{"id":"https://openalex.org/W2560639677","doi":"https://doi.org/10.1038/npjmgrav.2016.40","title":"Towards human exploration of space: The THESEUS review series on immunology research priorities","display_name":"Towards human exploration of space: The THESEUS review series on immunology research priorities","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2560639677","doi":"https://doi.org/10.1038/npjmgrav.2016.40","mag":"2560639677","pmid":"https://pubmed.ncbi.nlm.nih.gov/28725745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5515533"},"language":"en","primary_location":{"id":"doi:10.1038/npjmgrav.2016.40","doi":"https://doi.org/10.1038/npjmgrav.2016.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npjmgrav.2016.40","pdf_url":"https://www.nature.com/articles/npjmgrav201640.pdf","source":{"id":"https://openalex.org/S4210211936","display_name":"npj Microgravity","issn_l":"2373-8065","issn":["2373-8065"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Microgravity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/npjmgrav201640.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039276492","display_name":"Jean\u2010Pol Frippiat","orcid":"https://orcid.org/0000-0002-4027-6269","observed_orcids":["https://orcid.org/0000-0002-4027-6269"]},"institutions":[{"id":"https://openalex.org/I4387154726","display_name":"Stress, IMmunit\u00e9, PAthog\u00e8nes","ror":"https://ror.org/04f50n919","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Pol Frippiat","raw_affiliation_strings":["Stress Immunity Pathogens Laboratory, EA7300, Lorraine University, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stress Immunity Pathogens Laboratory, EA7300, Lorraine University, Nancy, France","institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045172445","display_name":"Brian E. Crucian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian E Crucian","raw_affiliation_strings":["NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012680905","display_name":"Dominique J.\u2010F. de Quervain","orcid":"https://orcid.org/0000-0001-7131-2464","observed_orcids":["https://orcid.org/0000-0001-7131-2464"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominique J-F de Quervain","raw_affiliation_strings":["Departments of Medicine and Psychology, University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Psychology, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082120013","display_name":"Daniela G. Grimm","orcid":"https://orcid.org/0000-0002-4991-3105","observed_orcids":["https://orcid.org/0000-0002-4991-3105"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Daniela Grimm","raw_affiliation_strings":["Department of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034940672","display_name":"Nicola Montano","orcid":"https://orcid.org/0000-0001-9206-0075","observed_orcids":["https://orcid.org/0000-0001-9206-0075"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Montano","raw_affiliation_strings":["Cardiovascular Neuroscience Laboratory, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy","Department of Biomedical and Clinical Sciences, Cardiovascular Neuroscience Laboratory, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Neuroscience Laboratory, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences, Cardiovascular Neuroscience Laboratory, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022650058","display_name":"Siegfried Praun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siegfried Praun","raw_affiliation_strings":["VF Services GmbH, Absam, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VF Services GmbH, Absam, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033686591","display_name":"Benno Roozendaal","orcid":"https://orcid.org/0000-0001-7013-2111","observed_orcids":["https://orcid.org/0000-0001-7013-2111"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Benno Roozendaal","raw_affiliation_strings":["Department of Cognitive Neuroscience, Radboud University Medical Centre and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Neuroscience, Radboud University Medical Centre and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405261313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013277891","display_name":"Gustav Schelling","orcid":"https://orcid.org/0000-0002-6538-0652","observed_orcids":["https://orcid.org/0000-0002-6538-0652"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gustav Schelling","raw_affiliation_strings":["Department of Anaesthesiology, 'Stress and Immunity' Laboratory, University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, 'Stress and