{"id":"https://openalex.org/W2563076263","doi":"https://doi.org/10.1158/1538-7445.am2015-4387","title":"Abstract 4387: Anti-tumor activity of TNF-gold nanodrugs tagged with tumor vasculature-homing peptides containing the NGR or isoDGR motives","display_name":"Abstract 4387: Anti-tumor activity of TNF-gold nanodrugs tagged with tumor vasculature-homing peptides containing the NGR or isoDGR motives","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2563076263","doi":"https://doi.org/10.1158/1538-7445.am2015-4387","mag":"2563076263"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-4387","doi":"https://doi.org/10.1158/1538-7445.am2015-4387","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-4387","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062787367","display_name":"Flavio Curnis","orcid":"https://orcid.org/0000-0002-7231-9569","observed_orcids":["https://orcid.org/0000-0002-7231-9569"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavio Curnis","raw_affiliation_strings":["San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040436989","display_name":"Anna Maria Gasparri","orcid":"https://orcid.org/0000-0002-1757-8699","observed_orcids":["https://orcid.org/0000-0002-1757-8699"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"AnnaMaria Gasparri","raw_affiliation_strings":["San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047480096","display_name":"Angelina Sacchi","orcid":"https://orcid.org/0000-0002-6594-0277","observed_orcids":["https://orcid.org/0000-0002-6594-0277"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelina Sacchi","raw_affiliation_strings":["San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061198060","display_name":"Martina Fiocchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Fiocchi","raw_affiliation_strings":["San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057238914","display_name":"Angelo Corti","orcid":"https://orcid.org/0000-0002-0893-6191","observed_orcids":["https://orcid.org/0000-0002-0893-6191"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Corti","raw_affiliation_strings":["San Raffaele Scientific Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Scientific Institute, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210133214"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"4387","last_page":"4387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ngr-peptide","display_name":"NGR peptide","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd13","display_name":"CD13","score":0.7039999961853027},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.8899999856948853},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.8069999814033508},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.7710000276565552},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.779960036277771},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5056703090667725},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.48023563623428345},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4635550081729889},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42571645975112915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4072696566581726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35768935084342957},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2053055465221405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20341870188713074},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.176218181848526},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.13722968101501465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-4387","doi":"https://doi.org/10.1158/1538-7445.am2015-4387","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-4387","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2296227037","https://openalex.org/W3170330061","https://openalex.org/W3113564840","https://openalex.org/W26267953","https://openalex.org/W2145921425","https://openalex.org/W2007510144","https://openalex.org/W2097903633","https://openalex.org/W2125430310","https://openalex.org/W3126382539","https://openalex.org/W2118243422"],"abstract_inverted_index":{"Abstract":[0],"Colloidal":[1],"gold":[2,20],"(Au)":[3],"is":[4],"a":[5,28,36,129,187],"well-tolerated":[6],"nanomaterial":[7],"currently":[8,50],"exploited":[9],"for":[10,256],"several":[11],"applications":[12],"in":[13,52,120],"the":[14,58,85,103,110,132,193,239,248,253],"field":[15],"of":[16,42,95,109,143,147,155,167,211,230,247,252],"nanomedicine.":[17],"In":[18],"particular,":[19],"nanoparticles":[21,48,62,80,198],"loaded":[22],"with":[23,31,64,81,93,127,185,199,234],"tumor":[24,33,65,104,200,235],"necrosis":[25],"factor-alpha":[26],"(TNF),":[27],"cytokine":[29],"endowed":[30],"anti":[32],"activity,":[34,208],"have":[35,56,69,77,204],"therapeutic":[37,71,107],"index":[38],"higher":[39],"than":[40],"that":[41,60,140,195],"TNF.":[43],"For":[44],"this":[45,74],"reason":[46],"TNF-gold":[47,61,79,197,231],"are":[49],"tested":[51],"cancer":[53],"patients.":[54],"We":[55],"addressed":[57],"hypothesis":[59],"tagged":[63,78,233],"vasculature":[66,201],"homing":[67,202],"peptides":[68,203,237],"improved":[70,206],"properties.":[72],"To":[73],"aim":[75],"we":[76],"albumin-peptide":[82],"conjugates":[83],"containing":[84,238],"NGR":[86,240],"(Asn-Gly-Arg)":[87],"or":[88,122,149,241],"isoDGR":[89,242],"(isoAsp-Gly-Arg)":[90],"motives,":[91],"i.e.":[92],"ligands":[94],"CD13":[96],"and":[97,115,125,174],"integrin":[98],"alphavbeta3,":[99],"respectively,":[100],"expressed":[101],"by":[102],"neovasculature.":[105],"The":[106,137],"properties":[108],"resulting":[111],"nanodrugs":[112,232],"(called":[113,135],"NGR-HSA/Au/TNF":[114,148,173],"isoDGR-HSA/Au/TNF)":[116],"were":[117,158,169],"then":[118],"investigated":[119],"fibrosarcoma-":[121],"lymphoma-bearing":[123],"mice":[124],"compared":[126],"those":[128],"nanodrug":[130],"lacking":[131],"targeting":[133,214],"peptide":[134],"HSA/Au/TNF).":[136],"results":[138],"showed":[139],"intravenous":[141],"administration":[142],"extremely":[144],"low":[145],"doses":[146,166],"isoDGR-HSA/Au/TNF":[150],"(equivalent":[151],"to":[152,160],"5":[153],"pg":[154],"bioactive":[156],"TNF/mouse)":[157],"sufficient":[159],"induce":[161],"anti-tumor":[162,183],"effects,":[163],"whereas":[164],"similar":[165],"HSA/Au/TNF":[168],"minimally":[170],"active.":[171],"Low-dose":[172],"isoDGR-HSA/Au/TNF,":[175],"but":[176],"not":[177],"HSA/Au/TNF,":[178],"could":[179],"also":[180],"exert":[181],"synergistic":[182],"effects":[184],"melphalan,":[186],"chemotherapeutic":[188],"drug.":[189],"These":[190],"findings":[191],"support":[192],"concept":[194],"tagging":[196],"an":[205,212],"antitumor":[207],"likely":[209],"because":[210],"active":[213],"mechanism.":[215],"Citation":[216],"Format:":[217],"Flavio":[218],"Curnis,":[219],"AnnaMaria":[220],"Gasparri,":[221],"Angelina":[222],"Sacchi,":[223],"Martina":[224],"Fiocchi,":[225],"Angelo":[226],"Corti.":[227],"Anti-tumor":[228],"activity":[229],"vasculature-homing":[236],"motives.":[243],"[abstract].":[244],"In:":[245],"Proceedings":[246],"106th":[249],"Annual":[250],"Meeting":[251],"American":[254],"Association":[255],"Cancer":[257,267],"Research;":[258],"2015":[259],"Apr":[260],"18-22;":[261],"Philadelphia,":[262],"PA.":[263],"Philadelphia":[264],"(PA):":[265],"AACR;":[266],"Res":[268],"2015;75(15":[269],"Suppl):Abstract":[270],"nr":[271],"4387.":[272],"doi:10.1158/1538-7445.AM2015-4387":[273]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2017-01-06T00:00:00"}
