{"id":"https://openalex.org/W2560926178","doi":"https://doi.org/10.1055/s-0036-1596114","title":"Strebloside, a Constituent of Streblus asper with Antineoplastic Activity","display_name":"Strebloside, a Constituent of Streblus asper with Antineoplastic Activity","publication_year":2016,"publication_date":"2016-12-14","ids":{"openalex":"https://openalex.org/W2560926178","doi":"https://doi.org/10.1055/s-0036-1596114","mag":"2560926178"},"language":"en","primary_location":{"id":"doi:10.1055/s-0036-1596114","doi":"https://doi.org/10.1055/s-0036-1596114","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0036-1596114","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013002429","display_name":"Alan Douglas Kinghorn","orcid":"https://orcid.org/0000-0002-6647-8707","observed_orcids":["https://orcid.org/0000-0002-6647-8707"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AD Kinghorn","raw_affiliation_strings":["Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046786261","display_name":"Yulin Ren","orcid":"https://orcid.org/0000-0003-3667-1466","observed_orcids":["https://orcid.org/0000-0003-3667-1466"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Ren","raw_affiliation_strings":["Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046574721","display_name":"WL Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WL Chen","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075893550","display_name":"DD Lantvit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DD Lantvit","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110461049","display_name":"Tran Ngoc Ninh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280772","display_name":"Vi\u1ec7n Sinh th\u00e1i v\u00e0 T\u00e0i nguy\u00ean sinh v\u1eadt","ror":"https://ror.org/03dth0f39","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4405276878","https://openalex.org/I4405280772","https://openalex.org/I70349855"]},{"id":"https://openalex.org/I70349855","display_name":"Vietnam Academy of Science and Technology","ror":"https://ror.org/02wsd5p50","country_code":"VN","type":"government","lineage":["https://openalex.org/I70349855"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"T Ngoc Ninh","raw_affiliation_strings":["Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam","institution_ids":["https://openalex.org/I4405280772","https://openalex.org/I70349855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112067320","display_name":"EJ Sass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EJ Sass","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110332740","display_name":"HB Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HB Chai","raw_affiliation_strings":["Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037891039","display_name":"X Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Zhang","raw_affiliation_strings":["Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108387280","display_name":"Djaja Doel Soejarto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802093357","display_name":"Field Museum of Natural History","ror":"https://ror.org/00mh9zx15","country_code":"US","type":"archive","lineage":["https://openalex.org/I2802093357"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DD Soejarto","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","Science and Education, Field Museum of Natural History, Chicago, IL 60605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Science and Education, Field Museum of Natural History, Chicago, IL 60605, USA","institution_ids":["https://openalex.org/I2802093357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103532728","display_name":"David M Lucas","orcid":"https://orcid.org/0000-0001-8201-0808","observed_orcids":["https://orcid.org/0000-0001-8201-0808"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DM Lucas","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089702500","display_name":"SM Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SM Swanson","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085056534","display_name":"JE Burdette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JE Burdette","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10993115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"S 01","first_page":"S1","last_page":"S381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streblus-asper","display_name":"Streblus asper","score":1.0},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5329999923706055},{"id":"https://openalex.org/keywords/g2-cell-cycle-arrest","display_name":"G2 cell cycle