{"id":"https://openalex.org/W2560107331","doi":null,"title":"Analysis of the role of mitochondrial morphology in autophagy","display_name":"Analysis of the role of mitochondrial morphology in autophagy","publication_year":2016,"publication_date":"2016-01-31","ids":{"openalex":"https://openalex.org/W2560107331","mag":"2560107331"},"language":"en","primary_location":{"id":"pmh:oai:paduaresearch.cab.unipd.it:9446","doi":null,"is_oa":false,"landing_page_url":"http://paduaresearch.cab.unipd.it/9446/1/tesi_complete.pdf","pdf_url":"http://paduaresearch.cab.unipd.it/9446/1/tesi_complete.pdf","source":{"id":"https://openalex.org/S4306401344","display_name":"Padua@research (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11577/3426749","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052629193","display_name":"Alice Nardin","orcid":"https://orcid.org/0000-0002-5180-6763","observed_orcids":["https://orcid.org/0000-0002-5180-6763"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alice Nardin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5180-6763","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052629193"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20024691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.6759999990463257},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.5699999928474426},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7279999852180481},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.7519999742507935},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/bapta","display_name":"BAPTA","score":0.6800000071525574},{"id":"https://openalex.org/keywords/carbonyl-cyanide-m-chlorophenylhydrazone","display_name":"CCCP","score":0.7749999761581421},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.9904972314834595},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.9037052392959595},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6338842511177063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6184564232826233},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5944227576255798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5641735196113586},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5524404048919678},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.4722957909107208},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4393059015274048},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.39364153146743774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32230788469314575},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12374436855316162},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10381683707237244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08187371492385864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07035717368125916},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:paduaresearch.cab.unipd.it:9446","doi":null,"is_oa":false,"landing_page_url":"http://paduaresearch.cab.unipd.it/9446/1/tesi_complete.pdf","pdf_url":"http://paduaresearch.cab.unipd.it/9446/1/tesi_complete.pdf","source":{"id":"https://openalex.org/S4306401344","display_name":"Padua@research (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesi di dottorato"},{"id":"pmh:oai:www.research.unipd.it:11577/3426749","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3426749","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2560107331","doi":null,"is_oa":false,"landing_page_url":"http://paduaresearch.cab.unipd.it/9446/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.research.unipd.it:11577/3426749","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3426749","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4318769524","https://openalex.org/W4390964886","https://openalex.org/W3170086283","https://openalex.org/W2106444069","https://openalex.org/W2155015733","https://openalex.org/W2043650582","https://openalex.org/W2020851684","https://openalex.org/W7099766282","https://openalex.org/W2034087770","https://openalex.org/W1979645469"],"abstract_inverted_index":{"PARK2":[0],"gene":[1,14],"encodes":[2],"for":[3],"an":[4],"E3":[5],"ubiquitin":[6],"ligase":[7],"called":[8],"Parkin.":[9,91],"Loss-of-function":[10],"mutations":[11],"in":[12,31,189,195,214],"this":[13],"cause":[15],"early":[16],"onset":[17],"of":[18,24,29,45,108,158,211,217],"Parkinson\u2019s":[19,218],"disease,":[20],"a":[21,116,212],"neurodegenerative":[22],"disorder":[23],"unknown":[25,95],"etiology.":[26],"The":[27],"role":[28],"Parkin":[30,52,66,104,114,131,151,166,178],"neuron":[32],"maintenance":[33],"is":[34,53,82,204],"still":[35],"unknown,":[36],"however":[37],"it":[38,60,89,93],"has":[39,115],"been":[40],"linked":[41],"to":[42,56,176,187,206],"the":[43,73,122,144,188,196,208],"regulation":[44],"mitochondria":[46,87],"dynamic.":[47],"Recent":[48],"works":[49],"show":[50],"that":[51,113,135,141,156,169,194],"selectively":[54,83],"recruited":[55],"dysfunctional":[57,86],"mitochondria,":[58],"where":[59,88],"mediates":[61],"their":[62],"elimination":[63],"via":[64],"autophagy.":[65],"translocation":[67,179],"and":[68,168],"Parkin-mediated":[69],"autophagy":[70],"depend":[71],"on":[72,85],"Serine/Threonine-protein":[74],"kinase":[75,79],"PINK1":[76,213],"(PTEN-induced":[77],"putative":[78],"1),":[80],"which":[81,96],"stabilized":[84],"recruits":[90],"However,":[92],"remains":[94],"cellular":[97],"signals":[98],"or":[99],"covalent":[100],"modifications":[101],"directly":[102],"regulate":[103],"translocation.":[105,152],"Confocal":[106],"microscopy":[107],"EYFP-Parkin":[109],"transfected":[110],"MEFs":[111],"shows":[112],"cytoplasmic":[117],"localization.":[118],"After":[119],"treatment":[120],"with":[121,137,143],"mitochondrial":[123],"uncoupling":[124],"agent":[125],"Carbonyl":[126],"cyanide":[127],"m-chlorophenyl":[128],"hydrazine":[129],"(CCCP),":[130],"appears":[132],"as":[133],"spots":[134],"co-localize":[136],"mitochondria.":[138],"We":[139,153],"found":[140,155],"pretreatment":[142],"Ca2+":[145,159],"selective":[146],"chelator":[147],"BAPTA":[148],"completely":[149],"blocked":[150],"also":[154],"inhibition":[157],"dependent":[160],"phosphatase":[161],"Calcineurin":[162,200],"A":[163],"(CnA)":[164],"impaired":[165],"recruitment":[167],"CaN":[170],"constitutive":[171,201],"active":[172,202],"expression":[173,203],"was":[174],"able":[175,205],"induce":[177],"per":[180],"se,":[181],"independently":[182],"from":[183],"PINK1.":[184],"In":[185],"accordance":[186],"vitro":[190],"data,":[191],"we":[192],"showed":[193],"Drosophila":[197],"fruit":[198],"fly,":[199],"rescue":[207],"climbing":[209],"ability":[210],"vivo":[215],"model":[216],"Disease.":[219]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-12-16T00:00:00"}
