{"id":"https://openalex.org/W2561996729","doi":"https://doi.org/10.1097/mol.0000000000000374","title":"Unbiased and targeted mass spectrometry for the HDL proteome","display_name":"Unbiased and targeted mass spectrometry for the HDL proteome","publication_year":2016,"publication_date":"2016-12-20","ids":{"openalex":"https://openalex.org/W2561996729","doi":"https://doi.org/10.1097/mol.0000000000000374","mag":"2561996729","pmid":"https://pubmed.ncbi.nlm.nih.gov/28002079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6211176"},"language":"en","primary_location":{"id":"doi:10.1097/mol.0000000000000374","doi":"https://doi.org/10.1097/mol.0000000000000374","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mol.0000000000000374","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6211176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015707475","display_name":"Sasha A. Singh","orcid":"https://orcid.org/0000-0003-0929-3164","observed_orcids":["https://orcid.org/0000-0003-0929-3164"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sasha A. Singh","raw_affiliation_strings":["Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division","fax: +1 617 730 7791","to Sasha A. Singh, PhD or Masanori Aikawa MD, PhD, The Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA. Tel: +1 617 730 7700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division","institution_ids":[]},{"raw_affiliation_string":"fax: +1 617 730 7791","institution_ids":[]},{"raw_affiliation_string":"to Sasha A. Singh, PhD or Masanori Aikawa MD, PhD, The Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA. Tel: +1 617 730 7700","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine","Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division","Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","fax: +1 617 730 7791","to Sasha A. Singh, PhD or Masanori Aikawa MD, PhD, The Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA. Tel: +1 617 730 7700"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Excellence in Vascular Biology, Cardiovascular Division, Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division","institution_ids":[]},{"raw_affiliation_string":"Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"fax: +1 617 730 7791","institution_ids":[]},{"raw_affiliation_string":"to Sasha A. Singh, PhD or Masanori Aikawa MD, PhD, The Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA. Tel: +1 617 730 7700","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015707475","https://openalex.org/A5064861833"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.2718,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.26878613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"1","first_page":"68","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.11060000211000443,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdl-proteome","display_name":"HDL proteome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hdl-metabolism","display_name":"HDL metabolism","score":0.699999988079071},{"id":"https://openalex.org/keywords/apolipoproteins","display_name":"apolipoproteins","score":0.8450000286102295},{"id":"https://openalex.org/keywords/parallel-reaction-monitoring","display_name":"parallel reaction monitoring","score":0.8730000257492065},{"id":"https://openalex.org/keywords/targeted-mass-spectrometry","display_name":"targeted mass spectrometry","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8258289098739624},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7149465084075928},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6844596862792969},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5814340114593506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4200075566768646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32616686820983887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3169819712638855},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.22714823484420776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.199350506067276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/mol.0000000000000374","doi":"https://doi.org/10.1097/mol.0000000000000374","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mol.0000000000000374","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},{"id":"pmid:28002079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28002079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in lipidology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6211176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6211176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Lipidol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6211176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6211176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Lipidol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G177560657","display_name":"PARP9 and PARP14 in atherosclerosis","funder_award_id":"R01HL126901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5772064934","display_name":"Dll4 in macrophage