Immunity' Laboratory, University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110747897","display_name":"Manfred Thiel","orcid":"https://orcid.org/0000-0002-6267-4380","observed_orcids":["https://orcid.org/0000-0002-6267-4380"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Thiel","raw_affiliation_strings":["Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102897730","display_name":"Oliver Ullrich","orcid":"https://orcid.org/0000-0002-4721-1038","observed_orcids":["https://orcid.org/0000-0002-4721-1038"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Oliver Ullrich","raw_affiliation_strings":["Institute of Anatomy, Faculty of Medicine, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Faculty of Medicine, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085612736","display_name":"Alexander Chouk\u00e8r","orcid":"https://orcid.org/0000-0002-0133-4104","observed_orcids":["https://orcid.org/0000-0002-0133-4104"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Chouk\u00e8r","raw_affiliation_strings":["Department of Anaesthesiology, 'Stress and Immunity' Laboratory, University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, 'Stress and Immunity' Laboratory, University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5039276492"],"corresponding_institution_ids":["https://openalex.org/I4387154726","https://openalex.org/I90183372"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.2984,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.78657617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"16040","last_page":"16040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/human-space-exploration","display_name":"human space exploration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/international-space-station-crew","display_name":"International Space Station crew","score":0.5770000219345093},{"id":"https://openalex.org/keywords/countermeasures","display_name":"countermeasures","score":0.656000018119812},{"id":"https://openalex.org/keywords/research-priorities","display_name":"research priorities","score":0.8299999833106995},{"id":"https://openalex.org/keywords/astronaut-health","display_name":"astronaut health","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.8236634731292725},{"id":"https://openalex.org/C2780179797","wikidata":"https://www.wikidata.org/wiki/Q345844","display_name":"Crew","level":2,"score":0.7665911912918091},{"id":"https://openalex.org/C104060986","wikidata":"https://www.wikidata.org/wiki/Q180046","display_name":"Space exploration","level":2,"score":0.5372185111045837},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.508030891418457},{"id":"https://openalex.org/C534819032","wikidata":"https://www.wikidata.org/wiki/Q752783","display_name":"Human spaceflight","level":3,"score":0.507977306842804},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.4431918263435364},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4272279739379883},{"id":"https://openalex.org/C178802073","wikidata":"https://www.wikidata.org/wiki/Q8421","display_name":"Aeronautics","level":1,"score":0.3983438014984131},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.30080151557922363},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2978495657444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2797057032585144},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26354163885116577},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20535162091255188},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20254820585250854},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.09514719247817993},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.1038/npjmgrav.2016.40","doi":"https://doi.org/10.1038/npjmgrav.2016.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npjmgrav.2016.40","pdf_url":"https://www.nature.com/articles/npjmgrav201640.pdf","source":{"id":"https://openalex.org/S4210211936","display_name":"npj Microgravity","issn_l":"2373-8065","issn":["2373-8065"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Microgravity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5515533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5515533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Microgravity","raw_type":"Text"},{"id":"pmid:28725745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28725745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ microgravity","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:133894","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/133894/1/npjmgrav201640.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/133894/1/npjmgrav201640.