{"id":"https://openalex.org/W2561488398","doi":"https://doi.org/10.1158/1538-7445.am2015-4085","title":"Abstract 4085: Depletion of Runx1 promotes epithelial to mesenchymal transition in breast cancer","display_name":"Abstract 4085: Depletion of Runx1 promotes epithelial to mesenchymal transition in breast cancer","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2561488398","doi":"https://doi.org/10.1158/1538-7445.am2015-4085","mag":"2561488398"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2015-4085","doi":"https://doi.org/10.1158/1538-7445.am2015-4085","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-4085","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102263218","display_name":"Deli Hong","orcid":"https://orcid.org/0000-0001-9863-4877","observed_orcids":["https://orcid.org/0000-0001-9863-4877"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deli Hong","raw_affiliation_strings":["University of Vermont, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Lian","raw_affiliation_strings":["University of Vermont, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Stein","raw_affiliation_strings":["University of Vermont, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110166645","display_name":"Gary Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Stein","raw_affiliation_strings":["University of Vermont, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"15_Supplement","first_page":"4085","last_page":"4085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9610000252723694},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.7120000123977661},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mcf10a","display_name":"MCF10A","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2778193527","wikidata":"https://www.wikidata.org/wiki/Q15320451","display_name":"RUNX1","level":4,"score":0.8777148723602295},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7029083967208862},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6623485088348389},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5838956236839294},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.51129150390625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5048056840896606},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4570986032485962},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44916918873786926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3512119650840759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2974972426891327},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.2774393558502197},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2586113512516022},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25018054246902466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2473985254764557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2377784252166748},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10614919662475586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08426764607429504}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2015-4085","doi":"https://doi.org/10.1158/1538-7445.am2015-4085","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2015-4085","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2484951254","https://openalex.org/W2590298312","https://openalex.org/W7042857668","https://openalex.org/W7014906257","https://openalex.org/W2987202071","https://openalex.org/W2803451141","https://openalex.org/W1848800158","https://openalex.org/W2605402577","https://openalex.org/W2886695231","https://openalex.org/W2051926999"],"abstract_inverted_index":{"Abstract":[0],"Runx1":[1,11,27,43,60,70,86,93,122,148,154,162,173,176,192,223,256,270,295],"is":[2,94],"an":[3,164],"essential":[4],"transcription":[5],"factor":[6,19],"for":[7,161,255,278,316],"definitive":[8],"hematopoiesis":[9],"and":[10,40,111,174,186,247,263],"translocations":[12],"are":[13,46],"well":[14,237],"established":[15],"as":[16,28,163,236,238],"the":[17,31,74,83,119,125,134,170,217,308,313],"causative":[18],"of":[20,30,59,66,76,85,147,153,216,234,241,294,307,312],"various":[21],"leukemias.":[22],"Recent":[23],"studies":[24],"have":[25],"identified":[26],"one":[29],"most":[32],"frequently":[33],"mutated":[34],"genes":[35],"in":[36,48,62,72,97,131,138,143,183,195,203,214,225,257,266,301],"breast":[37,51,106,113,132,267,281,302],"cancer":[38,88,107,114],"patients,":[39],"also":[41],"that":[42,69,77,92,121,191],"expression":[44,61,215,240],"levels":[45],"decreased":[47],"high-grade":[49],"primary":[50],"tumors":[52],"compared":[53,104],"to":[54,124,127,199,260,274,298],"low/mid-grade":[55],"tumors.":[56],"The":[57],"recognition":[58],"epithelial":[63,101,108,126,218,259,297],"lining":[64],"cells":[65,102,109,115,140,197,227],"glands":[67],"suggests":[68,158],"functions":[71],"maintaining":[73],"integrity":[75],"cell":[78,179],"layer.":[79],"Therefore":[80],"we":[81],"examined":[82],"role":[84,160,254],"during":[87],"progression.":[89],"We":[90,189],"found":[91],"highly":[95],"expressed":[96],"immortalized":[98],"human":[99],"mammary":[100],"(MCF10A)":[103],"with":[105,210],"(MCF7)":[110],"invasive":[112],"(MDA-MB-231).":[116],"To":[117,167],"test":[118],"hypothesis":[120],"contributes":[123],"mesenchymal":[128,208,242,261,299],"transition":[129,262,300],"(EMT)":[130],"cancer,":[133],"EMT":[135,165,230],"was":[136],"induced":[137,229],"MCF10A":[139,185,196],"which":[141],"resulted":[142],"a":[144,159,200,207,211,252],"50%":[145],"decrease":[146,213],"mRNA,":[149],"but":[150],"complete":[151],"loss":[152],"protein.":[155],"This":[156,269],"finding":[157],"suppressor.":[166],"further":[168],"address":[169],"relationship":[171],"between":[172],"EMT,":[175],"depleted":[177],"stable":[178],"lines":[180],"were":[181],"generated":[182],"both":[184],"MCF7":[187,226],"cells.":[188],"observed":[190],"knockdown":[193],"(90%)":[194],"leads":[198],"dramatic":[201],"change":[202],"their":[204],"morphology":[205],"towards":[206],"state,":[209],"concomitant":[212],"marker":[219],"E-cadherin.":[220],"In":[221],"addition":[222],"depletion":[224],"directly":[228],"state":[231],"by":[232],"repression":[233],"E-cadherin,":[235],"increased":[239],"genes,":[243],"including":[244],"vimentin,":[245],"N-cadherin":[246],"fibronectin.":[248],"Our":[249],"results":[250],"highlight":[251],"crucial":[253],"preventing":[258],"tumor":[264],"progression":[265],"cancer.":[268,282,303],"mediated":[271],"mechanism":[272],"points":[273],"novel":[275],"intervention":[276],"strategies":[277],"early":[279],"stage":[280],"Citation":[283],"Format:":[284],"Deli":[285],"Hong,":[286],"Jane":[287],"Lian,":[288],"Janet":[289],"Stein,":[290],"Gary":[291],"Stein.":[292],"Depletion":[293],"promotes":[296],"[abstract].":[304],"In:":[305],"Proceedings":[306],"106th":[309],"Annual":[310],"Meeting":[311],"American":[314],"Association":[315],"Cancer":[317,327],"Research;":[318],"2015":[319],"Apr":[320],"18-22;":[321],"Philadelphia,":[322],"PA.":[323],"Philadelphia":[324],"(PA):":[325],"AACR;":[326],"Res":[328],"2015;75(15":[329],"Suppl):Abstract":[330],"nr":[331],"4085.":[332],"doi:10.1158/1538-7445.AM2015-4085":[333]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-01-06T00:00:00"}