{"id":"https://openalex.org/W2559968880","doi":"https://doi.org/10.1007/s11011-016-9935-6","title":"Palmitic acid triggers cell apoptosis in RGC-5 retinal ganglion cells through the Akt/FoxO1 signaling pathway","display_name":"Palmitic acid triggers cell apoptosis in RGC-5 retinal ganglion cells through the Akt/FoxO1 signaling pathway","publication_year":2016,"publication_date":"2016-12-07","ids":{"openalex":"https://openalex.org/W2559968880","doi":"https://doi.org/10.1007/s11011-016-9935-6","mag":"2559968880","pmid":"https://pubmed.ncbi.nlm.nih.gov/27928692"},"language":"en","primary_location":{"id":"doi:10.1007/s11011-016-9935-6","doi":"https://doi.org/10.1007/s11011-016-9935-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11011-016-9935-6","pdf_url":null,"source":{"id":"https://openalex.org/S31409034","display_name":"Metabolic Brain Disease","issn_l":"0885-7490","issn":["0885-7490","1573-7365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Brain Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005006190","display_name":"Panshi Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panshi Yan","raw_affiliation_strings":["Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069545329","display_name":"Shu Tang","orcid":"https://orcid.org/0000-0002-3268-692X","observed_orcids":["https://orcid.org/0000-0002-3268-692X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Tang","raw_affiliation_strings":["Department of Pharmacy, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399689","display_name":"Haifeng Zhang","orcid":"https://orcid.org/0000-0003-2186-5073","observed_orcids":["https://orcid.org/0000-0003-2186-5073"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifeng Zhang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487803","display_name":"Yuanyuan Guo","orcid":"https://orcid.org/0000-0002-8235-1618","observed_orcids":["https://orcid.org/0000-0002-8235-1618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanyuan Guo","raw_affiliation_strings":["Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102732532","display_name":"Zhiwen Zeng","orcid":"https://orcid.org/0000-0002-9530-6701","observed_orcids":["https://orcid.org/0000-0002-9530-6701"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhiwen Zeng","raw_affiliation_strings":["Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China. zengzw1122@163.com","Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China. zengzw1122@163.com","institution_ids":[]},{"raw_affiliation_string":"Shenzhen Mental Health Center and Shenzhen Key Lab for Psychological Healthcare, Shenzhen, 518020, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108015089","display_name":"Qiang Wen","orcid":"https://orcid.org/0000-0002-3437-2457","observed_orcids":["https://orcid.org/0000-0002-3437-2457"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiang Wen","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China. qiangwen7619@163.com","Department of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China. qiangwen7619@163.com","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102732532","https://openalex.org/A5108015089"],"corresponding_institution_ids":["https://openalex.org/I38877650"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":2.778,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89982674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"32","issue":"2","first_page":"453","last_page":"460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":1.0},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.800000011920929},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9359999895095825},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rgc-5-cells","display_name":"RGC-5 cells","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7386571168899536},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.6177725195884705},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5903839468955994},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.564423680305481},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5600886344909668},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5386881828308105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5211805701255798},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.5015718936920166},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4961720407009125},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.49357903003692627},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4449988305568695},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36459970474243164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22606903314590454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15740099549293518},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.13671866059303284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11011-016-9935-6","doi":"https://doi.org/10.1007/s11011-016-9935-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11011-016-9935-6","pdf_url":null,"source":{"id":"https://openalex.org/S31409034","display_name":"Metabolic Brain Disease","issn_l":"0885-7490","issn":["0885-7490","1573-7365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Brain Disease","raw_type":"journal-article"},{"id":"pmid:27928692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27928692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic brain disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322766","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W876793526","https://openalex.org/W1510040584","https://openalex.org/W1590992230","https://openalex.org/W1604048158","https://openalex.org/W1876461672","https://openalex.org/W1942419053","https://openalex.org/W1967067335","https://openalex.org/W1968646478","https://openalex.org/W1972095168","https://openalex.org/W1975462549","https://openalex.org/W1976481038","https://openalex.org/W1997350836","https://openalex.org/W2000047595","https://openalex.org/W2004312953","https://openalex.org/W2017479089","https://openalex.org/W2025522799","https://openalex.org/W2048121649","https://openalex.org/W2050114521","https://openalex.org/W2051544795","https://openalex.org/W2071506925","https://openalex.org/W2078677507","https://openalex.org/W2082432128","https://openalex.org/W2082561352","https://openalex.org/W2099145720","https://openalex.org/W2104500335","https://openalex.org/W2109686686","https://openalex.org/W2113529261","https://openalex.org/W2124806139","https://openalex.org/W2129578178","https://openalex.org/W2145133410","https://openalex.org/W2154386543","https://openalex.org/W2156563694","https://openalex.org/W2195804964","https://openalex.org/W2266557276","https://openalex.org/W2432007315"],"related_works":["https://openalex.org/W2578137346","https://openalex.org/W2007735859","https://openalex.org/W2053434954","https://openalex.org/W1972095168","https://openalex.org/W2473343559","https://openalex.org/W2004072015","https://openalex.org/W6966472571","https://openalex.org/W2004260482","https://openalex.org/W2030683040","https://openalex.org/W2061017616"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-12-16T00:00:00"}