{"id":"https://openalex.org/W2563362274","doi":null,"title":"The Effects of Varenicline on Neurocognitive Function in Non-smokers with Schizophrenia","display_name":"The Effects of Varenicline on Neurocognitive Function in Non-smokers with Schizophrenia","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2563362274","mag":"2563362274"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/75091","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/75091","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b70aa6a5-823d-4648-90a7-d3e9c528ef53/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/b70aa6a5-823d-4648-90a7-d3e9c528ef53/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027947319","display_name":"Karolina Kozak","orcid":"https://orcid.org/0000-0003-2390-0493","observed_orcids":["https://orcid.org/0000-0003-2390-0493"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karolina Kozak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2390-0493","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027947319"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varenicline","display_name":"varenicline","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.984000027179718},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nonsmokers","display_name":"non-smokers","score":0.871999979019165},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9589999914169312},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/verbal-memory","display_name":"verbal memory","score":0.9039999842643738},{"id":"https://openalex.org/keywords/visuospatial-memory","display_name":"visuospatial memory","score":0.8259999752044678},{"id":"https://openalex.org/keywords/inattention","display_name":"inattention","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cognitive-enhancement","display_name":"cognitive enhancement","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2777053506","wikidata":"https://www.wikidata.org/wiki/Q411330","display_name":"Varenicline","level":3,"score":0.9115900993347168},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8335583209991455},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.765068531036377},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47694793343544006},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.46377816796302795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44614145159721375},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.40374431014060974},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.21710708737373352},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.1435207724571228}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/75091","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/75091","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b70aa6a5-823d-4648-90a7-d3e9c528ef53/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2563362274","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/75091?mode=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/75091","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/75091","pdf_url":"https://utoronto.scholaris.ca/bitstreams/b70aa6a5-823d-4648-90a7-d3e9c528ef53/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2563362274.pdf","grobid_xml":"https://content.openalex.org/works/W2563362274.grobid-xml"},"referenced_works_count":199,"referenced_works":["https://openalex.org/W173144656","https://openalex.org/W179281078","https://openalex.org/W193367814","https://openalex.org/W428428392","https://openalex.org/W917151330","https://openalex.org/W919128815","https://openalex.org/W1486663551","https://openalex.org/W1528478735","https://openalex.org/W1593832621","https://openalex.org/W1599446986","https://openalex.org/W1909773795","https://openalex.org/W1949836637","https://openalex.org/W1963673462","https://openalex.org/W1964413986","https://openalex.org/W1965198880","https://openalex.org/W1965233924","https://openalex.org/W1965332505","https://openalex.org/W1968322454","https://openalex.org/W1968333224","https://openalex.org/W1969800196","https://openalex.org/W1973029807","https://openalex.org/W1975673236","https://openalex.org/W1976455978","https://openalex.org/W1977138162","https://openalex.org/W1977