{"id":"https://openalex.org/W2558397261","doi":"https://doi.org/10.1182/blood.v112.11.312.312","title":"Hypermethylation of HOX Genes Is Associated with Longer Survival in Acute Myeloid Leukemia","display_name":"Hypermethylation of HOX Genes Is Associated with Longer Survival in Acute Myeloid Leukemia","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2558397261","doi":"https://doi.org/10.1182/blood.v112.11.312.312","mag":"2558397261"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.312.312","doi":"https://doi.org/10.1182/blood.v112.11.312.312","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.312.312","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027336256","display_name":"Jaroslav Jel\u0131\u0301nek","orcid":"https://orcid.org/0000-0002-2533-0220","observed_orcids":["https://orcid.org/0000-0002-2533-0220"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaroslav Jelinek","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037855721","display_name":"Heike Kroeger","orcid":"https://orcid.org/0000-0001-7726-7748","observed_orcids":["https://orcid.org/0000-0001-7726-7748"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heike Kroeger","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079731167","display_name":"Rong Lucy He","orcid":"https://orcid.org/0000-0001-6116-8163","observed_orcids":["https://orcid.org/0000-0001-6116-8163","https://orcid.org/0000-0002-6011-5964"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong He","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091380386","display_name":"Amanda J. Saraf","orcid":"https://orcid.org/0000-0002-0167-8716","observed_orcids":["https://orcid.org/0000-0002-0167-8716"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Saraf","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010915755","display_name":"Samantha F. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha F Lau","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tuong-Van Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuong-Van Nguyen","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103272597","display_name":"Michael W. Thomas","orcid":"https://orcid.org/0000-0002-7214-5570","observed_orcids":["https://orcid.org/0000-0002-7214-5570"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Thomas","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055885795","display_name":"Elizabeth J. Shpall","orcid":"https://orcid.org/0000-0003-3947-4126","observed_orcids":["https://orcid.org/0000-0003-3947-4126"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J Shpall","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016607292","display_name":"Steven Mitchell Kornblau","orcid":"https://orcid.org/0000-0002-5990-9548","observed_orcids":["https://orcid.org/0000-0002-5990-9548"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Kornblau","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083910226","display_name":"Carlos Bueso-Ramos","orcid":"https://orcid.org/0000-0003-0180-7124","observed_orcids":["https://orcid.org/0000-0003-0180-7124"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Bueso-Ramos","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M Kantarjian","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062330946","display_name":"Jean\u2010Pierre J. Issa","orcid":"https://orcid.org/0000-0003-2258-5030","observed_orcids":["https://orcid.org/0000-0003-2258-5030"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre J Issa","raw_affiliation_strings":["The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34351407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"112","issue":"11","first_page":"312","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-gene","display_name":"X gene","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8140000104904175},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7129999995231628},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hoxa5","display_name":"HOXA5","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hoxa9","display_name":"HOXA9","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hoxd9","display_name":"HOXD9","score":0.6299999952316284},{"id":"https://openalex.org/keywords/nor-1","display_name":"NOR-1","score":0.7129999995231628},{"id":"https://openalex.org/keywords/slc26a4","display_name":"SLC26A4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.5009999871253967},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.46000000834465027},{"id":"https://openalex.org/keywords/leukemia-prognosis","display_name":"leukemia prognosis","score":0.4519999921321869},{"id":"https://openalex.org/keywords/hoxa4","display_name":"HOXA4","score":0.41200000047683716},{"id":"https://openalex.org/keywords/hoxb13","display_name":"HOXB13","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hoxc4","display_name":"HOXC4","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.9648983478546143},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7416588068008423},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.616323709487915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6098325848579407},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5946484804153442},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5438315272331238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.506730854511261},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5057253837585449},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.42792218923568726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4127441942691803},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.13277894258499146},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0900023877620697}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