{"id":"https://openalex.org/W2561950964","doi":null,"title":"EVALUATION OF GENIPIN CROSS-LINKED FIBRIN GELS FOR TISSUE ENGINEERING OF HUMAN ARTICULAR CARTILAGE","display_name":"EVALUATION OF GENIPIN CROSS-LINKED FIBRIN GELS FOR TISSUE ENGINEERING OF HUMAN ARTICULAR CARTILAGE","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2561950964","mag":"2561950964"},"language":"en","primary_location":{"id":"mag:2561950964","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.90BSUPP_I.0880130a","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024983535","display_name":"Emma V. Dare","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma V. Dare","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110183849","display_name":"P. Poitras","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Poitras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077968787","display_name":"Jake Kaupp","orcid":"https://orcid.org/0000-0002-3217-3294","observed_orcids":["https://orcid.org/0000-0002-3217-3294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jake Kaupp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3217-3294","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003449102","display_name":"SD Waldman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SD Waldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D. J. Carlsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. J. Carlsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102857526","display_name":"Geoffrey F. Dervin","orcid":"https://orcid.org/0000-0002-4618-4090","observed_orcids":["https://orcid.org/0000-0002-4618-4090","https://orcid.org/0000-0002-2415-8553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey F. Dervin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2415-8553","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088885050","display_name":"May Griffith","orcid":"https://orcid.org/0000-0003-1222-6720","observed_orcids":["https://orcid.org/0000-0003-1222-6720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"May Griffith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1222-6720","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014317580","display_name":"Maxwell T. Hincke","orcid":"https://orcid.org/0000-0001-6134-5668","observed_orcids":["https://orcid.org/0000-0001-6134-5668","https://orcid.org/0000-0002-2859-1987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Hincke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1252,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43838294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"130","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genipin","display_name":"genipin","score":0.8740000128746033},{"id":"https://openalex.org/keywords/fibrin-gel","display_name":"fibrin gel","score":0.9449999928474426},{"id":"https://openalex.org/keywords/articular-cartilage-tissue-engineering","display_name":"articular cartilage tissue engineering","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chondrocyte-encapsulation","display_name":"chondrocyte encapsulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cartilage-scaffolds","display_name":"cartilage scaffolds","score":0.7599999904632568},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/proteoglycan-accumulation","display_name":"proteoglycan accumulation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.8610000014305115},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.8159999847412109},{"id":"https://openalex.org/keywords/stiffness","display_name":"stiffness","score":0.597000002861023},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6010000109672546},{"id":"https://openalex.org/keywords/autologous-fibrin","display_name":"autologous fibrin","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2781438746","wikidata":"https://www.wikidata.org/wiki/Q1463401","display_name":"Genipin","level":3,"score":0.8799303770065308},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.7775678634643555},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.7219364047050476},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6502200365066528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6219704151153564},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5904785394668579},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5474883913993835},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5118369460105896},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5018463134765625},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4510105550289154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.356662392616272},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.3090623915195465},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29443860054016113},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25831520557403564},