{"id":"https://openalex.org/W2562340897","doi":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","title":"Abstract IA23: Integrating chemical and functional genomics for leukemia discovery.","display_name":"Abstract IA23: Integrating chemical and functional genomics for leukemia discovery.","publication_year":2015,"publication_date":"2015-08-19","ids":{"openalex":"https://openalex.org/W2562340897","doi":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","mag":"2562340897"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3265.hemmal14-ia23","doi":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011985711","display_name":"Kimberly Stegmaier","orcid":"https://orcid.org/0000-0003-0218-7895","observed_orcids":["https://orcid.org/0000-0003-0218-7895"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberly Stegmaier","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011985711"],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"17_Supplement","first_page":"IA23","last_page":"IA23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pml-raralpha","display_name":"PML-RAR\u03b1","score":0.781000018119812},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.875},{"id":"https://openalex.org/keywords/quizartinib","display_name":"quizartinib","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dot1l","display_name":"DOT1L","score":0.949999988079071},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromatin-regulators","display_name":"chromatin regulators","score":0.7900000214576721},{"id":"https://openalex.org/keywords/metabolic-targets","display_name":"metabolic targets","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chemical-genomics","display_name":"chemical genomics","score":0.5860000252723694},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.8970000147819519},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.6990000009536743},{"id":"https://openalex.org/keywords/shrna-screen","display_name":"shRNA screen","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6504822373390198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5594661235809326},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.5117830634117126},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.5007379055023193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46107128262519836},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.45690810680389404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4508015811443329},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4481543302536011},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44183269143104553},{"id":"https://openalex.org/C2779982571","wikidata":"https://www.wikidata.org/wiki/Q25098780","display_name":"Differentiation therapy","level":5,"score":0.41572305560112},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.41532349586486816},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4128156304359436},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34820324182510376},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.31619149446487427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2605154812335968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22503137588500977},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.13706722855567932},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3265.hemmal14-ia23","doi":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3265.hemmal14-ia23","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2559715817","https://openalex.org/W2811164775","https://openalex.org/W2135031820","https://openalex.org/W2551737782","https://openalex.org/W7135234327","https://openalex.org/W2015378682","https://openalex.org/W2565816025","https://openalex.org/W3092632847","https://openalex.org/W2049468291","https://openalex.org/W1968904120"],"abstract_inverted_index":{"Abstract":[0],"Characterization":[1],"of":[2,6,20,46,54,67,82,90,105,117,171,204,223,229,240,275],"the":[3,28,44,47,52,65,80,88,98,103,115,150,169,174,202,238,276],"genomic":[4,216],"landscapes":[5],"cancer":[7,68],"with":[8,108,162,255],"new":[9,83],"technologies,":[10],"such":[11,75],"as":[12,76],"massively":[13],"parallel":[14],"sequencing,":[15],"has":[16,41],"catapulted":[17],"our":[18],"understanding":[19],"human":[21,33],"malignancies.":[22],"However,":[23],"many":[24],"questions":[25],"remain":[26],"about":[27],"true":[29],"genetic":[30,258],"dependencies":[31],"in":[32,102,121,160,168,193,196,247,250,253],"cancer,":[34],"and":[35,56,69,184,195,214,220,243,252,257,266],"for":[36,132,138,207,218,269],"most":[37],"malignancies,":[38],"therapeutic":[39],"impact":[40],"lagged":[42],"behind":[43],"unraveling":[45],"DNA":[48],"code.":[49],"In":[50,145],"principle,":[51],"integration":[53],"functional":[55,215,267],"chemical":[57,213,256,265],"genomics":[58,268],"offers":[59],"a":[60,128,146,224],"powerful":[61],"approach":[62,78],"to":[63,79,86,141,166,189,201,285],"decipher":[64],"mechanisms":[66],"inform":[70],"therapeutics.":[71],"We":[72,210],"have":[73,186,211,244],"applied":[74,212],"integrative":[77],"identification":[81],"targeted":[84,118],"strategies":[85],"induce":[87,142,190],"differentiation":[89,119,159,192,205],"acute":[91,109],"myeloid":[92],"leukemia":[93,111,270],"(AML)":[94],"cells.":[95],"Targeting":[96],"PML-RAR\u03b1,":[97],"fusion":[99],"protein":[100],"present":[101],"majority":[104,170],"patients":[106,161,172],"diagnosed":[107],"promyelocytic":[110],"(APL),":[112],"demonstrated":[113,188],"feasible":[114],"use":[116],"therapy":[120,206],"this":[122,208],"AML":[123,143,191,248],"subtype.":[124],"Emerging":[125],"data":[126],"support":[127,200],"role":[129],"not":[130],"only":[131],"transcription":[133],"factor-directed":[134],"therapy,":[135,140],"but":[136],"also":[137],"kinase-directed":[139],"differentiation.":[144,230],"recent":[147],"clinical":[148],"trial":[149],"FMS-like":[151],"tyrosine":[152],"kinase":[153],"3":[154],"(FLT3)":[155],"inhibitor":[156],"quizartinib":[157],"induced":[158],"FLT3-ITD-positive":[163],"AML,":[164],"leading":[165],"responses":[167],"receiving":[173],"drug.":[175],"Moreover,":[176],"newer":[177],"agents":[178],"targeting":[179],"chromatin":[180],"regulators":[181],"(e.g.,":[182],"DOT1L":[183],"BRD4)":[185],"been":[187,245],"vitro":[194,251],"vivo,":[197],"lending":[198],"additional":[199],"potential":[203],"disease.":[209],"screens":[217,242],"small-molecule":[219],"shRNA":[221],"inducers":[222],"complex":[225],"gene":[226],"expression":[227],"signature":[228],"Two":[231],"high":[232],"priority":[233],"metabolic":[234],"targets":[235],"emerged":[236],"at":[237],"intersection":[239],"these":[241],"validated":[246],"cells":[249],"vivo":[254],"perturbagens.":[259],"Citation":[260],"Format:":[261],"Kimberly":[262],"Stegmaier.":[263],"Integrating":[264],"discovery.":[271],"[abstract].":[272],"In:":[273],"Proceedings":[274],"AACR":[277],"Special":[278],"Conference":[279],"on":[280],"Hematologic":[281],"Malignancies:":[282],"Translating":[283],"Discoveries":[284],"Novel":[286],"Therapies;":[287],"Sep":[288],"20-23,":[289],"2014;":[290],"Philadelphia,":[291],"PA.":[292],"Philadelphia":[293],"(PA):":[294],"AACR;":[295],"Clin":[296],"Cancer":[297],"Res":[298],"2015;21(17":[299],"Suppl):Abstract":[300],"nr":[301],"IA23.":[302]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2017-01-06T00:00:00"}