{"id":"https://openalex.org/W2561377362","doi":null,"title":"Thyroid Hormone Mediation of T cell Proliferation and Survival; Implications for Hypothyroidism and Hyperthyroidism.","display_name":"Thyroid Hormone Mediation of T cell Proliferation and Survival; Implications for Hypothyroidism and Hyperthyroidism.","publication_year":2016,"publication_date":"2016-08-24","ids":{"openalex":"https://openalex.org/W2561377362","mag":"2561377362"},"language":"en","primary_location":{"id":"pmh:oai:https://spectrum.library.concordia.ca:981530","doi":null,"is_oa":true,"landing_page_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","pdf_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017081082","display_name":"Tanya Babiuk-Henry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tanya Babiuk-Henry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017081082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.8809999823570251},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.925000011920929},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.8700000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5529999732971191},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.703055739402771},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.6989837884902954},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6084693074226379},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5857219099998474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.585599958896637},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4977467358112335},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4655027985572815},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4476383328437805},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4174846112728119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38755157589912415},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37508103251457214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36960703134536743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3689442276954651},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3581206798553467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0924537181854248}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://spectrum.library.concordia.ca:981530","doi":null,"is_oa":true,"landing_page_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","pdf_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2561377362","doi":null,"is_oa":false,"landing_page_url":"https://spectrum.library.concordia.ca/id/eprint/981530/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:https://spectrum.library.concordia.ca:981530","doi":null,"is_oa":true,"landing_page_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","pdf_url":"https://spectrum.library.concordia.ca/981530/1/Babiuk-Henry_MSc_F2016.pdf","source":{"id":"https://openalex.org/S4306400871","display_name":"Spectrum Research Repository (Concordia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60158472","host_organization_name":"Concordia University","host_organization_lineage":["https://openalex.org/I60158472"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2561377362.pdf","grobid_xml":"https://content.openalex.org/works/W2561377362.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W157943544","https://openalex.org/W161326241","https://openalex.org/W575286240","https://openalex.org/W1492370649","https://openalex.org/W1558853803","https://openalex.org/W1601923831","https://openalex.org/W1606138580","https://openalex.org/W1672445637","https://openalex.org/W1963768101","https://openalex.org/W1965252014","https://openalex.org/W1966203663","https://openalex.org/W1966384302","https://openalex.org/W1969025512","https://openalex.org/W1976881265","https://openalex.org/W1978865944","https://openalex.org/W1979920051","https://openalex.org/W1980489432","https://openalex.org/W1980559827","https://openalex.org/W1982111232","https://openalex.org/W1982861164","https://openalex.org/W1983979014","https://openalex.org/W1984273763","https://openalex.org/W1985221982","https://openalex.org/W1986099137","https://openalex.org/W1986788190","https://openalex.org/W1988334089","https://openalex.org/W2000269988","https://openalex.org/W2005929810","https://openalex.org/W2011858504","https://openalex.org/W2012720431","https://openalex.org/W2018663037","https://openalex.org/W2021068750","https://openalex.org/W2021505095","https://openalex.org/W2021597697","https://openalex.org/W2024686567","https://openalex.org/W2026873176","https://openalex.org/W2029098594","https://openalex.org/W2030150321","https://openalex.org/W2031545586","https://openalex.org/W2038884154","https://openalex.org/W2042163502","https://openalex.org/W2042303337","https://openalex.org/W2043177564","https://openalex.org/W2048899027","https://openalex.org/W2051241287","https://openalex.org/W2051687467","https://openalex.org/W2052401940