{"id":"https://openalex.org/W2563559268","doi":null,"title":"Disturbed Object Processing in 5xFAD and 3xTG Mouse Models of Alzheimer's Disease: Going Beyond \"Object Recognition\"","display_name":"Disturbed Object Processing in 5xFAD and 3xTG Mouse Models of Alzheimer's Disease: Going Beyond \"Object Recognition\"","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2563559268","mag":"2563559268"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9952","pdf_url":"https://atrium.lib.uoguelph.ca/bitstreams/0ed6e9ea-27f6-4605-a230-f2b3b3113e3d/download","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://atrium.lib.uoguelph.ca/bitstreams/0ed6e9ea-27f6-4605-a230-f2b3b3113e3d/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087401678","display_name":"Samantha D. Creighton","orcid":"https://orcid.org/0000-0002-3463-2394","observed_orcids":["https://orcid.org/0000-0002-3463-2394"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samantha D. Creighton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3463-2394","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087401678"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.22190000116825104,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8429999947547913},{"id":"https://openalex.org/keywords/object-recognition","display_name":"object recognition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/object-processing","display_name":"object processing","score":0.6140000224113464},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9539999961853027},{"id":"https://openalex.org/keywords/3xtg-ad-mice","display_name":"3xTg-AD mice","score":0.9829999804496765},{"id":"https://openalex.org/keywords/object-location","display_name":"object location","score":0.8159999847412109},{"id":"https://openalex.org/keywords/temporal-order","display_name":"temporal order","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9409999847412109},{"id":"https://openalex.org/keywords/spatial-processing","display_name":"spatial processing","score":0.5350000262260437},{"id":"https://openalex.org/keywords/temporal-processing","display_name":"temporal processing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2781238097","wikidata":"https://www.wikidata.org/wiki/Q175026","display_name":"Object (grammar)","level":2,"score":0.6530320644378662},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.603935956954956},{"id":"https://openalex.org/C64876066","wikidata":"https://www.wikidata.org/wiki/Q5141226","display_name":"Cognitive neuroscience of visual object recognition","level":3,"score":0.5387360453605652},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5206388831138611},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.4384306073188782},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4145810306072235},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3869052827358246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3718487322330475},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3043963611125946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20601332187652588}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9952","pdf_url":"https://atrium.lib.uoguelph.ca/bitstreams/0ed6e9ea-27f6-4605-a230-f2b3b3113e3d/download","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2563559268","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9952","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9952","pdf_url":"https://atrium.lib.uoguelph.ca/bitstreams/0ed6e9ea-27f6-4605-a230-f2b3b3113e3d/download","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2563559268.pdf","grobid_xml":"https://content.openalex.org/works/W2563559268.grobid-xml"},"referenced_works_count":337,"referenced_works":["https://openalex.org/W123195486","https://openalex.org/W181367720","https://openalex.org/W1485047132","https://openalex.org/W1514507920","https://openalex.org/W1522338605","https://openalex.org/W1530531377","https://openalex.org/W1532989877","https://openalex.org/W1534454046","https://openalex.org/W1541961513","https://openalex.org/W1557865839","https://openalex.org/W1566600743","https://openalex.org/W1567578874","https://openalex.org/W1598852457","https://openalex.org/W1605394923","https://openalex.org/W1606587171","https://openalex.org/W1718512444","https://openalex.org/W1765834125","https://openalex.org/W1806950858","https://openalex.org/W1817128706","https://openalex.org/W1838