{"id":"https://openalex.org/W2559953988","doi":"https://doi.org/10.1371/journal.ppat.1006057","title":"The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages","display_name":"The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages","publication_year":2016,"publication_date":"2016-12-07","ids":{"openalex":"https://openalex.org/W2559953988","doi":"https://doi.org/10.1371/journal.ppat.1006057","mag":"2559953988","pmid":"https://pubmed.ncbi.nlm.nih.gov/27926943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5142792"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1006057","doi":"https://doi.org/10.1371/journal.ppat.1006057","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006057","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006057&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006057&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081429535","display_name":"Nadine Thiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Thiel","raw_affiliation_strings":["Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037898880","display_name":"Kirsten A. Keyser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirsten A. Keyser","raw_affiliation_strings":["Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049964954","display_name":"Niels A. W. Lemmermann","orcid":"https://orcid.org/0000-0001-9190-6497","observed_orcids":["https://orcid.org/0000-0001-9190-6497"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niels A. W. Lemmermann","raw_affiliation_strings":["Institute of Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9190-6497","affiliations":[{"raw_affiliation_string":"Institute of Virology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063594628","display_name":"Jennifer D. Oduro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer D. Oduro","raw_affiliation_strings":["Helmholtz Centre for Infection Research, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karen Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Wagner","raw_affiliation_strings":["Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085436476","display_name":"Carina Elsner","orcid":"https://orcid.org/0000-0001-6590-8413","observed_orcids":["https://orcid.org/0000-0001-6590-8413"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carina Elsner","raw_affiliation_strings":["Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6590-8413","affiliations":[{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036032049","display_name":"Anne Halenius","orcid":"https://orcid.org/0000-0001-6335-1017","observed_orcids":["https://orcid.org/0000-0001-6335-1017"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Halenius","raw_affiliation_strings":["Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064131245","display_name":"Tihana Lenac Rovi\u0161","orcid":"https://orcid.org/0000-0002-3299-1334","observed_orcids":["https://orcid.org/0000-0002-3299-1334"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Tihana Lenac Rovi\u0161","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000668280","display_name":"Melanie M. Brinkmann","orcid":"https://orcid.org/0000-0001-5431-6527","observed_orcids":["https://orcid.org/0000-0001-5431-6527"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie M. Brinkmann","raw_affiliation_strings":["Helmholtz Centre for Infection Research, Braunschweig, Germany","Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]},{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038051461","display_name":"Stipan Jonji\u0107","orcid":"https://orcid.org/0000-0001-5003-3108","observed_orcids":["https://orcid.org/0000-0001-5003-3108"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Stipan Jonji\u0107","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089185959","display_name":"Luka \u010ci\u010din\u2010\u0160ain","orcid":"https://orcid.org/0000-0003-3978-778X","observed_orcids":["https://orcid.org/0000-0003-3978-778X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luka Cicin-Sain","raw_affiliation_strings":["Helmholtz Centre for Infection Research, Braunschweig, Germany","Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz Centre for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210124929"]},{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067170407","display_name":"Martin Messerle","orcid":"https://orcid.org/0000-0002-1227-3933","observed_orcids":["https://orcid.org/0000-0002-1227-3933"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Messerle","raw_affiliation_strings":["Institute of Virology, Hannover Medical School, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1227-3933","affiliations":[{"raw_affiliation_string":"Institute of Virology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5067170407"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.249,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.82099621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"12","first_page":"e1006057","last_page":"e1006057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-cytomegalovirus","display_name":"murine