{"id":"https://openalex.org/W2559524664","doi":"https://doi.org/10.1182/blood.v106.11.108.108","title":"A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia.","display_name":"A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia.","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2559524664","doi":"https://doi.org/10.1182/blood.v106.11.108.108","mag":"2559524664"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.108.108","doi":"https://doi.org/10.1182/blood.v106.11.108.108","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.108.108","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012956545","display_name":"Scott A. Armstrong","orcid":"https://orcid.org/0000-0002-9099-4728","observed_orcids":["https://orcid.org/0000-0002-9099-4728"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Armstrong","raw_affiliation_strings":["Hematology/Oncology, Children\u2019s Hospital, Boston, MA, USA","Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology, Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guo Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo Wei","raw_affiliation_strings":["Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037957247","display_name":"Justin Lamb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Lamb","raw_affiliation_strings":["Cancer Genomics, Broad Institute, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics, Broad Institute, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052507376","display_name":"Joseph T. Opferman","orcid":"https://orcid.org/0000-0002-1147-5621","observed_orcids":["https://orcid.org/0000-0002-1147-5621"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Opferman","raw_affiliation_strings":["St. Jude Children\u2019s Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084242973","display_name":"David Twomey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Twomey","raw_affiliation_strings":["Cancer Genomics, Broad Institute, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics, Broad Institute, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002362786","display_name":"Ronald W. Stam","orcid":"https://orcid.org/0000-0003-4986-1656","observed_orcids":["https://orcid.org/0000-0003-4986-1656"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald Stam","raw_affiliation_strings":["Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035786690","display_name":"Monique L. den Boer","orcid":"https://orcid.org/0000-0002-5795-2921","observed_orcids":["https://orcid.org/0000-0002-5795-2921"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monique den Boer","raw_affiliation_strings":["Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082614208","display_name":"Stephen E. Sallan","orcid":"https://orcid.org/0000-0002-1064-8981","observed_orcids":["https://orcid.org/0000-0002-1064-8981"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen E. Sallan","raw_affiliation_strings":["Hematology/Oncology, Children\u2019s Hospital, Boston, MA, USA","Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology, Children\u2019s Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035292815","display_name":"Rob Pieters","orcid":"https://orcid.org/0000-0003-2997-3570","observed_orcids":["https://orcid.org/0000-0003-2997-3570"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob Pieters","raw_affiliation_strings":["Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001449157","display_name":"Todd R. Golub","orcid":"https://orcid.org/0000-0003-0113-2403","observed_orcids":["https://orcid.org/0000-0003-0113-2403"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd R. Golub","raw_affiliation_strings":["Cancer Genomics, Broad Institute, Cambridge, MA, USA","Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics, Broad Institute, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.3836,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67688223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"106","issue":"11","first_page":"108","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.878000020980835},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/reversal-of-drug-resistance","display_name":"drug resistance reversal","score":0.6859999895095825},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.671999990940094},{"id":"https://openalex.org/keywords/connectivity-map","display_name":"Connectivity Map","score":0.6990000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.6480000019073486},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7885321378707886},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6369538307189941},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5905078053474426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5230734944343567},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5028995871543884},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.49948930740356445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4978957176208496},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43915653228759766},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.4371853768825531},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4299094080924988},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42802512645721436},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4253462255001068},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.4199078679084778},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3845787048339844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22541147470474243},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20150429010391235