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Frippiat, Jean-Pol; Crucian, Brian E; de Quervain, Dominique J-F; Grimm, Daniela; Montano, Nicola; Praun, Siegfried; Roozendaal, Benno; Schelling, Gustav; Thiel, Manfred; Ullrich, Oliver; Chouk\u00e8r, Alexander (2016). Towards human exploration of space: The THESEUS review series on immunology research priorities. npj Microgravity, 2:16040.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/903fb880-68f1-4f5f-b5b7-bc81a5550e62","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/files/107130096/npjmgrav201640.pdf","pdf_url":"https://pure.au.dk/ws/files/107130096/npjmgrav201640.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jean-Pol, F, Crucian, B E, de Quervain, D, Grimm, D, Montano, N, Praun, S, Roozendaal, B, Schelling, G, Thiel, M, Ullrich, O & Chouk\u00e9r, A 2016, 'Towards human exploration of space: The THESEUS review series on immunology research priorities', npj Microgravity, vol. 2, 16040. https://doi.org/10.1038/npjmgrav.2016.40","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01903866v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-lorraine.fr/hal-01903866","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Microgravity, 2016, 2 (1), &#x27E8;10.1038/npjmgrav.2016.40&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/524036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/524036","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:37410","doi":null,"is_oa":false,"landing_page_url":"https://epub.ub.uni-muenchen.de/37410/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Microgravity","raw_type":"doc-type:article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/127699","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/127699","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frippiat, J.-P., Crucian, B. E., de Quervain, D. J.-F., Grimm, D., Montano, N., Praun, S., Roozendaal, B., Schelling, G., Thiel, M., Ullrich, O., & Chouk\u00e8r, A. (2016). Towards human exploration of space: The THESEUS review series on immunology research priorities. Npj Microgravity, 2, 16040. https://doi.org/10.1038/npjmgrav.2016.40","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-133894","doi":"https://doi.org/10.5167/uzh-133894","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-133894","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/npjmgrav.2016.40","doi":"https://doi.org/10.1038/npjmgrav.2016.40","is_oa":true,"landing_page_url":"https://doi.org/10.1038/npjmgrav.2016.40","pdf_url":"https://www.nature.com/articles/npjmgrav201640.pdf","source":{"id":"https://openalex.org/S4210211936","display_name":"npj Microgravity","issn_l":"2373-8065","issn":["2373-8065"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Microgravity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320309835","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40"},{"id":"https://openalex.org/F4320320301","display_name":"European Science Foundation","ror":"https://ror.org/04esata81"},{"id":"https://openalex.org/F4320321519","display_name":"Centre National d\u2019Etudes Spatiales","ror":"https://ror.org/04h1h0y33"},{"id":"https://openalex.org/F4320332567","display_name":"Biodesign Institute, Arizona State University","ror":"https://ror.org/03efmqc40"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2560639677.pdf","grobid_xml":"https://content.openalex.org/works/W2560639677.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W76417851","https://openalex.org/W77493494","https://openalex.org/W83195489","https://openalex.org/W132944752","https://openalex.org/W1120623956","https://openalex.org/W1518648676","https://openalex.org/W1547474393","https://openalex.org/W1756855932","https://openalex.org/W1824966615","https://openalex.org/W1943458378","https://openalex.org/W1946702933","https://openalex.org/W1964419874","https://openalex.org/W1964560277","https://openalex.org/W1965054121","https://openalex.org/W1969082595","https://openalex.org/W1969581053","https://openalex.org/W1970940393","https://openalex.org/W1975495128","https://openalex.org/W1975963773","https://openalex.org/W1978579788","https://openalex.org/W1978652454","https://openalex.org/W1987095853","https://openalex.org/W1988917025","https://openalex.org/W1990178759","https://openalex.org/W1990891254","https://openalex.org/W1990947374","https://openalex.org/W1991369801","https://openalex.org/W1999056435","https://openalex.org/W2003777316","https://openalex.org/W2004911664","https://openalex.org/W2009145869","https://openalex.org/W2009690260","https://openalex.org/W2014660126","https://openalex.org/W2020677834