{"id":"https://openalex.org/W2562645796","doi":"https://doi.org/10.1158/2326-6074.tumimm14-b62","title":"Abstract B62: Modulating innate-adaptive immune cell interactions to achieve tumor rejection","display_name":"Abstract B62: Modulating innate-adaptive immune cell interactions to achieve tumor rejection","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2562645796","doi":"https://doi.org/10.1158/2326-6074.tumimm14-b62","mag":"2562645796"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.tumimm14-b62","doi":"https://doi.org/10.1158/2326-6074.tumimm14-b62","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm14-b62","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018089720","display_name":"Ana Santos Almeida","orcid":"https://orcid.org/0000-0001-8997-2639","observed_orcids":["https://orcid.org/0000-0001-8997-2639"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana S. Almeida","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027981832","display_name":"Tim Kees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Kees","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006671000","display_name":"Mikala Egeblad","orcid":"https://orcid.org/0000-0002-3371-1445","observed_orcids":["https://orcid.org/0000-0002-3371-1445"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikala Egeblad","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2750212522"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"10_Supplement","first_page":"B62","last_page":"B62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5979999899864197},{"id":"https://openalex.org/keywords/innate-adaptive-immune-interaction","display_name":"innate-adaptive immune interaction","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.5680000185966492},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.44699999690055847},{"id":"https://openalex.org/keywords/co-culture-model","display_name":"co-culture model","score":0.7089999914169312},{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.9909999966621399},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anti-ctla-4","display_name":"anti-CTLA-4","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7366369366645813},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.727580726146698},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5536963939666748},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5473227500915527},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5473038554191589},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5460862517356873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5214638113975525},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.520950436592102},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4595675766468048},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.44475460052490234},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4412405788898468},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4405099153518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4306299090385437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3419598937034607},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17454665899276733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6074.tumimm14-b62","doi":"https://doi.org/10.1158/2326-6074.tumimm14-b62","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.tumimm14-b62","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmh:oai:repository.cshl.edu:40191","doi":null,"is_oa":false,"landing_page_url":"http://repository.cshl.edu/id/eprint/40191/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889880316","https://openalex.org/W4286488989","https://openalex.org/W4409482260","https://openalex.org/W2956982667","https://openalex.org/W3032112529","https://openalex.org/W4411567195","https://openalex.org/W7130557084","https://openalex.org/W4388684307","https://openalex.org/W2809740307","https://openalex.org/W2231548390"],"abstract_inverted_index":{"Abstract":[0],"A":[1,264],"variety":[2],"of":[3,108,115,198,201,255],"immune":[4,18,56,126,216,228,245],"cells,":[5,13,51,178],"the":[6,44,54,106,148,159,213,256],"most":[7],"abundant":[8],"being":[9],"macrophages":[10,28,61,149],"and":[11,22,32,40,58,62,156,181,203,222,262],"T":[12,46,64,83,161,179],"typically":[14],"infiltrate":[15],"tumors.":[16],"These":[17],"cells":[19,37,57,65,155,180],"can":[20,34,86,152,219],"recognize":[21],"kill":[23,35,153],"cancer":[24,36,154,177,231],"cells.":[25],"For":[26],"example,":[27],"activated":[29],"with":[30,176],"interferon-gamma":[31],"lipopolysaccharide":[33],"both":[38],"directly":[39],"indirectly,":[41],"by":[42,103,215],"enhancing":[43],"cytotoxic":[45,63],"cells'":[47],"killing":[48],"activities.":[49],"Cancer":[50,275],"however,":[52],"evade":[53],"attacking":[55],"even":[59],"re-instruct":[60],"to":[66,95,123,133,146,230,248],"facilitate":[67],"tumor":[68,96,250],"growth,":[69],"rather":[70],"than":[71],"halt":[72],"it.":[73],"It":[74],"is":[75,145],"now":[76],"clear":[77],"that":[78],"in":[79,193,232],"a":[80],"clinical":[81],"setting":[82],"cell":[84,162,191,246],"deactivation":[85],"be":[87,220],"overcome":[88,221],"using":[89,195],"anti-CTLA4":[90],"or":[91],"anti-PDL1":[92],"antibodies,":[93],"leading":[94],"regression.":[97],"Although":[98],"exciting":[99],"recoveries":[100],"are":[101,120,143,172],"experienced":[102],"many":[104],"patients,":[105],"majority":[107],"patients":[109],"do":[110],"not":[111],"have":[112],"long-term":[113],"benefits":[114],"such":[116],"treatments.":[117],"Therefore,":[118],"ways":[119],"urgently":[121],"needed":[122],"modify":[124],"these":[125,189],"activating":[127],"approaches":[128],"so":[129,150],"they":[130,151],"become":[131],"beneficial":[132],"an":[134],"expanded":[135],"patient":[136],"population.":[137],"One":[138],"underexplored":[139],"strategy,":[140],"which":[141],"we":[142,171,185],"undertaking,":[144],"re-activate":[147],"further":[157],"enhance":[158],"anti-tumor":[160],"responses.":[163],"To":[164],"test":[165],"different":[166],"strategies":[167],"for":[168,226],"re-activating":[169],"macrophages,":[170],"developing":[173],"co-culture":[174],"models":[175,200],"macrophages.":[182],"In":[183],"addition,":[184],"study":[186],"interactions":[187,247],"between":[188],"three":[190],"types":[192],"vivo,":[194],"intravital":[196],"imaging":[197],"mouse":[199],"breast":[202],"pancreatic":[204],"cancer.":[205],"Our":[206],"findings":[207],"will":[208],"offer":[209],"new":[210,224],"insights":[211],"into":[212],"mechanisms":[214],"suppressive":[217],"signals":[218],"generate":[223],"methods":[225],"studying":[227],"responses":[229],"real-time.":[233],"Citation":[234],"Format:":[235],"Ana":[236],"S.":[237],"Almeida,":[238],"Tim":[239],"Kees,":[240],"Mikala":[241],"Egeblad.":[242],"Modulating":[243],"innate-adaptive":[244],"achieve":[249],"rejection.":[251],"[abstract].":[252],"In:":[253],"Proceedings":[254],"AACR":[257],"Special":[258],"Conference:":[259],"Tumor":[260],"Immunology":[261],"Immunotherapy:":[263],"New":[265],"Chapter;":[266],"December":[267],"1-4,":[268],"2014;":[269],"Orlando,":[270],"FL.":[271],"Philadelphia":[272],"(PA):":[273],"AACR;":[274],"Immunol":[276],"Res":[277],"2015;3(10":[278],"Suppl):Abstract":[279],"nr":[280],"B62.":[281]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-06T00:00:00"}
