{"id":"https://openalex.org/W2563205193","doi":"https://doi.org/10.2174/1389450117666161221122432","title":"Targeting Cysteine Proteases from Plasmodium falciparum: A General Overview, Rational Drug Design and Computational Approaches for Drug Discovery","display_name":"Targeting Cysteine Proteases from Plasmodium falciparum: A General Overview, Rational Drug Design and Computational Approaches for Drug Discovery","publication_year":2018,"publication_date":"2018-03-19","ids":{"openalex":"https://openalex.org/W2563205193","doi":"https://doi.org/10.2174/1389450117666161221122432","mag":"2563205193","pmid":"https://pubmed.ncbi.nlm.nih.gov/28003005"},"language":"en","primary_location":{"id":"doi:10.2174/1389450117666161221122432","doi":"https://doi.org/10.2174/1389450117666161221122432","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389450117666161221122432","pdf_url":null,"source":{"id":"https://openalex.org/S140884253","display_name":"Current Drug Targets","issn_l":"1389-4501","issn":["1389-4501","1873-5592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066725706","display_name":"Boris Davy Bekono","orcid":"https://orcid.org/0000-0003-1077-4176","observed_orcids":["https://orcid.org/0000-0003-1077-4176"]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Boris D. Bekono","raw_affiliation_strings":["University of Yaounde I, Advanced Teacher Training College, Laboratory for Simulation and Molecular Biophysics, P.O. Box 47 Yaounde, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yaounde I, Advanced Teacher Training College, Laboratory for Simulation and Molecular Biophysics, P.O. Box 47 Yaounde, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015062918","display_name":"Fidele Ntie\u2010Kang","orcid":"https://orcid.org/0000-0003-0795-394X","observed_orcids":["https://orcid.org/0000-0003-0795-394X"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Fidele Ntie-Kang","raw_affiliation_strings":["Martin-Luther-Universitat Halle-Wittenberg, Institute for Pharmacy, Wolfgang- Langenbeck-Str. 4, 06120 Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin-Luther-Universitat Halle-Wittenberg, Institute for Pharmacy, Wolfgang- Langenbeck-Str. 4, 06120 Halle (Saale), Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032376934","display_name":"L. C. Owono Owono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1331070479","display_name":"Universit\u00e9 de Yaound\u00e9 I","ror":"https://ror.org/022zbs961","country_code":"CM","type":"education","lineage":["https://openalex.org/I1331070479"]}],"countries":["CM"],"is_corresponding":true,"raw_author_name":"Luc C. Owono Owono","raw_affiliation_strings":["University of Yaounde I, Advanced Teacher Training College, Laboratory for Simulation and Molecular Biophysics, P.O. Box 47 Yaounde, Cameroon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Yaounde I, Advanced Teacher Training College, Laboratory for Simulation and Molecular Biophysics, P.O. Box 47 Yaounde, Cameroon","institution_ids":["https://openalex.org/I1331070479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008342623","display_name":"Eug\u00e8ne Megnassan","orcid":"https://orcid.org/0000-0003-1505-5277","observed_orcids":["https://orcid.org/0000-0003-1505-5277"]},"institutions":[{"id":"https://openalex.org/I17024267","display_name":"Universit\u00e9 Nangui Abrogoua","ror":"https://ror.org/0462xwv27","country_code":"CI","type":"education","lineage":["https://openalex.org/I17024267"]}],"countries":["CI"],"is_corresponding":false,"raw_author_name":"Eugene Megnassan","raw_affiliation_strings":["University of Abobo-Adjame, UFR SFA, Laboratoire de Physique Fondamentale et Appliquee 02 BP 801, Abidjan 02, Cote D'Ivoire","University of Abobo-Adjame, UFR SFA, Laboratoire de Physique Fondamentale et Appliquee 02 BP 801, Abidjan 02, Cote D'Ivoire,0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Abobo-Adjame, UFR SFA, Laboratoire de Physique Fondamentale et Appliquee 02 BP 801, Abidjan 02, Cote D'Ivoire","institution_ids":["https://openalex.org/I17024267"]},{"raw_affiliation_string":"University of Abobo-Adjame, UFR SFA, Laboratoire de Physique Fondamentale et Appliquee 02 BP 801, Abidjan 02, Cote D'Ivoire,0","institution_ids":["https://openalex.org/I17024267"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015062918","https://openalex.org/A5032376934"],"corresponding_institution_ids":["https://openalex.org/I1331070479","https://openalex.org/I68956291"],"apc_list":null,"apc_paid":null,"fwci":4.8774,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.9519812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"501","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.972000002861023},{"id":"https://openalex.org/keywords/falcipains","display_name":"falcipains","score":0.871999979019165},{"id":"https://openalex.org/keywords/cysteine-protease","display_name":"cysteine protease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/falcipain-2","display_name":"falcipain-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/falcipain-3","display_name":"falcipain-3","score":1.0},{"id":"https://openalex.org/keywords/antimalarial-drug-targets","display_name":"antimalarial