{"id":"https://openalex.org/W2563597339","doi":"https://doi.org/10.1158/1538-7445.am2015-3026","title":"Abstract 3026: Gastric cancer associated variant of DNA polymerase Beta (Leu22Pro) induce genomic instability and cellular transformation","display_name":"Abstract 3026: Gastric cancer associated variant of DNA polymerase Beta (Leu22Pro) induce genomic instability and cellular transformation","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2563597339","doi":"https://doi.org/10.1158/1538-7445.am2015-3026","mag":"2563597339"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-3026","doi":"https://doi.org/10.1158/1538-7445.am2015-3026","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3026","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101403194","display_name":"Dawit Kidane","orcid":"https://orcid.org/0009-0000-3738-0930","observed_orcids":["https://orcid.org/0009-0000-3738-0930","https://orcid.org/0000-0002-3168-1326"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawit Kidane","raw_affiliation_strings":["1University of Texas-Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas-Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008126437","display_name":"Jenna Rozacky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna Rozacky","raw_affiliation_strings":["1University of Texas-Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas-Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031828516","display_name":"Joann Balazs Sweasy","orcid":"https://orcid.org/0000-0002-4503-0284","observed_orcids":["https://orcid.org/0000-0002-4503-0284"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joann B. Sweasy","raw_affiliation_strings":["2Yale School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"3026","last_page":"3026"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-beta","display_name":"DNA polymerase beta","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.875},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.9459999799728394},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8240000009536743},{"id":"https://openalex.org/keywords/replication-fork-collapse","display_name":"replication fork collapse","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7780009508132935},{"id":"https://openalex.org/C2778462844","wikidata":"https://www.wikidata.org/wiki/Q18030641","display_name":"DNA polymerase beta","level":5,"score":0.6662351489067078},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6515830755233765},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6507900357246399},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.5896983742713928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5585024356842041},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4893207252025604},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.46212977170944214},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.44164973497390747},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.43386879563331604},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3581603169441223},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3223501443862915},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2948068380355835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2703304588794708},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.12214788794517517},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-3026","doi":"https://doi.org/10.1158/1538-7445.am2015-3026","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3026","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1930897122","https://openalex.org/W2116796830","https://openalex.org/W2968751001","https://openalex.org/W2976105601","https://openalex.org/W2167423675","https://openalex.org/W3166276814","https://openalex.org/W4312103011","https://openalex.org/W2009900712","https://openalex.org/W1970774923","https://openalex.org/W2384490598"],"abstract_inverted_index":{"Abstract":[0],"DNA":[1,15,46,117,137,215,233],"polymerase":[2,47,88,138,234],"beta":[3,139],"(Pol":[4],"\u03b2)":[5],"is":[6,77,140,202],"a":[7],"key":[8],"enzyme":[9],"for":[10,60,79,122,190,255],"the":[11,69,82,87,94,123,126,130,247,252],"protection":[12],"of":[13,27,53,74,81,103,133,136,167,199,232,246,251],"oxidative":[14],"lesions":[16],"via":[17],"its":[18],"role":[19],"in":[20,148,159],"base":[21],"excision":[22],"repair":[23],"(BER).":[24],"Approximately":[25],"1/3":[26],"tumors":[28,39],"studied":[29],"to":[30,57,120,128,142,204,214],"date":[31],"express":[32],"Pol":[33,41,43],"\u03b2":[34,44,105],"variant":[35,102,179,231],"proteins,":[36],"and":[37,48,86,209,240],"several":[38],"overexpress":[40],"\u03b2.":[42],"possesses":[45],"dRP":[49,64,109,134,200],"lyase":[50,65,110,135,201],"activities,":[51],"both":[52],"which":[54,129],"are":[55,163],"known":[56],"be":[58],"important":[59],"efficient":[61],"BER.":[62],"The":[63],"activity":[66],"resides":[67],"within":[68],"8kDa":[70],"amino":[71],"terminal":[72],"domain":[73,89],"pol":[75,104],"\u03b2,":[76],"responsible":[78,189],"removal":[80],"5\u2032":[83],"phosphate":[84],"group":[85],"at":[90],"subsequent":[91],"steps":[92],"fills":[93],"gaps.":[95],"Previously,":[96],"we":[97,114,175],"demonstrated":[98],"that":[99,155,177,186],"gastric":[100,150],"cancer-associated":[101],"(Leu22Pro":[106],"(L22P))":[107],"lacks":[108],"function":[111,132,198],"in-vitro.":[112],"Here,":[113],"have":[115],"employed":[116],"fiber":[118],"labeling":[119],"quantify,":[121],"first":[124],"time,":[125],"extent":[127],"normal":[131,149,197],"critical":[141,203],"maintain":[143],"global":[144],"replication":[145,156,181,206,211],"fork":[146,157,207,212],"rates":[147,158],"epithelial":[151],"cells.":[152,172],"We":[153],"report":[154],"L22P":[160,178],"expressing":[161],"cells":[162],"on":[164],"average":[165],"half":[166],"those":[168],"observed":[169],"with":[170],"wild-type":[171],"In":[173],"addition,":[174],"show":[176],"promotes":[180],"dependent":[182],"double":[183,216],"strand":[184,217],"breaks":[185],"may":[187,195],"likely":[188],"chromosomal":[191],"aberrations.":[192],"These":[193],"data":[194],"implicate":[196],"stabilize":[205],"stall":[208],"prevent":[210],"collapse":[213],"breaks.":[218],"Citation":[219],"Format:":[220],"Dawit":[221],"Kidane,":[222],"Jenna":[223],"Rozacky,":[224],"Joann":[225],"B.":[226],"Sweasy.":[227],"Gastric":[228],"cancer":[229],"associated":[230],"Beta":[235],"(Leu22Pro)":[236],"induce":[237],"genomic":[238],"instability":[239],"cellular":[241],"transformation.":[242],"[abstract].":[243],"In:":[244],"Proceedings":[245],"106th":[248],"Annual":[249],"Meeting":[250],"American":[253],"Association":[254],"Cancer":[256,266],"Research;":[257],"2015":[258],"Apr":[259],"18-22;":[260],"Philadelphia,":[261],"PA.":[262],"Philadelphia":[263],"(PA):":[264],"AACR;":[265],"Res":[267],"2015;75(15":[268],"Suppl):Abstract":[269],"nr":[270],"3026.":[271],"doi:10.1158/1538-7445.AM2015-3026":[272]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-01-06T00:00:00"}
