{"id":"https://openalex.org/W2563595740","doi":"https://doi.org/10.1038/onc.2016.454","title":"The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination","display_name":"The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination","publication_year":2016,"publication_date":"2016-12-12","ids":{"openalex":"https://openalex.org/W2563595740","doi":"https://doi.org/10.1038/onc.2016.454","mag":"2563595740","pmid":"https://pubmed.ncbi.nlm.nih.gov/27941881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5354266"},"language":"en","primary_location":{"id":"doi:10.1038/onc.2016.454","doi":"https://doi.org/10.1038/onc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/onc.2016.454","pdf_url":"https://www.nature.com/articles/onc2016454.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/onc2016454.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047574440","display_name":"Eva Crosas\u2010Molist","orcid":"https://orcid.org/0000-0002-2408-0071","observed_orcids":["https://orcid.org/0000-0002-2408-0071"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"E Crosas-Molist","raw_affiliation_strings":["Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001350776","display_name":"Esther Bertr\u00e1n","orcid":"https://orcid.org/0000-0001-9356-7409","observed_orcids":["https://orcid.org/0000-0001-9356-7409"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E Bertran","raw_affiliation_strings":["Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001624241","display_name":"Irene Rodr\u00edguez\u2010Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6487-452X","observed_orcids":["https://orcid.org/0000-0002-6487-452X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Rodriguez-Hernandez","raw_affiliation_strings":["Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010383791","display_name":"Cecilia Herr\u00e1iz","orcid":"https://orcid.org/0000-0001-6912-0738","observed_orcids":["https://orcid.org/0000-0001-6912-0738"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Herraiz","raw_affiliation_strings":["Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006567612","display_name":"Gaia Cantelli","orcid":"https://orcid.org/0000-0003-2650-6280","observed_orcids":["https://orcid.org/0000-0003-2650-6280"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Cantelli","raw_affiliation_strings":["Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062447219","display_name":"\u00c0ngels Fabra","orcid":"https://orcid.org/0000-0003-3288-523X","observed_orcids":["https://orcid.org/0000-0003-3288-523X"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c0 Fabra","raw_affiliation_strings":["Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057625517","display_name":"Victoria Sanz\u2010Moreno","orcid":"https://orcid.org/0000-0002-5096-9456","observed_orcids":["https://orcid.org/0000-0002-5096-9456"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"V Sanz-Moreno","raw_affiliation_strings":["Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-5096-9456","affiliations":[{"raw_affiliation_string":"Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Randall Division of Cell and Molecular Biophysics, Tumour Plasticity Laboratory, New Hunt's House, Guy's Campus, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079797869","display_name":"Isabel Fabregat","orcid":"https://orcid.org/0000-0003-0136-8440","observed_orcids":["https://orcid.org/0000-0003-0136-8440"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"I Fabregat","raw_affiliation_strings":["Departament de Ci\u00e8ncies Fisiol\u00f2giques II, University of Barcelona, Barcelona, Spain","Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Ci\u00e8ncies Fisiol\u00f2giques II, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Molecular Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057625517","https://openalex.org/A5079797869"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210087039","https://openalex.org/I71999127"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":{"value":3832,"currency":"EUR","value_usd":4132},"fwci":3.8467,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.9508214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"36","issue":"21","first_page":"3002","last_page":"3014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.10090000182390213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumour-dissemination","display_name":"tumour dissemination","score":0.8180000185966492},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/actomyosin-contractility","display_name":"actomyosin contractility","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rhoc","display_name":"RhoC","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.6340000033378601},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.6370000243186951},{"id":"https://openalex.org/keywords/three-dimensional-matrix","display_name":"three-dimensional