{"id":"https://openalex.org/W2559905331","doi":"https://doi.org/10.1182/blood.v124.21.661.661","title":"A Biomarker Algorithm Defines Onset Grades of Acute Graft-Vs-Host Disease with Distinct Non-Relapse Mortality","display_name":"A Biomarker Algorithm Defines Onset Grades of Acute Graft-Vs-Host Disease with Distinct Non-Relapse Mortality","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2559905331","doi":"https://doi.org/10.1182/blood.v124.21.661.661","mag":"2559905331"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.661.661","doi":"https://doi.org/10.1182/blood.v124.21.661.661","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.661.661","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043877705","display_name":"John E. Levine","orcid":"https://orcid.org/0000-0002-5611-7828","observed_orcids":["https://orcid.org/0000-0002-5611-7828"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Levine","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101605321","display_name":"Thomas Braun","orcid":"https://orcid.org/0000-0002-7113-6998","observed_orcids":["https://orcid.org/0000-0002-7113-6998"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas M. Braun","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024499904","display_name":"Andrew C. Harris","orcid":"https://orcid.org/0000-0002-4538-8817","observed_orcids":["https://orcid.org/0000-0002-4538-8817"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew C. Harris","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034673327","display_name":"Ernst Holler","orcid":"https://orcid.org/0000-0003-2295-2187","observed_orcids":["https://orcid.org/0000-0003-2295-2187"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ernst Holler","raw_affiliation_strings":["University Hospital Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010838701","display_name":"Austin Taylor","orcid":"https://orcid.org/0000-0002-5864-711X","observed_orcids":["https://orcid.org/0000-0002-5864-711X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Austin Taylor","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008038245","display_name":"Holly K. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly K. Miller","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009204664","display_name":"John Martin Magenau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Magenau","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070132319","display_name":"Daniel Jordan Weisdorf","orcid":"https://orcid.org/0000-0001-8078-8579","observed_orcids":["https://orcid.org/0000-0001-8078-8579"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Weisdorf","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031812464","display_name":"Vincent T. Ho","orcid":"https://orcid.org/0000-0001-6839-3996","observed_orcids":["https://orcid.org/0000-0001-6839-3996"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent T Ho","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003078712","display_name":"Javier Bola\u00f1os\u2010Meade","orcid":"https://orcid.org/0000-0002-8340-1808","observed_orcids":["https://orcid.org/0000-0002-8340-1808"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Bola\u00f1os-Meade","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104852","display_name":"Amin Majid Alousi","orcid":"https://orcid.org/0000-0002-2498-8573","observed_orcids":["https://orcid.org/0000-0002-2498-8573"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin M. Alousi","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023099227","display_name":"James L.M. Ferrara","orcid":"https://orcid.org/0000-0001-8595-3940","observed_orcids":["https://orcid.org/0000-0001-8595-3940"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L.M. Ferrara","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010838701","https://openalex.org/A5024499904","https://openalex.org/A5034673327","https://openalex.org/A5101605321"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I3129555431"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32921811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"21","first_page":"661","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.921999990940094},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tnfr1","display_name":"TNFR1","score":0.921999990940094},{"id":"https://openalex.org/keywords/reg3a","display_name":"REG3A","score":0.9779999852180481},{"id":"https://openalex.org/keywords/st2","display_name":"ST2","score":1.0},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5820000171661377},{"id":"https://openalex.org/keywords/competing-risks-regression","display_name":"competing