{"id":"https://openalex.org/W2561415221","doi":"https://doi.org/10.1186/s12864-016-3352-4","title":"Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence","display_name":"Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2561415221","doi":"https://doi.org/10.1186/s12864-016-3352-4","mag":"2561415221","pmid":"https://pubmed.ncbi.nlm.nih.gov/28105936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5249001"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-016-3352-4","doi":"https://doi.org/10.1186/s12864-016-3352-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-3352-4","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-016-3352-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-016-3352-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024982753","display_name":"Kamil Can Kural","orcid":"https://orcid.org/0000-0003-1661-4616","observed_orcids":["https://orcid.org/0000-0003-1661-4616"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamil C. Kural","raw_affiliation_strings":["School of Systems Biology, George Mason University, Manassas, VA, 20110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Systems Biology, George Mason University, Manassas, VA, 20110, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129369030","display_name":"Neetu Tandon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123556","display_name":"GeneXplain (Germany)","ror":"https://ror.org/02qeyb550","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210123556"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Neetu Tandon","raw_affiliation_strings":["GeneXplain GmbH, 38302, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneXplain GmbH, 38302, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210123556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052562207","display_name":"Mikhail Y. Skoblov","orcid":"https://orcid.org/0000-0002-7293-3438","observed_orcids":["https://orcid.org/0000-0002-7293-3438"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail Skoblov","raw_affiliation_strings":["Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia","Research Centre for Medical Genetics, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia","institution_ids":["https://openalex.org/I153845743"]},{"raw_affiliation_string":"Research Centre for Medical Genetics, Moscow, Russia","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077477710","display_name":"Olga V Kel-Margoulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123556","display_name":"GeneXplain (Germany)","ror":"https://ror.org/02qeyb550","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210123556"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olga V. Kel-Margoulis","raw_affiliation_strings":["GeneXplain GmbH, 38302, Wolfenb\u00fcttel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GeneXplain GmbH, 38302, Wolfenb\u00fcttel, Germany","institution_ids":["https://openalex.org/I4210123556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065986636","display_name":"Ancha V. Baranova","orcid":"https://orcid.org/0000-0001-6810-5982","observed_orcids":["https://orcid.org/0000-0001-6810-5982"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU","US"],"is_corresponding":true,"raw_author_name":"Ancha V. Baranova","raw_affiliation_strings":["Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia. abaranov@gmu.edu","Research Centre for Medical Genetics, Moscow, Russia. abaranov@gmu.edu","School of Systems Biology, George Mason University, Manassas, VA, 20110, USA. abaranov@gmu.edu","Research Centre for Medical Genetics, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia. abaranov@gmu.edu","institution_ids":["https://openalex.org/I153845743"]},{"raw_affiliation_string":"Research Centre for Medical Genetics, Moscow, Russia. abaranov@gmu.edu","institution_ids":["https://openalex.org/I4210126689"]},{"raw_affiliation_string":"School of Systems Biology, George Mason University, Manassas, VA, 20110, USA. abaranov@gmu.edu","institution_ids":["https://openalex.org/I162714631"]},{"raw_affiliation_string":"Research Centre for Medical Genetics, Moscow, Russia","institution_ids":["https://openalex.org/I4210126689"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065986636"],"corresponding_institution_ids":["https://openalex.org/I153845743","https://openalex.org/I162714631","https://openalex.org/I4210126689"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.965,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68604179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"S14","first_page":"1030","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stress-induced-premature-senescence","display_name":"stress-induced premature senescence","score":0.9909999966621399},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mgat1","display_name":"MGAT1","score":0.7450000047683716},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.746999979019165},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.9750000238418579},{"id":"https://openalex.org/keywords/homeodomain-transcription-factor","display_name":"homeodomain transcription factor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/irx2","display_name":"IRX2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hmx1","display_name":"HMX1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/stromal-activation","display_name":"stromal activation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.799035906791687},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6492092609405518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5617943406105042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3371281027793884}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12864-016-3352-4","doi":"https://doi.org/10.1186/s12864-016-3352-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-3352-4","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-016-3352-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:28105936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28105936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5249001","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5249001/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:doi:10.13021/mars/8885","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1920/11352","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12864-016-3352-4","doi":"https://doi.org/10.1186/s12864-016-3352-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-3352-4","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-016-3352-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309029","display_name":"George Mason University","ror":"https://ror.org/02jqj7156"},{"id":"https://openalex.org/F4320332940","display_name":"College of Science, George Mason University","ror":"https://ror.org/02jqj7156"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2561415221.pdf","grobid_xml":"https://content.openalex.org/works/W2561415221.