{"id":"https://openalex.org/W2563294686","doi":"https://doi.org/10.1002/9781118493816.ch10","title":"Signaling in malaria parasites","display_name":"Signaling in malaria parasites","publication_year":2016,"publication_date":"2016-12-08","ids":{"openalex":"https://openalex.org/W2563294686","doi":"https://doi.org/10.1002/9781118493816.ch10","mag":"2563294686"},"language":"en","primary_location":{"id":"doi:10.1002/9781118493816.ch10","doi":"https://doi.org/10.1002/9781118493816.ch10","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118493816.ch10","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Malaria Research","raw_type":"other"},"volume":{"id":"https://openalex.org/W2566174374","display_name":"Advances in Malaria Research"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041282587","display_name":"Pushkar Sharma","orcid":"https://orcid.org/0000-0001-6861-0508","observed_orcids":["https://orcid.org/0000-0001-6861-0508"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pushkar Sharma","raw_affiliation_strings":["National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009984025","display_name":"Sudhir Kumar","orcid":"https://orcid.org/0000-0002-2847-393X","observed_orcids":["https://orcid.org/0000-0002-2847-393X"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudhir Kumar","raw_affiliation_strings":["National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156726"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"291","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.9020000100135803},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8180000185966492},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cyclic-nucleotides","display_name":"cyclic nucleotides","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.8820000290870667},{"id":"https://openalex.org/keywords/atypical-protein-kinases","display_name":"atypical protein kinases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asexual-blood-stage-development","display_name":"asexual blood stage development","score":0.9070000052452087},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7577371597290039},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6681792736053467},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6017738580703735},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5914928317070007},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5249212384223938},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5011072158813477},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.4720393419265747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47119995951652527},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.45519766211509705},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4504472017288208},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.44206932187080383},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4062122106552124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2590053677558899},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10258185863494873},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781118493816.ch10","doi":"https://doi.org/10.1002/9781118493816.ch10","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781118493816.ch10","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Malaria Research","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W115283090","https://openalex.org/W195201687","https://openalex.org/W1483613905","https://openalex.org/W1485297825","https://openalex.org/W1507391401","https://openalex.org/W1568062575","https://openalex.org/W1576958650","https://openalex.org/W1836858748","https://openalex.org/W1875580551","https://openalex.org/W1908694293","https://openalex.org/W1930237957","https://openalex.org/W1964881184","https://openalex.org/W1967763539","https://openalex.org/W1968007300","https://openalex.org/W1970339000","https://openalex.org/W1973541716","https://openalex.org/W1976073866","https://openalex.org/W1983260712","https://openalex.org/W1983696650","https://openalex.org/W1984767299","https://openalex.org/W1992557402","https://openalex.org/W1993127355","https://openalex.org/W1995636848","https://openalex.org/W1996760177","https://openalex.org/W1997667617","https://openalex.org/W2002279886","https://openalex.org/W2003902515","https://openalex.org/W2004388457","https://openalex.org/W2006001612","https://openalex.org/W2006270918","https://openalex.org/W2006740007","https://openalex.org/W2008924331","https://openalex.org/W2012983635","https://openalex.org/W2014960662","https://openalex.org/W2016500542","https://openalex.org/W2016728754","https://openalex.org/W2017047171","https://openalex.org/W2017822