cytomegalovirus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.527999997138977},{"id":"https://openalex.org/keywords/nedd4","display_name":"NEDD4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.6729999780654907},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.503000020980835},{"id":"https://openalex.org/keywords/tail-anchored-membrane-proteins","display_name":"tail-anchored membrane proteins","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6562095880508423},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5949574112892151},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5163615942001343},{"id":"https://openalex.org/C2776315342","wikidata":"https://www.wikidata.org/wiki/Q21105865","display_name":"SAMHD1","level":5,"score":0.48457491397857666},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.41513779759407043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3578000068664551},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3152567148208618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27397334575653076},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08861589431762695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0818522572517395},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018146","descriptor_name":"Muromegalovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1006057","doi":"https://doi.org/10.1371/journal.ppat.1006057","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006057","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006057&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4107543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5142792","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5142792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5142792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:27926943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27926943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:repository.helmholtz-hzi.de:10033/621015","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10033/621015","pdf_url":"https://repository.helmholtz-hzi.de/bitstream/10033/621015/1/Thiel%20et%20al.pdf","source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:a958b1c4b43f43a482e9b6719739faec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a958b1c4b43f43a482e9b6719739faec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 12, Iss 12, p e1006057 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4293176","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Mouse_Cytomegalovirus_Gene_m42_Targets_Surface_Expression_of_the_Protein_Tyrosine_Phosphatase_CD45_in_Infected_Macrophages/4293176","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:hzi.openrepository.com:10033/621015","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10033/621015","pdf_url":null,"source":{"id":"https://openalex.org/S4377196474","display_name":"HZI (Helmholtz Centre for Infection Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124929","host_organization_name":"Helmholtz Centre for Infection Research","host_organization_lineage":["https://openalex.org/I4210124929"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1006057","doi":"https://doi.org/10.1371/journal.ppat.1006057","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1006057","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006057&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2022467678","display_name":"Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector","funder_award_id":"322693","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G2577590881","display_name":null,"funder_award_id":"VH VI-424","funder_id":"https://openalex.org/F4320320876","funder_display_name":"Helmholtz-Gemeinschaft"},{"id":"https://openalex.org/G2919335290","display_name":null,"funder_award_id":"ERC StG 260934","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G3529164737","display_name":null,"funder_award_id":"SFB 900","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2559953988.pdf","grobid_xml":"https://content.openalex.org/works/W2559953988.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W179475632","https://openalex.org/W1482065222","https://openalex.org/W1498090319","https://openalex.org/W1539529772","https://openalex.org/W1581650643","https://openalex.org/W1596916547","https://openalex.org/W1600669018","https://openalex.org/W1608297032","https://openalex.org/W1656644461","https://openalex.org/W1851333263","https://openalex.org/W1901657789","https://openalex.org/W1906826083","https://openalex.org/W1966526764","https://openalex.org/W1972434619","https://openalex.org/W1982386923","https://openalex.org/W1983963541","https://openalex.org/W1987550826","https://openalex.org/W1992697897","https://openalex.org/W1999046674","https://openalex.org/W1999421885","https://openalex.org/W2001518190","https://openalex.org/W2004250476","https://openalex.org/W2005816533","https://openalex.org/W2008579889","https://openalex.org/W2012373229","https://openalex.org/W2014574326","https