{"id":"https://openalex.org/W2562442437","doi":null,"title":"Assessment of the expression of 5-HT receptors in thehippocampus of patients with temporal lobe epilepsy with hippocampal sclerosis","display_name":"Assessment of the expression of 5-HT receptors in thehippocampus of patients with temporal lobe epilepsy with hippocampal sclerosis","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2562442437","mag":"2562442437"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:7143","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","pdf_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052004680","display_name":"Hatun A. Alomar","orcid":"https://orcid.org/0000-0001-7495-0592","observed_orcids":["https://orcid.org/0000-0001-7495-0592"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hatun Alomar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052004680"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/5-ht3a-receptor","display_name":"5-HT3A receptor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/5-ht7-receptor","display_name":"5-HT7 receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.9089999794960022},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2777597344","wikidata":"https://www.wikidata.org/wiki/Q4421929","display_name":"Hippocampal sclerosis","level":4,"score":0.7156266570091248},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7096672058105469},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6770775318145752},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.6270450353622437},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5608105659484863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5493167042732239},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5339293479919434},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.5188387632369995},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.49912095069885254},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.49204155802726746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4383085370063782},{"id":"https://openalex.org/C2777350023","wikidata":"https://www.wikidata.org/wiki/Q1154226","display_name":"Aura","level":3,"score":0.41265010833740234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3747473657131195},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3674943745136261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34858039021492004},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3084239363670349},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:7143","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","pdf_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2562442437","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/7143/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:7143","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","pdf_url":"http://etheses.bham.ac.uk//id/eprint/7143/1/Alomar17PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2562442437.pdf","grobid_xml":"https://content.openalex.org/works/W2562442437.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W147799013","https://openalex.org/W236521477","https://openalex.org/W955401602","https://openalex.org/W1503696655","https://openalex.org/W1546276948","https://openalex.org/W1555935568","https://openalex.org/W1563662593","https://openalex.org/W1574063361","https://openalex.org/W1601085996","https://openalex.org/W1879709537","https://openalex.org/W1912530117","https://openalex.org/W1964071678","https://openalex.org/W1965953789","https://openalex.org/W1965961744","https://openalex.org/W1966126241","https://openalex.org/W1970597425","https://openalex.org/W1970613983","https://openalex.org/W1973704373","https://openalex.org/W1974600533","https://openalex.org/W1975807362","https://openalex.org/W1976476429","https://openalex.org/W1978153214","https://openalex.org/W1978933443","https://openalex.org/W1980136039","https://openalex.org/W1983747440","https://openalex.org/W1985964054","https://openalex.org/W1986300410","https://openalex.org/W1987685693","https://openalex.org/W1988297901","https://openalex.org/W1993818366","https://openalex.org/W1999944391","https://openalex.org/W2000134238","https://openalex.org/W2001863365","https://openalex.org/W2004352785","https://openalex.org/W2009418154","https://openalex.org/W2010150387","https://openalex.org/W2012948493","https://openalex.org/W2014106585","https://openalex.org/W2015408018","https://openalex.org/W2015513895","https://openalex.org/W2017083014","https://openalex.org/W2019073989","https://openalex.org/W2019322821","https://openalex.org/W2022608470","https://openalex.org/W2023863818","https://openalex.org/W2025050497","https://openalex.org/W2027757316","https://openalex.org/W2027851686","https://openalex.org/W2028778622","https://openalex.org/W2030795587","https://openalex.org/W2033960000","https://openalex.org/W2034474299","https://openalex.org/W2034796157","https://openalex.org/W2035658052","https://openalex.org/W2036002012","https://openalex.org/W2036200251","https://openalex.org/W2037173759","https://openalex.org/W2041120643","https://openalex.org/W2042688525","https://openalex.org/W2042737219","https://openalex.org/W2043368216","https://openalex.org/W2043551704","https://openalex.org/W2043949690","https://openalex.org/W2046176063","https://openalex.org/W2046807199","https://openalex.org/W2047219351","https://openalex.org/W2047990446","https://openalex.org/W2049836337","https://openalex.org/W2050190749","https://openalex.org/W2050771442","https://openalex.org/W2050780088","https://openalex.org/W2052596811","https://openalex.org/W2052942819","https://openalex.org/W2056294621","https://openalex.org/W2056776711","https://openalex.org/W2057596104","https://openalex.org/W2058711144","https://openalex.org/W2059307016","https://openalex.org/W2061376330","https://openalex.org/W2062029254","https://openalex.org/W2063395474","https://openalex.org/W2069707519","https://openalex.org/W2070013811","https://openalex.org/W2070823604","https://openalex.org/W2072686851","https://openalex.org/W2073869597","https://openalex.org/W2074055668","https://openalex.org/W2074962405","https://openalex.org/W2077357984","https://openalex.org/W2078909485","https://openalex.org/W2081308255","https://openalex.org/W2081458788","https://openalex.org/W2082223975","https://openalex.org/W2083979012","https://openalex.org/W2086215356","https://openalex.org/W2086812703","https://openalex.org/W2087019986","https://openalex.org/W2088160189","https://openalex.org/W2088835552","https://openalex.org/W2089421079","https://openalex.org/W2091036726","https://openalex.org/W2094201117","https://openalex.org/W2095821008","https://openalex.org/W2097542372","https://openalex.org/W2098762137","https://openalex.org/W2098990962","https://openalex.org/W2099249565","https://openalex.org/W2101417452","https://openalex.org/W2103249057","https://openalex.org/W2103880802","https://openalex.org/W2104407913","https://openalex.org/W2104459489","https://openalex.org/W2106643106","https://openalex.org/W2109860355","https://openalex.org/W2109991255","https://openalex.org/W2116414558","https://openalex.org/W2121879218","https://openalex.org/W2123882810","https://openalex.org/W2124009392","https://openalex.org/W2128587116","https://openalex.org/W2129719693","https://openalex.org/W2131576395","https://openalex.org/W2133942268","https://openalex.org/W2135062541","https://openalex.org/W2136911229","https://openalex.org/W2140516726","https://openalex.org/W2142496250","https://openalex.org/W2144813498","https://openalex.org/W2147692999","https://openalex.org/W2148111005","https://openalex.org/W2151527826","https://openalex.org/W2158646060","https://openalex.org/W2159752660","https://openalex.org/W2160855062","https://openalex.org/W2170741639","https://openalex.org/W2171416399","https://openalex.org/W2206607440","https://openalex.org/W2210029151","https://openalex.org/W2235125632","https://openalex.org/W2239632319","https://openalex.org/W2299963540","https://openalex.org/W2436039448","https://openalex.org/W2490337202","https://openalex.org/W2691413737","https://openalex.org/W4320800963"],"related_works":["https://openalex.org/W7008173527","https://openalex.org/W2587311339","https://openalex.org/W2101417452","https://openalex.org/W4213265077","https://openalex.org/W2051557601","https://openalex.org/W2119774379","https://openalex.org/W1987520241","https://openalex.org/W1532544448","https://openalex.org/W7120496208","https://openalex.org/W2109188956"],"abstract_inverted_index":{"Temporal":[0],"lobe":[1],"epilepsy":[2],"with":[3,37],"hippocampal":[4],"sclerosis":[5],"(TLE-HS)":[6],"is":[7,16],"the":[8,25,29,34,66,70,81,116,123,128,148,158,162,188,193,201],"most":[9],"common":[10],"type":[11,94],"of":[12,28,65,69,95,137,139,151,164,187,196,229],"pharmaco-resistant":[13],"epilepsy.":[14],"It":[15],"characterised":[17],"by":[18],"recurrent":[19],"focal":[20],"onset":[21],"seizure":[22,91,221],"that":[23,181],"affects":[24],"medial":[26],"part":[27],"temporal":[30],"lobe,":[31],"in":[32,47,73,115,120,147,192,222],"particular,":[33],"hippocampus.":[35],"Patients":[36],"TLE-HS":[38,118,152,206,223],"suffer":[39],"from":[40],"typical":[41],"aura":[42],"symptoms,":[43],"especially":[44],"epigastric":[45],"aura,":[46],"addition":[48,121],"to":[49,84,89,111,122,200,217,219],"psychological":[50],"symptoms":[51,55],"which":[52],"include":[53],"dysmnestic":[54],"such":[56],"as":[57,213],"memory":[58],"impairment":[59],"and":[60,77,80,103,105,127,144,177,225],"fear.":[61],"As":[62],"a":[63,86,214],"result":[64],"important":[67],"role":[68],"serotonergic":[71,98],"system":[72],"human":[74,117],"brain":[75],"physiological":[76],"pathological":[78],"functions":[79],"crucial":[82],"need":[83],"identify":[85],"novel":[87,215],"target":[88,216],"control":[90,220],"among":[92,205],"this":[93,165],"patient,":[96],"some":[97],"excitatory":[99,166,189,194],"(5-HT\\\\(_2\\\\)\\\\(_A\\\\),":[100],"5-HT\\\\(_3\\\\)A,":[101,140],"5-HT\\\\(_4\\\\)":[102],"5-HT\\\\(_7\\\\))":[104],"inhibitory":[106],"(5-HT\\\\(_1\\\\)\\\\(_A\\\\))":[107],"receptors":[108,125,146,160,212],"were":[109],"selected":[110],"study":[112,209],"using":[113,170],"immunohistochemistry":[114],"hippocampus,":[119],"purinergic":[124],"(P2x\\\\(_7\\\\))":[126],"orphan":[129],"G-protein":[130],"(GPR61).":[131],"The":[132,185],"results":[133],"indicate":[134],"variable":[135],"degree":[136],"upregulation":[138,186],"5-HT\\\\(_1\\\\)\\\\(_A\\\\),":[141],"5-HT\\\\(_4\\\\),":[142],"GPR61":[143],"P2x\\\\(_7\\\\)":[145],"sclerotic":[149],"hippocampi":[150],"patients.":[153,207],"Subsequent":[154],"studies":[155],"focused":[156],"on":[157],"5-HT\\\\(_3\\\\)A":[159,190],"expression;":[161],"overexpression":[163],"receptor":[167,175,191],"was":[168],"established":[169],"immunohistochemistry,":[171],"SDS-PAGE":[172],"western":[173],"blot,":[174],"autoradiography":[176],"radioligand":[178],"binding":[179],"assays":[180],"give":[182],"comparable":[183],"results.":[184],"neurons":[195],"hippocampus":[197],"may":[198],"contribute":[199],"neuronal":[202],"hyperexcitability":[203],"evident":[204],"This":[208],"proposed":[210],"5-HT\\\\(_3\\\\)":[211],"antagonise":[218],"patients":[224],"improve":[226],"their":[227],"quality":[228],"life.":[230]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-01-06T00:00:00"}