matrix","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8669799566268921},{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.7618851661682129},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6980880498886108},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.6552330255508423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4973771870136261},{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.4360312223434448},{"id":"https://openalex.org/C2777362581","wikidata":"https://www.wikidata.org/wiki/Q10881532","display_name":"Molecular oncology","level":4,"score":0.41004714369773865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37502381205558777},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.37112128734588623},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.328926146030426},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.31438305974006653},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3012576401233673},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21120721101760864},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19210651516914368},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08612120151519775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08603700995445251},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000205","descriptor_name":"Actomyosin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/onc.2016.454","doi":"https://doi.org/10.1038/onc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/onc.2016.454","pdf_url":"https://www.nature.com/articles/onc2016454.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4312272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5354266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27941881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27941881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/fa17b56f-75f4-4523-87da-5d4c731b5bd6","doi":null,"is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/fa17b56f-75f4-4523-87da-5d4c731b5bd6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crosas Molist, E, Bertran, E, Rodriguez Hernandez, I, Herraiz, C, Cantelli, G, Fabra, A, Sanz Moreno, V M & Fabregat, I 2016, 'The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination : NOX4 represses epithelial to amoeboid transition', Oncogene.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5354266","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5354266/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Text"},{"id":"mag:2890480711","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/the-nadph-oxidase-nox4-represses-epithelial-to-amoeboid-transition-and-efficient-tumour-dissemination(fa17b56f-75f4-4523-87da-5d4c731b5bd6).html","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Oncogene","raw_type":null}],"best_oa_location":{"id":"doi:10.1038/onc.2016.454","doi":"https://doi.org/10.1038/onc.2016.454","is_oa":true,"landing_page_url":"https://doi.org/10.1038/onc.2016.454","pdf_url":"https://www.nature.com/articles/onc2016454.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3634344204","display_name":null,"funder_award_id":"A12065","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3799972128","display_name":null,"funder_award_id":"24478","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3898918078","display_name":null,"funder_award_id":"12065","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3900107813","display_name":null,"funder_award_id":"C97993H","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G554619033","display_name":null,"funder_award_id":"BM1203 EU-ROS","funder_id":"https://openalex.org/F4320320366","funder_display_name":"European Cooperation in Science and Technology"},{"id":"https://openalex.org/G6161264265","display_name":null,"funder_award_id":"PIE13/00022","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G6321944941","display_name":null,"funder_award_id":"BM1203","funder_id":"https://openalex.org/F4320320366","funder_display_name":"European Cooperation in Science and Technology"},{"id":"https://openalex.org/G6332630260","display_name":null,"funder_award_id":"PIE13/00022","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8488729043","display_name":null,"funder_award_id":"2014SGR0334","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320366","display_name":"European Cooperation in Science and Technology","ror":"https://ror.org/01bstzn19"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320321764","display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","ror":"https://ror.org/03nc27g21"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2563595740.pdf","grobid_xml":"https://content.openalex.org/works/W2563595740.