name":"Kevin Arturo Nacho-Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Kevin A. Nacho-Vargas","raw_affiliation_strings":["Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico D.F., Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico D.F., Mexico","institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008716206","https://openalex.org/A5008888432","https://openalex.org/A5019831373","https://openalex.org/A5031900238","https://openalex.org/A5054928009","https://openalex.org/A5056466852","https://openalex.org/A5075025795","https://openalex.org/A5090304326","https://openalex.org/A5090459363"],"corresponding_institution_ids":["https://openalex.org/I164915025","https://openalex.org/I4210120064"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36908133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"4497","last_page":"4497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.9200000166893005},{"id":"https://openalex.org/keywords/peginterferon-alfa-2a","display_name":"peginterferon alfa-2a","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chronic-phase-cml","display_name":"chronic phase CML","score":0.843999981880188},{"id":"https://openalex.org/keywords/newly-diagnosed-cml","display_name":"newly diagnosed CML","score":0.8119999766349792},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/complete-cytogenetic-response","display_name":"complete cytogenetic response","score":0.9660000205039978},{"id":"https://openalex.org/keywords/major-molecular-response","display_name":"major molecular response","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sokal-risk-score","display_name":"Sokal risk score","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mexican-patients","display_name":"Mexican patients","score":0.5130000114440918},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6129999756813049},{"id":"https://openalex.org/keywords/interferon-therapy","display_name":"interferon therapy","score":0.5899999737739563},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3659999966621399},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8741809129714966},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.7124422788619995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6974823474884033},{"id":"https://openalex.org/C2776461080","wikidata":"https://www.wikidata.org/wiki/Q7160835","display_name":"Pegylated interferon","level":5,"score":0.5890770554542542},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5442296862602234},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.4480750560760498},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.42759907245635986},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.41818612813949585},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4152211546897888},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26750290393829346},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.4497.4497","doi":"https://doi.org/10.1182/blood.v116.21.4497.4497","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.4497.4497","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2484447464","https://openalex.org/W2994063079","https://openalex.org/W2565362587","https://openalex.org/W2558943357","https://openalex.org/W1984450483","https://openalex.org/W2550665546","https://openalex.org/W2083837013","https://openalex.org/W2322365534","https://openalex.org/W2564277077","https://openalex.org/W2979678322"],"abstract_inverted_index":{"Abstract":[0,1,203],"4497":[2],"Background:":[3],"IM":[4,42,86,120,122,160,170,277,284,304,343,347,358,373],"400mg":[5,43],"daily":[6,44,163,179],"is":[7,39,72,379,382,393],"the":[8,32,48,57,94,103,154,158,167,192,289,297],"current":[9],"standard":[10],"of":[11,13,18,34,53,85,96,105,157,195,252,267,291,299,331,333,356,368,372,402],"treatment":[12,196,334],"CP":[14],"CML.":[15,99],"Almost":[16],"70%":[17],"patients":[19,114,132,211,245,275,282],"achieve":[20],"complete":[21],"cytogenetic":[22],"response":[23,97,301],"(CCR)":[24],"at":[25,109,176,257],"12":[26,110,258],"months":[27],"(mo)":[28],"(IRIS":[29],"Trial)":[30],"and":[31,60,64,78,107,129,136,140,145,228,240,279,296,346],"rate":[33,95,290,298,367],"Major":[35],"Molecular":[36,146],"Response":[37],"(MMR)":[38],"40%":[40],"with":[41,74,115,119,248,276,283,335,388],"(TOPS":[45],"Trial).":[46],"On":[47],"other":[49,75,324],"hand,":[50],"low":[51,225,235],"doses":[52],"Peg-IFN":[54,88,124,172,187,286,310,336,351,362,377],"2a":[55,89,173,188,311,337,352,363,378],"has":[56],"same":[58],"efficacy":[59],"lower":[61],"toxicity":[62,387],"profile":[63],"cost":[65],"as":[66],"high":[67,229,241],"dose,":[68],"mainly":[69],"when":[70],"it":[71],"combined":[73],"drugs":[76],"(MRC":[77],"Hovon":[79],"groups,":[80],"Blood":[81],"2004;":[82],"103:4408).":[83],"Combination":[84],"+":[87,123,171,180,285,350,361,376],"or":[90,323],"Cytarabine":[91],"could":[92],"increase":[93,385],"in":[98,112,191,262,264,272,274,281,314,386],"Aims:":[100],"To":[101],"evaluate":[102],"rates":[104,355],"CCR":[106,256],"MMR":[108,269],"mo":[111,254,259,340],"Mexican":[113],"newly-diagnosed":[116],"CP-CML":[117],"treated":[118],"versus":[121],"2a.":[125,287],"Methods:":[126],"Between":[127],"2006":[128],"2008,":[130],"10":[131,210],"were":[133,148,212],"randomized":[134],"1:1":[135],"stratified":[137],"by":[138],"Sokal":[139,222],"Hasford":[141,232],"risk":[142,226,230,236,242],"groups.":[143],"Cytogenetic":[144],"assesments":[147],"available":[149],"for":[150,395],"all":[151],"patients.":[152,397],"In":[153,166],"arm":[155],"A":[156],"study":[159],"400":[161,177,305,344,348,359,374],"mg":[162,178,306,345,349,360,375],"was":[164,174,189,216,260,270,294,302,307,312,338],"delivered.":[165],"Arm":[168],"B":[169],"delivered":[175],"90":[181],"\u03bc":[182],"g":[183],"per":[184],"week":[185,194],"respectively.":[186],"started":[190],"7th":[193],"(Hochhaus":[197],"A,":[198],"et":[199],"al":[200],"ASCO":[201],"2003.":[202],"#2287).":[204],"Results:":[205],"For":[206],"this":[207,389],"initial":[208],"report,":[209],"analyzed,":[213],"median":[214,250,329],"age":[215],"35":[217],"years":[218],"(25-55),":[219],"50%":[220],"males;":[221],"score":[223,233],"was:":[224,234],"70%,":[227],"30%.":[231,243],"40%,":[237],"intermediate":[238],"30%":[239,280],"All":[244],"are":[246],"alive":[247],"a":[249,365,383],"follow-up":[251,392],"41":[253],"(30-48).":[255],"obtained":[261,271,353,364],"80%":[263],"both":[265],"arms":[266],"treatment.":[268],"10%":[273,295],"alone":[278],"Overall":[288],"primary":[292],"resistance":[293],"suboptimal":[300],"10%.":[303],"well":[308],"tolerated.":[309],"tolerated":[313],"most":[315],"patients,":[316],"but":[317],"needed":[318],"discontinuation":[319],"because":[320],"increased":[321],"cytopenias":[322],"non":[325],"hematologic":[326],"toxicities.":[327],"The":[328,370],"time":[330],"duration":[332],"6":[339],"(3-12).":[341],"Conclusions:":[342],"similar":[354],"CCR.":[357],"higher":[366],"MMR.":[369],"combination":[371],"feasible.":[380],"There":[381],"slight":[384],"combination.":[390],"Further":[391],"warranted":[394],"these":[396],"Disclosures:":[398],"No":[399],"relevant":[400],"conflicts":[401],"interest":[403],"to":[404],"declare.":[405]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}