{"id":"https://openalex.org/W2561042858","doi":"https://doi.org/10.1038/nrclinonc.2016.191","title":"Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer","display_name":"Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer","publication_year":2016,"publication_date":"2016-12-13","ids":{"openalex":"https://openalex.org/W2561042858","doi":"https://doi.org/10.1038/nrclinonc.2016.191","mag":"2561042858","pmid":"https://pubmed.ncbi.nlm.nih.gov/27958297"},"language":"en","primary_location":{"id":"doi:10.1038/nrclinonc.2016.191","doi":"https://doi.org/10.1038/nrclinonc.2016.191","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrclinonc.2016.191","pdf_url":null,"source":{"id":"https://openalex.org/S41981144","display_name":"Nature Reviews Clinical Oncology","issn_l":"1759-4774","issn":["1759-4774","1759-4782"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007424793","display_name":"Angela Joy George","orcid":"https://orcid.org/0000-0002-4295-7287","observed_orcids":["https://orcid.org/0000-0002-4295-7287"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela George","raw_affiliation_strings":["Cancer Genetics Unit, The Royal Marsden NHS Foundation, Fulham Road, London, SW3 6JJ, UK","Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics Unit, The Royal Marsden NHS Foundation, Fulham Road, London, SW3 6JJ, UK","institution_ids":["https://openalex.org/I1325846038"]},{"raw_affiliation_string":"Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014804968","display_name":"Stan B. Kaye","orcid":"https://orcid.org/0000-0003-3318-8575","observed_orcids":["https://orcid.org/0000-0003-3318-8575"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stan Kaye","raw_affiliation_strings":["Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065447416","display_name":"Susana N. Banerjee","orcid":"https://orcid.org/0000-0002-8840-7934","observed_orcids":["https://orcid.org/0000-0002-8840-7934"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Susana Banerjee","raw_affiliation_strings":["Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynaecology Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065447416"],"corresponding_institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"],"apc_list":null,"apc_paid":null,"fwci":2.1963,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.93184713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"5","first_page":"284","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/brca-mutation-testing","display_name":"BRCA mutation testing","score":0.871999979019165},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":1.0},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/homologous-recombination-deficiency","display_name":"homologous recombination deficiency","score":0.8859999775886536},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9810000061988831},{"id":"https://openalex.org/keywords/routine-cancer-care","display_name":"routine cancer care","score":0.47600001096725464},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9256993532180786},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.8915526866912842},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.886069118976593},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8475619554519653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6743600368499756},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5999528169631958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5336984395980835},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5111823678016663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43855413794517517},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4179856777191162},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4113515019416809},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3332393765449524},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.32658326625823975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17163383960723877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16800609230995178},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.16240182518959045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrclinonc.2016.191","doi":"https://doi.org/10.1038/nrclinonc.2016.191","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrclinonc.2016.191","pdf_url":null,"source":{"id":"https://openalex.org/S41981144","display_name":"Nature Reviews Clinical Oncology","issn_l":"1759-4774","issn":["1759-4774","1759-4782"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:27958297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27958297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W152086510","https://openalex.org/W754073086","https://openalex.org/W1564539641","https://openalex.org/W1606013786","https://openalex.org/W1898580708","https://openalex.org/W1965006127","https://openalex.org/W1967576773","https://openalex.org/W1973268287","https://openalex.org/W1980713899","https://openalex.org/W1989991921","https://openalex.org/W1992397774","https://openalex.org/W1993119044","https://openalex.org/W1994948218","https://openalex.org/W1996931025","https://openalex.org/W1999659306","https://openalex.org/W2000197817","https://openalex.org/W2002419036","https://openalex.org/W2002962154","https://openalex.org/W2005463423","https://openalex.org/W2009007206","https://openalex.org/W2015360671","https://openalex.org/W2015788609","https://openalex.org/W2025402387","https://openalex.org/W2025460005","https://openalex.org/W2033816200","https://openalex.org/W2044202291","https://openalex.org/W2045153367","https://openalex.org/W2054367725","https://openalex.org/W2057750876","https://openalex.org/W2065849886","https://openalex.org/W2070953479","https://openalex.org/W2073569331","https://openalex.org/W2073931597","https://openalex.org/W2084563311","https://openalex.org/W2086038769","https://openalex.org/W2086531857","https://openalex.org/W2089617691","https://openalex.org/W2094666871","https://openalex.org/W2094929011","https://openalex.org/W2096250359","https://openalex.org/W2098024955","https://openalex.org/W2098737737","https://openalex.org/W2101474154","https://openalex.org/W2102004732","https://openalex.org/W2103105022","https://openalex.org/W2103359718","https://openalex.org/W2105455398","https://openalex.org/W2106059513","https://openalex.org/W2106157865","https://openalex.org/W2110017381","https://openalex.org/W2111437716","https://openalex.org/W2111488265","https://openalex.org/W2112788544","https://openalex.org/W2117177285","https://openalex.org/W2117964602","https://openalex.org/W2123113463","https://openalex.org/W2124322375","https://openalex.org/W2124818930","https://openalex.org/W2126170418","https://openalex.org/W2130078242","https://openalex.org/W2133349572","https://openalex.org/W2135195813","https://openalex.org/W2135525536","https://openalex.org/W2137755195","https://openalex.org/W2142795777","https://openalex.org/W2147057518","https://openalex.org/W2147071985","https://openalex.org/W2151058376","https://openalex.org/W2151509048","https://openalex.org/W2160466424","https://openalex.org/W2163294504","https://openalex.org/W2164912823","https://openalex.org/W2167692560","https://openalex.org/W2168880218","https://openalex.org/W2171972386","https://openalex.org/W2173456459","https://openalex.org/W2179105349","https://openalex.org/W2199466904","https://openalex.org/W2216554257","https://openalex.org/W2221469903","https://openalex.org/W2224210111","https://openalex.org/W2263569243","https://openalex.org/W2270704840","https://openalex.org/W2289123598","https://openalex.org/W2289386828","https://openalex.org/W2294633761","https://openalex.org/W2335929230","https://openalex.org/W2338636771","https://openalex.org/W2344901254","https://openalex.org/W2345701447","https://openalex.org/W2379130638","https://openalex.org/W2403024681","https://openalex.org/W2461925062","https://openalex.org/W2463058287","https://openalex.org/W2471243592","https://openalex.org/W2528228811","https://openalex.org/W2530008699","https://openalex.org/W2601189063","https://openalex.org/W2737281927"],"related_works":["https://openalex.org/W2345680184","https://openalex.org/W2756379789","https://openalex.org/W2462544565","https://openalex.org/W2398878382","https://openalex.org/W3117058342","https://openalex.org/W2553749402","https://openalex.org/W2959185631","https://openalex.org/W3069478358","https://openalex.org/W2332185934","https://openalex.org/W4392634153"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-01-06T00:00:00"}
