{"id":"https://openalex.org/W2562063638","doi":"https://doi.org/10.1158/1538-7445.am2015-1277","title":"Abstract 1277: Tumor-specific human monoclonal antibodies isolated from cancer patients that bind antigens expressed on the outer plasma membrane of cancer cells","display_name":"Abstract 1277: Tumor-specific human monoclonal antibodies isolated from cancer patients that bind antigens expressed on the outer plasma membrane of cancer cells","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2562063638","doi":"https://doi.org/10.1158/1538-7445.am2015-1277","mag":"2562063638"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-1277","doi":"https://doi.org/10.1158/1538-7445.am2015-1277","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1277","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064555893","display_name":"Baron C. Heimbach","orcid":"https://orcid.org/0000-0002-6866-970X","observed_orcids":["https://orcid.org/0000-0002-6866-970X"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baron Heimbach","raw_affiliation_strings":["1Lankenau Institute for Medical Research, Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lankenau Institute for Medical Research, Wynnewood, PA;","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049547765","display_name":"Cezary R. Swider","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cezary Swider","raw_affiliation_strings":["2Immunome, Inc., Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Immunome, Inc., Wynnewood, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112110347","display_name":"Huiwu Zhao","orcid":"https://orcid.org/0009-0008-1617-2209","observed_orcids":["https://orcid.org/0009-0008-1617-2209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiwu Zhao","raw_affiliation_strings":["2Immunome, Inc., Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Immunome, Inc., Wynnewood, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110116134","display_name":"Paul Simon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Simon","raw_affiliation_strings":["2Immunome, Inc., Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Immunome, Inc., Wynnewood, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049901305","display_name":"R. Katherine Alpaugh","orcid":"https://orcid.org/0000-0002-6775-5323","observed_orcids":["https://orcid.org/0000-0002-6775-5323"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Katherine Alpaugh","raw_affiliation_strings":["3Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104017335","display_name":"Michael S. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476176","display_name":"Lankenau Medical Center","ror":"https://ror.org/00f2gwr16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624","https://openalex.org/I2802476176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Walker","raw_affiliation_strings":["4Lankenau Medical Center, Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Lankenau Medical Center, Wynnewood, PA;","institution_ids":["https://openalex.org/I2802476176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081120943","display_name":"David N. Krag","orcid":"https://orcid.org/0000-0001-5355-5999","observed_orcids":["https://orcid.org/0000-0001-5355-5999"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Krag","raw_affiliation_strings":["5University of Vermont, Burlington, VT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Vermont, Burlington, VT;","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017888322","display_name":"David A. Knight","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Knight","raw_affiliation_strings":["2Immunome, Inc., Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Immunome, Inc., Wynnewood, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tung Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tung Chan","raw_affiliation_strings":["6Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012061864","display_name":"Hossein Borghaei","orcid":"https://orcid.org/0000-0002-2577-4454","observed_orcids":["https://orcid.org/0000-0002-2577-4454"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hossein Borghaei","raw_affiliation_strings":["3Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048863725","display_name":"Scott K. Dessain","orcid":"https://orcid.org/0000-0002-4331-6799","observed_orcids":["https://orcid.org/0000-0002-4331-6799"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Dessain","raw_affiliation_strings":["1Lankenau Institute for Medical Research, Wynnewood, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Lankenau Institute for Medical Research, Wynnewood, PA;","institution_ids":["https://openalex.org/I182321934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"1277","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.6489999890327454},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6039999723434448},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.42899999022483826},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.47999998927116394},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.31700000166893005},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.5770000219345093},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7367743253707886},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6620707511901855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5781142115592957},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5364245772361755},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5221191644668579},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5070724487304688},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5037490725517273},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49879908561706543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4863446354866028},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43639662861824036},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.43605607748031616},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.415942907333374},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35592925548553467