869470","https://openalex.org/W1978007048","https://openalex.org/W1980253122","https://openalex.org/W1980507550","https://openalex.org/W1983805722","https://openalex.org/W1985332823","https://openalex.org/W1986462906","https://openalex.org/W1986677503","https://openalex.org/W1987834520","https://openalex.org/W1988220508","https://openalex.org/W1988552996","https://openalex.org/W1989544789","https://openalex.org/W1991965466","https://openalex.org/W1992179353","https://openalex.org/W1993112595","https://openalex.org/W1995529008","https://openalex.org/W1995611822","https://openalex.org/W1997437727","https://openalex.org/W2000073412","https://openalex.org/W2000326325","https://openalex.org/W2002540335","https://openalex.org/W2004570705","https://openalex.org/W2007001183","https://openalex.org/W2009074722","https://openalex.org/W2010282456","https://openalex.org/W2011464287","https://openalex.org/W2012336047","https://openalex.org/W2014397820","https://openalex.org/W2016445640","https://openalex.org/W2016530746","https://openalex.org/W2017378096","https://openalex.org/W2019718444","https://openalex.org/W2021620877","https://openalex.org/W2023076733","https://openalex.org/W2025771147","https://openalex.org/W2026810208","https://openalex.org/W2027621491","https://openalex.org/W2028931450","https://openalex.org/W2028935810","https://openalex.org/W2029450128","https://openalex.org/W2029891351","https://openalex.org/W2030883353","https://openalex.org/W2032496811","https://openalex.org/W2032866243","https://openalex.org/W2034530553","https://openalex.org/W2035097524","https://openalex.org/W2035367367","https://openalex.org/W2036597812","https://openalex.org/W2038935864","https://openalex.org/W2039714278","https://openalex.org/W2041068326","https://openalex.org/W2041236833","https://openalex.org/W2043941998","https://openalex.org/W2045314545","https://openalex.org/W2049324875","https://openalex.org/W2049939667","https://openalex.org/W2049992856","https://openalex.org/W2050409084","https://openalex.org/W2050666093","https://openalex.org/W2051592959","https://openalex.org/W2053457282","https://openalex.org/W2054023551","https://openalex.org/W2055122628","https://openalex.org/W2055762844","https://openalex.org/W2055930372","https://openalex.org/W2056919088","https://openalex.org/W2057837355","https://openalex.org/W2058225279","https://openalex.org/W2059717138","https://openalex.org/W2062419094","https://openalex.org/W2063163948","https://openalex.org/W2064281051","https://openalex.org/W2066193909","https://openalex.org/W2067130684","https://openalex.org/W2067495470","https://openalex.org/W2067874550","https://openalex.org/W2068450558","https://openalex.org/W2069122260","https://openalex.org/W2069169238","https://openalex.org/W2070192651","https://openalex.org/W2071488745","https://openalex.org/W2076510166","https://openalex.org/W2078514039","https://openalex.org/W2081056247","https://openalex.org/W2082074499","https://openalex.org/W2084399151","https://openalex.org/W2085002574","https://openalex.org/W2086629761","https://openalex.org/W2089182563","https://openalex.org/W2089912569","https://openalex.org/W2090979638","https://openalex.org/W2091188999","https://openalex.org/W2091585750","https://openalex.org/W2091673195","https://openalex.org/W2093235629","https://openalex.org/W2095210792","https://openalex.org/W2095334048","https://openalex.org/W2097744565","https://openalex.org/W2100773070","https://openalex.org/W2100828552","https://openalex.org/W2101520329","https://openalex.org/W2102366253","https://openalex.org/W2103655132","https://openalex.org/W2104387947","https://openalex.org/W2107793119","https://openalex.org/W2110387945","https://openalex.org/W2111504432","https://openalex.org/W2113308458","https://openalex.org/W2113381731","https://openalex.org/W2114367427","https://openalex.org/W2115487888","https://openalex.org/W2117279026","https://openalex.org/W2117389430","https://openalex.org/W2117633779","https://openalex.org/W2120827616","https://openalex.org/W2121948831","https://openalex.org/W2122921281","https://openalex.org/W2123569036","https://openalex.org/W2124533302","https://openalex.org/W2129208121","https://openalex.org/W2129372385","https