526658","https://openalex.org/W1886575365","https://openalex.org/W1895538680","https://openalex.org/W1965151684","https://openalex.org/W1965342510","https://openalex.org/W1965854886","https://openalex.org/W1966014719","https://openalex.org/W1966030520","https://openalex.org/W1967002445","https://openalex.org/W1967347174","https://openalex.org/W1967375871","https://openalex.org/W1967764121","https://openalex.org/W1967807767","https://openalex.org/W1967899016","https://openalex.org/W1968900405","https://openalex.org/W1969458613","https://openalex.org/W1969979382","https://openalex.org/W1970084030","https://openalex.org/W1972278675","https://openalex.org/W1972850922","https://openalex.org/W1973276273","https://openalex.org/W1973802652","https://openalex.org/W1975882651","https://openalex.org/W1976515190","https://openalex.org/W1977002082","https://openalex.org/W1977653833","https://openalex.org/W1979755700","https://openalex.org/W1980089981","https://openalex.org/W1980375629","https://openalex.org/W1980680161","https://openalex.org/W1980944036","https://openalex.org/W1981000616","https://openalex.org/W1981439874","https://openalex.org/W1981968760","https://openalex.org/W1982313782","https://openalex.org/W1982706802","https://openalex.org/W1983044979","https://openalex.org/W1983282794","https://openalex.org/W1983493842","https://openalex.org/W1984494019","https://openalex.org/W1986512401","https://openalex.org/W1987177328","https://openalex.org/W1987664383","https://openalex.org/W1987809028","https://openalex.org/W1988702928","https://openalex.org/W1989019042","https://openalex.org/W1989246753","https://openalex.org/W1989280457","https://openalex.org/W1989597480","https://openalex.org/W1990061193","https://openalex.org/W1990774375","https://openalex.org/W1991513124","https://openalex.org/W1993050097","https://openalex.org/W1993327095","https://openalex.org/W1995650022","https://openalex.org/W1995669157","https://openalex.org/W1996371165","https://openalex.org/W1997322387","https://openalex.org/W1998016856","https://openalex.org/W1998411467","https://openalex.org/W1998559329","https://openalex.org/W2000172037","https://openalex.org/W2000432347","https://openalex.org/W2002306490","https://openalex.org/W2002498062","https://openalex.org/W2002752208","https://openalex.org/W2003614844","https://openalex.org/W2004855983","https://openalex.org/W2006039762","https://openalex.org/W2006152123","https://openalex.org/W2006579719","https://openalex.org/W2007812767","https://openalex.org/W2007818439","https://openalex.org/W2008699078","https://openalex.org/W2009174342","https://openalex.org/W2009828191","https://openalex.org/W2010120109","https://openalex.org/W2010925911","https://openalex.org/W2011074122","https://openalex.org/W2011822716","https://openalex.org/W2012482368","https://openalex.org/W2012590437","https://openalex.org/W2012862746","https://openalex.org/W2013651799","https://openalex.org/W2013776593","https://openalex.org/W2015163544","https://openalex.org/W2015570166","https://openalex.org/W2016520377","https://openalex.org/W2016678016","https://openalex.org/W2017043269","https://openalex.org/W2017950146","https://openalex.org/W2018354461","https://openalex.org/W2019044369","https://openalex.org/W2019593939","https://openalex.org/W2020951538","https://openalex.org/W2022178570","https://openalex.org/W2023531011","https://openalex.org/W2023855839","https://openalex.org/W2024053743","https://openalex.org/W2024958674","https://openalex.org/W2026714379","https://openalex.org/W2026745182","https://openalex.org/W2026816538","https://openalex.org/W2028405984","https://openalex.org/W2028850203","https://openalex.org/W2029205666","https://openalex.org/W2030270894","https://openalex.org/W2030664361","https://openalex.org/W2031011158","https://openalex.org/W2031727962","https://openalex.org/W2031741650","https://openalex.org/W2032193569","https://openalex.org/W2032923343","https://openalex.org/W2033541440","https://openalex.org/W2034047883","https://openalex.org/W2034204213","https://openalex.org/W2034285129","https://openalex.org/W2034315250","https://openalex.org/W2034713237","https://openalex.org/W2035339855","https://openalex.org/W2036172794","https://openalex.org/W2036416179","https://openalex.org/W2037103764","https://openalex.org/W2037154303","https://openalex.org/W2037401041","https://openalex.org/W2038289033","https://openalex.org/W2038350410