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W879038605","https://openalex.org/W1175152041","https://openalex.org/W1503570761","https://openalex.org/W1565702568","https://openalex.org/W1715823723","https://openalex.org/W1871367169","https://openalex.org/W1910035193","https://openalex.org/W1963501822","https://openalex.org/W1964081206","https://openalex.org/W1964323367","https://openalex.org/W1967173409","https://openalex.org/W1968783143","https://openalex.org/W1971215115","https://openalex.org/W1972170345","https://openalex.org/W1976821656","https://openalex.org/W1984474513","https://openalex.org/W1986074141","https://openalex.org/W1987966101","https://openalex.org/W1988230895","https://openalex.org/W1993289420","https://openalex.org/W1998073026","https://openalex.org/W2004099033","https://openalex.org/W2006487228","https://openalex.org/W2010735936","https://openalex.org/W2015200386","https://openalex.org/W2024597705","https://openalex.org/W2025519885","https://openalex.org/W2026517317","https://openalex.org/W2026759417","https://openalex.org/W2028658650","https://openalex.org/W2031409539","https://openalex.org/W2032028059","https://openalex.org/W2033712039","https://openalex.org/W2041411379","https://openalex.org/W2053199336","https://openalex.org/W2065211332","https://openalex.org/W2070280275","https://openalex.org/W2075194900","https://openalex.org/W2083543572","https://openalex.org/W2085312694","https://openalex.org/W2090339804","https://openalex.org/W2096201751","https://openalex.org/W2098131661","https://openalex.org/W2099548111","https://openalex.org/W2099875681","https://openalex.org/W2114843025","https://openalex.org/W2115443612","https://openalex.org/W2123546830","https://openalex.org/W2125326682","https://openalex.org/W2132400614","https://openalex.org/W2134043156","https://openalex.org/W2142141154","https://openalex.org/W2143468862","https://openalex.org/W2149441684","https://openalex.org/W2151305493","https://openalex.org/W2154903097","https://openalex.org/W2167552306","https://openalex.org/W2179828787","https://openalex.org/W2219356350","https://openalex.org/W2234453634","https://openalex.org/W2258531487","https://openalex.org/W2418544662"],"related_works":["https://openalex.org/W4297943169","https://openalex.org/W2969394969","https://openalex.org/W7165953411","https://openalex.org/W4296007142","https://openalex.org/W3120390045","https://openalex.org/W3031939252","https://openalex.org/W2418544662","https://openalex.org/W2751939039","https://openalex.org/W2775187916","https://openalex.org/W2024597705"],"abstract_inverted_index":{"Epithelial":[0],"to":[1,14,21,39,84,115,176,180],"mesenchymal":[2,119],"transition":[3,16,41,59,178],"is":[4,70,82,160],"a":[5,33],"common":[6],"event":[7],"during":[8],"tumour":[9,112,181],"dissemination.":[10],"However,":[11],"direct":[12],"epithelial":[13,38,175],"amoeboid":[15,40,64,98,177],"has":[17],"not":[18],"been":[19],"characterized":[20],"date.":[22],"Here":[23],"we":[24],"provide":[25],"evidence":[26],"that":[27,116],"cells":[28],"from":[29],"hepatocellular":[30],"carcinoma":[31],"(HCC),":[32],"highly":[34],"metastatic":[35],"cancer,":[36],"undergo":[37],"in":[42,106,118],"physiological":[43],"environments,":[44],"such":[45],"as":[46],"organoids":[47],"or":[48,158],"three-dimensional":[49],"complex":[50],"matrices.":[51],"Furthermore,":[52],"the":[53],"NADPH":[54],"oxidase":[55],"NOX4":[56,68,81,101,123,137,150,168],"inhibits":[57],"this":[58],"and":[60,75,90,93,97,126,130,143,172],"therefore":[61],"suppresses":[62,124],"efficient":[63],"bleb-based":[65],"invasion.":[66,99],"Moreover,":[67,146],"expression":[69,129,138,148,154],"associated":[71,161],"with":[72,78,110,141,152,162],"E-cadherin":[73],"levels":[74,171],"inversely":[76,139],"correlated":[77],"invasive":[79],"features.":[80],"necessary":[83],"maintain":[85],"parenchymal":[86],"structures,":[87],"increase":[88],"cell-cell":[89],"cell-to-matrix":[91],"adhesion,":[92],"impair":[94],"actomyosin":[95,132,170],"contractility":[96],"Importantly,":[100],"gene":[102],"deletions":[103],"are":[104],"frequent":[105],"HCC":[107,135],"patients,":[108,136],"correlating":[109],"higher":[111],"grade.":[113],"Contrary":[114],"observed":[117],"cell":[120],"types,":[121],"here":[122],"Rho":[125],"Cdc42":[127,144,159],"GTPase":[128],"downstream":[131],"contractility.":[133],"In":[134],"correlates":[140],"RhoC":[142,157],"levels.":[145],"low":[147],"of":[149,155,167],"combined":[151],"high":[153],"either":[156],"worse":[163],"prognosis.":[164],"Therefore,":[165],"loss":[166],"increases":[169],"favours":[173],"an":[174],"contributing":[179],"aggressiveness.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-06T00:00:00"}
