{"id":"https://openalex.org/W2563613798","doi":"https://doi.org/10.1080/10409238.2016.1269717","title":"Nucleolus-like compartmentalization of the transcription machinery in fast-growing bacterial cells","display_name":"Nucleolus-like compartmentalization of the transcription machinery in fast-growing bacterial cells","publication_year":2016,"publication_date":"2016-12-23","ids":{"openalex":"https://openalex.org/W2563613798","doi":"https://doi.org/10.1080/10409238.2016.1269717","mag":"2563613798","pmid":"https://pubmed.ncbi.nlm.nih.gov/28006965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575888"},"language":"en","primary_location":{"id":"doi:10.1080/10409238.2016.1269717","doi":"https://doi.org/10.1080/10409238.2016.1269717","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10409238.2016.1269717","pdf_url":null,"source":{"id":"https://openalex.org/S55210418","display_name":"Critical Reviews in Biochemistry and Molecular Biology","issn_l":"0045-6411","issn":["0045-6411","1040-8355","1040-9238","1549-7798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Biochemistry and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575888","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103566506","display_name":"Ding Jun Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":true,"raw_author_name":"Ding Jun Jin","raw_affiliation_strings":["Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101912086","display_name":"Carmen Mata Mart\u00edn","orcid":"https://orcid.org/0000-0002-3875-3505","observed_orcids":["https://orcid.org/0000-0002-3875-3505"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Carmen Mata Martin","raw_affiliation_strings":["Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057733012","display_name":"Zhe Sun","orcid":"https://orcid.org/0000-0002-0634-7983","observed_orcids":["https://orcid.org/0000-0002-0634-7983"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Zhe Sun","raw_affiliation_strings":["Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060103682","display_name":"C\u00e9dric Cagliero","orcid":"https://orcid.org/0000-0001-7404-5453","observed_orcids":["https://orcid.org/0000-0001-7404-5453"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Cedric Cagliero","raw_affiliation_strings":["Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101428799","display_name":"Yan Ning Zhou","orcid":"https://orcid.org/0000-0002-5444-9271","observed_orcids":["https://orcid.org/0000-0002-5444-9271"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210123359","display_name":"National Cancer Institute","ror":"https://ror.org/02t771148","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210123359"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["UA","US"],"is_corresponding":false,"raw_author_name":"Yan Ning Zhou","raw_affiliation_strings":["Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103566506"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210123359","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.3941,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.36132813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"52","issue":"1","first_page":"96","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3156999945640564,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase","display_name":"RNA polymerase","score":0.8220000267028809},{"id":"https://openalex.org/keywords/transcription-machinery","display_name":"transcription machinery","score":0.7110000252723694},{"id":"https://openalex.org/keywords/transcription-factories","display_name":"transcription factories","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"ribosomal DNA","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rrna-operon","display_name":"rRNA operons","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7649999856948853},{"id":"https://openalex.org/keywords/super-resolution-imaging","display_name":"super-resolution imaging","score":0.6800000071525574},{"id":"https://openalex.org/keywords/transcription-replication-conflict","display_name":"transcription-replication conflict","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6890149116516113},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.6229672431945801},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5937256813049316},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.585515022277832},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.5786158442497253},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.5595843195915222},{"id":"https://openalex.org/C172407341","wikidata":"https://www.wikidata.org/wiki/Q7833931","display_name":"Transcription factories","level":5,"score":0.5017504692077637},{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.4914296865463257},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.48379677534103394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46308785676956177},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.45297756791114807},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4058913588523865},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.373431921005249},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3690263628959656},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.31773674488067627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3057210147380829},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2686743140220642},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0616530179977417},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/10409238.2016.1269717","doi":"https://doi.org/10.1080/10409238.2016.1269717","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10409238.2016.1269717","pdf_url":null,"source":{"id":"https://openalex.org/S55210418","display_name":"Critical Reviews in Biochemistry and Molecular Biology","issn_l":"0045-6411","issn":["0045-6411","1040-8355","1040-9238","1549-7798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Biochemistry