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1517051009","https://openalex.org/W1539368996","https://openalex.org/W1791748205","https://openalex.org/W1895453084","https://openalex.org/W1972132727","https://openalex.org/W1973300568","https://openalex.org/W1975799119","https://openalex.org/W1976986990","https://openalex.org/W1979386469","https://openalex.org/W1979720809","https://openalex.org/W1985732155","https://openalex.org/W1997709656","https://openalex.org/W2000737163","https://openalex.org/W2003607443","https://openalex.org/W2004871396","https://openalex.org/W2011152535","https://openalex.org/W2023205244","https://openalex.org/W2024209230","https://openalex.org/W2032304802","https://openalex.org/W2043014432","https://openalex.org/W2046766973","https://openalex.org/W2047330128","https://openalex.org/W2064720181","https://openalex.org/W2067418585","https://openalex.org/W2074092657","https://openalex.org/W2094036688","https://openalex.org/W2094831008","https://openalex.org/W2098873966","https://openalex.org/W2099396594","https://openalex.org/W2100695898","https://openalex.org/W2101163066","https://openalex.org/W2108446207","https://openalex.org/W2108654537","https://openalex.org/W2117912210","https://openalex.org/W2121358816","https://openalex.org/W2123703699","https://openalex.org/W2126731001","https://openalex.org/W2135030836","https://openalex.org/W2138788396","https://openalex.org/W2142715432","https://openalex.org/W2146526187","https://openalex.org/W2152443031","https://openalex.org/W2160377419","https://openalex.org/W2162009170","https://openalex.org/W2164540546","https://openalex.org/W2170163263","https://openalex.org/W2256476024","https://openalex.org/W2288253654"],"related_works":["https://openalex.org/W2883307144","https://openalex.org/W7136084290","https://openalex.org/W2037869103","https://openalex.org/W1964440144","https://openalex.org/W7160560596","https://openalex.org/W2328126338","https://openalex.org/W7024592751","https://openalex.org/W1978963781","https://openalex.org/W7136078804","https://openalex.org/W6939636756"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,98,123],"culturing":[2],"normal":[3],"diploid":[4],"cells,":[5],"senescence":[6,48,170],"may":[7,19],"either":[8,188],"happen":[9],"naturally,":[10],"in":[11,50,93,108,142,160,187,255],"the":[12,80,111,117,130,151,176,196,224,247,275],"form":[13],"of":[14,23,39,56,82,113,116,133,147,179,183,226,252,261,271,277],"replicative":[15,44],"senescence,":[16],"or":[17,190],"it":[18],"be":[20],"a":[21,33,220,229],"consequence":[22],"external":[24],"challenges":[25],"such":[26],"as":[27,89,219],"oxidative":[28],"stress.":[29],"Here":[30],"we":[31,213],"present":[32],"comparative":[34],"analysis":[35],"aimed":[36],"at":[37],"reconstruction":[38],"molecular":[40],"cascades":[41],"specific":[42],"for":[43,199,223,232,269],"(RS)":[45],"and":[46,59,70,74,84,95,120,129,210,241],"stressinduced":[47],"(SIPS)":[49],"human":[51],"fibroblasts.":[52,243],"RESULTS:":[53],"An":[54],"involvement":[55],"caspase-3/keratin-18":[57],"pathway":[58,65],"serine/threonine":[60],"kinase":[61],"Aurora":[62],"A/":[63],"MDM2":[64],"was":[66,106],"shared":[67],"between":[68],"RS":[69,94,99,189,240],"SIPS.":[71],"Moreover,":[72,141],"stromelysin/MMP3":[73],"N-acetylglucosaminyltransferase":[75],"enzyme":[76],"MGAT1,":[77],"which":[78,167],"initiates":[79],"synthesis":[81],"hybrid":[83],"complex":[85],"Nglycans,":[86],"were":[87],"identified":[88,214],"key":[90],"orchestrating":[91],"components":[92],"SIPS,":[96,124,143],"respectively.":[97],"only,":[100],"Aurora-B":[101,125],"driven":[102],"cell":[103],"cycle":[104],"signaling":[105,126],"deregulated":[107],"concert":[109],"with":[110,203],"suppression":[112],"anabolic":[114],"branches":[115,132],"fatty":[118],"acids":[119],"estrogen":[121],"metabolism.":[122],"is":[127,236,266],"deprioritized,":[128],"synthetic":[131],"cholesterol":[134],"metabolism":[135],"are":[136,163,192],"upregulated,":[137],"rather":[138],"than":[139],"downregulated.":[140],"proteasome/ubiquitin":[144],"ligase":[145],"pathways":[146],"protein":[148],"degradation":[149],"dominate":[150],"regulatory":[152],"landscape.":[153],"This":[154],"picture":[155],"indicates":[156],"that":[157,162,235,249],"SIPS":[158,191,242],"proceeds":[159],"cells":[161],"actively":[164],"fighting":[165],"stress":[166],"facilitates":[168],"premature":[169],"while":[171],"failing":[172],"to":[173],"completely":[174],"activate":[175],"orderly":[177],"program":[178],"RS.":[180],"The":[181,244],"promoters":[182],"genes":[184],"differentially":[185],"expressed":[186],"unusually":[193],"enriched":[194],"by":[195,238],"binding":[197],"sites":[198],"homeobox":[200],"family":[201],"proteins,":[202],"particular":[204],"emphasis":[205],"on":[206],"HMX1,":[207],"IRX2,":[208],"HDX":[209],"HOXC13.":[211],"Additionally,":[212],"Iroquois":[215],"Homeobox":[216],"2":[217],"(IRX2)":[218],"master":[221],"regulator":[222],"secretion":[225],"SPP1-encoded":[227],"osteopontin,":[228],"stromal":[230,257],"driver":[231],"tumor":[233],"growth":[234],"overexpressed":[237],"both":[239],"latter":[245],"supports":[246],"hypothesis":[248],"senescence-specific":[250],"de-repression":[251],"SPP1":[253],"aids":[254],"SIPS-dependent":[256],"activation.":[258],"CONCLUSIONS:":[259],"Reanalysis":[260],"previously":[262],"published":[263],"experimental":[264],"data":[265],"cost-effective":[267],"approach":[268],"extraction":[270],"additional":[272],"insignts":[273],"into":[274],"functioning":[276],"biological":[278],"systems.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-06T00:00:00"}