","https://openalex.org/W2053169725","https://openalex.org/W2058935900","https://openalex.org/W2062861616","https://openalex.org/W2063346783","https://openalex.org/W2065738111","https://openalex.org/W2066734610","https://openalex.org/W2069529815","https://openalex.org/W2071596157","https://openalex.org/W2073168934","https://openalex.org/W2073987611","https://openalex.org/W2074305443","https://openalex.org/W2082811829","https://openalex.org/W2083385526","https://openalex.org/W2083592295","https://openalex.org/W2085505738","https://openalex.org/W2088866640","https://openalex.org/W2089388021","https://openalex.org/W2091318799","https://openalex.org/W2095139063","https://openalex.org/W2095406075","https://openalex.org/W2100060388","https://openalex.org/W2102033822","https://openalex.org/W2110344506","https://openalex.org/W2114559477","https://openalex.org/W2115726265","https://openalex.org/W2118978221","https://openalex.org/W2121036968","https://openalex.org/W2130200917","https://openalex.org/W2138421443","https://openalex.org/W2140936682","https://openalex.org/W2141129148","https://openalex.org/W2155534232","https://openalex.org/W2156579478","https://openalex.org/W2159178673","https://openalex.org/W2159788755","https://openalex.org/W2160166542","https://openalex.org/W2162155294","https://openalex.org/W2164369677","https://openalex.org/W2168528745","https://openalex.org/W2169010806","https://openalex.org/W2169482975","https://openalex.org/W2186597857","https://openalex.org/W2230982680","https://openalex.org/W2238305360","https://openalex.org/W2265293024","https://openalex.org/W2269307100","https://openalex.org/W2290271902","https://openalex.org/W2337282293","https://openalex.org/W2337656852","https://openalex.org/W2394693206","https://openalex.org/W2400170620","https://openalex.org/W2402885963","https://openalex.org/W2419614597"],"related_works":["https://openalex.org/W2021245101","https://openalex.org/W2051241287","https://openalex.org/W2070651830","https://openalex.org/W2106272067","https://openalex.org/W2008059559","https://openalex.org/W2269307100","https://openalex.org/W2008122952","https://openalex.org/W3030794695","https://openalex.org/W2324390773","https://openalex.org/W1989056972"],"abstract_inverted_index":{"Hypothyroidism":[0],"and":[1,42,77,85,109,151,162,193,221,239],"hyperthyroidism":[2],"affect":[3,147],"5.9%":[4],"of":[5,10,18,67,79,94,160,165,196,208,227],"Americans":[6],"over":[7,103,132,154],"the":[8,26,38,111,170,191,224,228],"age":[9],"12.":[11],"It":[12],"is":[13],"not":[14,145],"known":[15],"how":[16,219],"dysregulation":[17],"thyroid":[19],"hormones":[20],"such":[21],"as":[22,118,212],"triiodothyronine":[23],"(T3),":[24],"impacts":[25,223],"immune":[27,229],"system.":[28,230],"\\n":[29,182],"\\nA":[30],"laboratory":[31],"model":[32],"system":[33],"was":[34,137],"used":[35],"to":[36,71,96,113,139,169,205],"study":[37],"interactions":[39],"between":[40],"T3":[41,73,95,124,136,166,188,232,243],"T":[43,46,81,129,140,148,173,197,236,250],"cells.":[44],"Jurkat":[45,80],"cells,":[47,82,172],"a":[48,104],"leukemic":[49],"lymphocyte":[50],"cell":[51,83,100,130,141,149,237,251],"line,":[52],"were":[53,89,167],"cultured":[54,171,199],"in":[55,200,247,249],"fetal":[56],"bovine":[57],"serum":[58],"(FBS)":[59],"restricted":[60],"growth":[61],"media":[62,98,203],"containing":[63],"four":[64],"different":[65],"levels":[66,233,244],"T3.":[68],"In":[69],"order":[70],"assess":[72],"activity":[74],"on":[75],"proliferation":[76,131,194],"survival":[78,101,192,238],"staining":[84],"flow":[86],"cytometry-based":[87],"techniques":[88],"used.":[90],"Adding":[91,123],"10":[92,125,163],"\u00b5g/mL":[93,126,164],"culture":[97],"increased":[99,128],"rates":[102,153],"20":[105],"day":[106],"period":[107],"(p<0.05)":[108],"allowed":[110],"cells":[112,174,198],"utilise":[114],"palmitic":[115],"acid":[116],"(PA)":[117],"an":[119],"alternative":[120],"energy":[121],"source.":[122],"significantly":[127,146],"12":[133,155],"days.":[134,156],"While":[135],"essential":[138],"survival,":[142],"it":[143],"did":[144],"apoptosis":[150],"necrosis":[152],"When":[157],"2":[158],"\u00b5M":[159],"PA":[161,179],"added":[168],"survived":[175],"better":[176],"than":[177],"with":[178],"alone":[180],"(p<0.05).":[181],"\\nThe":[183],"data":[184],"collected":[185],"demonstrates":[186],"that":[187],"promotes":[189],"both":[190],"rate":[195],"1%":[201],"FBS":[202],"due":[204],"enhanced":[206],"use":[207],"free":[209],"fatty":[210],"acids":[211],"fuel.":[213],"This":[214],"work":[215],"has":[216],"implications":[217],"for":[218],"hypothyroidism":[220],"hyperthyroidism,":[222],"proper":[225],"functioning":[226],"Low":[231],"could":[234],"decrease":[235],"proliferation,":[240],"while":[241],"high":[242],"may":[245],"result":[246],"changes":[248],"substrate":[252],"utilisation.":[253]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2017-01-06T00:00:00"}