","https://openalex.org/W2038809411","https://openalex.org/W2039965538","https://openalex.org/W2040579132","https://openalex.org/W2040836716","https://openalex.org/W2040852606","https://openalex.org/W2040853845","https://openalex.org/W2041139789","https://openalex.org/W2041142744","https://openalex.org/W2042113686","https://openalex.org/W2043029293","https://openalex.org/W2043407651","https://openalex.org/W2043617123","https://openalex.org/W2043824774","https://openalex.org/W2046053621","https://openalex.org/W2047945039","https://openalex.org/W2048505726","https://openalex.org/W2048622057","https://openalex.org/W2048865592","https://openalex.org/W2050912908","https://openalex.org/W2051218719","https://openalex.org/W2051514662","https://openalex.org/W2051951639","https://openalex.org/W2052096433","https://openalex.org/W2052742260","https://openalex.org/W2054388625","https://openalex.org/W2054675346","https://openalex.org/W2055409595","https://openalex.org/W2056092494","https://openalex.org/W2056170209","https://openalex.org/W2056287225","https://openalex.org/W2056942044","https://openalex.org/W2057144507","https://openalex.org/W2059148941","https://openalex.org/W2059153206","https://openalex.org/W2059171513","https://openalex.org/W2059215368","https://openalex.org/W2059308833","https://openalex.org/W2059401417","https://openalex.org/W2059721162","https://openalex.org/W2059937523","https://openalex.org/W2060105415","https://openalex.org/W2060642462","https://openalex.org/W2060784568","https://openalex.org/W2060851420","https://openalex.org/W2061211105","https://openalex.org/W2061419556","https://openalex.org/W2061495286","https://openalex.org/W2062949684","https://openalex.org/W2065769635","https://openalex.org/W2066151392","https://openalex.org/W2066785847","https://openalex.org/W2068108153","https://openalex.org/W2068477037","https://openalex.org/W2068606410","https://openalex.org/W2068784646","https://openalex.org/W2070030133","https://openalex.org/W2070488302","https://openalex.org/W2071006250","https://openalex.org/W2071148852","https://openalex.org/W2071695275","https://openalex.org/W2071726812","https://openalex.org/W2072193814","https://openalex.org/W2073997738","https://openalex.org/W2075481535","https://openalex.org/W2076800034","https://openalex.org/W2077279038","https://openalex.org/W2078140987","https://openalex.org/W2078459727","https://openalex.org/W2079493663","https://openalex.org/W2079821580","https://openalex.org/W2080238811","https://openalex.org/W2080348938","https://openalex.org/W2081483657","https://openalex.org/W2081954395","https://openalex.org/W2082044837","https://openalex.org/W2083184765","https://openalex.org/W2083882468","https://openalex.org/W2084972185","https://openalex.org/W2086333867","https://openalex.org/W2086662417","https://openalex.org/W2086725596","https://openalex.org/W2087568219","https://openalex.org/W2087787276","https://openalex.org/W2087914502","https://openalex.org/W2087943529","https://openalex.org/W2088267321","https://openalex.org/W2088269376","https://openalex.org/W2090586279","https://openalex.org/W2091007048","https://openalex.org/W2091182321","https://openalex.org/W2091359288","https://openalex.org/W2091662794","https://openalex.org/W2093419961","https://openalex.org/W2094063510","https://openalex.org/W2094118946","https://openalex.org/W2095056606","https://openalex.org/W2095677861","https://openalex.org/W2096410114","https://openalex.org/W2098463163","https://openalex.org/W2099002964","https://openalex.org/W2099528046","https://openalex.org/W2101715910","https://openalex.org/W2101843209","https://openalex.org/W2102411019","https://openalex.org/W2102815754","https://openalex.org/W2104227586","https://openalex.org/W2105517151","https://openalex.org/W2105624870","https://openalex.org/W2106464041","https://openalex.org/W2108149698","https://openalex.org/W2109181250","https://openalex.org/W2109268662","https://openalex.org/W2109727228","https://openalex.org/W2111570868","https://openalex.org/W2111627644","https://openalex.org/W2112052880","https://openalex.org/W2114129147","https://openalex.org/W2114781316","https://openalex.org/W2115378686","https://openalex.org/W2116451919","https://openalex.org/W2116633293","https://openalex.org/W2118414216","https://openalex.org/W2119632004","https://openalex.org/W2120145202","https://openalex.org/W2121325203","https://openalex.org/W2121428135","