risk regression","score":0.5979999899864197},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7523941993713379},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.5843279361724854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5799822211265564},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5390993356704712},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.4669994115829468},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.45129865407943726},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4134470820426941},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34269440174102783},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2879832684993744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.661.661","doi":"https://doi.org/10.1182/blood.v124.21.661.661","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.661.661","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4246682656","https://openalex.org/W2105179089","https://openalex.org/W205891179","https://openalex.org/W2589425123","https://openalex.org/W2596217949","https://openalex.org/W4394981536","https://openalex.org/W1967884931","https://openalex.org/W2993334270","https://openalex.org/W1966208568","https://openalex.org/W2593377882"],"abstract_inverted_index":{"Abstract":[0],"The":[1,305,648],"severity":[2,645,667],"of":[3,8,36,45,117,144,194,219,229,254,342,368,379,446,465,512,522,530,601,610,624,631,636,702,738,747,756],"symptoms":[4],"at":[5,42,72,332,392,646,650,668],"the":[6,43,115,135,197,215,227,233,264,270,299,364,389,407,428,443,466,595,599,602,669,700,712],"onset":[7,75,228,394,652],"graft":[9],"versus":[10],"host":[11],"disease":[12,658],"(GVHD)":[13],"does":[14,661],"not":[15,296,396,401,528,662],"accurately":[16],"define":[17,49,628],"risk,":[18],"and":[19,90,123,125,170,203,235,267,276,383,411,481,487,516,573,620,638],"thus":[20,309,698],"most":[21,716],"patients":[22,490],"(pts)":[23],"are":[24,326,687],"treated":[25,288],"alike":[26],"with":[27,189,223,258,375,398,427,491,551,588,633,664],"high":[28,713],"dose":[29],"systemic":[30],"steroids.":[31],"We":[32,64,113,161,261,359],"hypothesized":[33],"that":[34,56,68,173,182,370,503,560,627,660],"concentrations":[35,116],"one":[37,206],"or":[38,527],"more":[39],"plasma":[40,67,625],"biomarkers":[41,120,626,649],"time":[44],"GVHD":[46,74,104,149,179,230,301,318,372,384,393,632,651,740,749,758],"diagnosis":[47,150],"could":[48,57],"distinct":[50,415,634],"non-relapse":[51],"mortality":[52],"(NRM)":[53],"risk":[54,218,292,416,473,511,521,533,569,582,704,714],"grades":[55,180,302,432,542,604,630],"guide":[58],"treatment":[59,374,485,639],"in":[60,196,231,281,307,324,489,643,676],"a":[61,109,140,290,376,499,509,519,548,608],"multicenter":[62,100,272,365],"setting.":[63],"first":[65],"analyzed":[66],"was":[69,243,287,336],"prospectively":[70],"collected":[71],"acute":[73],"from":[76,80,134,148,166,720],"492":[77],"HCT":[78,95],"pts":[79,96,256,369,447,565,578,587,685,705,715],"2":[81,497,728],"centers,":[82],"which":[83,286,335],"we":[84,204,501,546,617],"randomly":[85],"divided":[86],"into":[87,311],"training":[88,136,198,234],"(n=328)":[89],"validation":[91,111,236,273,366],"(n=164)":[92],"sets;":[93],"300":[94],"who":[97,686],"enrolled":[98],"on":[99,187,363],"BMT":[101],"CTN":[102],"primary":[103,329],"therapy":[105,330,693],"clinical":[106,472,532,644,677,696],"trials":[107],"provided":[108],"second":[110,271],"set.":[112],"measured":[114],"3":[118,178,518,558,564,732],"prognostic":[119],"(TNFR1,":[121],"REG3\u03b1,":[122],"ST2)":[124],"used":[126],"competing":[127,291],"risks":[128,635],"regression":[129],"to":[130,138,168,210,245,269,437,439,450,543,654,689,691,706,718],"create":[131],"an":[132,622],"algorithm":[133,266,410,623,672],"set":[137,199,274,367],"compute":[139],"predicted":[141,508],"probability":[142],"(p)":[143],"6":[145],"mo":[146],"NRM":[147,183,220,242,282,308,399,419,513,523,571,584,637],"where":[151],"log[-log(1-p)]":[152],"=":[153],"-9.169":[154],"+":[155,159],"0.598(log2TNFR1)":[156],"-":[157],