{"id":"https://openalex.org/W2560166032","doi":null,"title":"Generation, characterization, and maintenance of trastuzumab-resistant HER2+ breast cancer cell lines.","display_name":"Generation, characterization, and maintenance of trastuzumab-resistant HER2+ breast cancer cell lines.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2560166032","mag":"2560166032","pmid":"https://pubmed.ncbi.nlm.nih.gov/27904779","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5126281"},"language":"en","primary_location":{"id":"pmid:27904779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27904779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5126281/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090505952","display_name":"Sandra Zazo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Zazo","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085440679","display_name":"Paula G\u00f3nz\u00e1lez-Alonso","orcid":"https://orcid.org/0000-0002-5343-8300","observed_orcids":["https://orcid.org/0000-0002-5343-8300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Gonz\u00e1lez-Alonso","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085189127","display_name":"Ester Mart\u00edn-Aparicio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ester Mart\u00edn-Aparicio","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081566259","display_name":"Cristina Chamizo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Chamizo","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010683740","display_name":"Ion Crist\u00f3bal","orcid":"https://orcid.org/0000-0003-0234-4213","observed_orcids":["https://orcid.org/0000-0003-0234-4213"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ion Crist\u00f3bal","raw_affiliation_strings":["Translational Oncology Division, Onco Health Institute, Health Research Institute FJD-UAM, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Division, Onco Health Institute, Health Research Institute FJD-UAM, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050291961","display_name":"Oriol Arp\u00ed","orcid":"https://orcid.org/0000-0002-5578-2092","observed_orcids":["https://orcid.org/0000-0002-5578-2092"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Oriol Arp\u00ed","raw_affiliation_strings":["Department of Medical Oncology, Hospital del Mar Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital del Mar Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045101760","display_name":"Ana Rovira","orcid":"https://orcid.org/0000-0003-1301-2599","observed_orcids":["https://orcid.org/0000-0003-1301-2599"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Rovira","raw_affiliation_strings":["Department of Medical Oncology, Hospital del Mar Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital del Mar Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029048001","display_name":"Joan Albanell","orcid":"https://orcid.org/0000-0003-1239-4580","observed_orcids":["https://orcid.org/0000-0003-1239-4580"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Albanell","raw_affiliation_strings":["Department of Medical Oncology, Hospital del Mar Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital del Mar Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025258875","display_name":"P\u00eelar Eroles","orcid":"https://orcid.org/0000-0003-2708-6206","observed_orcids":["https://orcid.org/0000-0003-2708-6206"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Eroles","raw_affiliation_strings":["Institute of Health Research INCLIVA Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Research INCLIVA Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026179323","display_name":"Ana M. Lluch","orcid":"https://orcid.org/0000-0003-2766-407X","observed_orcids":["https://orcid.org/0000-0003-2766-407X"]},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Lluch","raw_affiliation_strings":["Institute of Health Research INCLIVA Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Research INCLIVA Valencia, Spain","institution_ids":["https://openalex.org/I4210158373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006108242","display_name":"Juan Madoz\u2010G\u00farpide","orcid":"https://orcid.org/0000-0001-8094-4076","observed_orcids":["https://orcid.org/0000-0001-8094-4076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Madoz-G\u00farpide","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012974257","display_name":"Federico Rojo","orcid":"https://orcid.org/0000-0001-9989-0290","observed_orcids":["https://orcid.org/0000-0001-9989-0290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federico Rojo","raw_affiliation_strings":["Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, UAM E-28040 Madrid, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8449,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.86135796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"6","issue":"11","first_page":"2661","last_page":"2678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.7329999804496765},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ribosomal-protein-s6-phosphorylation","display_name":"S6 phosphorylation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-line-maintenance","display_name":"cell