{"id":"https://openalex.org/W2558508334","doi":"https://doi.org/10.1182/blood.v104.11.726.726","title":"Differential Phosphorylation of FANCA and FANCG Determines Response of Fanconi Anemia Core Complex to DNA Damage and S Phase.","display_name":"Differential Phosphorylation of FANCA and FANCG Determines Response of Fanconi Anemia Core Complex to DNA Damage and S Phase.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2558508334","doi":"https://doi.org/10.1182/blood.v104.11.726.726","mag":"2558508334"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.726.726","doi":"https://doi.org/10.1182/blood.v104.11.726.726","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.726.726","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026815549","display_name":"Jun Mi","orcid":"https://orcid.org/0000-0001-5788-3965","observed_orcids":["https://orcid.org/0000-0001-5788-3965"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Mi","raw_affiliation_strings":["Microbiology, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025519861","display_name":"Andrei Tomashevski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrei Tomashevski","raw_affiliation_strings":["Microbiology, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079834643","display_name":"Gary M. Kupfer","orcid":"https://orcid.org/0000-0002-3988-2894","observed_orcids":["https://orcid.org/0000-0002-3988-2894"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary M. Kupfer","raw_affiliation_strings":["Microbiology, University of Virginia Health System, Charlottesville, VA, USA","Pediatrics, University of Virginia Health System, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"Pediatrics, University of Virginia Health System, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I2799765794"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025519861"],"corresponding_institution_ids":["https://openalex.org/I2799765794"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25003027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"726","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/fanca","display_name":"FANCA","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fancg","display_name":"FANCG","score":1.0},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fa-core-complex","display_name":"FA core complex","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.968999981880188},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.7509999871253967},{"id":"https://openalex.org/keywords/monoubiquitination","display_name":"monoubiquitination","score":0.9139999747276306},{"id":"https://openalex.org/keywords/atr-kinase","display_name":"ATR kinase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2778993383","wikidata":"https://www.wikidata.org/wiki/Q17927056","display_name":"FANCA","level":5,"score":0.9566348791122437},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.7507764101028442},{"id":"https://openalex.org/C2776653068","wikidata":"https://www.wikidata.org/wiki/Q17927069","display_name":"FANCD2","level":5,"score":0.741096556186676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6508262157440186},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6072708964347839},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5753363966941833},{"id":"https://openalex.org/C2780307904","wikidata":"https://www.wikidata.org/wiki/Q2701649","display_name":"Phosphoserine","level":4,"score":0.5325355529785156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4626292884349823},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.413130521774292},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3559204936027527},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.34588271379470825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18400391936302185},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17548397183418274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.726.726","doi":"https://doi.org/10.1182/blood.v104.11.726.726","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.726.726","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W566608207","https://openalex.org/W2058831361","https://openalex.org/W2567657619","https://openalex.org/W7100333494","https://openalex.org/W2107610354","https://openalex.org/W2172034068","https://openalex.org/W1976314662","https://openalex.org/W7097525350","https://openalex.org/W7101105965","https://openalex.org/W2154421320"],"abstract_inverted_index":{"Abstract":[0],"Fanconi":[1],"anemia":[2],"(FA)":[3],"is":[4,45,189,210,234],"a":[5,98,120,184],"genetic":[6],"disease":[7,31],"marked":[8],"by":[9],"bone":[10],"marrow":[11],"failure,":[12],"congenital":[13],"defects,":[14],"and":[15,32,56,72,110,152,205],"cancer.":[16],"In":[17,64,81,179],"spite":[18],"of":[19,22,29,47,53,84,91,104,107,122,187,200,241,250,261],"the":[20,27,30,37,82,89,105,111,171,177,197,239,244,248,262],"identification":[21],"at":[23,48,128,137,149,212],"least":[24,49],"8":[25],"genes,":[26],"biochemistry":[28],"its":[33],"normal":[34],"pathway":[35,246],"in":[36,76,176,192,202,215,221,243,247],"cell":[38,263],"remains":[39],"elusive.":[40],"The":[41],"FA":[42,108,112,193,227,245],"core":[43,113],"complex":[44],"composed":[46],"5":[50],"proteins,":[51],"2":[52],"which,":[54],"FANCA":[55,71,160],"FANCG,":[57,85],"we":[58,67,86,131,195],"have":[59,87,169],"shown":[60],"to":[61,78,94,157,181,217,254],"be":[62],"phosphorylated.":[63],"these":[65],"studies,":[66],"show":[68],"that":[69,116],"both":[70,118,148,251],"FANCG":[73,101,143],"are":[74],"phosphorylated":[75,191,211],"response":[77,216],"DNA":[79,123,154,165,218,255],"damage.":[80,166],"case":[83],"mapped":[88],"site":[90],"this":[92],"phosphorylation":[93,135,146,161,198,242],"serine":[95,144,213],"7,":[96],"using":[97],"phosphoserine":[99],"7":[100,145],"antiserum.":[102],"Because":[103],"link":[106],"function":[109],"complex-dependent":[114],"monoubiquitination":[115],"occurs":[117,147,162],"as":[119,125,127,140,174,257,259],"result":[121],"damage":[124,155,219,256],"well":[126,258],"S":[129,138,150],"phase,":[130],"also":[132],"examined":[133],"if":[134],"occurred":[136],"phase":[139,151],"well.":[141],"While":[142],"after":[153,164],"(similar":[156],"FANCD2":[158],"monoubiquitination),":[159],"only":[163,220],"Recent":[167],"data":[168,237],"implicated":[170],"kinase":[172,209,233],"ATR":[173,188],"important":[175],"pathway.":[178],"order":[180],"assess":[182],"whether":[183],"downstream":[185],"target":[186],"differentially":[190],"cells,":[194,228],"tested":[196],"status":[199],"chk1":[201],"FA-A":[203],"mutant":[204,226],"corrected":[206,222],"cells.":[207],"Chk1":[208],"318":[214],"cells":[223],"but":[224],"not":[225],"while":[229],"signaling":[230],"through":[231],"chk2":[232],"unaffected.":[235],"These":[236],"suggest":[238],"importance":[240],"regulation":[249],"cellular":[252],"responses":[253],"engagement":[260],"cycle.":[264]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-12-08T00:00:00"}