drug targets","score":0.9089999794960022},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ligand-based-drug-design","display_name":"ligand-based drug design","score":0.9739999771118164},{"id":"https://openalex.org/keywords/inhibition-mechanism","display_name":"inhibition mechanism","score":0.5600000023841858},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/erythrocyte-invasion","display_name":"erythrocyte invasion","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8124476671218872},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7383900880813599},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6070841550827026},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6016753911972046},{"id":"https://openalex.org/C192071366","wikidata":"https://www.wikidata.org/wiki/Q2991682","display_name":"Drug design","level":2,"score":0.5833519101142883},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.47256606817245483},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4603772759437561},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.44375038146972656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42325639724731445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33450624346733093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31712114810943604},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.240278959274292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13503971695899963},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10517793893814087},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10104376077651978}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1389450117666161221122432","doi":"https://doi.org/10.2174/1389450117666161221122432","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389450117666161221122432","pdf_url":null,"source":{"id":"https://openalex.org/S140884253","display_name":"Current Drug Targets","issn_l":"1389-4501","issn":["1389-4501","1873-5592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Targets","raw_type":"journal-article"},{"id":"pmid:28003005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28003005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W1493715460","https://openalex.org/W1509115618","https://openalex.org/W1555217697","https://openalex.org/W1555648817","https://openalex.org/W1757126469","https://openalex.org/W1965438759","https://openalex.org/W1965771056","https://openalex.org/W1966485199","https://openalex.org/W1967823853","https://openalex.org/W1969246643","https://openalex.org/W1971808377","https://openalex.org/W1972181859","https://openalex.org/W1972208799","https://openalex.org/W1972959613","https://openalex.org/W1973780143","https://openalex.org/W1974931121","https://openalex.org/W1975675098","https://openalex.org/W1976458187","https://openalex.org/W1976757612","https://openalex.org/W1976957132","https://openalex.org/W1977134412","https://openalex.org/W1977724107","https://openalex.org/W1978354326","https://openalex.org/W1979641354","https://openalex.org/W1979847955","https://openalex.org/W1984075743","https://openalex.org/W1986658654","https://openalex.org/W1987213888","https://openalex.org/W1987575637","https://openalex.org/W1990296740","https://openalex.org/W1993418211","https://openalex.org/W1995713637","https://openalex.org/W1996101488","https://openalex.org/W1999264959","https://openalex.org/W2003316866","https://openalex.org/W2004285059","https://openalex.org/W2004778505","https://openalex.org/W2005716730","https://openalex.org/W2006569606","https://openalex.org/W2007416146","https://openalex.org/W2008036568","https://openalex.org/W2008590973","https://openalex.org/W2009972285","https://openalex.org/W2011716103","https://openalex.org/W2012863319","https://openalex.org/W2014894658","https://openalex.org/W2014947373","https://openalex.org/W2015501528","https://openalex.org/W2017256889","https://openalex.org/W2017640872","https://openalex.org/W2018732951","https://openalex.org/W2019462131","https://openalex.org/W2019555480","https://openalex.org/W2022558488","https://openalex.org/W2022863364","https://openalex.org/W2023631101","https://openalex.org/W2025738838","https://openalex.org/W2026319277","https://openalex.org/W2029116891","https://openalex.org/W2029985793","https://openalex.org/W2032986124","https://openalex.org/W2034037368","https://openalex.org/W2034258157","https://openalex.org/W2035627524","https://openalex.org/W2036600427","https://openalex.org/W2036943232","https://openalex.org/W2039736888","https://openalex.org/W2040826364","https://openalex.org/W2040856541","https://openalex.org/W2041704786","https://openalex.org/W2044456123","https://openalex.org/W2047869602","https://openalex.org/W2048023924","https://openalex.org/W2049899751","https://openalex.org/W2050273205","https://openalex.org/W2051207629","https://openalex.org/W2051527241","https://openalex.org/W2051992027","https://openalex.org/W2053110211","https