{"id":"https://openalex.org/W2558043390","doi":"https://doi.org/10.1186/s12986-016-0148-0","title":"Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis","display_name":"Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2558043390","doi":"https://doi.org/10.1186/s12986-016-0148-0","mag":"2558043390","pmid":"https://pubmed.ncbi.nlm.nih.gov/27980597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5134003"},"language":"en","primary_location":{"id":"doi:10.1186/s12986-016-0148-0","doi":"https://doi.org/10.1186/s12986-016-0148-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-016-0148-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12986-016-0148-0.pdf","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12986-016-0148-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112345918","display_name":"Shin\u2010Yu Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shin-Yu Tsai","raw_affiliation_strings":["School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059993032","display_name":"Pei-Chin Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Chin Chung","raw_affiliation_strings":["School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075104195","display_name":"Eddy Owaga","orcid":"https://orcid.org/0000-0003-2360-4563","observed_orcids":["https://orcid.org/0000-0003-2360-4563"]},"institutions":[{"id":"https://openalex.org/I344018163","display_name":"Dedan Kimathi University of Technology","ror":"https://ror.org/05jg5ty85","country_code":"KE","type":"education","lineage":["https://openalex.org/I344018163"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Eddy E. Owaga","raw_affiliation_strings":["Institute of Food Bioresources and Technology, Dedan Kimathi University of Technology, P.O. Box 657-10100, Nyeri, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Bioresources and Technology, Dedan Kimathi University of Technology, P.O. Box 657-10100, Nyeri, Kenya","institution_ids":["https://openalex.org/I344018163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073409159","display_name":"I-Jong Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Jong Tsai","raw_affiliation_strings":["School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pei-Yuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Yuan Wang","raw_affiliation_strings":["School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110041901","display_name":"Jeng\u2010I Tsai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeng-I Tsai","raw_affiliation_strings":["Yuan Lyu Technology Corporation, 10F-3, 120 Chung Cheng 1st Road, Kaohsiung, 802, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuan Lyu Technology Corporation, 10F-3, 120 Chung Cheng 1st Road, Kaohsiung, 802, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024737170","display_name":"Tien-Shun Yeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tien-Shun Yeh","raw_affiliation_strings":["Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085484847","display_name":"Rong\u2010Hong Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Rong-Hong Hsieh","raw_affiliation_strings":["School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085484847"],"corresponding_institution_ids":["https://openalex.org/I47519274"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":9.3642,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.98220759,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.37619999051094055,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-mangostin","display_name":"\u03b1-mangostin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mangosteen-pericarp-extract","display_name":"mangosteen pericarp extract","score":0.9419999718666077},{"id":"https://openalex.org/keywords/garcinia-mangostana","display_name":"Garcinia mangostana","score":0.902999997138977},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.46399998664855957},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6420000195503235},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.4909999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hepatic-triglycerides","display_name":"hepatic triglycerides","score":0.5479999780654907},{"id":"https://openalex.org/keywords/nadh-cytochrome-c-reductase","display_name":"NADH-cytochrome c reductase","score":0.8100000023841858},{"id":"https://openalex.org/keywords/succinate-cytochrome-c-reductase","display_name":"succinate-cytochrome c reductase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6567657589912415},{"id":"https://openalex.org/C2909826119","wikidata":"https://www.wikidata.org/wiki/Q170662","display_name":"Garcinia mangostana","level":2,"score":0.6236757040023804},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6021344661712646},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6020064949989319},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5999672412872314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5681661367416382},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.4996964931488037},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.47544193267822266},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.46419039368629456},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.45457834005355835},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.4265168309211731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42338889837265015},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.41383129358291626},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4125615954399109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3956336975097656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38472071290016174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18314549326896667},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1764099895954132},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.16018375754356384},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11519908905029297},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.07394856214523315},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12986-016-0148-0","doi":"https://doi.org/10.1186/s12986-016-0148-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-016-0148-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12986-016-0148-0.pdf","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4094476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5134003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5134003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5134003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutr Metab (Lond)","raw_type":"Text"},{"id":"pmid:27980597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27980597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12986-016-0148-0","doi":"https://doi.org/10.1186/s12986-016-0148-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-016-0148-0","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12986-016-0148-0.pdf","source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2558043390.pdf","grobid_xml":"https://content.openalex.org/works/W2558043390.