{"id":"https://openalex.org/W2558024485","doi":"https://doi.org/10.1182/blood.v104.11.918.918","title":"Prospective Study of Immunomodulation with GM-CSF, IL-2, and Rituximab Following Autologous Stem Cell Transplant (SCT) in Patients with Relapsed Lymphomas.","display_name":"Prospective Study of Immunomodulation with GM-CSF, IL-2, and Rituximab Following Autologous Stem Cell Transplant (SCT) in Patients with Relapsed Lymphomas.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2558024485","doi":"https://doi.org/10.1182/blood.v104.11.918.918","mag":"2558024485"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.918.918","doi":"https://doi.org/10.1182/blood.v104.11.918.918","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.918.918","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005159945","display_name":"Sonali M. Smith","orcid":"https://orcid.org/0000-0002-9893-4949","observed_orcids":["https://orcid.org/0000-0002-9893-4949"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonali M. Smith","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020140533","display_name":"David L. Grinblatt","orcid":"https://orcid.org/0000-0002-2118-0042","observed_orcids":["https://orcid.org/0000-0002-2118-0042"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Grinblatt","raw_affiliation_strings":["Northwestern University, Evanston, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085317448","display_name":"Thomas Frank Gajewski","orcid":"https://orcid.org/0000-0001-5727-3972","observed_orcids":["https://orcid.org/0000-0001-5727-3972"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Gajewski","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010577942","display_name":"Helena Harlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helena Harlin","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003362535","display_name":"Karen Welborne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Welborne","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036548279","display_name":"Kathy Conner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathy Conner","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072420982","display_name":"Richard A. Larson","orcid":"https://orcid.org/0000-0001-9168-3203","observed_orcids":["https://orcid.org/0000-0001-9168-3203"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Larson","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028012131","display_name":"Elizabeth Shima Rich","orcid":"https://orcid.org/0000-0002-3322-5359","observed_orcids":["https://orcid.org/0000-0002-3322-5359"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Rich","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060015628","display_name":"Olatoyosi M. Odenike","orcid":"https://orcid.org/0000-0002-4027-4124","observed_orcids":["https://orcid.org/0000-0002-4027-4124"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olatoyosi Odenike","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111920307","display_name":"Todd M. Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Zimmerman","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044134864","display_name":"Koen van Besien","orcid":"https://orcid.org/0000-0002-8164-6211","observed_orcids":["https://orcid.org/0000-0002-8164-6211"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koen van Besien","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010577942","https://openalex.org/A5036548279","https://openalex.org/A5085317448"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4246,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.68986371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"918","last_page":"918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-lymphoma","display_name":"relapsed lymphoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chemotherapy-induced-mobilization","display_name":"chemotherapy-induced mobilization","score":0.382999986410141},{"id":"https://openalex.org/keywords/beam-conditioning","display_name":"BEAM conditioning","score":0.7509999871253967},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.5540000200271606},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.6209999918937683},{"id":"https://openalex.org/keywords/post-transplant-maintenance","display_name":"post-transplant maintenance","score":0.40799999237060547},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.5830000042915344},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8319978713989258},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.806820809841156},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.7222801446914673},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.6539105772972107},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5708827972412109},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5182287693023682},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.5134085416793823},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4607656002044678},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4564533233642578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3231971263885498}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.918.918","doi":"https://doi.org/10.1182/blood.v104.11.918.918","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.918.918","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2062566755","https://openalex.org/W2167103668","https://openalex.org/W2084396664","https://openalex.org/W4238652745","https://openalex.org/W2761932222","https://openalex.org/W2748273929","https