{"id":"https://openalex.org/W2559907794","doi":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","title":"Nitric oxide-releasing nanoparticle combination therapy to overcome drug resistance in platinum-resistant breast cancers.","display_name":"Nitric oxide-releasing nanoparticle combination therapy to overcome drug resistance in platinum-resistant breast cancers.","publication_year":2011,"publication_date":"2011-09-20","ids":{"openalex":"https://openalex.org/W2559907794","doi":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","mag":"2559907794"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.27_suppl.278","doi":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046407367","display_name":"Marcus Laird Forrest","orcid":"https://orcid.org/0000-0002-0288-6138","observed_orcids":["https://orcid.org/0000-0002-0288-6138"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. L. Forrest","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103074573","display_name":"Shuang Cai","orcid":"https://orcid.org/0000-0003-2976-6918","observed_orcids":["https://orcid.org/0000-0003-2976-6918"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Cai","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Duan","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. S. Cohen","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011306921","display_name":"Qiaolu Yang","orcid":"https://orcid.org/0000-0002-6104-0511","observed_orcids":["https://orcid.org/0000-0002-6104-0511"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. Yang","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS; University of Kansas, Lawrence, KS; Department of Surgery, University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"27_suppl","first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.1062999963760376,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.7839999794960022},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.7960000038146973},{"id":"https://openalex.org/keywords/js-k","display_name":"JS-K","score":0.5529999732971191},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nanoparticle-conjugates","display_name":"nanoparticle conjugates","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7634655237197876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7475452423095703},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.6503419280052185},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.6134814620018005},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.586147665977478},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5243915915489197},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5080254077911377},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49408820271492004},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.48494699597358704},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.47001102566719055},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4439714252948761},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.4253341257572174},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41664761304855347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4146379828453064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3972417712211609},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3202451467514038},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3106454014778137},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25867605209350586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1947290301322937},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1219712495803833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0705098807811737}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.27_suppl.278","doi":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.27_suppl.278","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2759853499","https://openalex.org/W3039159022","https://openalex.org/W2757776576","https://openalex.org/W2914587133","https://openalex.org/W2567338548","https://openalex.org/W7096686468","https://openalex.org/W3204145501","https://openalex.org/W2123848076","https://openalex.org/W3217375083","https://openalex.org/W1972738065"],"abstract_inverted_index":{"278":[0],"Background:":[1],"The":[2,80,99,147,163,209],"most":[3],"successful":[4],"cancer":[5,30,109,167,248],"chemotherapy":[6],"regimens":[7],"usually":[8],"involve":[9],"the":[10,50,74,115,118,137,292],"administration":[11],"of":[12,24,52,76,102,117,194,230,244,258,272,296,303],"multiple":[13],"cytotoxic":[14],"agents":[15],"simultaneously.":[16],"Because":[17],"different":[18,22],"chemotherapies":[19],"may":[20,46],"have":[21,40,274],"mechanisms":[23],"action;":[25],"it":[26,273],"is":[27],"difficult":[28],"for":[29,73],"cells":[31,90,124,168],"to":[32,35,61,85,92,165,223,252,262],"become":[33],"resistant":[34],"combination":[36,64,120,139,210,298],"therapy.":[37],"Recent":[38],"investigations":[39],"discovered":[41],"that":[42],"nitric":[43,94,195],"oxide":[44,95,267],"(NO)":[45],"be":[47,86],"involved":[48],"in":[49,56,88,106,178,213,219,240,278,286,300],"reversal":[51],"cisplatin":[53,72,129,224,228],"(CDDP)":[54],"resistance":[55,285],"chemotherapy.":[57],"Therefore,":[58],"we":[59],"sought":[60],"develop":[62],"a":[63,67,156,173,190,241,256],"regimen":[65],"involving":[66],"NO-releasing":[68],"prodrug":[69,81,268],"(NO1)":[70],"and":[71,91,216,233,246,270,280,294],"treatment":[75,225],"breast":[77,108,166,305],"cancer.":[78,306],"Methods:":[79],"NO1":[82,103,188],"was":[83,104,150,169],"synthesized":[84],"localized":[87],"tumor":[89],"release":[93,193],"over":[96],"10":[97,259],"hours.":[98],"antiproliferative":[100],"activity":[101,277],"determined":[105,151],"human":[107,304],"cell":[110,148,220],"line,":[111],"MDA-MB-468LN.":[112],"To":[113],"evaluate":[114],"effectiveness":[116],"CDDP/NO":[119,138,297],"regimen,":[121],"platinum-resistant":[122],"MDA-MB-468LN":[123],"were":[125],"treated":[126],"with":[127],"either":[128],"alone":[130,226],"([CDDP]=0.01,":[131,140],"0.02":[132,141,232],"or":[133,136,142],"0.03":[134,143,234],"mM)":[135],"mM;":[144],"[NO1]=0.02":[145],"mM).":[146],"viability":[149],"48":[152],"hours":[153],"post-treatment":[154],"using":[155],"live/dead":[157],"trypan":[158],"blue":[159],"exclusion":[160],"assay.":[161],"Results:":[162],"toxicity":[164],"higher":[170],"than":[171,201],"JS-K,":[172],"systemic":[174],"NO":[175],"agent":[176],"currently":[177],"preclinical":[179],"development.":[180],"(NO1:":[181,203],"IC50=26\u00b5M;":[182],"JS-K:":[183,206],"IC50=42":[184],"\u00b5M).":[185],"In":[186],"addition,":[187],"had":[189],"long":[191],"sustained":[192],"oxide,":[196],"approximately":[197],"one":[198],"fold":[199],"longer":[200],"JS-K":[202],"t1/2=6":[204],"h;":[205],"t1/2=3":[207],"h).":[208],"treatments":[211],"resulted":[212],"6.6-,":[214],"6.9-":[215],"7.5-fold":[217],"increase":[218],"death":[221],"compared":[222,261],"at":[227],"concentrations":[229],"0.01,":[231],"mM,":[235],"respectively.":[236],"A":[237],"subsequent":[238],"study":[239],"murine":[242],"xenograft":[243],"head":[245],"neck":[247],"found":[249],"NO-1":[250,269],"conjugated":[251],"nanoparticles":[253,271],"increased":[254],"survival":[255],"mean":[257],"weeks":[260],"controls":[263],"(p<0.0001).":[264],"Conclusions:":[265],"Nitric":[266],"high":[275],"anticancer":[276],"vivo":[279],"they":[281],"can":[282],"reverse":[283],"platinum":[284],"vitro.":[287],"Ongoing":[288],"studies":[289],"are":[290],"examining":[291],"safety":[293],"efficacy":[295],"therapy":[299],"mouse":[301],"xenografts":[302]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-12-16T00:00:00"}
