{"id":"https://openalex.org/W2560722154","doi":"https://doi.org/10.1182/blood.v118.21.2327.2327","title":"Transfusion of Stored Autologous Blood Alters Reactive Hyperemia and Circulating Nitrite Levels in Healthy Volunteers","display_name":"Transfusion of Stored Autologous Blood Alters Reactive Hyperemia and Circulating Nitrite Levels in Healthy Volunteers","publication_year":2011,"publication_date":"2011-11-18","ids":{"openalex":"https://openalex.org/W2560722154","doi":"https://doi.org/10.1182/blood.v118.21.2327.2327","mag":"2560722154"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v118.21.2327.2327","doi":"https://doi.org/10.1182/blood.v118.21.2327.2327","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2327.2327","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079746187","display_name":"Lorenzo M. Berra","orcid":"https://orcid.org/0000-0003-2702-2093","observed_orcids":["https://orcid.org/0000-0003-2702-2093"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorenzo Berra","raw_affiliation_strings":["Anesthesia, MGH, Boston, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia, MGH, Boston, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065966636","display_name":"Sunny Dzik","orcid":"https://orcid.org/0000-0003-3844-4371","observed_orcids":["https://orcid.org/0000-0003-3844-4371"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Sunny Dzik","raw_affiliation_strings":["Harvard University, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University, Boston, MA, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053981133","display_name":"Andrea Coppadoro","orcid":"https://orcid.org/0000-0003-1759-4071","observed_orcids":["https://orcid.org/0000-0003-1759-4071"]},"institutions":[{"id":"https://openalex.org/I158133745","display_name":"MGH Institute of Health Professions","ror":"https://ror.org/037msyf12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I158133745"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Coppadoro","raw_affiliation_strings":["MGH, Boston, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH, Boston, USA,","institution_ids":["https://openalex.org/I158133745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101301","display_name":"Kenneth D. Bloch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth D. Bloch","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004313751","display_name":"Binglan Yu","orcid":"https://orcid.org/0000-0001-5496-2131","observed_orcids":["https://orcid.org/0000-0001-5496-2131"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Binglan Yu","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060759357","display_name":"Ester Spagnolli","orcid":"https://orcid.org/0000-0002-3687-2113","observed_orcids":["https://orcid.org/0000-0002-3687-2113"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ester Spagnolli","raw_affiliation_strings":["Anesthesia, MGH, Boston, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia, MGH, Boston, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054777906","display_name":"Andrea Ulrike Steinbicker","orcid":"https://orcid.org/0000-0002-5237-961X","observed_orcids":["https://orcid.org/0000-0002-5237-961X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea U. Steinbicker","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036280404","display_name":"Martin Feelisch","orcid":"https://orcid.org/0000-0003-2320-1158","observed_orcids":["https://orcid.org/0000-0003-2320-1158"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin Feelisch","raw_affiliation_strings":["University of Warwick Medical School, Coventry, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warwick Medical School, Coventry, United Kingdom,","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050463541","display_name":"Bernadette O. Fernandez","orcid":"https://orcid.org/0000-0001-6337-0381","observed_orcids":["https://orcid.org/0000-0001-6337-0381"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Bernadette Fernandez","raw_affiliation_strings":["University of Warwick Medical School, Warwick, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warwick Medical School, Warwick, United Kingdom,","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058609949","display_name":"Christopher P. Stowell","orcid":"https://orcid.org/0000-0003-1548-6085","observed_orcids":["https://orcid.org/0000-0003-1548-6085"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher Stowell","raw_affiliation_strings":["Pathology, MGH, Boston, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, MGH, Boston, USA,","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113673942","display_name":"Shaw H. Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaw H Warren","raw_affiliation_strings":["Pediatrics, MGH, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, MGH, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tian Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tian Lin","raw_affiliation_strings":["Pediatrics, MGH, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, MGH, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073059702","display_name":"Warren M. Zapol","orcid":"https://orcid.org/0000-0002-0359-3660","observed_orcids":["https://orcid.org/0000-0002-0359-3660"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Warren M. Zapol","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004313751","https://openalex.org/A5036280404","https://openalex.org/A5050463541","https://openalex.org/A5053981133","https://openalex.org/A5054777906","https://openalex.org/A5058609949","https://openalex.org/A5060759357","https://openalex.org/A5073059702","https://openalex.org/A5079746187","https://openalex.org/A5109101301","https://openalex.org/A5113673942"],"corresponding_institution_ids":["https://openalex.org/I158133745","https://openalex.org/I39555362","https://openalex.org/I4210087915"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35340282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"118","issue":"21","first_page":"2327","last_page":"2327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stored-red-blood-cells","display_name":"stored