line maintenance","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9850651025772095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6303896307945251},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.629753053188324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5490085482597351},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5047401189804077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48496532440185547},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45199328660964966},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.43292945623397827},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.4279625713825226},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4179114103317261},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.41094696521759033},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3969346582889557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36408308148384094},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.35462686419487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32132649421691895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2636549472808838},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11359468102455139},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07234960794448853}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:27904779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27904779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5126281","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5126281/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmh:oai:repositori.upf.edu:10230/33707","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10230/33707","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2560166032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27904779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5126281","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5126281/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W130977966","https://openalex.org/W1606090394","https://openalex.org/W1644299043","https://openalex.org/W1949953198","https://openalex.org/W1966937303","https://openalex.org/W1967304777","https://openalex.org/W1971267920","https://openalex.org/W1974685860","https://openalex.org/W1980704667","https://openalex.org/W1992847318","https://openalex.org/W1998728654","https://openalex.org/W2014457594","https://openalex.org/W2024651005","https://openalex.org/W2027542837","https://openalex.org/W2027684043","https://openalex.org/W2034091339","https://openalex.org/W2040935952","https://openalex.org/W2041993682","https://openalex.org/W2047419828","https://openalex.org/W2051051838","https://openalex.org/W2059411043","https://openalex.org/W2068326740","https://openalex.org/W2073385822","https://openalex.org/W2098544382","https://openalex.org/W2098791934","https://openalex.org/W2101979288","https://openalex.org/W2107426197","https://openalex.org/W2108501693","https://openalex.org/W2109439031","https://openalex.org/W2129750399","https://openalex.org/W2131831158","https://openalex.org/W2141393790","https://openalex.org/W2146384083","https://openalex.org/W2157208434","https://openalex.org/W2168057516","https://openalex.org/W2168420558","https://openalex.org/W2172118845","https://openalex.org/W2235523093","https://openalex.org/W2264655007","https://openalex.org/W4244087642"],"related_works":["https://openalex.org/W4390104090","https://openalex.org/W2590038306","https://openalex.org/W2213952892","https://openalex.org/W2567562590","https://openalex.org/W4393038852","https://openalex.org/W2963340003","https://openalex.org/W1977974091","https://openalex.org/W3133557694","https://openalex.org/W2941463217","https://openalex.org/W4236647267"],"abstract_inverted_index":{"gene":[0],"copy":[1],"numbers":[2],"in":[3,44,74],"others.":[4],"Using":[5],"a":[6,61,78,101],"phospho-antibody":[7],"array":[8],"we":[9],"analyzed":[10],"the":[11,84,89,108],"status":[12],"of":[13,49,66,88,110,112],"kinase":[14],"receptors":[15],"and":[16,27,38,57],"effectors":[17],"from":[18],"different":[19],"cellular":[20],"pathways.":[21],"This":[22],"revealed":[23],"that":[24,95],"HER2,":[25],"AKT,":[26],"S6RP":[28],"presented":[29],"high":[30],"phosphorylation":[31,45],"levels":[32,46],"with":[33],"specific":[34],"variations":[35],"between":[36,55],"sensitive":[37,56],"resistant":[39,58,97],"populations.":[40],"In":[41],"addition,":[42],"differences":[43],"for":[47],"several":[48],"those":[50,71],"pathways":[51],"targets":[52],"were":[53],"found":[54],"lines.":[59],"Furthermore,":[60],"biochemical":[62],"study":[63],"characterized":[64],"patterns":[65],"molecular":[67],"alterations":[68],"similar":[69],"to":[70,86,104],"commonly":[72],"described":[73],"breast":[75],"cancer.":[76],"Finally,":[77],"subcutaneous":[79],"xenograft":[80],"murine":[81],"model":[82],"confirmed":[83],"resistance":[85],"trastuzumab":[87,113],"established":[90],"cell":[91],"line.":[92],"We":[93],"conclude":[94],"these":[96],"BCCLs":[98],"can":[99],"be":[100],"valuable":[102],"tool":[103],"gain":[105],"insight":[106],"into":[107],"mechanisms":[109],"acquisition":[111],"resistance.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-12-16T00:00:00"}
