{"id":"https://openalex.org/W2561440456","doi":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","title":"Abstract A1-28: Chromosome fusions triggered by noncoding RNA","display_name":"Abstract A1-28: Chromosome fusions triggered by noncoding RNA","publication_year":2015,"publication_date":"2015-11-15","ids":{"openalex":"https://openalex.org/W2561440456","doi":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","mag":"2561440456"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.transcagen-a1-28","doi":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042242555","display_name":"John R. Bracht","orcid":"https://orcid.org/0000-0001-8042-7685","observed_orcids":["https://orcid.org/0000-0001-8042-7685"]},"institutions":[{"id":"https://openalex.org/I181401687","display_name":"American University","ror":"https://ror.org/052w4zt36","country_code":"US","type":"education","lineage":["https://openalex.org/I181401687"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Bracht","raw_affiliation_strings":["1American University, Washington, DC,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1American University, Washington, DC,","institution_ids":["https://openalex.org/I181401687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101605308","display_name":"Xing Wang","orcid":"https://orcid.org/0000-0002-2029-4160","observed_orcids":["https://orcid.org/0000-0002-2029-4160"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Wang","raw_affiliation_strings":["2Rensselaer Polytechnic Institute, Troy, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Rensselaer Polytechnic Institute, Troy, NY,","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114132720","display_name":"Keerthi S. Shetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keerthi Shetty","raw_affiliation_strings":["3Yale University, New Haven, CT,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Yale University, New Haven, CT,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Chen","raw_affiliation_strings":["4Princeton University, Princeton, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ,","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044820964","display_name":"Mariusz Nowacki","orcid":"https://orcid.org/0000-0003-4894-2905","observed_orcids":["https://orcid.org/0000-0003-4894-2905"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mariusz Nowacki","raw_affiliation_strings":["5University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041227024","display_name":"Sierra McCloud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sierra McCloud","raw_affiliation_strings":["4Princeton University, Princeton, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ,","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110530654","display_name":"Derek M. Clay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Clay","raw_affiliation_strings":["4Princeton University, Princeton, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ,","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073999639","display_name":"Laura F. Landweber","orcid":"https://orcid.org/0000-0002-7030-8540","observed_orcids":["https://orcid.org/0000-0002-7030-8540"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Landweber","raw_affiliation_strings":["4Princeton University, Princeton, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ,","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"22_Supplement_1","first_page":"A1","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-fusion","display_name":"chromosome fusion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/piwi-interacting-rnas","display_name":"piRNA","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oxytricha-trifallax","display_name":"Oxytricha trifallax","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ciliates","display_name":"ciliates","score":0.6729999780654907},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.5879999995231628},{"id":"https://openalex.org/keywords/cancer-transformation","display_name":"cancer transformation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7080045938491821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6199783086776733},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6180465221405029},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5721868276596069},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.4935954809188843},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.47847291827201843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4724721610546112},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4366152286529541},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.43053334951400757},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36046290397644043}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.transcagen-a1-28","doi":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.transcagen-a1-28","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417813484","https://openalex.org/W4399581658","https://openalex.org/W2991030764","https://openalex.org/W2318224129","https://openalex.org/W2809057482","https://openalex.org/W4232939570","https://openalex.org/W4405596875","https://openalex.org/W2625729821","https://openalex.org/W333480696","https://openalex.org/W7160449968"],"abstract_inverted_index":{"Abstract":[0],"Chromosomal":[1],"fusion":[2,66,99,117,127,158],"is":[3],"a":[4,49,105,125,130],"frequent":[5],"occurrence":[6],"in":[7,96,100,118],"cancer":[8,38],"cells":[9,113],"and":[10,44,68,114,129,159],"can":[11],"promote":[12],"transformation":[13,47],"through":[14],"the":[15,34,37,89,101,147,189,196],"generation":[16],"of":[17,36,91,149,188,195],"oncogenic":[18],"gene":[19],"products.":[20],"There":[21],"are":[22,140],"two":[23],"non-exclusive":[24],"models":[25],"for":[26,61],"how":[27],"these":[28,136],"chromosome":[29,58,77,116,131,157],"fusions":[30,42,139,180],"may":[31],"occur:":[32],"(1)":[33],"instability":[35],"genome":[39,154],"produces":[40],"chromosomal":[41,98],"randomly":[43],"those":[45],"promoting":[46,97],"enjoy":[48],"selective":[50],"advantage,":[51],"or":[52],"(2)":[53,62],"some":[54],"non-random":[55],"mechanism":[56],"drives":[57],"fusion.":[59,78],"Evidence":[60],"comes":[63],"from":[64],"recurrent":[65],"events":[67],"correlative":[69],"human":[70],"data":[71],"linking":[72],"noncoding":[73,92,150,183],"RNA":[74],"expression":[75],"with":[76],"To":[79],"help":[80],"address":[81],"this":[82],"important":[83],"fundamental":[84],"question,":[85],"we":[86],"functionally":[87],"tested":[88],"role":[90],"RNA,":[93],"specifically":[94],"piRNAs,":[95],"ciliate,":[102],"Oxytricha":[103],"trifallax,":[104],"microbial":[106],"eukaryote.":[107],"We":[108],"microinjected":[109],"custom":[110],"piRNAs":[111],"into":[112],"observed":[115],"four":[119,122],"cases":[120],"(of":[121],"tested),":[123],"including":[124,156],"double":[126],"event":[128,133],"circularization":[132],"(self-fusion).":[134],"Furthermore,":[135],"RNA-mediated":[137],"inter-and-intra-chromosomal":[138],"heritable":[141],"over":[142],"multiple":[143],"sexual":[144],"generations,":[145],"illustrating":[146],"ability":[148],"RNAs":[151],"to":[152],"program":[153],"architecture,":[155],"circularization.":[160],"Citation":[161],"Format:":[162],"John":[163],"Bracht,":[164],"Xing":[165],"Wang,":[166],"Keerthi":[167],"Shetty,":[168],"Xiao":[169],"Chen,":[170],"Mariusz":[171],"Nowacki,":[172],"Sierra":[173],"McCloud,":[174],"Derek":[175],"Clay,":[176],"Laura":[177],"Landweber.":[178],"Chromosome":[179],"triggered":[181],"by":[182],"RNA.":[184],"[abstract].":[185],"In:":[186],"Proceedings":[187],"AACR":[190],"Special":[191],"Conference":[192],"on":[193],"Translation":[194],"Cancer":[197,208],"Genome;":[198],"Feb":[199],"7-9,":[200],"2015;":[201],"San":[202],"Francisco,":[203],"CA.":[204],"Philadelphia":[205],"(PA):":[206],"AACR;":[207],"Res":[209],"2015;75(22":[210],"Suppl":[211],"1):Abstract":[212],"nr":[213],"A1-28.":[214]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-01-06T00:00:00"}