{"id":"https://openalex.org/W2560171553","doi":"https://doi.org/10.1111/dom.12845","title":"Robust GLP \u20101 secretion by basic L \u2010amino acids does not require the GPRC6A receptor","display_name":"Robust GLP \u20101 secretion by basic L \u2010amino acids does not require the GPRC6A receptor","publication_year":2016,"publication_date":"2016-12-10","ids":{"openalex":"https://openalex.org/W2560171553","doi":"https://doi.org/10.1111/dom.12845","mag":"2560171553","pmid":"https://pubmed.ncbi.nlm.nih.gov/27943578"},"language":"en","primary_location":{"id":"doi:10.1111/dom.12845","doi":"https://doi.org/10.1111/dom.12845","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12845","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090584338","display_name":"Christoffer Clemmensen","orcid":"https://orcid.org/0000-0003-2456-9667","observed_orcids":["https://orcid.org/0000-0003-2456-9667"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE","DK"],"is_corresponding":false,"raw_author_name":"Christoffer Clemmensen","raw_affiliation_strings":["Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","Institute for Diabetes and Obesity Helmholtz Diabetes Center, Helmholtz Zentrum M\u00fcnchen  Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Institute for Diabetes and Obesity Helmholtz Diabetes Center, Helmholtz Zentrum M\u00fcnchen  Munich Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033083840","display_name":"Christinna V. J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-6089-899X","observed_orcids":["https://orcid.org/0000-0001-6089-899X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christinna V. J\u00f8rgensen","raw_affiliation_strings":["Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036051312","display_name":"Sanela Smajilovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sanela Smajilovic","raw_affiliation_strings":["Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089455458","display_name":"Hans Br\u00e4uner\u2010Osborne","orcid":"https://orcid.org/0000-0001-9495-7388","observed_orcids":["https://orcid.org/0000-0001-9495-7388"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Hans Br\u00e4uner\u2010Osborne","raw_affiliation_strings":["Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089455458"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":2.5616,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89585258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"4","first_page":"599","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.12319999933242798,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gprc6a","display_name":"GPRC6A","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1-secretion","display_name":"glucagon-like peptide-1 secretion","score":0.8370000123977661},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/l-ornithine","display_name":"L-ornithine","score":1.0},{"id":"https://openalex.org/keywords/amino-acid-sensing","display_name":"amino acid sensing","score":0.6729999780654907},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5639603734016418},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5540682673454285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5090141296386719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2251216471195221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1927412450313568}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024361","descriptor_name":"Amino Acids, Basic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/dom.12845","doi":"https://doi.org/10.1111/dom.12845","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12845","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:27943578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27943578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:50434","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50434","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes Obes. Metab. 19, 599-603 (2017)","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/fba8c718-3607-4e4e-84ab-8f11f85f0be7","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/fba8c718-3607-4e4e-84ab-8f11f85f0be7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clemmensen, C, J\u00f8rgensen, C V, Smajilovic, S & Br\u00e4uner-Osborne, H 2017, 'Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor', Diabetes, Obesity and Metabolism, vol. 19, no. 4, pp. 599-603. https://doi.org/10.1111/dom.12845","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:50434","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50434","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes Obes. Metab. 19, 599-603 (2017)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6019799851","display_name":null,"funder_award_id":"R210-2015-4001","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"}],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W814962454","https://openalex.org/W1527938810","https://openalex.org/W1986121767","https://openalex.org/W1987151103","https://openalex.org/W1987245647","https://openalex.org/W1995834963","https://openalex.org/W2007244966","https://openalex.org/W2012999911","https://openalex.org/W2020115894","https://openalex.org/W2024253268","https://openalex.org/W2025079391","https://openalex.org/W2033805482","https://openalex.org/W2036971420","https://openalex.org/W2047063331","https://openalex.org/W2050946651","https://openalex.org/W2062237920","https://openalex.org/W2066460470","https://openalex.org/W2070771474","https://openalex.org/W2098439015","https://openalex.org/W2099363221","https://openalex.org/W2140207339","https://openalex.org/W2152907862","https://openalex.org/W2260142409","https://openalex.org/W2346176715"],"related_works":["https://openalex.org/W1987245647","https://openalex.org/W1987151103","https://openalex.org/W2395556395","https://openalex.org/W2080748413","https://openalex.org/W2166424749","https://openalex.org/W3002293608","https://openalex.org/W4413969430","https://openalex.org/W2047063331","https://openalex.org/W7146261580","https://openalex.org/W3135743878"],"abstract_inverted_index":{"The":[0],"G":[1],"protein-coupled":[2],"receptor":[3,39,56],"GPRC6A":[4,38,55,70,79,111],"(GPCR,":[5],"Class":[6],"C,":[7],"group":[8],"6,":[9],"subtype":[10],"A)":[11],"has":[12],"been":[13],"proposed":[14],"to":[15,26,30,40,51,106,126,183],"be":[16],"a":[17,107,162],"sensor":[18],"for":[19,59],"basic":[20],"L-amino":[21,41],"acids":[22],"that":[23,92,159,168,185],"are":[24],"hypothesized":[25],"translate":[27],"ingestive":[28],"behaviour":[29],"endocrine":[31],"information.":[32],"However,":[33],"the":[34,37,54,136,143,169,180],"contribution":[35],"of":[36,63,95,174],"acid-induced":[42,61],"glucagon-like":[43],"peptide":[44],"1":[45],"(GLP-1)":[46],"secretion":[47,62,134],"is":[48,57,161,179],"unclear.":[49],"Therefore,":[50],"discover":[52],"whether":[53],"indispensible":[58],"amino":[60,121],"GLP-1,":[64],"we":[65],"treated,":[66],"with":[67,78],"oral":[68,93],"gavage,":[69],"knock-out":[71],"(KO)":[72],"and":[73,82,84,98,113,123,138,148,166],"wild-type":[74],"(WT)":[75],"littermate":[76],"mice":[77,115,145],"ligands":[80],"(L-arginine":[81],"L-ornithine)":[83],"assessed":[85],"GLP-1":[86,104,133,164,190],"levels":[87,105],"in":[88,110,142,192],"circulation.":[89],"We":[90],"found":[91],"administration":[94],"both":[96],"L-arginine":[97,160],"L-ornithine":[99,187],"significantly":[100],"increased":[101],"total":[102],"plasma":[103],"similar":[108],"level":[109],"KO":[112,144],"WT":[114],"15":[116],"minutes":[117,128],"after":[118,129],"gavage":[119,130],"(both":[120],"acids)":[122],"accumulated":[124],"up":[125],"60":[127],"(L-arginine).":[131],"Conversely,":[132],"at":[135],"30-":[137],"60-minute":[139],"time":[140],"points":[141],"was":[146],"attenuated":[147],"did":[149],"not":[150],"reach":[151],"statistical":[152],"significance.":[153],"In":[154,176],"summary,":[155],"these":[156],"data":[157],"confirm":[158],"potent":[163],"secretagogue":[165],"show":[167,184],"main":[170],"effect":[171],"occurs":[172],"independently":[173],"GPRC6A.":[175],"addition,":[177],"this":[178],"first":[181],"study":[182],"also":[186],"powerfully":[188],"elicits":[189],"release":[191],"vivo.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-12-16T00:00:00"}