.312.312","doi":"https://doi.org/10.1182/blood.v112.11.312.312","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.312.312","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.6499999761581421}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096330966","https://openalex.org/W2591284740","https://openalex.org/W3194502062","https://openalex.org/W2104088686","https://openalex.org/W2109499489","https://openalex.org/W2109159904","https://openalex.org/W4407254090","https://openalex.org/W2304263633","https://openalex.org/W2987166784","https://openalex.org/W2573069031"],"abstract_inverted_index":{"Abstract":[0,245],"HOX":[1,10,35,69,88,100,123,258,269,385,464],"genes":[2,15,36,53,70,89,101,124,193,213,219,270,386,401],"regulate":[3],"developmental":[4],"processes":[5],"and":[6,94,185,191,201,211,234,282,288,296,306,313,319,329,332,350,359,377,394,447,456,493],"tissue":[7],"differentiation.":[8],"The":[9],"family":[11],"consists":[12],"of":[13,34,45,52,68,86,98,121,133,138,189,206,218,254,265,317,344,347,368,384,413,425,434,441,475,479],"39":[14],"forming":[16],"paralogs":[17],"assembled":[18],"in":[19,40,71,90,103,125,135,150,158,161,230,271,301,361,372,400,418,467],"4":[20,29,307],"separate":[21],"clusters":[22],"(A,":[23],"B,":[24],"C":[25],"&":[26,114],"D)":[27],"on":[28,257,463],"chromosomes.":[30],"Translocations":[31],"or":[32],"dysregulation":[33],"are":[37,360],"frequently":[38],"found":[39],"leukemia.":[41],"Since":[42],"DNA":[43,80,119,255],"methylation":[44,67,81,120,205,217,256,392,423,446,466],"CpG":[46],"islands":[47],"at":[48,130],"transcriptional":[49],"start":[50],"sites":[51],"leads":[54],"to":[55,60,65,224,249,285,339,390,472],"permanent":[56],"epigenetic":[57,484],"silencing":[58,486],"equivalent":[59],"loss-of-function":[61],"mutations,":[62],"we":[63,221,261],"sought":[64],"investigate":[66],"acute":[72],"myeloid":[73],"leukemia":[74],"(AML).":[75],"We":[76,116],"performed":[77],"a":[78,96,337,353,362,369,476],"comprehensive":[79],"analysis":[82],"by":[83,277,428,498],"bisulfite":[84,429],"pyrosequencing":[85],"31":[87],"24":[91,272],"AML":[92,104,140,159,419,468],"patients":[93,160,273,308,373,420],"characterized":[95],"subset":[97],"10":[99,268],"hypermethylated":[102,375],"(HOXA4,":[105],"HOXA5,":[106,169,207,292,348],"HOXA6,":[107,171,208,293,349],"HOXA7,":[108,173,294],"HOXA9,":[109,175,209,295],"HOXB13,":[110,177],"HOXC4,":[111,179,210],"HOXC10,":[112,181],"HOXD1":[113],"HOXD9).":[115],"next":[117],"measured":[118],"these":[122],"the":[126,131,144,252,266,439],"bone":[127],"marrow":[128],"obtained":[129],"time":[132,280],"diagnosis":[134],"another":[136],"set":[137],"67":[139],"patients.":[141],"Hypermethylation":[142,188],"exceeding":[143],"upper":[145],"95%":[146],"confidence":[147],"limit":[148],"established":[149],"23":[151],"normal":[152,286],"control":[153],"blood":[154,290],"samples":[155],"was":[156,194,322,398,407,416],"observed":[157,399,417],"proportions":[162],"shown":[163],"after":[164],"gene":[165,259,406,465,485],"names:":[166],"HOXA4,":[167],"84%;":[168],"35%;":[170],"53%;":[172],"19%;":[174],"26%;":[176],"62%;":[178],"51%;":[180],"39%;":[182],"HOXD1,":[183],"82%;":[184],"HOXD9,":[186],"75%.":[187],"HOXA5":[190,318,376,405,414],"HOXA6":[192,333,378],"associated":[195,226,323,489],"with":[196,216,227,274,324,352,365,374,421,482,490],"longer":[197,491],"overall":[198],"survival":[199,327,341,492],"(P=0.05":[200],"0.007,":[202],"respectively).":[203,315],"Additionally,":[204],"HOXD9":[212],"significantly":[214,325],"correlated":[215,389],"that":[220,487],"previously":[222],"showed":[223,336],"be":[225],"good":[228,363,370],"prognosis":[229,371],"AML,":[231],"namely":[232],"NOR1":[233],"SLC26A4":[235],"(Kroeger":[236],"et":[237],"al.,":[238],"Blood,":[239],"2007,":[240],"110:":[241],"ASH":[242],"Annual":[243],"Meeting":[244],"595).":[246],"In":[247,459],"order":[248],"better":[250],"understand":[251],"impact":[253],"silencing,":[260],"analyzed":[262],"mRNA":[263,334,415],"expression":[264,346,382,397,412,451],"above":[267],"available":[275,449],"RNA":[276],"TaqMan":[278],"real":[279],"PCR":[281,436],"compared":[283],"it":[284],"adult":[287],"cord":[289],"cells.":[291],"HOXC10":[297],"mRNAs":[298,321],"were":[299,387],"overexpressed":[300],"5,":[302],"7,":[303],"8,":[304],"12,":[305],"(21%,":[309],"29%,":[310],"33%,":[311],"50%,":[312],"17%,":[314],"Overexpression":[316],"HOXA7":[320,351],"shortened":[326],"(P<0.001":[328],"P=0.005,":[330],"respectively),":[331],"overexpression":[335],"trend":[338],"worse":[340],"(P=0.09).":[342],"Associations":[343],"increased":[345],"poor":[354],"outcome":[355],"suggest":[356],"functional":[357],"significance":[358],"agreement":[364],"our":[366,461,473],"observation":[367],"genes.":[379],"As":[380],"expected,":[381],"levels":[383],"inversely":[388],"their":[391],"status":[393],"no":[395],"significant":[396],"methylated":[402,455],"over":[403],"50%.":[404],"an":[408],"exception,":[409],"since":[410],"high":[411],"average":[422],"densities":[424],"66-87%":[426],"detected":[427],"pyrosequencing.":[430],"Bisulfite":[431],"genomic":[432],"sequencing":[433],"cloned":[435],"products":[437],"revealed":[438],"presence":[440],"alleles":[442,453],"completely":[443],"free":[444],"from":[445],"thus":[448],"for":[450,496],"beside":[452],"fully":[454],"presumably":[457],"silenced.":[458],"conclusion,":[460],"data":[462],"provide":[469],"additional":[470],"support":[471],"concept":[474],"distinct":[477],"category":[478],"\u2018epigenetic":[480],"AML\u2019":[481],"pronounced":[483],"is":[488],"greater":[494],"potential":[495],"cure":[497],"chemotherapy.":[499]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-12-08T00:00:00"}
