{"id":"https://openalex.org/W2562075475","doi":null,"title":"Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts.","display_name":"Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2562075475","mag":"2562075475","pmid":"https://pubmed.ncbi.nlm.nih.gov/27822411","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5088285"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5088285","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5088285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5088285","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023758911","display_name":"Doudou Li","orcid":"https://orcid.org/0000-0002-6139-9452","observed_orcids":["https://orcid.org/0000-0002-6139-9452"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Doudou Li","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102815996","display_name":"Chao Qu","orcid":"https://orcid.org/0000-0002-7655-6318","observed_orcids":["https://orcid.org/0000-0002-7655-6318"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Qu","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103916711","display_name":"Zhouyu Ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhouyu Ning","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619547","display_name":"Haiyong Wang","orcid":"https://orcid.org/0000-0002-0658-4479","observed_orcids":["https://orcid.org/0000-0002-0658-4479","https://orcid.org/0009-0006-4732-9972"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyong Wang","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056336376","display_name":"Kun Zang","orcid":"https://orcid.org/0009-0005-2744-735X","observed_orcids":["https://orcid.org/0009-0005-2744-735X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zang","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060360779","display_name":"Liping Zhuang","orcid":"https://orcid.org/0000-0003-1998-8250","observed_orcids":["https://orcid.org/0000-0003-1998-8250"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Zhuang","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018913195","display_name":"Lianyu Chen","orcid":"https://orcid.org/0000-0003-3731-8592","observed_orcids":["https://orcid.org/0000-0003-3731-8592"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianyu Chen","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634561","display_name":"Peng Wang","orcid":"https://orcid.org/0000-0003-4666-9706","observed_orcids":["https://orcid.org/0000-0003-4666-9706"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Fudan University Shanghai Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Fudan University Shanghai Cancer Center","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003930955","display_name":"Zhiqiang Meng","orcid":"https://orcid.org/0000-0003-3593-6098","observed_orcids":["https://orcid.org/0000-0003-3593-6098","https://orcid.org/0000-0001-7550-3129"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Meng","raw_affiliation_strings":["Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","Integrative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Oncology, Fudan University Shanghai Cancer CenterShanghai, China; Department of Oncology, Shanghai Medical College, Fudan UniversityShanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Integrative Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6969,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.91667816,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"10","first_page":"2192","last_page":"2206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06710000336170197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9269999861717224},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9649999737739563},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7791769504547119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7402025461196899},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.691891074180603},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6707841157913208},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5985972881317139},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5520522594451904},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4823403060436249},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.48076745867729187},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.4806736409664154},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4725898206233978},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.433917760848999},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4319569170475006},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.43012118339538574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4249490797519684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3002554774284363},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.25481563806533813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22983673214912415},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15064522624015808},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.1387496292591095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5088285","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5088285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:27822411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27822411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:2562075475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27822411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5088285","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5088285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1572890328","https://openalex.org/W1607276234","https://openalex.org/W1912124796","https://openalex.org/W1964081206","https://openalex.org/W1965037168","https://openalex.org/W1965207164","https://openalex.org/W1969999498","https://openalex.org/W1974873303","https://openalex.org/W1980901401","https://openalex.org/W1989025666","https://openalex.org/W1990241649","https://openalex.org/W1998753120","https://openalex.org/W1999355130","https://openalex.org/W2008714016","https://openalex.org/W2016360721","https://openalex.org/W2020189113","https://openalex.org/W2025823278","https://openalex.org/W2032972527","https://openalex.org/W2033278321","https://openalex.org/W2036165289","https://openalex.org/W2037099316","https://openalex.org/W2050479503","https://openalex.org/W2053645995","https://openalex.org/W2055091294","https://openalex.org/W2062809449","https://openalex.org/W2078502914","https://openalex.org/W2090721857","https://openalex.org/W2100751052","https://openalex.org/W2101037339","https://openalex.org/W2102810283","https://openalex.org/W2104416279","https://openalex.org/W2104892374","https://openalex.org/W2107441200","https://openalex.org/W2111895881","https://openalex.org/W2131070390","https://openalex.org/W2134603265","https://openalex.org/W2142755954","https://openalex.org/W2145924501","https://openalex.org/W2155784435","https://openalex.org/W2156323704","https://openalex.org/W2156365755","https://openalex.org/W2168631000","https://openalex.org/W2169281418","https://openalex.org/W2170056461","https://openalex.org/W2170202192","https://openalex.org/W2170552969","https://openalex.org/W3134530972","https://openalex.org/W4247785462"],"related_works":["https://openalex.org/W2087677309","https://openalex.org/W7130431961","https://openalex.org/W4304688491","https://openalex.org/W895614535","https://openalex.org/W7095919806","https://openalex.org/W2045940880","https://openalex.org/W2550160158","https://openalex.org/W4210703390","https://openalex.org/W2594360359","https://openalex.org/W2166223410"],"abstract_inverted_index":{"The":[0],"tumor":[1,67,129],"microenvironment":[2],"is":[3],"of":[4,13,42,60,142],"crucial":[5],"importance":[6],"affecting":[7],"treatment":[8],"and":[9,39,47,70,92,110,124],"prognosis.":[10],"High":[11],"degree":[12],"carcinoma-associated":[14],"fibroblast":[15],"(CAF)":[16],"infiltration":[17],"occurs":[18],"in":[19,45,48,50],"pancreatic":[20,77,88,106,121,152],"cancer,":[21],"though":[22],"its":[23],"effect":[24],"on":[25,76],"radiotherapy":[26],"remains":[27],"unclear.":[28],"In":[29,80],"this":[30],"study,":[31],"we":[32,82],"demonstrated":[33],"that":[34,84,103],"radiation":[35,104,156],"enhanced":[36],"the":[37,58,96,117,140,148],"migration-":[38],"invasion-promoting":[40],"capacity":[41],"CAFs":[43,125],"both":[44],"vitro":[46],"vivo":[49],"a":[51],"lung":[52],"metastasis":[53],"model.":[54],"Radiation":[55],"exposure":[56],"increased":[57],"expression":[59],"CXCL12":[61,65],"by":[62,94,112,133],"CAFs.":[63],"CAF-derived":[64],"promoted":[66,87,105],"cell":[68,90,108,130],"EMT":[69,91,111],"invasion":[71,93,109,131],"directly,":[72],"acting":[73],"through":[74],"CXCR4":[75],"cancer":[78,89,107,122,153],"cells.":[79],"addition,":[81],"showed":[83],"CXCL12-CXCR4":[85],"signaling":[86],"activating":[95,113],"P38":[97],"pathway.":[98],"Therefore,":[99],"our":[100],"study":[101],"concluded":[102],"CAFs,":[114],"while":[115],"inhibiting":[116],"CXCL12/CXCR4":[118],"interaction":[119],"between":[120],"cells":[123],"could":[126],"potentially":[127],"attenuate":[128],"induced":[132],"radiation,":[134],"which":[135],"provides":[136],"an":[137],"opportunity":[138],"for":[139,150],"development":[141],"novel":[143],"therapeutic":[144],"targets":[145],"to":[146],"improve":[147],"prognosis":[149],"human":[151],"treated":[154],"with":[155],"therapy.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-01-06T00:00:00"}