{"id":"https://openalex.org/W2558038482","doi":"https://doi.org/10.1182/blood.v106.11.1772.1772","title":"Changes in Bone Metabolism Induced by Short-Term Treatment with G-CSF for the Mobilization of Allogeneic Hematopoietic Progenitor Cells.","display_name":"Changes in Bone Metabolism Induced by Short-Term Treatment with G-CSF for the Mobilization of Allogeneic Hematopoietic Progenitor Cells.","publication_year":2005,"publication_date":"2005-11-16","ids":{"openalex":"https://openalex.org/W2558038482","doi":"https://doi.org/10.1182/blood.v106.11.1772.1772","mag":"2558038482"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v106.11.1772.1772","doi":"https://doi.org/10.1182/blood.v106.11.1772.1772","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.1772.1772","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074209268","display_name":"Frank Kroschinsky","orcid":"https://orcid.org/0000-0002-4235-7580","observed_orcids":["https://orcid.org/0000-0002-4235-7580"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank P. Kroschinsky","raw_affiliation_strings":["Medical Dept I, University Hospital, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Dept I, University Hospital, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109182829","display_name":"Sybille Bergmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sybille Bergmann","raw_affiliation_strings":["Institute for Laboratory Medicine, University Hospital, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Laboratory Medicine, University Hospital, Dresden, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012418335","display_name":"Kirsten Poppe\u2010Thiede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirsten Poppe-Thiede","raw_affiliation_strings":["Medical Dept I, University Hospital, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Dept I, University Hospital, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037427703","display_name":"Gabriele Siegert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriele Siegert","raw_affiliation_strings":["Institute for Laboratory Medicine, University Hospital, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Laboratory Medicine, University Hospital, Dresden, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091390824","display_name":"Claudia Rutt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Rutt","raw_affiliation_strings":["German Bone Marrow Donor Center (DKMS), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Bone Marrow Donor Center (DKMS), Tuebingen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017002895","display_name":"Gerhard Ehninger","orcid":"https://orcid.org/0000-0003-0056-0422","observed_orcids":["https://orcid.org/0000-0003-0056-0422"]},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Ehninger","raw_affiliation_strings":["Medical Dept I, University Hospital, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Dept I, University Hospital, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31645646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"11","first_page":"1772","last_page":"1772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lenograstim","display_name":"lenograstim","score":0.7480000257492065},{"id":"https://openalex.org/keywords/bone-formation-markers","display_name":"bone formation markers","score":0.6919999718666077},{"id":"https://openalex.org/keywords/bone-resorption-markers","display_name":"bone resorption markers","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bone-specific-alkaline-phosphatase","display_name":"bone-specific alkaline phosphatase","score":0.7639999985694885},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.7070000171661377},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.6480000019073486},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/telopeptides","display_name":"telopeptides","score":0.7850000262260437},{"id":"https://openalex.org/keywords/deoxypyridinoline","display_name":"deoxypyridinoline","score":0.8999999761581421},{"id":"https://openalex.org/keywords/stem-cell-donors","display_name":"stem cell donors","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7466080188751221},{"id":"https://openalex.org/C2777371436","wikidata":"https://www.wikidata.org/wiki/Q3237071","display_name":"Leukapheresis","level":4,"score":0.7299512028694153},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.615167498588562},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5761754512786865},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.5378140211105347},{"id":"https://openalex.org/C2779171977","wikidata":"https://www.wikidata.org/wiki/Q3151081","display_name":"Filgrastim","level":4,"score":0.5157244801521301},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.505558967590332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49359285831451416},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.43600401282310486},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.4356977641582489},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3583239018917084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32439881563186646},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.20565462112426758},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1646915078163147},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.1586543321609497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12214097380638123},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.09947365522384644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v106.11.1772.1772","doi":"https://doi.org/10.1182/blood.v106.11.1772.1772","