https://openalex.org/W2122065036","https://openalex.org/W2125172225","https://openalex.org/W2125998077","https://openalex.org/W2126108937","https://openalex.org/W2131320161","https://openalex.org/W2131621857","https://openalex.org/W2134547791","https://openalex.org/W2135082924","https://openalex.org/W2135111297","https://openalex.org/W2136466563","https://openalex.org/W2136623897","https://openalex.org/W2136901555","https://openalex.org/W2138878035","https://openalex.org/W2140542463","https://openalex.org/W2140788457","https://openalex.org/W2141311043","https://openalex.org/W2141842377","https://openalex.org/W2142467924","https://openalex.org/W2143798330","https://openalex.org/W2144529104","https://openalex.org/W2144531560","https://openalex.org/W2144854908","https://openalex.org/W2147930131","https://openalex.org/W2147970286","https://openalex.org/W2148721608","https://openalex.org/W2150320931","https://openalex.org/W2151060040","https://openalex.org/W2151664809","https://openalex.org/W2151852115","https://openalex.org/W2152165298","https://openalex.org/W2152446053","https://openalex.org/W2154130844","https://openalex.org/W2154360214","https://openalex.org/W2154973096","https://openalex.org/W2157005122","https://openalex.org/W2159320983","https://openalex.org/W2159984692","https://openalex.org/W2160212383","https://openalex.org/W2161451109","https://openalex.org/W2162803014","https://openalex.org/W2163114360","https://openalex.org/W2163115168","https://openalex.org/W2163583269","https://openalex.org/W2165805186","https://openalex.org/W2166006001","https://openalex.org/W2166267133","https://openalex.org/W2166416515","https://openalex.org/W2166704587","https://openalex.org/W2168312889","https://openalex.org/W2169195417","https://openalex.org/W2170644095","https://openalex.org/W2170844152","https://openalex.org/W2171542393","https://openalex.org/W2182763281","https://openalex.org/W2232548624","https://openalex.org/W2267069368","https://openalex.org/W2279179827","https://openalex.org/W2299967951","https://openalex.org/W2461678824","https://openalex.org/W4210605243","https://openalex.org/W4243958611","https://openalex.org/W4365787461","https://openalex.org/W4407744560","https://openalex.org/W7100236080","https://openalex.org/W7110819555"],"related_works":["https://openalex.org/W2909377691","https://openalex.org/W2299993074","https://openalex.org/W2017031780","https://openalex.org/W4214877014","https://openalex.org/W4311758288","https://openalex.org/W4391486528","https://openalex.org/W2900668365","https://openalex.org/W2569077447","https://openalex.org/W7205557017","https://openalex.org/W2535993867"],"abstract_inverted_index":{"Object":[0],"recognition":[1],"not":[2],"a":[3],"unitary":[4],"process,":[5],"and":[6,66,76,79,90,99,107,119,128,133,146],"there":[7],"are":[8],"many":[9],"uncharacterized":[10],"facets":[11],"of":[12,27,35,47,130,143],"object":[13,28,48,50,53,70,131],"processing":[14,29,57,62],"that":[15,43],"have":[16],"relevance":[17],"to":[18,136],"Alzheimer\u2019s":[19],"disease":[20],"(AD).":[21],"To":[22],"elucidate":[23],"the":[24,138],"specific":[25,141],"nature":[26],"deficits":[30],"in":[31,73],"transgenic":[32],"mouse":[33],"models":[34],"AD,":[36],"we":[37],"systematically":[38],"evaluated":[39],"performance":[40],"on":[41,86],"tasks":[42],"manipulate":[44],"different":[45],"types":[46],"information:":[49],"identity":[51],"(i.e.,":[52],"recognition:":[54],"OR),":[55],"spatial":[56,101],"(object":[58],"location;":[59],"OL),":[60],"temporal":[61],"(temporal":[63],"order;":[64],"TO),":[65],"multisensory":[67],"perception":[68],"(multisensory":[69],"oddity;":[71],"MSO)":[72],"12-month-old":[74],"male":[75],"female":[77],"5xFAD":[78,82],"3xTG":[80,93,113],"mice.":[81],"mice":[83,114],"were":[84,103],"impaired":[85,116],"OR,":[87,98],"OL,":[88,117],"TO":[89,118],"MSO.":[91,120],"Conversely,":[92],"females":[94,108],"had":[95,109,115],"intact":[96,110],"short-term":[97,111],"when":[100],"cues":[102],"minimized":[104],"both":[105],"males":[106],"OR.":[112],"Results":[121],"reveal":[122],"dissociations":[123],"across":[124],"AD":[125,144],"strain,":[126],"sex,":[127],"type":[129],"processing,":[132],"should":[134],"help":[135],"clarify":[137],"relationship":[139],"between":[140],"aspects":[142],"pathology":[145],"object-related":[147],"information":[148],"processing.":[149]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}