","https://openalex.org/W2025186129","https://openalex.org/W2028244711","https://openalex.org/W2029923678","https://openalex.org/W2032962321","https://openalex.org/W2042752159","https://openalex.org/W2048915757","https://openalex.org/W2049978550","https://openalex.org/W2050986536","https://openalex.org/W2052143567","https://openalex.org/W2054453066","https://openalex.org/W2054874071","https://openalex.org/W2055903609","https://openalex.org/W2056919244","https://openalex.org/W2058021161","https://openalex.org/W2059193195","https://openalex.org/W2067664087","https://openalex.org/W2067949717","https://openalex.org/W2068060752","https://openalex.org/W2069169998","https://openalex.org/W2069833430","https://openalex.org/W2074178753","https://openalex.org/W2076211107","https://openalex.org/W2076564468","https://openalex.org/W2078874082","https://openalex.org/W2083021739","https://openalex.org/W2090169509","https://openalex.org/W2090634239","https://openalex.org/W2096916192","https://openalex.org/W2099431779","https://openalex.org/W2112050754","https://openalex.org/W2112425814","https://openalex.org/W2114682229","https://openalex.org/W2115132640","https://openalex.org/W2123322798","https://openalex.org/W2127783560","https://openalex.org/W2129869260","https://openalex.org/W2130536825","https://openalex.org/W2130851152","https://openalex.org/W2131534920","https://openalex.org/W2131643056","https://openalex.org/W2131683459","https://openalex.org/W2132661305","https://openalex.org/W2133148337","https://openalex.org/W2136746620","https://openalex.org/W2137042254","https://openalex.org/W2138954062","https://openalex.org/W2141563578","https://openalex.org/W2149948081","https://openalex.org/W2152812755","https://openalex.org/W2159373976","https://openalex.org/W2163683111","https://openalex.org/W2166982707","https://openalex.org/W2167559194","https://openalex.org/W2168927628","https://openalex.org/W2169526305","https://openalex.org/W2273099552","https://openalex.org/W2297907353","https://openalex.org/W2318864768","https://openalex.org/W2331071860","https://openalex.org/W2415268118","https://openalex.org/W2548179736","https://openalex.org/W2594591188","https://openalex.org/W4235412292"],"related_works":["https://openalex.org/W7128642525","https://openalex.org/W4254548452","https://openalex.org/W7019758791","https://openalex.org/W2067664087","https://openalex.org/W2808186163","https://openalex.org/W2532842629","https://openalex.org/W2493793768","https://openalex.org/W2991652042","https://openalex.org/W2339153470","https://openalex.org/W2534336751"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,33,54,78,96,103,115,157],"the":[2,31,52,55,76,91,94,151,155],"immune":[3,34,46,152],"system":[4,153],"occurs":[5],"during":[6,15],"spaceflight":[7,37,148],"and":[8,81,106,121,124,154],"may":[9],"represent":[10],"a":[11,85,101,112,164],"crew":[12,132],"health":[13],"risk":[14],"exploration":[16],"missions":[17],"because":[18],"astronauts":[19],"are":[20],"challenged":[21],"by":[22],"many":[23],"stressors.":[24],"Therefore,":[25],"it":[26],"is":[27],"crucial":[28],"to":[29,41,44,61,88,125,134,143],"understand":[30],"biology":[32],"modulation":[35],"under":[36,48],"conditions":[38],"in":[39,75,122],"order":[40],"be":[42],"able":[43],"maintain":[45],"homeostasis":[47],"such":[49,110],"challenges.":[50],"In":[51],"framework":[53],"THESEUS":[56],"project":[57],"whose":[58],"aim":[59],"was":[60],"develop":[62],"an":[63],"integrated":[64],"life":[65],"sciences":[66],"research":[67],"roadmap":[68],"regarding":[69],"human":[70],"space":[71,79],"exploration,":[72],"experts":[73],"working":[74],"field":[77],"immunology,":[80],"related":[82],"disciplines,":[83],"established":[84],"questionnaire":[86],"sent":[87],"scientists":[89],"around":[90],"world.":[92],"From":[93],"review":[95],"collected":[97],"answers,":[98],"they":[99],"deduced":[100],"list":[102],"key":[104],"issues":[105],"provided":[107],"several":[108],"recommendations":[109,140],"as":[111],"maximal":[113],"exploitation":[114],"currently":[116],"available":[117],"resources":[118],"on":[119,150],"Earth":[120],"space,":[123],"increase":[126],"increments":[127],"duration":[128],"for":[129],"some":[130],"ISS":[131],"members":[133],"12":[135],"months":[136],"or":[137],"longer.":[138],"These":[139],"should":[141],"contribute":[142],"improve":[144],"our":[145],"knowledge":[146],"about":[147],"effects":[149],"development":[156],"countermeasures":[158],"that,":[159],"beyond":[160],"astronauts,":[161],"could":[162],"have":[163],"societal":[165],"impact.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-12-16T00:00:00"}