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v106.11.1772.1772","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061183320","https://openalex.org/W2054771515","https://openalex.org/W2324168559","https://openalex.org/W4233481492","https://openalex.org/W2084032150","https://openalex.org/W2100100879","https://openalex.org/W2118168943","https://openalex.org/W2979783564","https://openalex.org/W2774091514","https://openalex.org/W2325900563"],"abstract_inverted_index":{"Abstract":[0],"Short-term":[1],"treatment":[2,33,83,118,122,394],"with":[3,36,119,365],"granulocyte":[4],"colony-stimulating":[5],"factor":[6],"(G-CSF)":[7],"has":[8],"become":[9],"a":[10,105,177,312,330,340,410],"standard":[11],"procedure":[12],"for":[13,84,136,176,182,230],"the":[14,45,48,61,67,110,162,306,315,386,389,428,436,440,444,458,461,476],"mobilization":[15,382,462],"of":[16,50,70,88,124,148,165,179,293,296,305,317,333,362,378,391,412,439,447,460,467,478],"allogeneic":[17,399],"peripheral":[18],"blood":[19,149],"progenitor":[20],"cells":[21],"(PBPC)":[22],"in":[23,34,40,53,104,112,194,279,314,355,398,430,443],"healthy":[24],"donors.":[25,402],"While":[26],"osteopenia":[27],"was":[28,262,327,350],"observed":[29],"after":[30,171,248,424],"G-CSF":[31,41,82,324,392,425],"long-term":[32],"patients":[35],"chronic":[37],"neutropenia":[38],"and":[39,66,145,150,168,174,185,211,223,270,299,310,449,472,475],"overexpressing":[42],"animal":[43],"models,":[44],"information":[46],"about":[47],"effects":[49],"G-SCF":[51],"priming":[52],"PBPC":[54],"donors":[55,93,196,213,357,448],"is":[56,258,407],"limited.":[57],"Bone":[58],"pain":[59],"as":[60],"most":[62],"frequent":[63],"acute":[64],"toxicity":[65],"transient":[68,479],"increase":[69,332,343],"serum":[71,224],"alkaline":[72,220,253],"phosphatase":[73,221,254],"suggest":[74],"an":[75,376,455],"effect":[76],"on":[77,142,381,395,457],"bone":[78,113,183,186,219,231,363,396,414,468],"metabolism":[79,114,397,469],"also":[80,321],"during":[81],"mobilization.":[85],"A":[86],"total":[87],"93":[89],"unrelated":[90],"stem":[91,400],"cell":[92,189,401],"(21":[94],"female,":[95],"72":[96],"male;":[97],"median":[98],"age":[99],"35":[100],"years)":[101],"were":[102,140,152,191,198,214,320],"included":[103,199],"prospective":[106],"study":[107],"to":[108,237,242,264,285,346,418],"investigate":[109],"changes":[111,429],"induced":[115],"by":[116,260,323,329,409,470],"short-term":[117,393],"G-CSF.":[120],"Mobilization":[121],"consisted":[123],"7.5":[125],"\u03bcg/kg":[126],"body":[127],"weight":[128],"lenograstim":[129],"(Granocyte\u2122,":[130],"Chugai":[131],"Pharma":[132],"Inc.,":[133],"Tokyo,":[134],"Japan)":[135],"five":[137],"days.":[138],"Leukaphereses":[139],"performed":[141,193],"day":[143,164],"5":[144],"6.":[146],"Samples":[147],"urine":[151,280,431],"taken":[153],"at":[154,161,200,216,267,271,352,358],"pre-donation":[155],"health-check":[156],"(before":[157],"rhG-CSF":[158],"stimulation,":[159],"baseline),":[160],"first":[163,371],"apheresis":[166],"(leukapheresis)":[167],"four":[169],"weeks":[170,247,423],"donation":[172],"(follow-up)":[173],"tested":[175],"panel":[178],"biochemical":[180],"markers":[181,229,364],"formation":[184,232],"resorption.":[187],"Stem":[188],"collections":[190],"not":[192,374,420,453],"all":[195,356],"who":[197],"baseline,":[201],"therefore":[202,450],"data":[203],"from":[204,208,235,283,344],"leukapheresis":[205,238,268,347,372],"are":[206,227,303],"available":[207],"73":[209],"donors,":[210],"63":[212],"examined":[215],"follow-up.":[217,359],"Serum":[218,336],"(BAP)":[222],"ostase":[225],"which":[226,257,302,326,416],"both":[228],"significantly":[233,282],"increased":[234,281,413],"baseline":[236,243,284,345],"(p<0.0001).":[239],"Both":[240],"returned":[241],"values":[244],"within":[245,435],"4":[246,422],"donation.":[249],"In":[250,384],"contrast":[251],"tartrat-resistent":[252],"(TRAP)":[255],"5b,":[256],"produced":[259],"osteoclasts,":[261],"found":[263,351],"be":[265,419],"decreased":[266],"(p=0.001)":[269],"follow-up":[272,286],"(p=0.005).":[273],"The":[274,291,464],"collagen":[275],"type":[276],"I":[277],"crosslinks":[278],"(telopeptides":[287],"p=0.022;":[288],"deoxypyridinoline":[289],"p=0,012).":[290],"ligand":[292],"receptor":[294,308],"activator":[295],"NF-kB":[297],"(RANKL)":[298],"osteoprotergerin":[300],"(OPG),":[301],"members":[304],"TNF":[307],"family":[309],"play":[311],"role":[313],"regulation":[316,466],"osteoclast":[318],"recruitment":[319],"affected":[322],"treatment,":[325],"reflected":[328],"significant":[331,342],"OPG/RANKL-ratio":[334],"(p=0.01).":[335],"parathormon":[337],"(PTH)":[338],"showed":[339],"highly":[341],"(p<0.0001),":[348],"but":[349],"normal":[353,437],"ranges":[354,438],"Pearson\u2019s":[360],"correlation":[361],"circulating":[366],"CD34+":[367],"hematopoietic":[368],"progenitors":[369],"before":[370],"did":[373],"reveal":[375],"impact":[377,456],"these":[379],"parameters":[380],"efficacy.":[383],"conclusion":[385],"results":[387],"confirm":[388],"influence":[390],"An":[403],"initial":[404],"osteoblastic":[405],"stimulation":[406],"followed":[408],"period":[411],"resorption":[415],"seems":[417],"finished":[421],"treatment.":[426],"However,":[427],"crosslink":[432],"concentrations":[433],"occurred":[434],"used":[441],"assays":[442],"vast":[445],"majority":[446],"we":[451],"do":[452],"assume":[454],"safety":[459],"procedure.":[463],"complex":[465],"humoral":[471],"cellular":[473],"effectors":[474],"cause":[477],"hyperparathyroidism":[480],"need":[481],"further":[482],"investigations.":[483]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-12-08T00:00:00"}