red blood cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/autologous-blood-transfusion","display_name":"autologous blood transfusion","score":0.9039999842643738},{"id":"https://openalex.org/keywords/reactive-hyperemia-index","display_name":"reactive hyperemia index","score":0.843999981880188},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nitric-oxide-scavenging","display_name":"nitric oxide scavenging","score":0.9620000123977661},{"id":"https://openalex.org/keywords/free-hemoglobin","display_name":"free hemoglobin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/red-blood-cell-storage-lesion","display_name":"red blood cell storage lesion","score":0.675000011920929},{"id":"https://openalex.org/keywords/reactive-hyperemia","display_name":"reactive hyperemia","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7605796456336975},{"id":"https://openalex.org/C2780920261","wikidata":"https://www.wikidata.org/wiki/Q1363810","display_name":"Packed red blood cells","level":3,"score":0.5789610743522644},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5782958269119263},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5690754652023315},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.5622861385345459},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5193106532096863},{"id":"https://openalex.org/C2776768635","wikidata":"https://www.wikidata.org/wiki/Q3427301","display_name":"Volunteer","level":2,"score":0.5172163248062134},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5145189166069031},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.4558814764022827},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30678701400756836},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2829161286354065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27294260263442993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08763113617897034},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v118.21.2327.2327","doi":"https://doi.org/10.1182/blood.v118.21.2327.2327","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v118.21.2327.2327","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999665276","https://openalex.org/W1627054669","https://openalex.org/W2105367624","https://openalex.org/W2345624085","https://openalex.org/W2595866329","https://openalex.org/W1983210318","https://openalex.org/W4235162707","https://openalex.org/W7098326480","https://openalex.org/W2529966809","https://openalex.org/W2432687561"],"abstract_inverted_index":{"Abstract":[0,1],"2327":[2],"Background:":[3],"Transfusion":[4,208],"of":[5,51,81,85,133,152,165,194,202,209,252,256],"human":[6],"blood":[7,24,173,318],"stored":[8,53,87,139,157,196,204,212],"for":[9,54,213,311],"over":[10],"2":[11,116],"weeks":[12],"is":[13,216],"associated":[14,217],"with":[15,218],"increased":[16,191,219],"mortality":[17],"and":[18,58,83,102,111,118,145,160,182,221,263,266,301,317],"morbidity.":[19],"During":[20],"storage,":[21],"packed":[22],"red":[23],"cells":[25],"(PRBC)":[26],"progressively":[27],"release":[28],"hemoglobin,":[29],"which":[30],"avidly":[31],"binds":[32],"nitric":[33,289,315],"oxide":[34,290,316],"(NO).":[35],"We":[36,60],"hypothesized":[37],"that":[38],"the":[39,74,179,185,250],"NO":[40,228],"mediated":[41],"hyperemic":[42],"response":[43],"following":[44],"ischemia":[45],"would":[46],"be":[47,269],"reduced":[48,222],"after":[49,121,131,150,155,192,200],"transfusion":[50,132,151,193,201],"PRBC":[52,140,158,205,211],"40":[55,214],"days.":[56],"Methods":[57],"results:":[59],"conducted":[61],"a":[62,97],"cross-over":[63],"randomized":[64],"interventional":[65],"study,":[66],"enrolling":[67],"ten":[68],"healthy":[69],"adults.":[70],"Nine":[71],"volunteers":[72],"completed":[73],"study.":[75],"Each":[76],"volunteer":[77],"received":[78],"one":[79,84],"unit":[80],"40-day":[82,134,153,195],"3-day":[86,138,156,203],"autologous":[88,210],"leukoreduced":[89],"PRBC,":[90,197],"on":[91,287,313],"different":[92],"study":[93],"days":[94,215],"according":[95],"to":[96,137,226,249,259,271,296],"randomization":[98],"scheme.":[99],"Blood":[100],"withdrawal":[101],"reactive":[103],"hyperemia":[104],"index":[105],"(RHI)":[106],"measurements":[107],"were":[108,148],"performed":[109],"before":[110],"10":[112],"minutes,":[113],"1":[114],"hour,":[115],"hours,":[117],"4":[119],"hours":[120],"transfusion.":[122],"The":[123,241],"RHI":[124],"was":[125],"lower":[126],"(13%":[127],"mean":[128],"post-transfusion":[129],"difference)":[130],"as":[135,170,172],"compared":[136],"(p=0.01).":[141,206],"Plasma":[142,163,188],"cell-free":[143,231],"hemoglobin":[144],"bilirubin":[146],"levels":[147,164],"higher":[149],"than":[154],"(p=0.02":[159],"0.001,":[161],"respectively).":[162],"potassium,":[166],"LDH,":[167],"haptoglobin,":[168],"cytokines,":[169],"well":[171],"pressure,":[174],"did":[175],"not":[176,199],"differ":[177],"between":[178],"two":[180],"transfusions":[181],"remained":[183],"within":[184],"normal":[186],"range.":[187],"nitrite":[189],"concentrations":[190],"but":[198],"Conclusions:":[207],"hemolysis":[220],"RHI,":[223],"possibly":[224],"due":[225],"enhanced":[227],"scavenging":[229],"by":[230,292],"oxyhemoglobin.":[232],"Disclosures:":[233],"Bloch:":[234],"Massachusetts":[235,242,293],"General":[236,243,275,294],"Hospital:":[237,276],"Patents":[238,277,320],"&":[239,278,321],"Royalties,":[240],"Hospital":[244,295],"has":[245,309],"filed":[246],"patents":[247,286,312],"related":[248],"use":[251],"small":[253],"molecule":[254],"inhibitors":[255],"BMP":[257],"signaling":[258],"modulate":[260],"iron":[261],"metabolism,":[262],"PBY,":[264],"RTP":[265],"KDB":[267],"may":[268],"eligible":[270],"receive":[272],"royalties.":[273],"Yu:Massachusetts":[274],"Royalties.":[279,322],"Zapol:Dr.":[280],"Warren":[281],"Zapol":[282,308],"receives":[283],"royalties":[284],"from":[285],"inhaled":[288,314],"licensed":[291],"Linde":[297],"Corp,":[298,303],"Munich,":[299],"Germany,":[300],"Ikaria":[302],"Clinton,":[304],"New":[305],"Jersey.":[306],"Dr.":[307],"applied":[310],"t:":[319]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-12-16T00:00:00"}