115","https://openalex.org/W2019851585","https://openalex.org/W2021489498","https://openalex.org/W2022304951","https://openalex.org/W2023413594","https://openalex.org/W2023910665","https://openalex.org/W2025636478","https://openalex.org/W2026483075","https://openalex.org/W2030002022","https://openalex.org/W2030126092","https://openalex.org/W2032057393","https://openalex.org/W2033721665","https://openalex.org/W2034720263","https://openalex.org/W2034920086","https://openalex.org/W2036041437","https://openalex.org/W2039873071","https://openalex.org/W2040619015","https://openalex.org/W2041294499","https://openalex.org/W2041789288","https://openalex.org/W2046825488","https://openalex.org/W2048930070","https://openalex.org/W2052932787","https://openalex.org/W2057019052","https://openalex.org/W2057830631","https://openalex.org/W2059692646","https://openalex.org/W2061944620","https://openalex.org/W2066396328","https://openalex.org/W2074004956","https://openalex.org/W2074760017","https://openalex.org/W2074865940","https://openalex.org/W2075117194","https://openalex.org/W2076148782","https://openalex.org/W2078356213","https://openalex.org/W2081961986","https://openalex.org/W2082379606","https://openalex.org/W2083200592","https://openalex.org/W2084319889","https://openalex.org/W2090454518","https://openalex.org/W2092943158","https://openalex.org/W2093012648","https://openalex.org/W2093590217","https://openalex.org/W2096483998","https://openalex.org/W2097432311","https://openalex.org/W2097629005","https://openalex.org/W2099767800","https://openalex.org/W2101883070","https://openalex.org/W2102547408","https://openalex.org/W2103812334","https://openalex.org/W2104606350","https://openalex.org/W2106176044","https://openalex.org/W2108998020","https://openalex.org/W2109122531","https://openalex.org/W2111127068","https://openalex.org/W2112855946","https://openalex.org/W2116004188","https://openalex.org/W2116872412","https://openalex.org/W2123179582","https://openalex.org/W2133052195","https://openalex.org/W2134118778","https://openalex.org/W2154816348","https://openalex.org/W2156160408","https://openalex.org/W2158745436","https://openalex.org/W2159472972","https://openalex.org/W2161167008","https://openalex.org/W2164139183","https://openalex.org/W2165318062","https://openalex.org/W2168345658","https://openalex.org/W2171422864","https://openalex.org/W2176061808","https://openalex.org/W2403737796","https://openalex.org/W2407153889","https://openalex.org/W4295216797"],"related_works":["https://openalex.org/W2109474493","https://openalex.org/W2003380001","https://openalex.org/W2045809999","https://openalex.org/W2401653389","https://openalex.org/W2943163397","https://openalex.org/W2074004956","https://openalex.org/W1984767299","https://openalex.org/W3136418919","https://openalex.org/W1965066435","https://openalex.org/W2601630722"],"abstract_inverted_index":{"Extracellular":[0],"signals":[1,17],"are":[2,96],"received":[3],"by":[4,65],"receptors":[5],"present":[6],"at":[7],"the":[8,12,21,32,42,52,59,99,111,114,130,137],"cell":[9],"surface,":[10],"and":[11,35,38,48,71,88,113,121,123],"information":[13],"encoded":[14],"in":[15,51],"these":[16],"is":[18,136],"transmitted":[19],"inside":[20],"cell,":[22],"its":[23],"biochemical":[24],"machinery":[25],"eliciting":[26],"biological":[27],"responses.":[28],"The":[29,74],"sequencing":[30],"of":[31,44,58,61,101,132],"Plasmodium":[33,62],"genome":[34],"subsequent":[36],"bioinformatics":[37],"computational":[39],"analyses":[40],"indicated":[41],"presence":[43],"several":[45,78],"interesting":[46],"gene":[47],"protein":[49,80,85,90],"families":[50],"parasite.":[53,105],"This":[54],"chapter":[55],"discusses":[56],"some":[57],"features":[60],"signaling":[63,94],"regulated":[64],"second":[66],"messengers":[67],"like":[68,118],"calcium,":[69],"phosphoinositides,":[70],"cyclic":[72],"nucleotides.":[73],"malaria":[75],"parasite":[76],"contains":[77],"eukaryotic":[79],"kinases,":[81],"which":[82,109],"includes":[83],"eukaryotic-like":[84],"kinases":[86,91],"(ePK)":[87],"atypical":[89],"(aPK).":[92],"Several":[93],"proteins":[95],"essential":[97],"for":[98],"development":[100,131],"asexual":[102],"blood":[103],"stage":[104],"A":[106],"multidisciplinary":[107],"approach,":[108],"combines":[110],"traditional":[112],"modern":[115],"high-throughput":[116],"approaches":[117],"genomics,":[119],"proteomics,":[120],"chemical":[122],"systems":[124],"biology":[125],"will":[126],"hopefully":[127],"lead":[128],"to":[129],"parasite-signaling":[133],"maps,":[134],"as":[135],"case":[138],"with":[139],"other":[140],"organisms.":[141]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2017-01-06T00:00:00"}