://openalex.org/W2130578280","https://openalex.org/W2132748057","https://openalex.org/W2133053824","https://openalex.org/W2133750612","https://openalex.org/W2134335897","https://openalex.org/W2134705835","https://openalex.org/W2135163605","https://openalex.org/W2135734842","https://openalex.org/W2137395053","https://openalex.org/W2139385647","https://openalex.org/W2140606211","https://openalex.org/W2140909692","https://openalex.org/W2141246891","https://openalex.org/W2142087193","https://openalex.org/W2143238807","https://openalex.org/W2143532348","https://openalex.org/W2144671685","https://openalex.org/W2146406172","https://openalex.org/W2148180564","https://openalex.org/W2150790731","https://openalex.org/W2151012619","https://openalex.org/W2151111038","https://openalex.org/W2152736948","https://openalex.org/W2154200052","https://openalex.org/W2160546125","https://openalex.org/W2162606711","https://openalex.org/W2163574850","https://openalex.org/W2164386461","https://openalex.org/W2164418506","https://openalex.org/W2165321423","https://openalex.org/W2166090261","https://openalex.org/W2170069078","https://openalex.org/W2170194206","https://openalex.org/W2170256757","https://openalex.org/W2170725202","https://openalex.org/W2171980237","https://openalex.org/W2172000844","https://openalex.org/W2172201169","https://openalex.org/W2176223631","https://openalex.org/W2181792687","https://openalex.org/W2191515858","https://openalex.org/W2223532918","https://openalex.org/W2226061200","https://openalex.org/W2257438068","https://openalex.org/W2328176206","https://openalex.org/W2340896985","https://openalex.org/W2403202245","https://openalex.org/W2465403597","https://openalex.org/W2500732855","https://openalex.org/W2883261595","https://openalex.org/W2912009534","https://openalex.org/W4234210156","https://openalex.org/W4250204111","https://openalex.org/W4297850989"],"related_works":["https://openalex.org/W2607659224","https://openalex.org/W2609703870","https://openalex.org/W2226061200","https://openalex.org/W2035367367","https://openalex.org/W2993740699","https://openalex.org/W1986462906","https://openalex.org/W2120520802","https://openalex.org/W2515020774","https://openalex.org/W2102770635","https://openalex.org/W7095627532"],"abstract_inverted_index":{"Background:":[0],"Effective":[1],"treatments":[2],"for":[3,18],"neurocognitive":[4,67,79,142],"deficiencies":[5],"among":[6],"schizophrenia":[7,60,145],"patients":[8,83,117,146],"remain":[9],"an":[10],"unmet":[11],"need.":[12],"The":[13],"nicotinic":[14],"partial-agonist":[15],"varenicline,":[16],"approved":[17],"smoking":[19],"cessation,":[20],"has":[21],"been":[22],"shown":[23],"to":[24,85,102],"enhance":[25],"neurocognition":[26],"in":[27,32,57,113,135,144,147],"schizophrenia,":[28],"but":[29],"its":[30],"effects":[31,47],"non-smokers":[33,58],"are":[34],"unknown.":[35],"Methods:":[36],"This":[37],"study":[38],"was":[39,132],"a":[40,148],"randomized,":[41],"double-blind,":[42],"placebo-controlled,":[43],"cross-over":[44],"design":[45],"assessing":[46],"of":[48],"3":[49],"different":[50],"varenicline":[51],"doses":[52],"(0,":[53],"1,":[54],"and":[55,62,96,128],"2mg/day)":[56],"with":[59],"(n=15)":[61,65],"non-psychiatric":[63],"controls":[64,100,122],"on":[66,88,105,108],"performance.":[68,130],"Primary":[69],"outcome":[70],"assessed":[71,77],"working":[72],"memory,":[73],"while":[74,99],"secondary":[75],"outcomes":[76],"other":[78],"domains.":[80,110],"Results:":[81],"Overall":[82],"appeared":[84,101],"perform":[86,103],"better":[87,104],"1mg/day":[89],"dose":[90,107],"across":[91],"visuospatial":[92],"working-memory,":[93],"verbal":[94],"memory":[95],"executive":[97,125],"function,":[98,126],"2mg/day":[106,115],"these":[109],"Across":[111],"time":[112],"the":[114],"dose,":[116],"demonstrated":[118],"increased":[119],"inattentiveness,":[120],"whereas":[121],"had":[123],"greater":[124],"attention,":[127],"decision-making":[129],"Varenicline":[131,139],"generally":[133],"well-tolerated":[134],"both":[136],"groups.":[137],"Conclusions:":[138],"may":[140],"treat":[141],"dysfunction":[143],"non-linear":[149],"dose-related":[150],"fashion.":[151]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}