://openalex.org/W2021658855","https://openalex.org/W2023132632","https://openalex.org/W2028192767","https://openalex.org/W2030172852","https://openalex.org/W2037951817","https://openalex.org/W2038980978","https://openalex.org/W2043504853","https://openalex.org/W2043687376","https://openalex.org/W2045407060","https://openalex.org/W2046616214","https://openalex.org/W2054989155","https://openalex.org/W2057563271","https://openalex.org/W2064890413","https://openalex.org/W2066212316","https://openalex.org/W2066455030","https://openalex.org/W2070883852","https://openalex.org/W2071201507","https://openalex.org/W2075713339","https://openalex.org/W2077383117","https://openalex.org/W2078320539","https://openalex.org/W2083665788","https://openalex.org/W2088966331","https://openalex.org/W2095498551","https://openalex.org/W2096310526","https://openalex.org/W2097691794","https://openalex.org/W2101217278","https://openalex.org/W2103484711","https://openalex.org/W2104839535","https://openalex.org/W2104984927","https://openalex.org/W2108367007","https://openalex.org/W2114876320","https://openalex.org/W2117754842","https://openalex.org/W2118130619","https://openalex.org/W2121070193","https://openalex.org/W2121160579","https://openalex.org/W2128902404","https://openalex.org/W2131777296","https://openalex.org/W2132282141","https://openalex.org/W2134408144","https://openalex.org/W2134805829","https://openalex.org/W2136722399","https://openalex.org/W2141089307","https://openalex.org/W2142712000","https://openalex.org/W2144924504","https://openalex.org/W2149269468","https://openalex.org/W2152624886","https://openalex.org/W2153252006","https://openalex.org/W2153523299","https://openalex.org/W2154143583","https://openalex.org/W2154282895","https://openalex.org/W2159702641","https://openalex.org/W2162863785","https://openalex.org/W2165894667","https://openalex.org/W2168020827","https://openalex.org/W2220848672","https://openalex.org/W2346194751"],"related_works":["https://openalex.org/W2088026615","https://openalex.org/W2116405550","https://openalex.org/W2128902404","https://openalex.org/W4403263278","https://openalex.org/W7099197212","https://openalex.org/W2125024220","https://openalex.org/W2141056328","https://openalex.org/W2008579889","https://openalex.org/W2743796451","https://openalex.org/W3159520575"],"abstract_inverted_index":{"The":[0,132,170],"receptor-like":[1],"protein":[2,142],"tyrosine":[3],"phosphatase":[4],"CD45":[5,48,72,96,159,223,232],"is":[6,49,148],"expressed":[7,143],"on":[8],"the":[9,22,28,43,64,86,173,176,197,229],"surface":[10,45],"of":[11,13,24,37,47,53,56,68,76,79,85,95,125,157,168,175,192,200,205,231,242],"cells":[12,26,186,237],"hematopoietic":[14],"origin":[15],"and":[16,147,166,181,189],"has":[17],"a":[18,54,152,193,239],"pivotal":[19],"role":[20,124],"for":[21,71,127,216,224],"function":[23],"these":[25,217],"in":[27,112,130,185,196,203,234],"immune":[29],"response.":[30],"Here":[31],"we":[32],"report":[33],"that":[34,162,172,190,208],"following":[35],"infection":[36,81],"macrophages":[38],"with":[39,102,144],"mouse":[40],"cytomegalovirus":[41],"(MCMV)":[42],"cell":[44,89],"expression":[46,75,233],"drastically":[50],"diminished.":[51],"Screening":[52],"set":[55],"MCMV":[57],"deletion":[58,105],"mutants":[59],"allowed":[60],"us":[61],"to":[62,92,118,150],"identify":[63],"viral":[65,80,108,128],"gene":[66,134],"m42":[67,77,104,126,133,163,188,201,209],"being":[69],"responsible":[70],"down-modulation.":[73],"Moreover,":[74],"independent":[78],"upon":[82],"retroviral":[83],"transduction":[84],"RAW264.7":[87],"macrophage":[88],"line":[90],"led":[91],"comparable":[93],"regulation":[94],"expression.":[97],"In":[98,227],"immunocompetent":[99],"mice":[100],"infected":[101],"an":[103,122,139,212],"mutant":[106],"lower":[107],"titers":[109],"were":[110,183],"observed":[111],"all":[113],"tissues":[114],"examined":[115],"when":[116],"compared":[117],"wildtype":[119],"MCMV,":[120],"indicating":[121],"important":[123],"replication":[129],"vivo.":[131],"product":[135],"was":[136],"identified":[137],"as":[138,211],"18":[140],"kDa":[141],"early":[145],"kinetics":[146],"predicted":[149],"be":[151],"tail-anchored":[153],"membrane":[154],"protein.":[155],"Tracking":[156],"surface-resident":[158],"molecules":[160],"revealed":[161],"induces":[164],"internalization":[165],"degradation":[167],"CD45.":[169],"observation":[171],"amounts":[174],"E3":[177],"ubiquitin":[178,219],"ligases":[179],"Itch":[180],"Nedd4":[182],"diminished":[184],"expressing":[187],"disruption":[191],"PY":[194],"motif":[195],"N-terminal":[198],"part":[199],"resulted":[202],"loss":[204],"function,":[206],"suggest":[207],"acts":[210],"activator":[213],"or":[214],"adaptor":[215],"Nedd4-like":[218],"ligases,":[220],"which":[221],"mark":[222],"lysosomal":[225],"degradation.":[226],"conclusion,":[228],"down-modulation":[230],"MCMV-infected":[235],"myeloid":[236],"represents":[238],"novel":[240],"pathway":[241],"virus-host":[243],"interaction.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-12-16T00:00:00"}