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23418697714805603},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2292582094669342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22301560640335083},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.20540153980255127},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.20166808366775513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1286897361278534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12464410066604614},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.06259161233901978},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2561950964","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.90BSUPP_I.0880130a","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2291160775","https://openalex.org/W2093820413","https://openalex.org/W2567039492","https://openalex.org/W2039911230","https://openalex.org/W7099459390","https://openalex.org/W2922196352","https://openalex.org/W2101566778","https://openalex.org/W1026875293","https://openalex.org/W2196391893","https://openalex.org/W2052841211"],"abstract_inverted_index":{"Purpose:":[0],"The":[2,23,75,93,214,255,272],"objective":[3],"of":[4,12,26,115,123,156,182,189,216,253,299,342],"this":[5,147,246],"project":[6],"is":[7,30,247],"to":[8,202,306,337],"determine":[9],"the":[10,27,32,52,116,160,190,251,261,285,301,340,343],"suitability":[11],"modified":[13],"fibrin":[14,28,53,81,273,316,344],"hydrogels":[15,317],"as":[16,320],"scaffolds":[17,322],"for":[18,98,172,323],"articular":[19,60,65,324],"cartilage":[20,66,325],"tissue":[21,326],"engineering.":[22,327],"attractive":[24],"feature":[25],"system":[29],"that":[31,44,180,228,245,294],"gel":[33],"precursors":[34],"are":[35],"available":[36],"in":[37,129,146,159,212,234,250,329],"autologous":[38],"form.":[39],"We":[40],"have":[41],"previously":[42],"demonstrated":[43],"genipin,":[45],"a":[46,153],"naturally":[47],"occurring":[48],"cross-linking":[49,218],"agent,":[50],"stabilizes":[51],"gel.":[54,345],"Methods:":[57],"Human":[59],"chondrocytes":[61,230],"were":[62,78,96,144],"isolated":[63],"from":[64,68],"harvested":[67],"consenting":[69],"patients":[70],"undergoing":[71],"total":[72],"knee":[73],"arthroplasty.":[74],"human":[76],"cells":[77],"encapsulated":[79,137,229],"into":[80,279],"gels":[82,95,117,161],"where":[83],"gelation":[84],"was":[85,118,152,184,194,200,275,287,297],"induced":[86],"by":[87,136,149,268],"combining":[88],"fibrinogen,":[89],"thrombin,":[90],"and":[91,107,139,142,199,208,238,244,270,281,290],"genipin.":[92,164,254],"resulting":[94],"evaluated":[97],"extracellular":[99],"matrix":[100],"(ECM)":[101],"production,":[102],"mechanical":[103],"properties,":[104],"cell":[105,124,223],"viability,":[106],"biodegradation.":[108],"Results:":[111],"No":[113],"breakdown":[114],"detected":[119,145],"during":[120],"5":[121,242],"weeks":[122,128,243],"culture.":[125,213],"After":[126],"several":[127],"culture,":[130],"histology":[131,269],"indicates":[132],"significant":[133],"proteoglycan":[134],"production":[135],"cells,":[138],"collagen":[140,236],"II":[141,237],"aggrecan":[143,239],"ECM":[148,158,183,263],"immunostaining.":[150,271],"There":[151],"greater":[154],"accumulation":[155,181],"cartilage-like":[157],"cross-linked":[162],"with":[163,186,260],"Dynamic":[165],"compression":[166],"tests":[167],"performed":[168],"at":[169,209],"0.1":[170],"Hz":[171],"10":[173],"cycles":[174],"using":[175,196],"an":[176,232,308],"MTS":[177],"machine":[178],"indicate":[179],"associated":[185],"increased":[187,249],"stiffness":[188],"material.":[191],"Cell":[192],"viability":[193],"assessed":[195],"live/dead":[197],"staining,":[198],"found":[201],"be":[203,335],">50%":[204],"after":[205,282],"24":[206],"hours":[207],"1":[210],"week":[211],"presence":[215,252],"genipin":[217],"did":[219,303],"not":[220,304],"significantly":[221],"affect":[222],"viability.":[224],"Real-Time":[225],"RT-PCR":[226],"indicated":[227,293],"show":[231,318],"increase":[233],"Sox9,":[235],"expression":[240,257],"over":[241],"further":[248],"gene":[256],"results":[258],"agreed":[259],"enhanced":[262],"seen":[264],"under":[265],"these":[266],"conditions":[267],"material":[274,286,302],"also":[276],"implanted":[277],"subcutaneously":[278],"rats":[280],"30":[283],"days":[284],"removed,":[288],"sectioned":[289],"evaluated.":[291],"Immunostaining":[292],"while":[295],"there":[296],"evidence":[298],"biodegradation,":[300],"appear":[305],"cause":[307],"inflammatory":[309],"response.":[310],"Conclusions:":[313],"Modified":[315],"potential":[319,341],"cellular":[321],"An":[328],"vivo":[330],"orthopaedic":[331],"model":[332],"must":[333],"now":[334],"developed":[336],"fully":[338],"evaluate":[339],"Funding":[348],":":[350],"Other":[351],"Education":[352],"Grant":[353]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-01-06T00:00:00"}
