{"id":"https://openalex.org/W2561836037","doi":null,"title":"Analgesia followed by long-term hyperalgesia generated by disinhibition of the basolateral amygdala","display_name":"Analgesia followed by long-term hyperalgesia generated by disinhibition of the basolateral amygdala","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2561836037","mag":"2561836037"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1543","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/486","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1543&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1543&context=oa_theses","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053305084","display_name":"Derek Atchley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Derek Atchley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053305084"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-induced-analgesia","display_name":"stress-induced analgesia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/stress-induced-hyperalgesia","display_name":"stress-induced hyperalgesia","score":0.996999979019165},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gaba-a-receptor-antagonism","display_name":"GABA-A receptor antagonism","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bicuculline-methiodide","display_name":"bicuculline methiodide","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gabaergic-transmission","display_name":"GABAergic neurotransmission","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tail-shock","display_name":"tail shock","score":0.6800000071525574},{"id":"https://openalex.org/keywords/vocalizations","display_name":"vocalizations","score":0.6769999861717224},{"id":"https://openalex.org/keywords/stress-hormones","display_name":"stress hormones","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.8571152091026306},{"id":"https://openalex.org/C2776599063","wikidata":"https://www.wikidata.org/wiki/Q5282244","display_name":"Disinhibition","level":2,"score":0.7340373992919922},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6935337781906128},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5975051522254944},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.597011923789978},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41969767212867737},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3824502229690552},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3571470379829407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35487377643585205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25764578580856323},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08359640836715698},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.0712314248085022},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1543","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/486","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1543&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},{"id":"mag:2561836037","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1543&context=oa_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_theses-1543","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_theses/486","pdf_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=1543&context=oa_theses","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Theses","raw_type":"thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2561836037.pdf","grobid_xml":"https://content.openalex.org/works/W2561836037.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W112333178","https://openalex.org/W1015756911","https://openalex.org/W1231274610","https://openalex.org/W1489737221","https://openalex.org/W1950317766","https://openalex.org/W1960644352","https://openalex.org/W1965086309","https://openalex.org/W1965847958","https://openalex.org/W1966868909","https://openalex.org/W1969032152","https://openalex.org/W1969303073","https://openalex.org/W1970111741","https://openalex.org/W1973164494","https://openalex.org/W1974649820","https://openalex.org/W1979292389","https://openalex.org/W1982921144","https://openalex.org/W1984853152","https://openalex.org/W1988130989","https://openalex.org/W1991051558","https://openalex.org/W2001897444","https://openalex.org/W2002664363","https://openalex.org/W2004928159","https://openalex.org/W2006563521","https://openalex.org/W2009482341","https://openalex.org/W2015641096","https://openalex.org/W2016719580","https://openalex.org/W2018800690","https://openalex.org/W2022221011","https://openalex.org/W2024395140","https://openalex.org/W2024655460","https://openalex.org/W2034775655","https://openalex.org/W2034888872","https://openalex.org/W2035912882","https://openalex.org/W2036584770","https://openalex.org/W2036872212","https://openalex.org/W2039669163","https://openalex.org/W2040162562","https://openalex.org/W2045877296","https://openalex.org/W2047467222","https://openalex.org/W2048968739","https://openalex.org/W2051766953","https://openalex.org/W2051893555","https://openalex.org/W2053967275","https://openalex.org/W2057005094","https://openalex.org/W2062085705","https://openalex.org/W2062746952","https://openalex.org/W2071135425","https://openalex.org/W2072401461","https://openalex.org/W2076068537","https://openalex.org/W2076368132","https://openalex.org/W2079660727","https://openalex.org/W2082577535","https://openalex.org/W2083495513","https://openalex.org/W2084070063","https://openalex.org/W2086578118","https://openalex.org/W2089138873","https://openalex.org/W2093090171","https://openalex.org/W2098848290","https://openalex.org/W2114770633","https://openalex.org/W2123258170","https://openalex.org/W2138184969","https://openalex.org/W2138512124","https://openalex.org/W2144933081","https://openalex.org/W2151840645","https://openalex.org/W2155025568","https://openalex.org/W2158553737","https://openalex.org/W2166370054","https://openalex.org/W2168056696","https://openalex.org/W2173532358","https://openalex.org/W2262272603","https://openalex.org/W2411671943","https://openalex.org/W2412953837","https://openalex.org/W4239024596"],"related_works":["https://openalex.org/W2058830115","https://openalex.org/W2009646296","https://openalex.org/W3199575537","https://openalex.org/W2105616924","https://openalex.org/W7165061683","https://openalex.org/W2078455464","https://openalex.org/W2035697946","https://openalex.org/W2274653385","https://openalex.org/W4210620767","https://openalex.org/W1982342679"],"abstract_inverted_index":{"Stress":[0],"produces":[1],"bimodal":[2],"effects":[3,80],"on":[4],"pain":[5,12,90,115,127],"peception.":[6],"During":[7],"exposure":[8,22],"to":[9,23,29,55,76,120],"a":[10,24,41,66,82,105,133],"stressor":[11,25,83],"responses":[13],"are":[14],"inibited":[15],"(i.e.":[16,34],"stress-induced":[17,35,60],"analgesia).":[18],"However,":[19],"following":[20,88,104,112,142],"long-term":[21],"increases":[26],"in":[27,135],"responsiveness":[28,91,116,128],"painful":[30],"stimuli":[31],"may":[32],"develop":[33],"hyperalgesia).":[36],"Here":[37],"I":[38],"evaluated":[39],"how":[40],"key":[42],"component":[43],"of":[44,51,58,81],"the":[45,56,71,78,108,139],"subcortical":[46],"defense":[47],"circuit":[48],"and":[49,62,100,110],"target":[50],"stress":[52,143],"hormones":[53],"contributes":[54],"development":[57],"both":[59],"analgesia":[61],"hyperalgesia.":[63],"Bicuculline":[64],"methiodide,":[65],"GABAA":[67],"antagonist,":[68],"injected":[69],"into":[70],"basolateral":[72,140],"amygdala":[73,141],"was":[74,92],"used":[75],"mimic":[77],"neural":[79],"or":[84],"threat":[85],"exposure.":[86,144],"Immediately":[87],"injection":[89,114],"decreased":[93],"as":[94],"measured":[95],"by":[96,132],"vocalizations":[97],"after":[98],"discharge":[99],"vocolizations":[101],"during":[102],"shock":[103],"tailshock.":[106],"In":[107],"days":[109],"weeks":[111],"bicuculline":[113],"became":[117],"elevated":[118],"compared":[119],"control":[121],"rats.":[122],"These":[123],"findings":[124],"suggest":[125],"that":[126],"can":[129],"be":[130],"mediated":[131],"reduction":[134],"GABAergic":[136],"signalling":[137],"within":[138]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
