{"id":"https://openalex.org/W2561182005","doi":"https://doi.org/10.1093/nar/gkw1186","title":"PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c","display_name":"PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c","publication_year":2016,"publication_date":"2016-11-25","ids":{"openalex":"https://openalex.org/W2561182005","doi":"https://doi.org/10.1093/nar/gkw1186","mag":"2561182005","pmid":"https://pubmed.ncbi.nlm.nih.gov/27932482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5389558"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkw1186","doi":"https://doi.org/10.1093/nar/gkw1186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw1186","pdf_url":"https://academic.oup.com/nar/article-pdf/45/5/2408/16666868/gkw1186.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/45/5/2408/16666868/gkw1186.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045645676","display_name":"Gang Pan","orcid":"https://orcid.org/0000-0003-4243-1821","observed_orcids":["https://orcid.org/0000-0003-4243-1821"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gang Pan","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088555276","display_name":"Adam Ameur","orcid":"https://orcid.org/0000-0001-6085-6749","observed_orcids":["https://orcid.org/0000-0001-6085-6749"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Adam Ameur","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053703926","display_name":"Stefan Enroth","orcid":"https://orcid.org/0000-0002-5056-9137","observed_orcids":["https://orcid.org/0000-0002-5056-9137"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan Enroth","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000313609","display_name":"Madhusudhan Bysani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Madhusudhan Bysani","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062437810","display_name":"Helena Nord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Helena Nord","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040276109","display_name":"Marco Cavalli","orcid":"https://orcid.org/0000-0003-1143-1431","observed_orcids":["https://orcid.org/0000-0003-1143-1431"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marco Cavalli","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004593392","display_name":"Magnus Essand","orcid":"https://orcid.org/0000-0002-9725-0422","observed_orcids":["https://orcid.org/0000-0002-9725-0422"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Magnus Essand","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025350717","display_name":"Ulf B Gyllensten","orcid":"https://orcid.org/0000-0002-6316-3355","observed_orcids":["https://orcid.org/0000-0002-6316-3355"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf Gyllensten","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066763304","display_name":"Claes Wadelius","orcid":"https://orcid.org/0000-0002-2033-7829","observed_orcids":["https://orcid.org/0000-0002-2033-7829"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Claes Wadelius","raw_affiliation_strings":["Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75237, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066763304"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.5365,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.81439555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"5","first_page":"2408","last_page":"2422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2694999873638153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patz1","display_name":"PATZ1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fads1","display_name":"FADS1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fads2","display_name":"FADS2","score":0.9139999747276306},{"id":"https://openalex.org/keywords/alu-elements","display_name":"Alu elements","score":0.5509999990463257},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.5740000009536743},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":1.0},{"id":"https://openalex.org/keywords/enhancer-activity","display_name":"enhancer activity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/long-chain-polyunsaturated-fatty-acids","display_name":"long-chain polyunsaturated fatty acids","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/allele-specific-regulation","display_name":"allele-specific regulation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/intron-1","display_name":"intron 1","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9143713712692261},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6210822463035583},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5126904249191284},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.49769166111946106},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4879316985607147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40666913986206055}],"mesh":[{"descriptor_ui":"D000090943","descriptor_name":"Delta-5 Fatty Acid Desaturase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020087","descriptor_name":"Alu Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044943","descriptor_name":"Fatty Acid Desaturases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051780","descriptor_name":"Sterol Regulatory Element Binding Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkw1186","doi":"https://doi.org/10.1093/nar/gkw1186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw1186","pdf_url":"https://academic.oup.com/nar/article-pdf/45/5/2408/16666868/gkw1186.