{"id":"https://openalex.org/W2561908156","doi":"https://doi.org/10.1158/1538-7445.am2015-2059","title":"Abstract 2059: Novel roles for GNA13 and RHOA as tumor suppressor genes","display_name":"Abstract 2059: Novel roles for GNA13 and RHOA as tumor suppressor genes","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2561908156","doi":"https://doi.org/10.1158/1538-7445.am2015-2059","mag":"2561908156"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-2059","doi":"https://doi.org/10.1158/1538-7445.am2015-2059","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-2059","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015043722","display_name":"Morgan O\u2019Hayre","orcid":"https://orcid.org/0000-0003-0965-7773","observed_orcids":["https://orcid.org/0000-0003-0965-7773"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan O'hayre","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064921157","display_name":"Asuka Inoue","orcid":"https://orcid.org/0000-0003-0805-4049","observed_orcids":["https://orcid.org/0000-0003-0805-4049"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asuka Inoue","raw_affiliation_strings":["2Tohoku University, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tohoku University, Sendai, Japan;","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034852834","display_name":"Katiuchia Uzzun Sales","orcid":"https://orcid.org/0000-0002-3768-5790","observed_orcids":["https://orcid.org/0000-0002-3768-5790"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katiuchia Sales","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004550798","display_name":"Irina Kufareva","orcid":"https://orcid.org/0000-0001-9083-7039","observed_orcids":["https://orcid.org/0000-0001-9083-7039"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Kufareva","raw_affiliation_strings":["3University of California, San Diego, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of California, San Diego, La Jolla, CA;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020292494","display_name":"Juan Luis Callejas Valera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Luis Callejas Valera","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001430135","display_name":"Fukun Guo","orcid":"https://orcid.org/0000-0002-8820-7633","observed_orcids":["https://orcid.org/0000-0002-8820-7633"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fukun Guo","raw_affiliation_strings":["4Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037387913","display_name":"Constantinos Marios Mikelis","orcid":"https://orcid.org/0000-0002-6119-3307","observed_orcids":["https://orcid.org/0000-0002-6119-3307"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constantinos Mikelis","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031863969","display_name":"Giovanni DiPasquale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni DiPasquale","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049004274","display_name":"Kira Finkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kira Finkel","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026162371","display_name":"Junken Aoki","orcid":"https://orcid.org/0000-0001-9435-1896","observed_orcids":["https://orcid.org/0000-0001-9435-1896"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junken Aoki","raw_affiliation_strings":["2Tohoku University, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tohoku University, Sendai, Japan;","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020584779","display_name":"Yi Zheng","orcid":"https://orcid.org/0000-0001-7089-6074","observed_orcids":["https://orcid.org/0000-0001-7089-6074"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zheng","raw_affiliation_strings":["4Cincinnati Children's Hospital Medical Center, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cincinnati Children's Hospital Medical Center, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006083279","display_name":"Thomas Henrik Bugge","orcid":"https://orcid.org/0000-0001-7046-4060","observed_orcids":["https://orcid.org/0000-0001-7046-4060"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H. Bugge","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038753309","display_name":"Jorge Silvio Gutkind","orcid":"https://orcid.org/0000-0002-5150-4482","observed_orcids":["https://orcid.org/0000-0002-5150-4482"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Silvio Gutkind","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"2059","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gna13","display_name":"GNA13","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/g-protein-mutations","display_name":"G protein mutations","score":0.6439999938011169},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-mutations","display_name":"cancer