{"id":"https://openalex.org/W2563595357","doi":"https://doi.org/10.1158/1538-7445.am2015-3180","title":"Abstract 3180: Regulation of stem cells by the tumor suppressor PP2A-B56\u03b1","display_name":"Abstract 3180: Regulation of stem cells by the tumor suppressor PP2A-B56\u03b1","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2563595357","doi":"https://doi.org/10.1158/1538-7445.am2015-3180","mag":"2563595357"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-3180","doi":"https://doi.org/10.1158/1538-7445.am2015-3180","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3180","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054867789","display_name":"Mahnaz Janghorban","orcid":"https://orcid.org/0000-0002-3405-6104","observed_orcids":["https://orcid.org/0000-0002-3405-6104"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahnaz Janghorban","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069689342","display_name":"Derek K. Zachman","orcid":"https://orcid.org/0000-0003-1433-8400","observed_orcids":["https://orcid.org/0000-0003-1433-8400"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Zachman","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381768","display_name":"Xiaoyan Wang","orcid":"https://orcid.org/0000-0001-7406-5008","observed_orcids":["https://orcid.org/0000-0001-7406-5008","https://orcid.org/0009-0004-5381-9383"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyan Wang","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076074507","display_name":"Anupriya Agarwal","orcid":"https://orcid.org/0000-0002-8319-6162","observed_orcids":["https://orcid.org/0000-0002-8319-6162"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupriya Agarwal","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391361","display_name":"WH Fleming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Fleming","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081536984","display_name":"Rosalie C. Sears","orcid":"https://orcid.org/0000-0003-1558-2413","observed_orcids":["https://orcid.org/0000-0003-1558-2413"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalie Sears","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"3180","last_page":"3180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.1331000030040741,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.6539999842643738},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.746999979019165},{"id":"https://openalex.org/keywords/epidermal-stem-cells","display_name":"epidermal stem cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mammospheres","display_name":"mammospheres","score":0.5899999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.4569999873638153},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.4650000035762787},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4699999988079071},{"id":"https://openalex.org/keywords/gene-trap-mice","display_name":"gene trap mice","score":0.5019999742507935},{"id":"https://openalex.org/keywords/epidermal-hyperproliferation","display_name":"epidermal hyperproliferation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.6460000276565552},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.8922284841537476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.561308741569519},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5416527390480042},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4981551170349121},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46934783458709717},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4658568501472473},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.432691365480423},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.41015559434890747},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3413873314857483},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.30821263790130615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2910139262676239},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.28097769618034363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1983444094657898}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-3180","doi":"https://doi.org/10.1158/1538-7445.am2015-3180","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-3180","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2772300025","https://openalex.org/W2761478733","https://openalex.org/W1971212979","https://openalex.org/W2563835270","https://openalex.org/W2149754768","https://openalex.org/W7096101941","https://openalex.org/W2077038948","https://openalex.org/W2916954261","https://openalex.org/W2782250500","https://openalex.org/W248785419"],"abstract_inverted_index":{"Abstract":[0],"Protein":[1],"phosphatase":[2],"2":[3],"A":[4,109],"(PP2A)":[5],"is":[6,56,149,169,423],"one":[7,176],"of":[8,70,122,140,155,200,236,282,296,305,369,375,382,403,412,417,437,465,493,504,509],"the":[9,108,120,138,153,164,198,233,237,248,252,262,297,324,328,373,380,387,401,415,462,471,497,505,510],"major":[10],"cellular":[11],"Serine-Threonine":[12],"phosphatases":[13],"and":[14,25,42,63,92,110,114,184,205,255,293,301,323,357,359,420,448,470,476],"regulates":[15],"numerous":[16],"signaling":[17],"pathways,":[18],"including":[19,89],"stem":[20,104,161,203,312,332,340,377,384,405,418,451,494],"cell":[21,26,79,132,173,206,313,341,446,452],"self-renewal,":[22],"proliferation,":[23],"differentiation,":[24],"survival.":[27],"The":[28,228,265],"PP2A":[29,50,54,95,115,157],"holoenzyme":[30],"has":[31,177,188],"3":[32],"subunits:":[33],"a":[34,38,43,242],"catalytic":[35],"(C)":[36],"subunit,":[37,41,47],"structural":[39],"(A)":[40],"variable":[44],"regulatory":[45],"(B)":[46],"which":[48,81],"directs":[49],"to":[51,58,151,192,196,251,290,310,317,345,427,434,444,457,460],"specific":[52,156],"targets.":[53],"inhibition":[55],"required":[57],"completely":[59],"transform":[60],"human":[61,102,172],"cells":[62,204,322,385,419,426,495],"siRNA":[64],"screens":[65],"have":[66,211,284],"shown":[67],"that":[68,134,166,410,421],"loss":[69,273,368,411,431,467],"B56\u03b1,":[71],"B56\u03b3,":[72],"or":[73],"PR72/PR130":[74],"B":[75],"subunits":[76],"results":[77],"in":[78,84,100,129,159,182,202,208,232,261,338,353,386,450,468],"transformation,":[80,174],"are":[82],"involved":[83],"negatively":[85],"regulating":[86,101,160],"oncogenic":[87],"pathways":[88],"Wnt,":[90],"Akt,":[91],"Myc.":[93],"Moreover,":[94],"plays":[96],"an":[97,336],"important":[98,170,424,438],"role":[99,181,199],"embryonic":[103],"cells,":[105],"where":[106],"both":[107,352],"C":[111],"subunit":[112],"levels":[113],"activity":[116,436],"gradually":[117],"increase":[118,337],"during":[119],"course":[121],"differentiation.":[123],"Our":[124,407],"preliminary":[125],"data":[126],"also":[127,371],"demonstrates":[128],"breast":[130],"cancer":[131],"lines":[133],"B56\u03b1":[135,144,167,201,213,218,238,272,370,413,422,430,466],"overexpression":[136],"decreases":[137],"number":[139,304,374,381,402,416],"mammospheres":[141],"whereas":[142],"inhibiting":[143],"increases":[145,414],"them.":[146],"Further":[147],"research":[148],"needed":[150],"address":[152],"function":[154],"complexes":[158],"cells.":[162,227,333,406],"Despite":[163],"fact":[165],"depletion":[168],"for":[171,327,425,513],"no":[175,185],"reported":[178],"on":[179],"its":[180],"vivo":[183],"mouse":[186],"model":[187,408],"ever":[189],"been":[190],"generated":[191,212,217],"our":[193],"knowledge.":[194],"Therefore,":[195],"study":[197],"transformation":[207],"vivo,":[209],"we":[210,269,348,365],"knockout":[214,219],"mice.":[215],"We":[216,334],"mice":[220,283,395],"using":[221,315],"commercially":[222],"available":[223],"gene":[224,229,239,253,259],"trap":[225,230,254],"ES":[226],"sits":[231],"first":[234,249],"intron":[235],"and,":[240],"through":[241],"splice":[243],"acceptor":[244],"site,":[245],"splices":[246],"out":[247],"exon":[250],"therefore":[256],"stops":[257],"whole":[258,263],"transcription":[260],"body.":[264],"primary":[266,463],"phenotypic":[267],"effect":[268,464],"observed":[270],"with":[271,396],"was":[274,389],"spontaneous":[275],"skin":[276,286,339,346,354,469,474],"lesion":[277],"formation.":[278],"Thus":[279],"far":[280],"40%":[281],"developed":[285],"lesions":[287,475],"between":[288,473],"11":[289],"21":[291],"months":[292],"showed":[294],"hyper-proliferation":[295],"epidermis,":[298],"hair":[299,306],"follicles,":[300],"dermis.":[302],"Increased":[303],"follicles":[307],"prompted":[308],"us":[309],"perform":[311],"assays":[314,326],"BrDU":[316],"label":[318],"long":[319],"term":[320],"label-retaining":[321],"colony":[325],"fast":[329],"adhering":[330],"keratinocyte":[331],"found":[335,349],"numbers.":[342],"In":[343],"addition":[344],"lesions,":[347,355],"increased":[350,372,400,435],"inflammation":[351],"liver,":[356],"spleen":[358],"some":[360],"enlarged":[361],"lymph":[362],"nodes.":[363],"Next":[364],"asked":[366],"whether":[367],"hematopoietic":[376,383],"cell.":[378],"Although":[379],"periphery":[388],"unchanged":[390],"under":[391],"normal":[392],"condition,":[393],"treating":[394],"granulocyte":[397],"colony-stimulating":[398],"factor":[399],"circulating":[404],"suggests":[409],"maintain":[428],"homeostasis;":[429],"can":[432],"lead":[433],"oncogenes,":[439],"such":[440],"as":[441],"cMyc,":[442],"leading":[443],"aberrant":[445],"growth":[447],"defects":[449],"maintenance.":[453],"More":[454],"experiments":[455],"need":[456],"be":[458],"done":[459],"understand":[461],"interplay":[472],"inflammation.":[477],"Citation":[478],"Format:":[479],"Mahnaz":[480],"Janghorban,":[481],"Derek":[482],"Zachman,":[483],"Xiaoyan":[484],"Wang,":[485],"Anupriya":[486],"Agarwal,":[487],"William":[488],"Fleming,":[489],"Rosalie":[490],"Sears.":[491],"Regulation":[492],"by":[496],"tumor":[498],"suppressor":[499],"PP2A-B56\u03b1.":[500],"[abstract].":[501],"In:":[502],"Proceedings":[503],"106th":[506],"Annual":[507],"Meeting":[508],"American":[511],"Association":[512],"Cancer":[514,524],"Research;":[515],"2015":[516],"Apr":[517],"18-22;":[518],"Philadelphia,":[519],"PA.":[520],"Philadelphia":[521],"(PA):":[522],"AACR;":[523],"Res":[525],"2015;75(15":[526],"Suppl):Abstract":[527],"nr":[528],"3180.":[529],"doi:10.1158/1538-7445.AM2015-3180":[530]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-01-06T00:00:00"}