activation","funder_award_id":"R01HL107550","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W21743595","https://openalex.org/W416269607","https://openalex.org/W569448388","https://openalex.org/W1488193441","https://openalex.org/W1579539545","https://openalex.org/W1803908051","https://openalex.org/W1816043936","https://openalex.org/W1848461833","https://openalex.org/W1963292950","https://openalex.org/W1979021931","https://openalex.org/W1984403117","https://openalex.org/W1989376534","https://openalex.org/W1990839024","https://openalex.org/W1993577107","https://openalex.org/W1996682849","https://openalex.org/W2010686434","https://openalex.org/W2011267199","https://openalex.org/W2025623225","https://openalex.org/W2029901299","https://openalex.org/W2034742038","https://openalex.org/W2037078037","https://openalex.org/W2041792934","https://openalex.org/W2043276694","https://openalex.org/W2047929205","https://openalex.org/W2060170477","https://openalex.org/W2062203442","https://openalex.org/W2067184832","https://openalex.org/W2067365659","https://openalex.org/W2070679875","https://openalex.org/W2076791734","https://openalex.org/W2086201613","https://openalex.org/W2094744791","https://openalex.org/W2100903963","https://openalex.org/W2105084411","https://openalex.org/W2108818213","https://openalex.org/W2111697619","https://openalex.org/W2119600030","https://openalex.org/W2124100671","https://openalex.org/W2126838623","https://openalex.org/W2128633067","https://openalex.org/W2129388952","https://openalex.org/W2136644649","https://openalex.org/W2137885916","https://openalex.org/W2146786317","https://openalex.org/W2151131770","https://openalex.org/W2152095891","https://openalex.org/W2159559291","https://openalex.org/W2171259749","https://openalex.org/W2177021195","https://openalex.org/W2183098386","https://openalex.org/W2187577412","https://openalex.org/W2235840267","https://openalex.org/W2272446569","https://openalex.org/W2288718157","https://openalex.org/W2294885876","https://openalex.org/W2295761418","https://openalex.org/W2297945512","https://openalex.org/W2307570313","https://openalex.org/W2314036331","https://openalex.org/W2325429075","https://openalex.org/W2345735224","https://openalex.org/W2430794023","https://openalex.org/W2462038997","https://openalex.org/W2466034354","https://openalex.org/W2511156686","https://openalex.org/W2514194003","https://openalex.org/W2526116264","https://openalex.org/W2549828506","https://openalex.org/W6659239534","https://openalex.org/W6729434925"],"related_works":["https://openalex.org/W1504990083","https://openalex.org/W3126438082","https://openalex.org/W1479923745","https://openalex.org/W4412559852","https://openalex.org/W2965695387","https://openalex.org/W2272446569","https://openalex.org/W2261641880","https://openalex.org/W2425713604","https://openalex.org/W2147990253","https://openalex.org/W1816043936"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Mass":[3,193],"spectrometry":[4,37,50,87,98,164,194],"is":[5,11,132,148],"an":[6,115],"ever":[7],"evolving":[8],"technology":[9,59],"that":[10,112,128,144,179],"equipped":[12],"with":[13],"a":[14,55,160,196],"variety":[15,197],"of":[16,35,48,84,118,172,198,211],"tools":[17,199],"for":[18],"protein":[19,155],"research.":[20],"Some":[21],"lipoprotein":[22],"studies,":[23],"especially":[24],"those":[25,63],"pertaining":[26],"to":[27,38,62,71,101,106,168,202],"HDL":[28,40,90,104,119,130,138,145,173,185],"biology,":[29],"have":[30,113,126],"been":[31],"exploiting":[32],"the":[33,46,58,79,82,94,103,107,129,137,170,183,208],"versatility":[34],"mass":[36,49,86,97,163],"understand":[39,72],"function":[41],"through":[42,81,205],"its":[43,153,206],"proteome.":[44],"Despite":[45],"role":[47],"in":[51,149,175],"advancing":[52],"research":[53],"as":[54],"whole,":[56],"however,":[57],"remains":[60],"obscure":[61],"without":[64],"hands":[65],"on":[66],"experience,":[67],"but":[68],"still":[69],"wishing":[70],"it.":[73],"In":[74],"this":[75],"review,":[76],"we":[77],"walk":[78],"reader":[80],"coevolution":[83],"common":[85],"workflows":[88],"and":[89,177,200],"research,":[91],"starting":[92],"from":[93],"basic":[95],"unbiased":[96],"methods":[99,111],"used":[100,167],"profile":[102],"proteome":[105,131],"most":[108],"recent":[109],"targeted":[110,162],"enabled":[114],"unprecedented":[116],"view":[117],"metabolism.":[120],"RECENT":[121],"FINDINGS:":[122],"Unbiased":[123],"global":[124],"proteomics":[125],"demonstrated":[127],"organized":[133],"into":[134],"subgroups":[135],"across":[136],"size":[139,186],"fractions":[140],"providing":[141],"further":[142],"evidence":[143],"functional":[146],"heterogeneity":[147],"part":[150],"governed":[151],"by":[152],"varying":[154],"constituents.":[156],"Parallel":[157],"reaction":[158],"monitoring,":[159],"novel":[161],"method,":[165],"was":[166],"monitor":[169],"metabolism":[171],"apolipoproteins":[174,180],"humans":[176],"revealed":[178],"contained":[181],"within":[182],"same":[184],"fraction":[187],"exhibit":[188],"diverse":[189],"metabolic":[190],"properties.":[191],"SUMMARY:":[192],"provides":[195],"strategies":[201],"facilitate":[203],"understanding,":[204],"proteins,":[207],"complex":[209],"biology":[210],"HDL.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}