mutations","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.858583390712738},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6224960684776306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.531304121017456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5296877026557922},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4764840304851532},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34480059146881104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3380935788154602},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2222656011581421}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-2059","doi":"https://doi.org/10.1158/1538-7445.am2015-2059","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-2059","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050549532","https://openalex.org/W2287829455","https://openalex.org/W2734942203","https://openalex.org/W4291736526","https://openalex.org/W2808743966","https://openalex.org/W4285097145","https://openalex.org/W2773200456","https://openalex.org/W2220673670","https://openalex.org/W3075108714","https://openalex.org/W2791645463"],"abstract_inverted_index":{"Abstract":[0],"G-protein":[1,82],"coupled":[2],"receptors":[3],"(GPCRs)":[4],"and":[5,18,22,38,62,72,100,109,111,133,146,155,164,185,202,263],"G-proteins":[6,61],"are":[7,123,187],"critical":[8],"signal":[9],"transduction":[10],"molecules":[11,31],"that":[12,120,173],"regulate":[13],"cell":[14,95,104,107,150,183],"survival,":[15],"proliferation,":[16],"motility":[17],"differentiation.":[19],"However,":[20],"mutations":[21,59,76,122,134,175],"disruptions":[23],"in":[24,46,60,77,93,135,139,176,180,189,204,205,223],"the":[25,47,78,81,174,220,273,278],"expression":[26],"or":[27],"function":[28,198,215,218],"of":[29,40,49,52,141,167,272,277],"these":[30,121,181],"have":[32,54,66,90,157],"been":[33,91,159],"linked":[34,160],"to":[35,69,161],"growth,":[36],"progression":[37],"metastasis":[39],"various":[41],"cancers.":[42],"Recently,":[43],"major":[44],"efforts":[45],"area":[48],"genome-wide":[50],"sequencing":[51],"tumors":[53],"unveiled":[55],"numerous":[56],"previously":[57,158],"uncharacterized":[58],"GPCRs,":[63],"which":[64],"could":[65],"significant":[67,126],"implications":[68],"cancer":[70,129,207],"initiation":[71],"progression.":[73],"In":[74],"particular,":[75],"gene":[79,130],"encoding":[80],"G13":[83,154],"(GNA13)":[84],"and/or":[85,178],"its":[86],"downstream":[87],"effector,":[88],"RhoA,":[89],"identified":[92],"B":[94,103,149,182],"lymphomas":[96,184],"(particularly":[97],"Burkitt's":[98,144],"lymphoma":[99,145],"Diffuse":[101,147],"Large":[102,148],"Lymphoma),":[105],"T":[106],"lymphomas,":[108],"Head":[110],"Neck":[112],"Squamous":[113],"Cell":[114],"Carcinomas":[115],"(HNSCCs).":[116],"Our":[117],"analyses":[118],"indicate":[119,194],"highly":[124],"statistically":[125],"over":[127],"background":[128],"mutation":[131],"rate,":[132],"GNA13":[136,177,201,262],"alone":[137],"occur":[138],"\u223c10-15%":[140],"patients":[142],"with":[143],"Lymphoma.":[151],"Surprisingly,":[152],"although":[153],"RhoA":[156],"cellular":[162],"transformation":[163],"metastatic":[165],"potential":[166],"epithelial":[168],"cancers,":[169],"our":[170,192,210],"data":[171,211],"suggests":[172],"RHOA":[179,203,264],"HNSCC":[186],"inhibitory":[188],"nature.":[190],"Furthermore,":[191],"results":[193],"a":[195,213],"tumor":[196,216,266],"suppressive":[197,217],"for":[199,219,261,281],"wild-type":[200],"vivo":[206],"models.":[208],"Overall,":[209],"suggest":[212],"novel":[214],"G13/RhoA":[221],"axis":[222],"multiple":[224],"human":[225],"malignancies.":[226],"Citation":[227],"Format:":[228],"Morgan":[229],"O'hayre,":[230],"Asuka":[231],"Inoue,":[232],"Katiuchia":[233],"Sales,":[234],"Irina":[235],"Kufareva,":[236],"Juan":[237],"Luis":[238],"Callejas":[239],"Valera,":[240],"Fukun":[241],"Guo,":[242],"Constantinos":[243],"Mikelis,":[244],"Giovanni":[245],"DiPasquale,":[246],"Kira":[247],"Finkel,":[248],"Junken":[249],"Aoki,":[250],"Yi":[251],"Zheng,":[252],"Thomas":[253],"H.":[254],"Bugge,":[255],"J.":[256],"Silvio":[257],"Gutkind.":[258],"Novel":[259],"roles":[260],"as":[265],"suppressor":[267],"genes.":[268],"[abstract].":[269],"In:":[270],"Proceedings":[271],"106th":[274],"Annual":[275],"Meeting":[276],"American":[279],"Association":[280],"Cancer":[282,292],"Research;":[283],"2015":[284],"Apr":[285],"18-22;":[286],"Philadelphia,":[287],"PA.":[288],"Philadelphia":[289],"(PA):":[290],"AACR;":[291],"Res":[293],"2015;75(15":[294],"Suppl):Abstract":[295],"nr":[296],"2059.":[297],"doi:10.1158/1538-7445.AM2015-2059":[298]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