"0.028(log2REG3\u03b1)":[158],"0.189(log2ST2).":[160],"then":[162],"rank":[163],"ordered":[164],"p":[165],"lowest":[167],"highest":[169],"identified":[171],"thresholds":[172,195,268,412],"met":[174,200],"predetermined":[175],"criteria":[176],"for":[177,293,316,340,356,418,554,570,583,598],"so":[181],"would":[184],"increase":[185],"15%":[186],"average":[188],"each":[190,208,212,224,317,341,421,451],"grade.":[191,213],"A":[192],"range":[193],"these":[201,255,531],"criteria,":[202],"chose":[205],"near":[207],"median":[209],"demarcate":[211],"In":[214,615],"resulting":[216],"grades,":[217,545],"significantly":[221,312,567,580],"increased":[222],"grade":[225,319,345,349,352,391,423,454,456,459,462,468,496,506,517,563,576,591],"after":[226,373],"both":[232,555],"sets":[237],"(FIG":[238,283,424,469],"1A,B).":[239],"Most":[240],"(80%)":[241],"due":[244],"steroid-refractory":[246],"GI":[247,259,656,665],"GVHD,":[248],"even":[249],"though":[250],"surprisingly":[251],"only":[252],"half":[253],"presented":[257],"symptoms.":[260],"next":[262],"applied":[263],"biomarker":[265,409,741,750,759],"(n=300)":[275],"observed":[277],"similarly":[278],"significant":[279],"differences":[280,306,323,642],"1C).":[284],"Relapse,":[285],"as":[289,476,498],"NRM,":[294],"did":[295,395],"differ":[297],"among":[298],"three":[300,414,629],"(Figure":[303,320],"1D-F).":[304],"translated":[310],"different":[313,339],"overall":[314],"survival":[315,325,488],"1G-I).":[321],"These":[322],"explained":[327],"by":[328],"response":[331,486],"day":[333],"28,":[334],"highly":[337],"statistically":[338],"Ann":[343,430,452,494,504,540,561,574,589],"Arbor":[344,431,453,495,505,541,562,575,590],"(grade":[346],"1,":[347,457],"81%;":[348],"2,":[350,460],"68%;":[351],"3,":[353],"46%;":[354],"p<0.001":[355],"all":[357],"comparisons).":[358],"performed":[360],"additional":[361],"analyses":[362],"developed":[371,619],"wide":[377],"spectrum":[378],"supportive":[380],"care,":[381],"conditioning":[382],"prophylaxis":[385],"practices.":[386],"As":[387],"expected,":[388],"Glucksberg":[390,422,467,544,603],"correlate":[397,663],"(data":[400],"shown).":[402],"Despite":[403],"small":[404],"sample":[405],"sizes,":[406],"same":[408,444],"defined":[413],"strata":[417],"within":[420],"2A-C).":[425],"Pts":[426],"higher":[429,520,568],"were":[433,448,535],"usually":[434],"less":[435,581],"likely":[436,688,717],"respond":[438,690],"treatment.":[440],"Unexpectedly,":[441],"approximately":[442],"proportion":[445],"assigned":[449],"(~25%":[455],"~55%":[458],"~20%":[461],"3)":[463],"regardless":[464],"2D-F).":[470],"Several":[471],"factors,":[474],"such":[475],"donor":[477],"type,":[478],"age,":[479],"conditioning,":[480],"HLA-match,":[482],"can":[483,683],"predict":[484],"GVHD.":[492],"Using":[493],"reference,":[500],"found":[502],"1":[507,577,724],"lower":[510],"(range":[514,524],"0.16-0.32)":[515],"1.4-2.9),":[525],"whether":[526],"any":[529],"factors":[534],"present.":[536],"To":[537],"directly":[538],"compare":[539],"fit":[547],"multivariate":[549],"model":[550],"simultaneous":[552],"adjustment":[553],"grades.":[556,614],"FIG":[557],"shows":[559],"had":[566,579],"(p=0.005)":[572],"(p=0.002)":[585],"than":[586],"2.":[592,730],"By":[593],"contrast,":[594],"confidence":[596],"intervals":[597],"HRs":[600],"encompassed":[605],"1.0,":[606],"demonstrating":[607],"lack":[609],"statistical":[611],"significance":[612],"between":[613],"conclusion,":[616],"have":[618],"validated":[621],"failure":[640],"despite":[641,694],"presentation.":[647],"appear":[653],"reflect":[655],"tract":[657],"activity":[659],"symptom":[666],"time.":[670],"This":[671],"may":[673],"be":[674],"useful":[675],"trial":[678],"design.":[679],"For":[680],"example,":[681],"it":[682],"exclude":[684],"standard":[692],"severe":[695],"presentations,":[697],"limiting":[699],"exposure":[701],"low":[703],"investigational":[707,721],"agents":[708],"while":[709],"also":[710],"identifying":[711],"benefit":[719],"approaches.":[722],"Figure":[723,725,727,729,731,733],"1.":[726],"3.":[734],"Disclosures":[735],"Levine:":[736],"University":[737],"Michigan:":[739,748,757],"patent":[742,751,760],"Patents":[743,752,761],"&":[744,753,762],"Royalties.":[745,754,763],"Braun:University":[746],"Ferrara:University":[755]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-12-16T00:00:00"}
