{"id":"https://openalex.org/W255949367","doi":null,"title":"Pyruvate dehydrogenase/sub b/ phosphatase inhibition by NADH and dihydrolipoamide along with effects of and capacity for binding the phosphatase to the bovine kidney transacetylase-protein X subcomplex","display_name":"Pyruvate dehydrogenase/sub b/ phosphatase inhibition by NADH and dihydrolipoamide along with effects of and capacity for binding the phosphatase to the bovine kidney transacetylase-protein X subcomplex","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W255949367","mag":"255949367"},"language":"en","primary_location":{"id":"mag:255949367","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6899071-pyruvate-dehydrogenase-sub-phosphatase-inhibition-nadh-dihydrolipoamide-along-effects-capacity-binding-phosphatase-bovine-kidney-transacetylase-protein-subcomplex","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033810613","display_name":"T.E. Roche","orcid":"https://orcid.org/0000-0001-5401-8183","observed_orcids":["https://orcid.org/0000-0001-5401-8183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T.E. Roche","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5401-8183","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058929353","display_name":"Mohammed Rahmatullah","orcid":"https://orcid.org/0000-0002-0216-7977","observed_orcids":["https://orcid.org/0000-0002-0216-7977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Rahmatullah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0216-7977","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044698553","display_name":"James F. Maher","orcid":"https://orcid.org/0000-0002-5608-7999","observed_orcids":["https://orcid.org/0000-0002-5608-7999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James F. Maher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5608-7999","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadh-inhibition","display_name":"NADH inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dihydrolipoamide","display_name":"dihydrolipoamide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-x","display_name":"protein X","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dihydrolipoyl-dehydrogenase","display_name":"dihydrolipoyl dehydrogenase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/arsenite-inhibition","display_name":"arsenite inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/thiol-reduction","display_name":"thiol reduction","score":0.7329999804496765},{"id":"https://openalex.org/keywords/phosphatase-activation","display_name":"phosphatase activation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bovine-kidney","display_name":"bovine kidney","score":0.5720000267028809},{"id":"https://openalex.org/keywords/enzyme-complex-assembly","display_name":"enzyme complex assembly","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C120763696","wikidata":"https://www.wikidata.org/wiki/Q419337","display_name":"Dihydrolipoamide dehydrogenase","level":4,"score":0.8617855310440063},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.8387129306793213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.696955680847168},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.5166569352149963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5063549280166626},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5061630606651306},{"id":"https://openalex.org/C2777824588","wikidata":"https://www.wikidata.org/wiki/Q414783","display_name":"Dithiothreitol","level":3,"score":0.4771230220794678},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4713297188282013},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.45430099964141846},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.4542929530143738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36494773626327515}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:255949367","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6899071-pyruvate-dehydrogenase-sub-phosphatase-inhibition-nadh-dihydrolipoamide-along-effects-capacity-binding-phosphatase-bovine-kidney-transacetylase-protein-subcomplex","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1617680548","https://openalex.org/W1537202229","https://openalex.org/W1583528288","https://openalex.org/W2013929290","https://openalex.org/W1967255894","https://openalex.org/W1484792585","https://openalex.org/W2201450162","https://openalex.org/W1596023781","https://openalex.org/W1506667936","https://openalex.org/W2412664363"],"abstract_inverted_index":{"NADH":[0,42,57,67,97,112,119,185],"inhibits":[1],"PDH/sub":[2],"b/":[3],"phosphatase":[4,39,64,85,95,104,122,130],"activity":[5,105],"when":[6,17],"/sup":[7,18],"32/P-PDH":[8,19],"is":[9,20],"associated":[10,49],"with":[11,50,86],"the":[12,27,31,38,51,63,69,94,109,150,164,170,188],"intact":[13],"complex":[14,83],"but":[15],"not":[16,72],"prepared":[21],"free":[22],"of":[23,26,30,46,62,81,93,103,111,115,128,137,152,169,187],"other":[24],"components":[25],"complex.":[28],"Addition":[29],"transacetylase-protein":[32],"X":[33,154,160,174],"(E2-X)":[34],"subcomplex":[35,52,139],"both":[36],"activated":[37,133],"and":[40,68,84],"restored":[41],"inhibition.":[43,58],"Low":[44],"levels":[45],"dihydrolipoyl":[47],"dehydrogenase":[48],"might":[53],"be":[54,132],"required":[55],"for":[56],"Dihydrolipoamide":[59],"gave":[60],"inhibition":[61,75,92,102,186],"equivalent":[65],"to":[66,149,163,184],"combination":[70],"did":[71],"give":[73],"additional":[74],"suggesting":[76,113],"a":[77,177],"common":[78],"mechanism.":[79],"Pretreatment":[80],"phosphorylated":[82],"2.0":[87],"mM":[88],"dithiothreitol":[89],"nearly":[90],"eliminated":[91],"by":[96,118,134],"or":[98],"dihydrolipoamide.":[99],"Strong":[100],"arsenite":[101],"occurred":[106],"only":[107],"in":[108,143],"presence":[110],"modification":[114],"thiols":[116],"reduced":[117],"can":[120],"alter":[121],"activity.":[123],"Only":[124],"about":[125],"6":[126],"molecules":[127],"purified":[129],"could":[131],"1":[135],"molecule":[136],"E2-X":[138],"(initial":[140],"velocities":[141],"measured":[142],"15s":[144],"period).":[145],"Since":[146,172],"that":[147],"corresponded":[148],"number":[151],"protein":[153,159,173],"rather":[155],"than":[156],"E2":[157],"subunits,":[158],"may":[161,181],"contribute":[162,183],"Ca/sup":[165],"2":[166],"+/-dependent":[167],"binding":[168],"phosphatase.":[171,189],"also":[175,182],"contains":[176],"lipoyl":[178],"moiety,":[179],"it":[180]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}