and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:28006965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28006965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in biochemistry and molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5575888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Rev Biochem Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5575888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Rev Biochem Mol Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6374948078","display_name":null,"funder_award_id":"Z99 CA999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G845508235","display_name":"Transcription Regulation and Pathogenesis in H. pylori","funder_award_id":"Z01BC010633","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F8394932145","display_name":"Intramural Research Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1512810258","https://openalex.org/W1514185915","https://openalex.org/W1539919995","https://openalex.org/W1581453124","https://openalex.org/W1600267336","https://openalex.org/W1781531090","https://openalex.org/W1788241743","https://openalex.org/W1853950746","https://openalex.org/W1878240447","https://openalex.org/W1883779479","https://openalex.org/W1887260861","https://openalex.org/W1935785178","https://openalex.org/W1953641791","https://openalex.org/W1970864226","https://openalex.org/W1977680104","https://openalex.org/W1978522349","https://openalex.org/W1981188497","https://openalex.org/W1982563397","https://openalex.org/W1992358363","https://openalex.org/W1993973779","https://openalex.org/W2006568501","https://openalex.org/W2013430210","https://openalex.org/W2022694949","https://openalex.org/W2027573386","https://openalex.org/W2033549300","https://openalex.org/W2033742799","https://openalex.org/W2033766178","https://openalex.org/W2035659472","https://openalex.org/W2039160511","https://openalex.org/W2049725457","https://openalex.org/W2054927793","https://openalex.org/W2058940094","https://openalex.org/W2061805367","https://openalex.org/W2064038671","https://openalex.org/W2081114359","https://openalex.org/W2090009283","https://openalex.org/W2090232842","https://openalex.org/W2093538379","https://openalex.org/W2102707800","https://openalex.org/W2105028012","https://openalex.org/W2121366176","https://openalex.org/W2124983475","https://openalex.org/W2128355851","https://openalex.org/W2131224273","https://openalex.org/W2135364630","https://openalex.org/W2141733032","https://openalex.org/W2143820677","https://openalex.org/W2149241780","https://openalex.org/W2149366594","https://openalex.org/W2154047008","https://openalex.org/W2157144047","https://openalex.org/W2157937275","https://openalex.org/W2159859422","https://openalex.org/W2161006911","https://openalex.org/W2193206319","https://openalex.org/W2222228083","https://openalex.org/W2327011266","https://openalex.org/W2417633366","https://openalex.org/W2469522767","https://openalex.org/W2514171770","https://openalex.org/W4245171140"],"related_works":["https://openalex.org/W2121366176","https://openalex.org/W1514185915","https://openalex.org/W2974185312","https://openalex.org/W2161006911","https://openalex.org/W2058751385","https://openalex.org/W2801528673","https://openalex.org/W1978522349","https://openalex.org/W2584882193","https://openalex.org/W2802615574","https://openalex.org/W1548784612"],"abstract_inverted_index":{"We":[0],"have":[1,28],"learned":[2],"a":[3],"great":[4],"deal":[5],"about":[6],"RNA":[7,90,103,138,155,186],"polymerase":[8,91],"(RNA":[9,92],"Pol),":[10],"transcription":[11,35,48,76,97,122,163,195,203],"factors,":[12],"and":[13,50,96,106,114,170,194,204],"the":[14,34,47,55,59,71,75,117,121,135,146,152,202,214,217],"transcriptional":[15],"regulation":[16],"mechanisms":[17],"in":[18,58,67,78,101,116,177,182,210,222],"prokaryotes":[19],"for":[20,124,165],"specific":[21],"genes,":[22,126],"operons,":[23],"or":[24],"transcriptomes.":[25],"However,":[26],"we":[27],"only":[29],"begun":[30],"to":[31,45,51,160,173,212],"understand":[32],"how":[33],"machinery":[36,57,77,123],"is":[37],"three-dimensionally":[38],"(3D)":[39],"organized":[40],"into":[41],"bacterial":[42,184],"chromosome":[43],"territories":[44],"orchestrate":[46],"process":[49],"maintain":[52],"harmony":[53],"with":[54,94],"replication":[56,205],"cell.":[60],"Much":[61],"progress":[62],"has":[63,109],"been":[64],"made":[65],"recently":[66],"our":[68],"understanding":[69],"of":[70,74,89,120,128,148],"spatial":[72,118],"organization":[73,119],"fast-growing":[79,183,223],"Escherichia":[80],"coli":[81],"cells":[82],"using":[83],"state-of-the-art":[84],"superresolution":[85],"imaging":[86],"techniques.":[87],"Co-imaging":[88],"Pol)":[93],"DNA":[95],"elongation":[98],"factors":[99],"involved":[100],"ribosomal":[102],"(rRNA)":[104],"synthesis,":[105],"ribosome":[107,171],"biogenesis":[108,172],"revealed":[110],"similarities":[111],"between":[112,216],"bacteria":[113],"eukaryotes":[115],"growth":[125,176],"most":[127],"which":[129],"are":[130,141,158,207],"rRNA":[131,149,167],"genes.":[132],"Evidence":[133],"supports":[134],"notion":[136],"that":[137],"Pol":[139,156,187,191],"molecules":[140],"concentrated,":[142],"forming":[143],"foci":[144,157,188],"at":[145],"clustering":[147],"operons":[150],"resembling":[151],"eukaryotic":[153,190],"nucleolus.":[154],"proposed":[159],"be":[161],"active":[162],"factories":[164,196],"both":[166],"genes":[168],"expression":[169],"support":[174],"maximal":[175],"optimal":[178],"growing":[179],"conditions.":[180],"Thus,":[181],"cells,":[185],"mimic":[189],"I":[192],"activity,":[193],"resemble":[197],"nucleolus-like":[198],"compartmentation.":[199],"In":[200],"addition,":[201],"machineries":[206],"mostly":[208],"segregated":[209],"space":[211],"avoid":[213],"conflict":[215],"two":[218],"major":[219],"cellular":[220],"functions":[221],"cells.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}