},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.273418664932251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.239647775888443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-1277","doi":"https://doi.org/10.1158/1538-7445.am2015-1277","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1277","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1550064565","https://openalex.org/W1939999801","https://openalex.org/W2081070014","https://openalex.org/W2082773090","https://openalex.org/W7099002115","https://openalex.org/W2080010071","https://openalex.org/W2029052488","https://openalex.org/W1575288972","https://openalex.org/W2042714335","https://openalex.org/W2157461065"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Cancer":[2,517,527],"cells":[3,325,349],"express":[4],"novel":[5,399],"antigens":[6,72,174,210,405,494],"that":[7,20,27,35,70,99,211,262,391,397,436,492],"reflect":[8],"their":[9],"transformed":[10],"state":[11],"and":[12,34,142,175,191,278,303,333,342,371,457],"may":[13,441,449],"engender":[14],"an":[15,343],"antibody":[16,447],"response.":[17],"We":[18,82,107,126,164],"hypothesize":[19],"some":[21],"of":[22,38,48,66,78,180,196,203,219,237,282,296,305,311,323,347,365,383,411,426,501,507,512],"these":[23,39],"auto-antibodies":[24],"detect":[25],"neo-antigens":[26],"are":[28,40,212],"shared":[29],"by":[30,95,225,244,321,335],"diverse":[31],"tumor":[32,173,288],"types":[33],"a":[36,85,248],"subset":[37],"expressed":[41,73,214,232,267,406,495],"on":[42,75,215,233,256,270,276,294,315,408,420,496],"the":[43,76,124,172,177,197,216,234,241,257,263,312,316,339,351,358,389,409,421,437,445,497,508,513],"outer":[44,217,235,258,317,422,498],"plasma":[45,499],"membrane":[46,500],"(PM)":[47],"cancer":[49,68,79,104,116,140,148,158,207,220,386,432,455,490,502],"cells,":[50,239,272],"but":[51,273],"not":[52,251,416],"normal":[53,271],"cells.":[54,80,221,503],"Here,":[55],"we":[56],"describe":[57],"two":[58,181],"human":[59,90,115,121,485],"mAbs,":[60],"isolated":[61,199,488],"from":[62,129,135,156,200,385,489],"lymph":[63,130,201],"node":[64],"B-cells":[65,128,155],"breast":[67,139,206,277,431],"patients,":[69,149],"bind":[71,100,208,398,404,493],"only":[74,213,268,407],"surface":[77,410],"Methods:":[81],"have":[83],"optimized":[84],"hybridoma":[86],"method":[87],"for":[88,97,286,375,453,516],"cloning":[89],"IgG":[91,122],"monoclonal":[92,486],"antibodies":[93,396,487],"(mAbs)":[94],"screening":[96],"those":[98],"to":[101,161,170,209,230,254,429],"live,":[102],"heterologous":[103],"cell":[105,110,117,299,433],"lines.":[106],"use":[108,127],"whole":[109],"immunofluorescence":[111],"binding":[112],"assays":[113],"with":[114,123,205,328,338,350,393],"lines,":[118],"detecting":[119],"cell-reactive":[120],"Operetta.":[125],"nodes":[131,202],"obtained":[132],"at":[133],"surgery":[134],"stage":[136],"I,":[137],"ER+PR+":[138],"patients":[141,159,204,387,392,491],"Stage":[143],"I":[144],"or":[145],"II":[146],"lung":[147,157,300],"as":[150,152,377],"well":[151],"peripheral":[153],"blood":[154],"responsive":[160],"PD-1":[162],"inhibitors.":[163],"used":[165],"cDNA":[166],"library":[167],"expression":[168,331],"methods":[169],"identify":[171,450],"characterized":[176],"tumor-specific":[178],"activities":[179],"mAbs":[182,198,367,384,403],"using":[183],"immunohistochemistry":[184],"(IHC),":[185],"gene":[186],"transfection,":[187],"flow":[188,336],"cytometry,":[189],"immunoblotting,":[190],"invasion":[192,356,434],"assays.":[193],"Results:":[194],"Two":[195,402],"PM":[218,236,318],"The":[222,309,424],"antigen":[223,242,265,314,330],"recognized":[224,243,253],"mAb":[226,245,340,352,427],"9H2":[227,264],"is":[228,247,266,274,372],"known":[229],"be":[231,442],"metastatic":[238],"while":[240],"2B9":[246,313,341,353,428],"cytoplasmic":[249],"protein":[250],"previously":[252,417],"exist":[255],"PM.":[259,423],"IHC":[260],"demonstrates":[261],"rarely":[269],"commonly":[275],"colon":[279],"cancers":[280,301],"(3":[281],"4":[283,297],"samples":[284,302],"tested":[285],"each":[287],"type).":[289],"Binding":[290],"was":[291,319],"also":[292],"seen":[293],"2":[295],"small":[298],"1":[304],"3":[306],"pancreatic":[307],"cancers.":[308],"existence":[310],"confirmed":[320],"study":[322],"293T":[324],"transiently":[326],"transfected":[327],"MYC-tagged":[329],"constructs":[332],"analyzed":[334],"cytometry":[337],"anti-myc":[344],"mAb.":[345],"Treatment":[346],"MDA-MB-231":[348],"substantially":[354],"reduced":[355],"in":[357],"transwell":[359],"migration":[360],"assay.":[361],"An":[362],"additional":[363],"panel":[364,382],"12":[366],"exhibited":[368],"internalizing":[369],"activity":[370],"being":[373],"evaluated":[374],"efficacy":[376],"antibody-drug":[378],"conjugates":[379],"Conclusion:":[380],"Our":[381],"supports":[388],"hypothesis":[390],"malignancies":[394],"make":[395],"cancer-specific":[400],"antigens.":[401],"malignant":[412],"cells;":[413],"one":[414],"has":[415],"been":[418],"detected":[419],"ability":[425],"inhibit":[430],"suggests":[435],"anti-tumor":[438],"immune":[439],"response":[440],"functional.":[443],"Studying":[444],"anti-cancer":[446],"repertoire":[448],"new":[451],"targets":[452],"mAb-based":[454],"diagnostics":[456],"therapeutics.":[458],"Citation":[459],"Format:":[460],"Baron":[461],"Heimbach,":[462],"Cezary":[463],"Swider,":[464],"Huiwu":[465],"Zhao,":[466],"Paul":[467],"Simon,":[468],"R.":[469],"Katherine":[470],"Alpaugh,":[471],"Michael":[472],"Walker,":[473],"David":[474,476],"Krag,":[475],"Knight,":[477],"Tung":[478],"Chan,":[479],"Hossein":[480],"Borghaei,":[481],"Scott":[482],"Dessain.":[483],"Tumor-specific":[484],"[abstract].":[504],"In:":[505],"Proceedings":[506],"106th":[509],"Annual":[510],"Meeting":[511],"American":[514],"Association":[515],"Research;":[518],"2015":[519],"Apr":[520],"18-22;":[521],"Philadelphia,":[522],"PA.":[523],"Philadelphia":[524],"(PA):":[525],"AACR;":[526],"Res":[528],"2015;75(15":[529],"Suppl):Abstract":[530],"nr":[531],"1277.":[532],"doi:10.1158/1538-7445.AM2015-1277":[533]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-01-06T00:00:00"}