{"id":"https://openalex.org/W2561711916","doi":"https://doi.org/10.1158/1538-7445.am2015-1509","title":"Abstract 1509: Leptin drives mammary stem cell self-renewal via the mTOR pathway","display_name":"Abstract 1509: Leptin drives mammary stem cell self-renewal via the mTOR pathway","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2561711916","doi":"https://doi.org/10.1158/1538-7445.am2015-1509","mag":"2561711916"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-1509","doi":"https://doi.org/10.1158/1538-7445.am2015-1509","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1509","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076927934","display_name":"Ray Esper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray Esper","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041474768","display_name":"Michael K. Dame","orcid":"https://orcid.org/0000-0003-3760-1654","observed_orcids":["https://orcid.org/0000-0003-3760-1654"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Dame","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112562583","display_name":"Shannon D. McClintock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon McClintock","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Becky Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Becky Simon","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max Wicha","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112905614","display_name":"Dean E. Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Brenner","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"1509","last_page":"1509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.996999979019165},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.7400000095367432},{"id":"https://openalex.org/keywords/aldh-cells","display_name":"ALDH+ cells","score":0.6859999895095825},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.7179999947547913},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ribosomal-protein-s6-phosphorylation","display_name":"S6 phosphorylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.652999997138977},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/breast-reduction","display_name":"breast reduction","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8318270444869995},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6312382817268372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6164272427558899},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5953395366668701},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5252606272697449},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5211156010627747},{"id":"https://openalex.org/C2780745355","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Stromal vascular fraction","level":3,"score":0.5184916257858276},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5155482292175293},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.48272082209587097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4672876000404358},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4646209180355072},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45679453015327454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42929643392562866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39930784702301025},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2146560549736023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17459943890571594},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.09004521369934082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-1509","doi":"https://doi.org/10.1158/1538-7445.am2015-1509","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-1509","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011348544","https://openalex.org/W1781050812","https://openalex.org/W4210387537","https://openalex.org/W7136371374","https://openalex.org/W2319062744","https://openalex.org/W6921204090","https://openalex.org/W6902533731","https://openalex.org/W2401393812","https://openalex.org/W1551690619","https://openalex.org/W1848483485"],"abstract_inverted_index":{"Abstract":[0],"Normal":[1],"tissue":[2,120],"stem":[3,35,67,82,95,127,136,151,194,226,255,280,319],"cells":[4,25,36,44,96,137,152,256,293],"exist":[5],"in":[6,28,52,70,85,98,118,138,147,170,219,294],"either":[7],"a":[8,29,48,75,86,132,162,167,180,243,246,295],"quiescent":[9,30,42,191,225,254,296],"or":[10],"proliferating/self-renewing":[11],"phenotypic":[12,274],"state":[13,51,297],"with":[14,166,175,184,231,239,258,264],"different":[15],"patterns":[16],"of":[17,77,92,103,121,135,156,234,329,334],"gene":[18],"expression.":[19],"In":[20],"the":[21,23,33,41,66,71,101,110,142,190,220,259,323,330,335],"breast,":[22],"CD44+/CD24\u2212":[24,43,247],"are":[26,37],"retained":[27],"state,":[31],"while":[32],"ALDH+":[34,50,222,250],"actively":[38],"self-renewing":[39,49],"cells;":[40],"must":[45],"transition":[46,244],"through":[47],"order":[53],"to":[54,131,237,241,248],"differentiate":[55],"into":[56],"mature":[57],"mammary":[58,150,318],"cells.":[59,223],"The":[60,224],"adipose-rich":[61],"stroma":[62],"that":[63,79,109,115,141,267],"makes":[64],"up":[65],"cell":[68,83,128,195,227,281,320],"niche":[69],"human":[72,149,198],"breast":[73,94,104,119,126],"is":[74,145,270],"source":[76],"leptin":[78,235,265],"may":[80,289],"alter":[81],"phenotype":[84],"paracrine":[87],"manner.":[88],"A":[89],"larger":[90,133],"population":[91,134],"proliferating":[93,193,221,251],"could,":[97],"turn,":[99],"increase":[100,169],"risk":[102],"cancer.":[105],"We":[106],"previously":[107],"demonstrated":[108,266],"increased":[111,125],"local":[112],"leptin/adiponectin":[113],"ratio":[114],"commonly":[116],"occurs":[117],"obese":[122],"women":[123],"promotes":[124],"self-renewal":[129,283,321],"leading":[130],"vivo,":[139],"and":[140,179,192,202,298],"mTOR":[143,171,205,260,268,324],"pathway":[144],"activated":[146],"normal":[148],"by":[153,207,284],"physiologic":[154,163,232],"concentrations":[155,233],"adipokines,":[157],"including":[158],"leptin.":[159],"There":[160],"was":[161,217,229],"dose":[164],"response,":[165],"measurable":[168],"activity":[172,206,269],"over":[173],"baseline":[174],"31.25":[176],"ng/ml":[177],"leptin,":[178],"near":[181],"maximal":[182],"effect":[183],"125":[185],"ng/ml.":[186],"Here,":[187],"we":[188],"isolated":[189],"fractions":[196],"from":[197,245],"reduction":[199],"mammoplasty":[200],"samples":[201],"measured":[203],"basal":[204],"ELISA":[208],"for":[209,272,338],"phosphorylated":[210],"S6":[211],"ribosomal":[212],"protein":[213],"(pS6/tS6":[214],"ratio),":[215],"which":[216],"greater":[218],"fraction":[228],"treated":[230,257],"prior":[236],"resorting":[238],"FACS":[240],"measure":[242],"an":[249],"phenotype.":[252],"Parallel":[253],"inhibitor":[261],"everolimus":[262],"simultaneously":[263],"necessary":[271],"this":[273],"switch.":[275],"If":[276],"inflammatory":[277],"adipokines":[278],"promote":[279],"symmetric":[282],"activating":[285],"mTOR,":[286],"targeted":[287],"interventions":[288],"maintain":[290],"potential":[291],"tumor-initiating":[292],"reduce":[299],"cancer":[300],"incidence.":[301],"Citation":[302],"Format:":[303],"Ray":[304],"Esper,":[305],"Michael":[306],"Dame,":[307],"Shannon":[308],"McClintock,":[309],"Becky":[310],"Simon,":[311],"Max":[312],"Wicha,":[313],"Dean":[314],"Brenner.":[315],"Leptin":[316],"drives":[317],"via":[322],"pathway.":[325],"[abstract].":[326],"In:":[327],"Proceedings":[328],"106th":[331],"Annual":[332],"Meeting":[333],"American":[336],"Association":[337],"Cancer":[339,349],"Research;":[340],"2015":[341],"Apr":[342],"18-22;":[343],"Philadelphia,":[344],"PA.":[345],"Philadelphia":[346],"(PA):":[347],"AACR;":[348],"Res":[350],"2015;75(15":[351],"Suppl):Abstract":[352],"nr":[353],"1509.":[354],"doi:10.1158/1538-7445.AM2015-1509":[355]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-01-06T00:00:00"}