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1490154674","https://openalex.org/W1717573228","https://openalex.org/W1850860196","https://openalex.org/W1876464893","https://openalex.org/W1889932477","https://openalex.org/W1977194186","https://openalex.org/W2005839814","https://openalex.org/W2016711642","https://openalex.org/W2023247485","https://openalex.org/W2027328852","https://openalex.org/W2035083374","https://openalex.org/W2050725858","https://openalex.org/W2051705688","https://openalex.org/W2052466095","https://openalex.org/W2065612971","https://openalex.org/W2070549269","https://openalex.org/W2092403733","https://openalex.org/W2102596998","https://openalex.org/W2112291880","https://openalex.org/W2115788076","https://openalex.org/W2140299645","https://openalex.org/W2168526937","https://openalex.org/W2253375633","https://openalex.org/W2277907718","https://openalex.org/W2414852181","https://openalex.org/W2463620414"],"related_works":["https://openalex.org/W3201092834","https://openalex.org/W2253375633","https://openalex.org/W7112081822","https://openalex.org/W3010875264","https://openalex.org/W2624059108","https://openalex.org/W2994247661","https://openalex.org/W7213540670","https://openalex.org/W3208200909","https://openalex.org/W4212943772","https://openalex.org/W3024344246"],"abstract_inverted_index":{"Non-alcoholic":[0],"fatty":[1,133,172,225],"liver":[2,135,164,215,262],"disease":[3],"(NAFLD)":[4],"is":[5,19],"caused":[6],"by":[7],"multiple":[8],"factors":[9,23],"including":[10],"hepatic":[11,51,76,228,323],"oxidative":[12],"stress,":[13],"lipotoxicity,":[14],"and":[15,31,78,86,90,153,196,204,227,231,248,254,289,298,307,311,336,364],"mitochondrial":[16,84,154,205,276,338],"dysfunction.":[17],"Obesity":[18],"among":[20],"the":[21,38,54,67,79,124,159,184,212,261,269,357,362],"risk":[22],"for":[24,120],"NAFLD":[25],"alongside":[26],"type":[27],"2":[28],"diabetes":[29],"mellitus":[30],"hyperlipidemia.":[32],"\u03b1-":[33],"mangostin":[34],"(\u03b1-MG)":[35],"extracts":[36],"from":[37,305],"pericarps":[39],"of":[40,61,70,186,207,240,345,349,359,366],"mangosteen":[41,116],"(":[42],"Garcinia":[43],"mangostana":[44],"Linn.)":[45],"may":[46],"regulate":[47],"high":[48,73,326],"fat":[49,74],"diet-induced":[50,75],"steatosis;":[52],"however":[53],"underlying":[55,80],"mechanisms":[56,81],"remain":[57],"unknown.":[58],"The":[59,217,347],"aim":[60],"this":[62],"study":[63,350],"was":[64],"to":[65,83,180],"investigate":[66],"regulatory":[68],"effect":[69],"\u03b1-MG":[71,187,273,321,360],"on":[72,99,194,356],"steatosis":[77,324],"related":[82],"functionality":[85],"apoptosis":[87,208,344],"in":[88,91,160,211,260,270,325,361],"vivo":[89],"vitro.":[92],"Sprague":[93],"Dawley":[94],"(SD)":[95],"rats":[96,329],"were":[97,126,166,209],"fed":[98,328],"either":[100],"AIM":[101],"93-M":[102],"control":[103,316],"diet,":[104],"a":[105,352],"high-fat":[106,110],"diet":[107,111],"(HFD),":[108],"or":[109],"supplemented":[112],"with":[113,168,265,315],"25":[114],"mg/day":[115],"pericarp":[117],"extract":[118],"(MGE)":[119],"11":[121],"weeks.":[122],"Thereafter,":[123,183],"following":[125],"determined:":[127],"body":[128],"weight":[129],"change,":[130],"plasma":[131,223],"free":[132,171,224],"acids,":[134],"triglyceride":[136],"content,":[137],"antioxidant":[138,241,334],"enzymes":[139,242],"(superoxide":[140],"dismutase,":[141],"SOD;":[142],"glutathione,":[143],"GSH;":[144],"glutathione":[145,148],"peroxidase,":[146],"GPx;":[147],"reductase":[149,252,257],"GRd;":[150],"catalase,":[151],"CAT)":[152],"complex":[155],"enzyme":[156],"activities.":[157],"In":[158,268],"vitro":[161,271],"study,":[162,272],"primary":[163,214],"cells":[165],"treated":[167],"1":[169],"mM":[170],"acid":[173,177,233],"(FFA)":[174],"(palmitate:":[175],"oleate":[176],"=":[178],"2:0.25)":[179],"induce":[181],"steatosis.":[182],"effects":[185],"(10":[188],"\u03bcM,":[189,191],"20":[190],"30":[192],"\u03bcM)":[193],"total":[195],"mitochondria":[197,201],"ROS":[198],"(tROS,":[199],"mitoROS),":[200],"bioenergetic":[202],"functions,":[203],"pathway":[206],"examined":[210],"FFA-treated":[213],"cells.":[216],"MGE":[218],"group":[219],"showed":[220],"significantly":[221,274],"decreased":[222,285],"acids":[226],"triglycerides":[229],"(TG)":[230],"thiorbarbituric":[232],"reactive":[234],"substances":[235],"(TBARS)":[236],"levels;":[237],"increased":[238,275],"activities":[239,259,313],"(SOD,":[243],"GSH,":[244],"GPx,":[245],"GRd,":[246],"CAT);":[247],"enhanced":[249,279,332],"NADH-cytochrome":[250],"c":[251,256,300,302],"(NCCR)":[253],"succinate-cytochrome":[255],"(SCCR)":[258],"tissue":[263],"compared":[264,314],"HFD":[266],"group.":[267,317],"membrane":[277],"potential,":[278],"cellular":[280,333],"oxygen":[281],"consumption":[282],"rate":[283],"(OCR),":[284],"tROS":[286],"(total":[287],"ROS)":[288,292],"mitoROS":[290],"(mitochondrial":[291],"levels":[293],";":[294],"reduced":[295,308],"Ca":[296],"2+":[297],"cytochrome":[299],"(cyt":[301],")":[303],"release":[304],"mitochondria,":[306],"caspases":[309],"9":[310],"3":[312],"These":[318],"findings":[319,348],"demonstrate":[320],"attenuated":[322],"fat-diet":[327],"potentially":[330],"through":[331],"capacity":[335],"improved":[337],"functions":[339],"as":[340,342],"well":[341],"suppressed":[343],"hepatocytes.":[346],"represent":[351],"novel":[353],"nutritional":[354],"approach":[355],"use":[358],"prevention":[363],"management":[365],"NAFLD.":[367]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-12-08T00:00:00"}