://openalex.org/W2054163016","https://openalex.org/W2054226801","https://openalex.org/W2055058477","https://openalex.org/W2055813456","https://openalex.org/W2057995901","https://openalex.org/W2059734457","https://openalex.org/W2061846376","https://openalex.org/W2062733000","https://openalex.org/W2063165473","https://openalex.org/W2064905840","https://openalex.org/W2068603872","https://openalex.org/W2070596299","https://openalex.org/W2070828985","https://openalex.org/W2072337823","https://openalex.org/W2075682016","https://openalex.org/W2075716788","https://openalex.org/W2079730685","https://openalex.org/W2079756825","https://openalex.org/W2079990173","https://openalex.org/W2080481923","https://openalex.org/W2081327421","https://openalex.org/W2081703573","https://openalex.org/W2083328485","https://openalex.org/W2083436957","https://openalex.org/W2083762132","https://openalex.org/W2089829590","https://openalex.org/W2091165046","https://openalex.org/W2091869585","https://openalex.org/W2092703185","https://openalex.org/W2093061925","https://openalex.org/W2093221205","https://openalex.org/W2093246960","https://openalex.org/W2101227006","https://openalex.org/W2103215838","https://openalex.org/W2103730208","https://openalex.org/W2108002481","https://openalex.org/W2110872379","https://openalex.org/W2112200517","https://openalex.org/W2112319860","https://openalex.org/W2114994173","https://openalex.org/W2116688431","https://openalex.org/W2121315016","https://openalex.org/W2125677289","https://openalex.org/W2127078730","https://openalex.org/W2128378359","https://openalex.org/W2130479394","https://openalex.org/W2130482668","https://openalex.org/W2130580441","https://openalex.org/W2131316262","https://openalex.org/W2132043145","https://openalex.org/W2133236892","https://openalex.org/W2133824167","https://openalex.org/W2135498635","https://openalex.org/W2141429378","https://openalex.org/W2143287044","https://openalex.org/W2157008176","https://openalex.org/W2157017502","https://openalex.org/W2157716963","https://openalex.org/W2160649586","https://openalex.org/W2163603183","https://openalex.org/W2166622264","https://openalex.org/W2170277594","https://openalex.org/W2174636944","https://openalex.org/W2267784093","https://openalex.org/W2315328667","https://openalex.org/W2322401989","https://openalex.org/W2411837942","https://openalex.org/W2953013631","https://openalex.org/W3150291107","https://openalex.org/W4246995357"],"related_works":["https://openalex.org/W1854810044","https://openalex.org/W2553548503","https://openalex.org/W3045995536","https://openalex.org/W4238293527","https://openalex.org/W2060851522","https://openalex.org/W1967404732","https://openalex.org/W2226749982","https://openalex.org/W2022849573","https://openalex.org/W109051875","https://openalex.org/W1989543759"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"Plasmodium":[2],"falciparum":[3],"cysteine":[4,115,181],"proteases,":[5,182],"also":[6],"known":[7],"as":[8,60],"falcipains,":[9],"are":[10,51,134,159],"involved":[11],"in":[12,65,171],"different":[13],"erythrocytic":[14],"cycle":[15],"processes":[16],"of":[17,23,35,46,91,105,108,112,130,143,153,166,174],"the":[18,32,47,66,74,78,92,97,103,106,128,150,172,180],"malaria":[19],"parasite,":[20],"e.g.":[21],"hydrolysis":[22],"host":[24],"haemoglobin,":[25],"erythrocyte":[26,29],"invasion,":[27],"and":[28,42,110,122,145,184],"rupture.":[30],"With":[31],"biochemical":[33],"characterization":[34],"four":[36],"falcipains":[37],"so":[38],"far,":[39],"FP-2":[40,183],"(falcipain-2)":[41],"FP-3":[43],"(falcipain-3),":[44],"members":[45],"papain-like":[48],"CAC1":[49],"family,":[50],"essential":[52,101],"haemoglobinases.":[53],"They":[54],"could":[55,72],"therefore":[56],"be":[57,165],"referred":[58],"to":[59,81,168,178],"potential":[61],"anti-malarial":[62],"drug":[63,98,124,175],"targets":[64,158],"search":[67],"for":[68,102,127],"novel":[69],"therapies,":[70],"which":[71],"ease":[73],"burden":[75],"caused":[76],"by":[77],"increasing":[79],"resistance":[80],"current":[82],"antimalarial":[83],"drugs.":[84],"OBJECTIVES:":[85],"This":[86,162],"review":[87,163],"provides":[88],"a":[89,138,141],"summary":[90],"most":[93],"important":[94],"results,":[95],"highlighting":[96],"design":[99,129,176],"approaches":[100,126],"understanding":[104],"mechanism":[107],"inhibition":[109],"discovery":[111,125],"inhibitors":[113,133],"against":[114,156],"proteases":[116],"from":[117],"P.":[118],"falciparum.":[119],"RESULTS:":[120],"Rational":[121],"computer-aided":[123],"promising":[131],"falcipain":[132],"described":[135],"herein,":[136],"with":[137],"focus":[139],"on":[140],"variety":[142],"structure-based":[144],"ligand-based":[146],"modeling":[147],"approaches.":[148],"Moreover,":[149],"key":[151],"features":[152],"ligand":[154],"recognition":[155],"these":[157],"emphasized.":[160],"CONCLUSION:":[161],"would":[164],"interest":[167],"scientists":[169],"engaged":[170],"development":[173],"strategies":[177],"target":[179],"FP-3.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
