{"id":"https://openalex.org/W2557915420","doi":null,"title":"Production of Cystatin C Wild Type and Stabilized Mutants.","display_name":"Production of Cystatin C Wild Type and Stabilized Mutants.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2557915420","mag":"2557915420","pmid":"https://pubmed.ncbi.nlm.nih.gov/27683345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4975236"},"language":"en","primary_location":{"id":"pmid:27683345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27683345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4975236/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109810845","display_name":"Joanna Pollak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Pollak","raw_affiliation_strings":["Department of Laboratory Medicine, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz , Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz , Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077766919","display_name":"Aneta Szyma\u0144ska","orcid":"https://orcid.org/0000-0002-8664-2041","observed_orcids":["https://orcid.org/0000-0002-8664-2041"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aneta Szymanska","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Chemistry, University of Gda\u0144sk , Gda\u0144sk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Chemistry, University of Gda\u0144sk , Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I40413290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102013890","display_name":"Veronica Lindstr\u00f6m","orcid":"https://orcid.org/0000-0002-7213-0264","observed_orcids":["https://orcid.org/0000-0002-7213-0264"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Veronica Lindstrom","raw_affiliation_strings":["Department of Clinical Chemistry and Pharmacology, Lund University , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Pharmacology, Lund University , Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052836792","display_name":"ANDERS O. GRUBB","orcid":"https://orcid.org/0000-0002-0125-3662","observed_orcids":["https://orcid.org/0000-0002-0125-3662"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Grubb","raw_affiliation_strings":["Department of Clinical Chemistry and Pharmacology, Lund University , Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Pharmacology, Lund University , Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"4","first_page":"166","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":1.0},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.9229999780654907},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.9470000267028809},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.7850000262260437},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dimerization","display_name":"dimerization","score":0.859000027179718},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.9121419787406921},{"id":"https://openalex.org/C2780412452","wikidata":"https://www.wikidata.org/wiki/Q4505907","display_name":"Cystatin","level":4,"score":0.7186641693115234},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.690115213394165},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6537395715713501},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.574979841709137},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5111427903175354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4705241918563843},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3990596532821655},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38497695326805115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35068583488464355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3187628388404846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1524849832057953},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:27683345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27683345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4975236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4975236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},{"id":"pmh:oai:lup.lub.lu.se:640ac852-1071-4ed3-b7de-ccfdca16f689","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/640ac852-1071-4ed3-b7de-ccfdca16f689","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1650-3414","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2557915420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27683345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4975236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4975236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1496215511","https://openalex.org/W1860073488","https://openalex.org/W1965846111","https://openalex.org/W1967325819","https://openalex.org/W1981832221","https://openalex.org/W1985388329","https://openalex.org/W1998096679","https://openalex.org/W2038556994","https://openalex.org/W2039502252","https://openalex.org/W2045331904","https://openalex.org/W2078566578","https://openalex.org/W2079893739","https://openalex.org/W2082429191","https://openalex.org/W2084786578","https://openalex.org/W2090586240","https://openalex.org/W2095238968","https://openalex.org/W2154359351","https://openalex.org/W4240929891"],"related_works":["https://openalex.org/W1997834560","https://openalex.org/W7015738335","https://openalex.org/W2417996824","https://openalex.org/W1985388329","https://openalex.org/W2101438304","https://openalex.org/W3146551259","https://openalex.org/W2159391891","https://openalex.org/W1967325819","https://openalex.org/W834556212","https://openalex.org/W2158339579"],"abstract_inverted_index":{"Cystatin":[0],"C":[1,63,74,83],"is":[2],"produced":[3],"in":[4,21,37,78,97],"all":[5],"nucleated":[6],"cells.":[7],"It":[8],"has":[9],"various":[10],"functions":[11],"and":[12,46,53,58,64,89],"biological":[13],"activities.":[14],"Researchers":[15],"are":[16],"focused":[17],"on":[18],"its":[19],"role":[20],"kidney":[22],"diseases":[23],"as":[24,32,92,94],"a":[25,33,95],"marker":[26],"of":[27,39,48,60,68,87],"glomerular":[28],"filtration":[29],"but":[30],"also":[31],"very":[34],"important":[35],"link":[36],"development":[38],"amyloid":[40],"diseases.":[41],"This":[42],"work":[43],"describes":[44],"expression":[45],"purification":[47],"both":[49],"wild":[50],"type":[51],"(wt)":[52],"stabilized":[54],"form":[55],"(stab":[56],"1":[57],"2)":[59],"wt":[61],"cystatin":[62,69,73,82],"amyloid-forming":[65],"L68Q":[66],"mutant":[67],"C.":[70],"The":[71],"recombinant":[72],"can":[75],"be":[76],"used":[77],"projects":[79],"requiring":[80],"pure":[81],"to":[84],"examine":[85],"models":[86],"dimerization":[88],"fibrils":[90],"formation":[91],"well":[93],"standard":[96],"clinical":[98],"tests.":[99]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-12-08T00:00:00"}