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11438187956809998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.108.108","doi":"https://doi.org/10.1182/blood.v106.11.108.108","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.108.108","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988377311","https://openalex.org/W2582427827","https://openalex.org/W2352675264","https://openalex.org/W2134054690","https://openalex.org/W2108752981","https://openalex.org/W3006903599","https://openalex.org/W7097690993","https://openalex.org/W2550669303","https://openalex.org/W1544532093","https://openalex.org/W2316611023"],"abstract_inverted_index":{"Abstract":[0],"Glucocorticoids":[1],"(GC)":[2],"remain":[3],"a":[4,25,80,111,178,226,294,336,418],"cornerstone":[5],"of":[6,15,24,49,60,99,113,141,149,174,243,246,253,260,276,303,308,330,353,369,386,409,425,438],"treatment":[7,98],"for":[8,82,343,399,421,429],"acute":[9],"lymphoblastic":[10],"leukemia":[11],"(ALL),":[12],"and":[13,36,56,211,219,257,271,282,292,319,332,411],"failure":[14],"GC":[16,37,53,160,163,247,348,383,405],"to":[17,29,171,183,222,313,360,382],"induce":[18,159],"apoptosis":[19,224],"in":[20,34,39,162,188,268,289,338,347,422,442],"vitro":[21],"is":[22,169,341],"predictive":[23],"poor":[26],"prognosis.":[27],"Strategies":[28],"pharmacologically":[30],"overcome":[31],"drug":[32,61],"resistance":[33,38,198,312,406],"general,":[35],"particular,":[40],"are":[41,397],"lacking.":[42],"We":[43,151,286],"hypothesized":[44],"that":[45,138,156,199,229,297,335,391],"gene":[46,57,70,263],"expression":[47,58,71,266,275,340,365],"signatures":[48,59],"disease":[50],"states":[51],"(e.g.":[52],"resistant":[54,127,164,214],"ALL)":[55],"action":[62],"could":[63],"be":[64],"computationally":[65],"connected":[66],"by":[67,117,202],"systematically":[68],"performing":[69],"profiling":[72],"on":[73,91,234],"cells":[74,218,221,273,291,358,381],"treated":[75],"with":[76,110,124],"known":[77,170],"drugs.":[78],"As":[79],"pilot":[81],"the":[83,134,139,142,147,154,185,189,208,241,251,254,261,301,304,328,344,367,413],"Connectivity":[84,135,414,433],"Map":[85,136,415,434],"concept,":[86],"we":[87,176,249],"profiled":[88],"~300":[89],"drugs":[90,441],"Affymetrix":[92],"U113A":[93],"arrays":[94],"following":[95],"6":[96],"hour":[97],"MCF7,":[100],"HL60":[101],"or":[102,126,237],"PC3":[103],"cells.":[104,166,322],"This":[105],"signature":[106,112,140,148,256],"database":[107,435],"was":[108,200,284],"queried":[109],"GC-sensitive":[114,125],"ALL":[115,380],"obtained":[116],"comparing":[118],"pre-treatment":[119],"marrow":[120],"blasts":[121],"from":[122],"patients":[123],"ALL.":[128],"Using":[129],"Kolmogorov-Smirnov":[130],"based":[131],"computational":[132],"analysis,":[133],"indicated":[137],"mTOR":[143,186],"inhibitor":[144],"rapamycin":[145,157,168,203,227,244,331,378,403],"matched":[146],"GC-sensitivity.":[150],"thus":[152],"tested":[153],"hypothesis":[155],"would":[158],"sensitivity":[161],"lymphoid":[165],"Because":[167],"act":[172],"downstream":[173],"AKT,":[175],"used":[177],"constitutively":[179],"active":[180],"AKT":[181],"(myr-AKT)":[182],"activate":[184],"pathway":[187],"glucocorticoid-sensitive":[190],"murine":[191],"T-cell":[192],"line":[193],"2B4.":[194],"Myr-AKT":[195],"induced":[196],"glucocorticoid":[197,213,311],"reversible":[201],"treatment.":[204],"Rapamycin":[205],"also":[206],"reversed":[207],"GC-resistance":[209,255],"signature,":[210],"sensitized":[212],"human":[215],"CEM-c1":[216,270,357],"T-ALL":[217],"2B4":[220,272,290,314],"GC-induced":[223,374],"at":[225],"dose":[228],"alone":[230],"had":[231],"no":[232],"effect":[233],"cell":[235],"proliferation":[236],"survival.":[238],"To":[239],"determine":[240],"mechanism":[242],"induction":[245],"sensitivity,":[248],"examined":[250],"components":[252],"noted":[258],"overexpression":[259],"anti-apoptotic":[262],"MCL-1.":[264,387],"MCL-1":[265,309,324,339,354,363],"decreased":[267],"rapamycin-treated":[269],"whereas":[274],"other":[277],"multi-domain":[278],"antiapoptotic":[279],"molecules":[280],"BCL-2":[281],"BCL-xL":[283],"unaffected.":[285],"over-expressed":[287],"Mcl-1":[288],"developed":[293],"transgenic":[295],"mouse":[296],"expresses":[298],"mcl-1":[299],"under":[300],"control":[302],"H2-K":[305],"promoter.":[306],"Over-expression":[307],"conferred":[310],"cells,":[315],"primary":[316],"splenic":[317],"B":[318],"CD8+":[320],"T":[321],"Furthermore":[323],"over-expression":[325],"protected":[326],"against":[327],"combination":[329,394,427],"glucocorticoids,":[333],"suggesting":[334],"decrease":[337],"necessary":[342],"rapamycin-mediated":[345],"increase":[346],"sensitivity.":[349],"Conversely,":[350],"shRNA-mediated":[351],"knockdown":[352],"rendered":[355],"GC-resistant":[356,400],"sensitive":[359],"GC.":[361],"Finally,":[362],"over":[364],"sequestered":[366],"majority":[368],"proapoptotic":[370],"BIM,":[371],"even":[372],"after":[373],"BIM":[375],"expression.":[376],"Thus,":[377],"sensitizes":[379],"through":[384],"down-regulation":[385,408],"These":[388],"data":[389],"indicate":[390],"(1)":[392],"rapamycin/GC":[393],"clinical":[395],"trials":[396],"warranted":[398],"ALL,":[401],"(2)":[402],"reverses":[404],"via":[407],"MCL-1,":[410],"(3)":[412],"approach":[416],"represents":[417],"novel":[419],"strategy":[420],"silico":[423],"identification":[424],"promising":[426],"therapies":[428],"cancer.":[430],"A":[431],"public-access":[432],"containing":[436],"profiles":[437],"all":[439],"FDA-approved":[440],"therefore":[443],"warranted.":[444]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-12-08T00:00:00"}