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4248952","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5389558","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27932482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27932482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5389558","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5389558/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gkw1186","doi":"https://doi.org/10.1093/nar/gkw1186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkw1186","pdf_url":"https://academic.oup.com/nar/article-pdf/45/5/2408/16666868/gkw1186.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6274399334","display_name":null,"funder_award_id":"521-2010-3505","funder_id":"https://openalex.org/F4320324119","funder_display_name":"Uppsala Universitet"},{"id":"https://openalex.org/G6416999858","display_name":null,"funder_award_id":"621-2011-6052","funder_id":"https://openalex.org/F4320324119","funder_display_name":"Uppsala Universitet"}],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":"https://ror.org/0554ckj21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2561182005.pdf","grobid_xml":"https://content.openalex.org/works/W2561182005.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W14343093","https://openalex.org/W1574460558","https://openalex.org/W1964733653","https://openalex.org/W1969465720","https://openalex.org/W1988681882","https://openalex.org/W1989568128","https://openalex.org/W1989590412","https://openalex.org/W1992911777","https://openalex.org/W2002122781","https://openalex.org/W2006141598","https://openalex.org/W2009718837","https://openalex.org/W2022993325","https://openalex.org/W2042560956","https://openalex.org/W2043842514","https://openalex.org/W2044926535","https://openalex.org/W2045102835","https://openalex.org/W2047155548","https://openalex.org/W2051541780","https://openalex.org/W2056799556","https://openalex.org/W2058598374","https://openalex.org/W2060082192","https://openalex.org/W2060593129","https://openalex.org/W2061240655","https://openalex.org/W2070496049","https://openalex.org/W2072000048","https://openalex.org/W2078290510","https://openalex.org/W2082004242","https://openalex.org/W2089555306","https://openalex.org/W2094020735","https://openalex.org/W2095595424","https://openalex.org/W2096325702","https://openalex.org/W2097695579","https://openalex.org/W2098132849","https://openalex.org/W2098323244","https://openalex.org/W2103755866","https://openalex.org/W2104549677","https://openalex.org/W2106779017","https://openalex.org/W2118295070","https://openalex.org/W2124756504","https://openalex.org/W2128476271","https://openalex.org/W2138904934","https://openalex.org/W2143625465","https://openalex.org/W2145820796","https://openalex.org/W2149243265","https://openalex.org/W2159228663","https://openalex.org/W2163722216","https://openalex.org/W2164339823","https://openalex.org/W2166711199","https://openalex.org/W2167541774","https://openalex.org/W2169718193","https://openalex.org/W2170504439","https://openalex.org/W2172146316","https://openalex.org/W2177180777","https://openalex.org/W2259938310","https://openalex.org/W2317934215"],"related_works":["https://openalex.org/W2885854004","https://openalex.org/W2795137662","https://openalex.org/W1521788365","https://openalex.org/W2087246553","https://openalex.org/W2141964702","https://openalex.org/W2052431418","https://openalex.org/W1964284218","https://openalex.org/W2045102835","https://openalex.org/W642930808","https://openalex.org/W7214751848"],"abstract_inverted_index":{"The":[0,86,111,120],"FADS1":[1,76],"and":[2,36,79,127,133],"FADS2":[3],"genes":[4],"in":[5,13,24,44,68,72,96],"the":[6,10,14,49,64,93,124,128,136],"FADS":[7],"cluster":[8],"encode":[9],"rate-limiting":[11],"enzymes":[12],"synthesis":[15],"of":[16,34,39,46,75,89,101,109,131,139,145],"long-chain":[17],"polyunsaturated":[18],"fatty":[19],"acids":[20],"(LC-PUFAs).":[21],"Genetic":[22],"variation":[23],"this":[25,140],"region":[26],"has":[27],"been":[28,58],"associated":[29],"with":[30,116],"a":[31,82,103,117],"large":[32],"number":[33],"diseases":[35],"traits":[37],"many":[38],"them":[40],"correlated":[41],"to":[42,53],"differences":[43],"metabolism":[45],"PUFAs.":[47],"However,":[48],"causative":[50],"variants":[51],"leading":[52],"these":[54],"associations":[55],"have":[56],"not":[57],"identified.":[59],"Here":[60],"we":[61],"find":[62],"that":[63],"multiallelic":[65],"rs174557":[66],"located":[67],"an":[69],"AluYe5":[70],"element":[71],"intron":[73],"1":[74],"is":[77,92],"functional":[78],"lies":[80],"within":[81],"PATZ1":[83,112,126],"binding":[84,100,113,122],"site.":[85,119],"derived":[87],"allele":[88],"rs174557,":[90],"which":[91,142],"common":[94],"variant":[95],"most":[97],"populations,":[98],"diminishes":[99],"PATZ1,":[102],"transcription":[104],"factor":[105],"conferring":[106],"allele-specific":[107],"downregulation":[108],"FADS1.":[110,146],"site":[114],"overlaps":[115],"SP1":[118,132],"competitive":[121],"between":[123],"suppressive":[125],"activating":[129],"complex":[130],"SREBP1c":[134],"determines":[135],"enhancer":[137],"activity":[138],"region,":[141],"regulates":[143],"expression":[144]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-01-06T00:00:00"}