://openalex.org/W2094454764","https://openalex.org/W2094591637","https://openalex.org/W2109553227","https://openalex.org/W2488602574"],"abstract_inverted_index":{"Abstract":[0],"SCT":[1,321,440],"induces":[2],"durable":[3],"remissions":[4],"in":[5,22,62,91,260,264,269,325,422,494],"approximately":[6],"30\u201350%":[7],"of":[8,13,34,47,56,65,79,122,163,244,286,356,372,405,411,436,448,478,504,507],"patients":[9],"with":[10,195,274,426],"chemosensitive":[11,92],"relapse":[12,249],"large":[14,204],"B-cell":[15],"Hodgkin\u2019s":[16],"lymphoma.":[17,28,94],"Cure":[18],"rates":[19],"are":[20,323,416,420,498,517],"lower":[21],"recurrent":[23],"follicular":[24,215,275],"and":[25,74,113,130,176,190,228,267,322,388,393,418,465,486,492,500,516],"mantle":[26,210],"cell":[27,124,206,211,306],"Peri-transplant":[29],"rituximab":[30,81,154,177],"might":[31],"improve":[32],"duration":[33],"remission":[35],"somewhat,":[36],"due":[37,314,343],"to":[38,58,248,256,278,292,315,344],"purging":[39],"effects":[40],"on":[41],"stem":[42,123,305],"cells":[43,297],"and/or":[44,361],"by":[45,82,160],"elimination":[46],"minimal":[48],"residual":[49],"disease.":[50],"We":[51,69,87],"hypothesized":[52,71],"that":[53,72,303],"the":[54,77,311,326,331,357,439,466],"addition":[55],"GM-CSF":[57,73,107,132,164],"chemotherapy":[59],"priming":[60],"results":[61],"improved":[63],"mobilization":[64,103],"immunologic":[66,84],"effector":[67,85],"cells.":[68,86],"further":[70],"IL-2":[75,170,385],"enhance":[76],"efficacy":[78,503],"post-SCT":[80,333,339,358,479],"upregulating":[83],"studied":[88],"these":[89],"concepts":[90],"relapsed":[93,196],"The":[95,234,455,476],"treatment":[96,245,433],"regimen":[97,506],"was":[98,135,158,237,250,258],"as":[99,481],"follows:":[100],"1)":[101],"following":[102,127,453],"chemotherapy,":[104],"pts":[105,152,194,302,319,329,336,351,365,413],"received":[106,153,337,430],"200":[108],"mcg/m2/d":[109,134],"starting":[110,117,144,443],"day":[111,118,181],"+4":[112],"G-CSF":[114],"10":[115,261],"mcg/kg/day":[116],"+9":[119],"until":[120,139],"completion":[121],"apheresis;":[125],"2)":[126],"BEAM":[128],"conditioning":[129],"SCT,":[131],"250":[133],"started":[136,369],"d":[137,145],"+1":[138],"ANC":[140],">1500":[141],"cells/mL;":[142],"3)":[143],"30":[146],"(but":[147],"no":[148],"later":[149],"than":[150],"d120),":[151],"375":[155],"mg/m2.":[156],"This":[157],"followed":[159],"3":[161,270,350],"cycles":[162],"(250":[165],"mcg/d":[166],"SQ":[167,173],"days":[168,174,407,452,462],"1\u20135),":[169],"(1.5":[171],"MIU/m2/d":[172],"6\u201312),":[175],"(375":[178],"mg/m2":[179],"IV":[180,376],"9)":[182],"q":[183],"21":[184,318,412],"days.":[185],"Results:":[186],"Between":[187],"December":[188],"2001":[189],"July":[191],"2004,":[192],"24":[193],"lymphomas":[197],"were":[198,298],"enrolled.":[199],"Histologic":[200],"subtypes":[201],"include":[202,374],"diffuse":[203],"B":[205],"lymphoma":[207,212,216,220,225,231,276],"(11":[208],"pts),":[209,214,218,222,379],"(5":[213],"(3":[217,221],"Hodgkin":[219],"marginal":[223],"zone":[224],"(1":[226,232,383,391,399],"pt)":[227],"small":[229],"lymphocytic":[230],"pt).":[233,400],"median":[235,285,403,456,467],"age":[236],"46":[238],"yrs":[239],"(range,":[240,290,408,463],"21\u201366).":[241],"Median":[242],"number":[243],"regimens":[246,434],"prior":[247,255,432],"1(range":[251],"1\u20135).":[252],"Disease":[253],"status":[254],"transplant":[257],"CR/CRu":[259],"pts,":[262,266,283],"PR":[263],"8":[265],"SD":[268],"pts.":[271],"One":[272,424],"pt":[273,425],"failed":[277],"mobilize.":[279],"For":[280],"all":[281],"other":[282],"a":[284,394,402],"7.83":[287],"x":[288,294],"106":[289],"2.1":[291],"46.4":[293],"106)":[295],"CD34+":[296],"successfully":[299],"collected.":[300],"Two":[301],"had":[304,429],"collection":[307],"did":[308,352],"not":[309,353,367,471],"undergo":[310],"planned":[312],"HDT/SCT":[313,415],"disease":[316,450],"progression.":[317],"underwent":[320],"included":[324],"analysis.":[327,519],"9":[328],"completed":[330],"entire":[332],"immunotherapy,":[334],"7":[335],"incomplete":[338],"immunotherapy":[340,359,373],"(":[341],"4":[342],"toxicity,":[345],"2":[346,364],"noncompliance,":[347],"1":[348],"other)and":[349],"receive":[354],"any":[355],"(refusal":[360],"insurance":[362],"denial);":[363],"have":[366,513],"yet":[368,472],"immunotherapy.":[370,444,508],"Toxicities":[371],"grade":[375,380,395],"neutropenia":[377],"(2":[378],"III":[381],"thrombocytopenia":[382],"pt),":[384,392],"associated":[386],"hypotension":[387],"chest":[389],"pain":[390],"II":[396],"cutaneous":[397],"eruption":[398],"With":[401],"follow-up":[404],"365":[406],"113\u2013677),":[409],"19":[410],"undergoing":[414,518],"alive,":[417],"18":[419],"still":[421],"remission.":[423],"SLL":[427],"who":[428],"5":[431],"died":[435,447],"sepsis":[437],"after":[438],"but":[441],"before":[442],"Another":[445],"patient":[446],"progressive":[449],"581":[451],"SCT.":[454],"progression":[457],"free":[458],"survival":[459,469],"is":[460,484],"664":[461],"113\u2013669),":[464],"overall":[468],"has":[470],"been":[473,514],"reached.":[474],"Summary:":[475],"delivery":[477],"immunomodulation":[480],"described":[482],"above":[483],"feasible":[485],"relatively":[487],"well":[488],"tolerated.":[489],"Early":[490],"PFS":[491],"OS":[493],"this":[495,505],"ongoing":[496],"study":[497],"encouraging":[499],"suggest":[501],"therapeutic":[502],"Samples":[509],"for":[510],"correlative":[511],"studies":[512],"collected":[515]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}