arrest","score":0.8109999895095825},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9850000143051147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.6200000047683716},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5860000252723694},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/moraceae","display_name":"Moraceae","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2780255822","wikidata":"https://www.wikidata.org/wiki/Q156579","display_name":"Moraceae","level":2,"score":0.8966494798660278},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7696166634559631},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5610644817352295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5504199862480164},{"id":"https://openalex.org/C2779362140","wikidata":"https://www.wikidata.org/wiki/Q1938846","display_name":"Ficus","level":2,"score":0.5352901220321655},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5250415802001953},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.47121018171310425},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37842634320259094},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3593817353248596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25188934803009033},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.24670878052711487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17386507987976074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0036-1596114","doi":"https://doi.org/10.1055/s-0036-1596114","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0036-1596114","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2562294901","https://openalex.org/W2333908046","https://openalex.org/W4281557761","https://openalex.org/W2016622542","https://openalex.org/W7148478786","https://openalex.org/W2090692735","https://openalex.org/W4285058522","https://openalex.org/W2017585303","https://openalex.org/W2316340464","https://openalex.org/W4390814126"],"abstract_inverted_index":{"Moraceae":[0],"is":[1,27],"a":[2,45,53,208],"family":[3],"of":[4,13,56,60,116,124,240,254],"flowering":[5],"plants":[6],"distributed":[7],"in":[8,64,207,210,236,276],"tropical":[9],"and":[10,30,84,86,92,105,166,198,272],"subtropical":[11],"regions,":[12],"which":[14],"the":[15,57,73,160,194,241,266,270],"genus":[16],"Streblus":[17,24],"contains":[18],"about":[19],"25":[20],"species":[21,42],"[1].":[22],",":[23],"asper":[25,62],"Lour.":[26],"used":[28],"medicinally,":[29],"several":[31],"cardiac":[32,94],"glycosides":[33,95],"have":[34],"been":[35],"characterized":[36],"as":[37,258],"cytotoxic":[38,71,192],"components":[39],"from":[40,50,98,111],"this":[41,99],"[2,3].":[43],"In":[44],"search":[46],"for":[47,156],"anticancer":[48],"agents":[49],"higher":[51],"plants,":[52],"chloroform-soluble":[54],"extract":[55],"stem":[58],"bark":[59],"S.":[61],"collected":[63],"Vietnam":[65],"was":[66,172,190,282],"found":[67,131,173],"to":[68,132,174],"be":[69,133,175],"highly":[70,176],"toward":[72,159,182],"HT-29":[74,137],"human":[75,144,161,184,196,200],"colon":[76,145],"cancer":[77,202],"cell":[78,169,203,218,228,256,263,267],"line.":[79],"Three":[80],"new":[81,104],"(3'-demethylkamaloside,":[82],"19-hydroxykamaloside,":[83],"6'-hydroxykamaloside)":[85],"two":[87,106,217],"known":[88,107],"(3-":[89],"O":[90],"-\u03b2-D-fucopyranosylperiplogenin":[91],"strebloside)":[93],"were":[96,120],"isolated":[97],"plant":[100],"sample,":[101],"with":[102,128,231],"six":[103],"analogues":[108],"being":[109],"synthesized":[110],"strebloside":[112,147,171,220,248],"[4].":[113],"The":[114],"structures":[115],"all":[117,129],"compounds":[118],"obtained":[119],"determined":[121],"by":[122,260,284,292],"analysis":[123],"their":[125],"spectroscopic":[126],"data,":[127],"isolates":[130],"potently":[134],"active":[135],"against":[136,141,193,215],"cells.":[138,188,278],"When":[139,205],"tested":[140],"CCD-112CoN":[142],"normal":[143,183],"cells,":[146],"did":[148],"not":[149],"show":[150],"any":[151,239],"discernible":[152],"activity.":[153],"On":[154],"evaluation":[155],"its":[157,250,261],"cytotoxicity":[158,251],"MV4":[162],"\u2013":[163],"11,":[164],"THP-1,":[165],"Kasumi-1":[167],"leukemia":[168],"lines,":[170,219],"cytotoxic,":[177],"but":[178],"showed":[179,226,246],"little":[180],"toxicity":[181],"peripheral":[185],"blood":[186],"mononuclear":[187],"Strebloside":[189],"also":[191],"MDA-MB-231":[195],"breast":[197],"OVCAR3":[199,277],"ovarian":[201],"lines.":[204],"evaluated":[206],"murine":[209],"vivo":[211],"hollow":[212],"fiber":[213],"assay":[214],"these":[216],"(ip,":[221],"5":[222],"mg/kg/day,":[223],"four":[224],"days)":[225],"significant":[227],"growth":[229],"inhibition,":[230],"no":[232],"side":[233],"effects":[234],"observed":[235],"mice":[237],"at":[238,269],"doses":[242],"used.":[243],"Mechanistic":[244],"studies":[245],"that":[247],"mediates":[249],"through":[252,265],"induction":[253],"tumor":[255],"apoptosis,":[257],"indicated":[259],"blocking":[262],"progression":[264],"cycle":[268],"G2-phase":[271],"inducing":[273],"PARP":[274],"cleavage":[275],"Acknowledgements:":[279],"This":[280],"work":[281],"supported":[283],"program":[285],"project":[286],"grant":[287],"P01":[288],"CA":[289],"125066":[290],"funded":[291],"NCI,":[293],"NIH,":[294],"Bethesda,":[295],"MD,":[296],"USA.":[297]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2017-01-06T00:00:00"}
